{"id":"https://openalex.org/W4412506550","doi":"https://doi.org/10.1021/acsami.5c09445","title":"Ocular Soluble Microneedle Patch Loaded with Immunogenic Cell Death Inducer PKHB1 Peptide for Alleviating Herpes Simplex Keratitis","display_name":"Ocular Soluble Microneedle Patch Loaded with Immunogenic Cell Death Inducer PKHB1 Peptide for Alleviating Herpes Simplex Keratitis","publication_year":2025,"publication_date":"2025-07-21","ids":{"openalex":"https://openalex.org/W4412506550","doi":"https://doi.org/10.1021/acsami.5c09445","pmid":"https://pubmed.ncbi.nlm.nih.gov/40685578"},"language":"en","primary_location":{"id":"doi:10.1021/acsami.5c09445","doi":"https://doi.org/10.1021/acsami.5c09445","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsami.5c09445","pdf_url":null,"source":{"id":"https://openalex.org/S164001016","display_name":"ACS Applied Materials & Interfaces","issn_l":"1944-8244","issn":["1944-8244","1944-8252"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-2","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Materials &amp; Interfaces","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101653006","display_name":"Yun He","orcid":"https://orcid.org/0000-0003-1145-3833","observed_orcids":["https://orcid.org/0000-0003-1145-3833"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun He","raw_affiliation_strings":["Department of Burns and Plastic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School","Department of Ophthalmology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School","Nanjing University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burns and Plastic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School","institution_ids":["https://openalex.org/I4210111013"]},{"raw_affiliation_string":"Department of Ophthalmology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School","institution_ids":["https://openalex.org/I4210111013"]},{"raw_affiliation_string":"Nanjing University","institution_ids":["https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100366446","display_name":"Di Zhang","orcid":"https://orcid.org/0009-0001-8301-2538","observed_orcids":["https://orcid.org/0009-0001-8301-2538"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Di Zhang","raw_affiliation_strings":["Department of Ophthalmology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School","Nanjing University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School","institution_ids":["https://openalex.org/I4210111013"]},{"raw_affiliation_string":"Nanjing University","institution_ids":["https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010922735","display_name":"Jiao Liu","orcid":"https://orcid.org/0000-0002-8485-8332","observed_orcids":["https://orcid.org/0000-0002-8485-8332"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiao Liu","raw_affiliation_strings":["Department of Ophthalmology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School","Nanjing University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School","institution_ids":["https://openalex.org/I4210111013"]},{"raw_affiliation_string":"Nanjing University","institution_ids":["https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103887829","display_name":"Junwen Ouyang","orcid":"https://orcid.org/0009-0006-4860-4876","observed_orcids":["https://orcid.org/0009-0006-4860-4876"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junwen Ouyang","raw_affiliation_strings":["Department of Ophthalmology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School","Nanjing University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School","institution_ids":["https://openalex.org/I4210111013"]},{"raw_affiliation_string":"Nanjing University","institution_ids":["https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115595640","display_name":"Chengxiao Zhang","orcid":"https://orcid.org/0009-0001-1689-506X","observed_orcids":["https://orcid.org/0009-0001-1689-506X"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengxiao Zhang","raw_affiliation_strings":["Department of Ophthalmology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School","Nanjing University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School","institution_ids":["https://openalex.org/I4210111013"]},{"raw_affiliation_string":"Nanjing University","institution_ids":["https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028785687","display_name":"Qian Tan","orcid":"https://orcid.org/0000-0001-7710-7082","observed_orcids":["https://orcid.org/0000-0001-7710-7082"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qian Tan","raw_affiliation_strings":["Department of Burns and Plastic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School","Nanjing University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Burns and Plastic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School","institution_ids":["https://openalex.org/I4210111013"]},{"raw_affiliation_string":"Nanjing University","institution_ids":["https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063281600","display_name":"Jiaxuan Jiang","orcid":"https://orcid.org/0000-0002-7889-5209","observed_orcids":["https://orcid.org/0000-0002-7889-5209"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiaxuan Jiang","raw_affiliation_strings":["Department of Ophthalmology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School","Nanjing University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School","institution_ids":["https://openalex.org/I4210111013"]},{"raw_affiliation_string":"Nanjing University","institution_ids":["https://openalex.org/I881766915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103392724","display_name":"Kai Hu","orcid":"https://orcid.org/0000-0001-6340-6057","observed_orcids":["https://orcid.org/0000-0001-6340-6057"]},"institutions":[{"id":"https://openalex.org/I4210111013","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210111013"]},{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Kai Hu","raw_affiliation_strings":["Department of Ophthalmology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School","Nanjing University"],"raw_orcid":"https://orcid.org/0000-0001-6340-6057","affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School","institution_ids":["https://openalex.org/I4210111013"]},{"raw_affiliation_string":"Nanjing University","institution_ids":["https://openalex.org/I881766915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5028785687","https://openalex.org/A5063281600","https://openalex.org/A5103392724"],"corresponding_institution_ids":["https://openalex.org/I4210111013","https://openalex.org/I881766915"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.0811,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.86433292,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"17","issue":"30","first_page":"42824","last_page":"42837"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.6606000065803528,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.6606000065803528,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.27559998631477356,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.020600000396370888,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/herpes-simplex-keratitis","display_name":"herpes simplex keratitis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/immunogenic-cell-death","display_name":"immunogenic cell death","score":0.9940000176429749},{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-1","display_name":"herpes simplex virus type 1","score":0.859000027179718},{"id":"https://openalex.org/keywords/ocular-drug-delivery","display_name":"ocular drug delivery","score":0.8790000081062317},{"id":"https://openalex.org/keywords/antigen-presenting-cells","display_name":"antigen-presenting cells","score":0.9760000109672546},{"id":"https://openalex.org/keywords/hsv-1-replication","display_name":"HSV-1 replication","score":0.7549999952316284},{"id":"https://openalex.org/keywords/anterior-segment-diseases","display_name":"anterior segment diseases","score":0.6079999804496765}],"concepts":[{"id":"https://openalex.org/C2778560704","wikidata":"https://www.wikidata.org/wiki/Q757838","display_name":"Keratitis","level":2,"score":0.7247549891471863},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.679186999797821},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6755819320678711},{"id":"https://openalex.org/C2225953","wikidata":"https://www.wikidata.org/wiki/Q1661899","display_name":"Inducer","level":3,"score":0.6643189191818237},{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.4402337670326233},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.2977430820465088},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2643832266330719},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16452446579933167},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.15733826160430908},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14593005180358887},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.07254195213317871},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009339","descriptor_name":"Needles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009339","descriptor_name":"Needles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016849","descriptor_name":"Keratitis, Herpetic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016849","descriptor_name":"Keratitis, Herpetic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016849","descriptor_name":"Keratitis, Herpetic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016849","descriptor_name":"Keratitis, Herpetic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016849","descriptor_name":"Keratitis, Herpetic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016849","descriptor_name":"Keratitis, Herpetic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018259","descriptor_name":"Herpesvirus 1, Human","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018259","descriptor_name":"Herpesvirus 1, Human","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acsami.5c09445","doi":"https://doi.org/10.1021/acsami.5c09445","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsami.5c09445","pdf_url":null,"source":{"id":"https://openalex.org/S164001016","display_name":"ACS Applied Materials & Interfaces","issn_l":"1944-8244","issn":["1944-8244","1944-8252"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-2","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Materials &amp; Interfaces","raw_type":"journal-article"},{"id":"pmid:40685578","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40685578","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS applied materials & interfaces","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7099999785423279,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2291893289","display_name":null,"funder_award_id":"BK20241725","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"},{"id":"https://openalex.org/G3443971679","display_name":null,"funder_award_id":"81870695","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5223194690","display_name":null,"funder_award_id":"BK20201114","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"},{"id":"https://openalex.org/G6676039032","display_name":null,"funder_award_id":"YKK21095","funder_id":"https://openalex.org/F4320325407","funder_display_name":"Nanjing Municipal Health Bureau"},{"id":"https://openalex.org/G7585744442","display_name":null,"funder_award_id":"2022-LCYJ-MS-36","funder_id":"https://openalex.org/F4320330237","funder_display_name":"Nanjing Drum Tower Hospital"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322769","display_name":"Natural Science Foundation of Jiangsu Province","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320325407","display_name":"Nanjing Municipal Health Bureau","ror":"https://ror.org/0067hwx77"},{"id":"https://openalex.org/F4320330237","display_name":"Nanjing Drum Tower Hospital","ror":"https://ror.org/026axqv54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W2103323325","https://openalex.org/W2499467511","https://openalex.org/W2793077245","https://openalex.org/W2793745928","https://openalex.org/W2896384067","https://openalex.org/W2897491969","https://openalex.org/W2899970640","https://openalex.org/W2900833416","https://openalex.org/W2980894837","https://openalex.org/W3011642937","https://openalex.org/W3020058005","https://openalex.org/W3029335665","https://openalex.org/W3039670164","https://openalex.org/W3091423606","https://openalex.org/W3099500949","https://openalex.org/W3118886838","https://openalex.org/W3119803887","https://openalex.org/W3165115954","https://openalex.org/W3170112522","https://openalex.org/W3195911684","https://openalex.org/W3203664410","https://openalex.org/W4205238879","https://openalex.org/W4211133027","https://openalex.org/W4220686130","https://openalex.org/W4226114945","https://openalex.org/W4226411874","https://openalex.org/W4280606798","https://openalex.org/W4297255902","https://openalex.org/W4309288196","https://openalex.org/W4309610061","https://openalex.org/W4310482437","https://openalex.org/W4386531277","https://openalex.org/W4388837378","https://openalex.org/W4392671817","https://openalex.org/W4399880087","https://openalex.org/W4399947190","https://openalex.org/W4400999028","https://openalex.org/W4404514447"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2019580555","https://openalex.org/W2410647555","https://openalex.org/W2057088712","https://openalex.org/W2132518213","https://openalex.org/W4404995717","https://openalex.org/W2016187641","https://openalex.org/W2752583934","https://openalex.org/W1199680426","https://openalex.org/W1992159633"],"abstract_inverted_index":{"Herpes":[0],"simplex":[1,13],"keratitis":[2],"(HSK)":[3],"is":[4,50],"a":[5,42,69,89,139],"chronic,":[6],"sight-threatening":[7],"ocular":[8,47,123],"condition":[9],"caused":[10],"by":[11,53,121],"herpes":[12],"virus":[14,38],"type":[15],"1":[16],"(HSV-1).":[17],"Due":[18],"to":[19,35],"the":[20,31,37,81,109,151],"limited":[21],"efficacy":[22],"and":[23,104,130,147],"significant":[24],"side":[25],"effects":[26],"of":[27,60,80,96,153],"current":[28],"treatments,":[29],"enhancing":[30],"host\u2019s":[32],"immune":[33],"response":[34],"clear":[36],"has":[39],"emerged":[40],"as":[41],"promising":[43],"therapeutic":[44],"strategy.":[45],"However,":[46],"drug":[48,100],"delivery":[49,79],"often":[51],"hindered":[52],"physiological":[54],"barriers,":[55],"resulting":[56],"in":[57],"low":[58],"bioavailability":[59],"topical":[61],"eye":[62],"drops.":[63],"To":[64],"address":[65],"this,":[66],"we":[67],"developed":[68],"hyaluronic":[70],"acid":[71],"methacryloyl-based":[72],"soluble":[73],"microneedle":[74],"(MN)":[75],"patch":[76,137],"for":[77,93,144,150],"targeted":[78],"immunogenic":[82],"cell":[83],"death":[84],"inducer":[85],"PKHB1":[86],"peptide,":[87],"offering":[88],"novel":[90],"treatment":[91],"approach":[92],"HSK.":[94],"Characterization":[95],"PKHB1-MNs":[97,113],"demonstrated":[98],"sustained":[99],"release,":[101],"high":[102],"bioavailability,":[103],"favorable":[105],"biosafety":[106],"profiles.":[107],"In":[108],"HSK":[110,146],"mouse":[111],"model,":[112],"enhanced":[114],"CD8":[115],"+":[116],"T":[117],"cell-mediated":[118],"adaptive":[119],"immunity":[120],"modulating":[122],"antigen-presenting":[124],"cells,":[125],"thereby":[126],"reducing":[127],"HSV-1":[128],"replication":[129],"effectively":[131],"alleviating":[132],"HSK-induced":[133],"lesions.":[134],"The":[135],"MN":[136],"represents":[138],"promising,":[140],"minimally":[141],"invasive":[142],"strategy":[143],"treating":[145],"holds":[148],"potential":[149],"management":[152],"other":[154],"anterior":[155],"segment":[156],"diseases.":[157]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-02T10:15:12.560889","created_date":"2025-10-10T00:00:00"}
