{"id":"https://openalex.org/W4412511751","doi":"https://doi.org/10.1002/jcp.70065","title":"The Role of Transient Receptor Potential Canonical 3 (TRPC3) in Wound Healing","display_name":"The Role of Transient Receptor Potential Canonical 3 (TRPC3) in Wound Healing","publication_year":2025,"publication_date":"2025-07-01","ids":{"openalex":"https://openalex.org/W4412511751","doi":"https://doi.org/10.1002/jcp.70065","pmid":"https://pubmed.ncbi.nlm.nih.gov/40685953"},"language":"en","primary_location":{"id":"doi:10.1002/jcp.70065","doi":"https://doi.org/10.1002/jcp.70065","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.70065","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040061977","display_name":"Rima B. Patel","orcid":"https://orcid.org/0000-0001-9048-312X","observed_orcids":["https://orcid.org/0000-0001-9048-312X"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rima Patel","raw_affiliation_strings":["Department of Physiology, College of Medicine University of Tennessee Health Science Center Memphis TN USA"],"raw_orcid":"https://orcid.org/0000-0001-9048-312X","affiliations":[{"raw_affiliation_string":"Department of Physiology, College of Medicine University of Tennessee Health Science Center Memphis TN USA","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119021680","display_name":"Lily Waltz","orcid":"https://orcid.org/0000-0003-1884-4204","observed_orcids":["https://orcid.org/0000-0003-1884-4204"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lily Waltz","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Medicine University of Tennessee Health Science Center Memphis TN USA","Department of Pharmacology Addiction Science and Toxicology, College of Medicine University of Tennessee Health Science Center Memphis TN USA"],"raw_orcid":"https://orcid.org/0000-0003-1884-4204","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Medicine University of Tennessee Health Science Center Memphis TN USA","institution_ids":["https://openalex.org/I160606119"]},{"raw_affiliation_string":"Department of Pharmacology Addiction Science and Toxicology, College of Medicine University of Tennessee Health Science Center Memphis TN USA","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113459316","display_name":"Gemma Toogood","orcid":"https://orcid.org/0009-0008-0281-0986","observed_orcids":["https://orcid.org/0009-0008-0281-0986"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gemma Toogood","raw_affiliation_strings":["Department of Physiology, College of Medicine University of Tennessee Health Science Center Memphis TN USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, College of Medicine University of Tennessee Health Science Center Memphis TN USA","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100318325","display_name":"W\u011bi Li","orcid":"https://orcid.org/0000-0002-9522-4474","observed_orcids":["https://orcid.org/0000-0002-9522-4474","https://orcid.org/0000-0003-4136-3409","https://orcid.org/0009-0009-9141-6389"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wei Li","raw_affiliation_strings":["Department of Pharmaceutical Sciences, College of Medicine University of Tennessee Health Science Center Memphis TN USA"],"raw_orcid":"https://orcid.org/0000-0002-9522-4474","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, College of Medicine University of Tennessee Health Science Center Memphis TN USA","institution_ids":["https://openalex.org/I160606119"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100737479","display_name":"Junwang Xu","orcid":"https://orcid.org/0000-0001-7905-8915","observed_orcids":["https://orcid.org/0000-0001-7905-8915"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Junwang Xu","raw_affiliation_strings":["Department of Physiology, College of Medicine University of Tennessee Health Science Center Memphis TN USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, College of Medicine University of Tennessee Health Science Center Memphis TN USA","institution_ids":["https://openalex.org/I160606119"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100318325","https://openalex.org/A5100737479"],"corresponding_institution_ids":["https://openalex.org/I160606119"],"apc_list":{"value":5230,"currency":"USD","value_usd":5230},"apc_paid":null,"fwci":0.5698,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.45121951,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"240","issue":"7","first_page":"e70065","last_page":"e70065"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.6406000256538391,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.6406000256538391,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.3490999937057495,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trpc3","display_name":"TRPC3","score":1.0},{"id":"https://openalex.org/keywords/transient-receptor-potential-channels","display_name":"TRP channels","score":0.7720000147819519},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.9829999804496765},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chronic-wounds","display_name":"chronic wounds","score":0.7940000295639038},{"id":"https://openalex.org/keywords/diabetic-ulcers","display_name":"diabetic ulcers","score":0.9950000047683716},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.8809999823570251},{"id":"https://openalex.org/keywords/tissue-repair","display_name":"tissue repair","score":0.5720000267028809},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.531000018119812},{"id":"https://openalex.org/keywords/cell-proliferation-and-migration","display_name":"cell proliferation and migration","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C155164980","wikidata":"https://www.wikidata.org/wiki/Q304043","display_name":"Transient receptor potential channel","level":3,"score":0.8033711910247803},{"id":"https://openalex.org/C2780383360","wikidata":"https://www.wikidata.org/wiki/Q15322900","display_name":"TRPC3","level":5,"score":0.7107571363449097},{"id":"https://openalex.org/C3018844941","wikidata":"https://www.wikidata.org/wiki/Q6718887","display_name":"Non canonical","level":2,"score":0.6629328727722168},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.6517088413238525},{"id":"https://openalex.org/C2780799671","wikidata":"https://www.wikidata.org/wiki/Q17087362","display_name":"Transient (computer programming)","level":2,"score":0.5527700781822205},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3801421523094177},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3769395649433136},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3730488419532776},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34283190965652466},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33592545986175537},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.26866453886032104},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17266103625297546},{"id":"https://openalex.org/C170488646","wikidata":"https://www.wikidata.org/wiki/Q7671459","display_name":"TRPC","level":4,"score":0.05398145318031311},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050052","descriptor_name":"TRPC Cation Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050052","descriptor_name":"TRPC Cation Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/jcp.70065","doi":"https://doi.org/10.1002/jcp.70065","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.70065","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},{"id":"pmid:40685953","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40685953","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3641565321","display_name":"The role of long non-coding RNA GAS5 in diabetic wounds","funder_award_id":"R01GM128660","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000872596","display_name":"Targeting TRPC3 Channels for Epileptic Seizures","funder_award_id":"R33NS124923","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W1493270913","https://openalex.org/W1904795858","https://openalex.org/W1930588275","https://openalex.org/W1934528477","https://openalex.org/W1963793057","https://openalex.org/W1999920289","https://openalex.org/W2003340858","https://openalex.org/W2017253185","https://openalex.org/W2042342392","https://openalex.org/W2045670036","https://openalex.org/W2047067845","https://openalex.org/W2056064788","https://openalex.org/W2056274427","https://openalex.org/W2064169979","https://openalex.org/W2070166908","https://openalex.org/W2087104781","https://openalex.org/W2122373218","https://openalex.org/W2123823383","https://openalex.org/W2124964548","https://openalex.org/W2126469092","https://openalex.org/W2127903487","https://openalex.org/W2133496985","https://openalex.org/W2134094618","https://openalex.org/W2141600581","https://openalex.org/W2154262877","https://openalex.org/W2168924147","https://openalex.org/W2253619901","https://openalex.org/W2406725033","https://openalex.org/W2517674795","https://openalex.org/W2518970279","https://openalex.org/W2558500810","https://openalex.org/W2562021066","https://openalex.org/W2564817594","https://openalex.org/W2570895916","https://openalex.org/W2735913246","https://openalex.org/W2736827087","https://openalex.org/W2771457674","https://openalex.org/W2792199596","https://openalex.org/W2796273293","https://openalex.org/W2801190461","https://openalex.org/W2884899306","https://openalex.org/W2901627449","https://openalex.org/W2919210669","https://openalex.org/W2924358453","https://openalex.org/W2941335149","https://openalex.org/W2947124803","https://openalex.org/W2994957157","https://openalex.org/W2999006542","https://openalex.org/W3003046396","https://openalex.org/W3003857551","https://openalex.org/W3004139788","https://openalex.org/W3006093013","https://openalex.org/W3009847683","https://openalex.org/W3018267877","https://openalex.org/W3091175966","https://openalex.org/W3105715144","https://openalex.org/W3106125810","https://openalex.org/W3169192468","https://openalex.org/W3175916258","https://openalex.org/W3185796936","https://openalex.org/W3194734729","https://openalex.org/W3206629031","https://openalex.org/W3214315607","https://openalex.org/W4229000673","https://openalex.org/W4286490573","https://openalex.org/W4292998399","https://openalex.org/W4293367346","https://openalex.org/W4296251990","https://openalex.org/W4296268835","https://openalex.org/W4317698859","https://openalex.org/W4366993103","https://openalex.org/W4384627205","https://openalex.org/W4386293767","https://openalex.org/W4387902845","https://openalex.org/W4392709588","https://openalex.org/W4393255425","https://openalex.org/W4401522130","https://openalex.org/W4408398940","https://openalex.org/W4410591077"],"related_works":["https://openalex.org/W4399863290","https://openalex.org/W4409975216","https://openalex.org/W2007175311","https://openalex.org/W7214214881","https://openalex.org/W3009847683","https://openalex.org/W4291396191","https://openalex.org/W4317745828","https://openalex.org/W7163158553","https://openalex.org/W2608978822","https://openalex.org/W2746679593"],"abstract_inverted_index":{"Wound":[0],"healing":[1,19],"is":[2],"a":[3,33,62,148,189],"complex,":[4],"highly":[5],"orchestrated":[6],"process":[7],"involving":[8],"distinct":[9],"yet":[10],"overlapping":[11],"phases:":[12],"hemostasis,":[13],"inflammation,":[14],"proliferation,":[15,43],"and":[16,23,44,91,117,132,171,199],"remodeling.":[17],"Effective":[18],"requires":[20],"precise":[21],"cellular":[22,38,94],"molecular":[24],"interactions":[25],"across":[26],"these":[27],"phases,":[28],"with":[29],"calcium":[30,48,89],"signaling":[31,123],"playing":[32],"pivotal":[34],"role":[35,107,195],"in":[36,110,162,181,196,203],"modulating":[37],"responses":[39,95],"such":[40,113],"as":[41,61,114,147],"migration,":[42],"differentiation.":[45],"Among":[46],"the":[47,51,74,92,105,142,166,172],"channels":[49],"involved,":[50],"Transient":[52],"Receptor":[53],"Potential":[54],"Canonical":[55],"(TRPC)":[56],"family,":[57],"particularly":[58],"TRPC3,":[59],"emerged":[60],"key":[63],"modulator":[64],"of":[65,77,82,88,108,144,168,174,192],"wound":[66,83,126,154,182,197],"repair":[67,198],"processes.":[68],"In":[69],"this":[70],"review,":[71],"we":[72,140,157],"explore":[73],"dynamic":[75],"contributions":[76],"TRPC3":[78,109,122,146],"to":[79,129,151,177,187],"each":[80],"phase":[81],"healing,":[84,127],"highlighting":[85],"its":[86,200],"regulation":[87],"fluxes":[90],"downstream":[93],"critical":[96],"for":[97],"effective":[98],"tissue":[99],"repair.":[100],"We":[101],"will":[102,158],"further":[103],"discuss":[104,159],"altered":[106],"pathological":[111],"conditions,":[112],"chronic":[115],"wounds":[116],"diabetic":[118],"ulcers,":[119],"where":[120],"aberrant":[121],"disrupts":[124],"normal":[125,153],"contributing":[128],"impaired":[130],"resolution":[131],"fibrosis.":[133],"By":[134],"summarizing":[135],"findings":[136],"from":[137],"recent":[138],"studies,":[139],"underscore":[141],"potential":[143,202],"targeting":[145],"therapeutic":[149,201],"strategy":[150],"restore":[152],"healing.":[155],"Finally,":[156],"future":[160],"directions":[161],"TRPC3-targeted":[163],"interventions,":[164],"including":[165],"development":[167],"selective":[169],"modulators":[170],"use":[173],"TRPC3-targeting":[175],"therapy,":[176],"address":[178],"unmet":[179],"needs":[180],"care.":[183],"This":[184],"review":[185],"aims":[186],"provide":[188],"comprehensive":[190],"overview":[191],"TRPC3's":[193],"multifaceted":[194],"regenerative":[204],"medicine.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}