{"id":"https://openalex.org/W4412480573","doi":"https://doi.org/10.1016/j.semarthrit.2025.152794","title":"Genome-wide association study for loci associated with positive antinuclear antibodies","display_name":"Genome-wide association study for loci associated with positive antinuclear antibodies","publication_year":2025,"publication_date":"2025-07-16","ids":{"openalex":"https://openalex.org/W4412480573","doi":"https://doi.org/10.1016/j.semarthrit.2025.152794","pmid":"https://pubmed.ncbi.nlm.nih.gov/40706259"},"language":"en","primary_location":{"id":"doi:10.1016/j.semarthrit.2025.152794","doi":"https://doi.org/10.1016/j.semarthrit.2025.152794","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.semarthrit.2025.152794","pdf_url":null,"source":{"id":"https://openalex.org/S140349950","display_name":"Seminars in Arthritis and Rheumatism","issn_l":"0049-0172","issn":["0049-0172","1532-866X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Arthritis and Rheumatism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069114837","display_name":"Jing Cui","orcid":"https://orcid.org/0000-0001-8657-1741","observed_orcids":["https://orcid.org/0000-0001-8657-1741"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jing Cui","raw_affiliation_strings":["Department of Medicine, Division of Rheumatology, Inflammation, and Immunity, Section of Clinical Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: jcui@bwh.harvard.edu"],"raw_orcid":"https://orcid.org/0000-0001-8657-1741","affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Rheumatology, Inflammation, and Immunity, Section of Clinical Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: jcui@bwh.harvard.edu","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051251200","display_name":"Jeong Yee","orcid":"https://orcid.org/0000-0001-8439-143X","observed_orcids":["https://orcid.org/0000-0001-8439-143X"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Jeong Yee","raw_affiliation_strings":["Department of Medicine, Division of Rheumatology, Inflammation, and Immunity, Section of Clinical Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; School of Pharmacy, Sungkyunkwan University, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Rheumatology, Inflammation, and Immunity, Section of Clinical Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; School of Pharmacy, Sungkyunkwan University, Seoul, South Korea","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984","https://openalex.org/I848706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003836713","display_name":"Hongshu Guan","orcid":"https://orcid.org/0000-0003-2158-5805","observed_orcids":["https://orcid.org/0000-0003-2158-5805"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongshu Guan","raw_affiliation_strings":["Department of Medicine, Division of Rheumatology, Inflammation, and Immunity, Section of Clinical Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Rheumatology, Inflammation, and Immunity, Section of Clinical Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001481488","display_name":"Jack Ellrodt","orcid":"https://orcid.org/0000-0002-5157-5707","observed_orcids":["https://orcid.org/0000-0002-5157-5707"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jack Ellrodt","raw_affiliation_strings":["Department of Medicine, Division of Rheumatology, Inflammation, and Immunity, Section of Clinical Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; University of New England, College of Osteopathic Medicine, Portland, ME, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Rheumatology, Inflammation, and Immunity, Section of Clinical Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; University of New England, College of Osteopathic Medicine, Portland, ME, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064215101","display_name":"Emily G. Oakes","orcid":"https://orcid.org/0000-0002-1701-6258","observed_orcids":["https://orcid.org/0000-0002-1701-6258"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily G. Oakes","raw_affiliation_strings":["Department of Medicine, Division of Rheumatology, Inflammation, and Immunity, Section of Clinical Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Rheumatology, Inflammation, and Immunity, Section of Clinical Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050464646","display_name":"Liming Liang","orcid":"https://orcid.org/0000-0001-8261-3174","observed_orcids":["https://orcid.org/0000-0001-8261-3174"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liming Liang","raw_affiliation_strings":["Department of Genetics, Harvard TH Chan School of Public Health, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Harvard TH Chan School of Public Health, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086351530","display_name":"Karen H. Costenbader","orcid":"https://orcid.org/0000-0002-8972-9388","observed_orcids":["https://orcid.org/0000-0002-8972-9388","https://orcid.org/0000-0002-5104-7672"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen H. Costenbader","raw_affiliation_strings":["Department of Medicine, Division of Rheumatology, Inflammation, and Immunity, Section of Clinical Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Rheumatology, Inflammation, and Immunity, Section of Clinical Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5069114837"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"],"apc_list":{"value":4370,"currency":"USD","value_usd":4370},"apc_paid":null,"fwci":0.7228,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.71495489,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"74","issue":null,"first_page":"152794","last_page":"152794"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.01850000023841858,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antinuclear-antibodies","display_name":"antinuclear antibodies","score":0.9779999852180481},{"id":"https://openalex.org/keywords/ana-titer","display_name":"ANA titer","score":0.6869999766349792},{"id":"https://openalex.org/keywords/ana-patterns","display_name":"ANA patterns","score":0.7730000019073486},{"id":"https://openalex.org/keywords/hla-dqb1-0201","display_name":"HLA-DQB1*0201","score":0.8960000276565552},{"id":"https://openalex.org/keywords/hla-alleles","display_name":"HLA alleles","score":0.8090000152587891},{"id":"https://openalex.org/keywords/heritability","display_name":"heritability","score":0.734000027179718},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.6309999823570251},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.5730000138282776},{"id":"https://openalex.org/keywords/european-ancestry","display_name":"European ancestry","score":0.4970000088214874},{"id":"https://openalex.org/keywords/electronic-health-records","display_name":"electronic health records","score":0.621999979019165},{"id":"https://openalex.org/keywords/genotype-imputation","display_name":"genotype imputation","score":0.4189999997615814}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8972225189208984},{"id":"https://openalex.org/C149443304","wikidata":"https://www.wikidata.org/wiki/Q185390","display_name":"Anti-nuclear antibody","level":4,"score":0.8035346269607544},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.5470399260520935},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5199938416481018},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.47094547748565674},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36914604902267456},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2949996292591095},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.19653883576393127},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.19086509943008423},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.14279642701148987},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06934463977813721}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000974","descriptor_name":"Antibodies, Antinuclear","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000974","descriptor_name":"Antibodies, Antinuclear","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000974","descriptor_name":"Antibodies, Antinuclear","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.semarthrit.2025.152794","doi":"https://doi.org/10.1016/j.semarthrit.2025.152794","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.semarthrit.2025.152794","pdf_url":null,"source":{"id":"https://openalex.org/S140349950","display_name":"Seminars in Arthritis and Rheumatism","issn_l":"0049-0172","issn":["0049-0172","1532-866X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Arthritis and Rheumatism","raw_type":"journal-article"},{"id":"pmid:40706259","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40706259","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in arthritis and rheumatism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306998","display_name":"Lupus Foundation of America","ror":"https://ror.org/033b6cz88"},{"id":"https://openalex.org/F4320307776","display_name":"Merck","ror":"https://ror.org/02891sr49"},{"id":"https://openalex.org/F4320308573","display_name":"Gilead Sciences","ror":"https://ror.org/056546b03"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1501940489","https://openalex.org/W1970834742","https://openalex.org/W1980087924","https://openalex.org/W1985031981","https://openalex.org/W1985437611","https://openalex.org/W1990622566","https://openalex.org/W2019045080","https://openalex.org/W2021654061","https://openalex.org/W2030065155","https://openalex.org/W2033151532","https://openalex.org/W2060527750","https://openalex.org/W2073739597","https://openalex.org/W2075283457","https://openalex.org/W2076925862","https://openalex.org/W2078610240","https://openalex.org/W2109845269","https://openalex.org/W2119444539","https://openalex.org/W2139014118","https://openalex.org/W2161633633","https://openalex.org/W2163013660","https://openalex.org/W2166320441","https://openalex.org/W2168125177","https://openalex.org/W2173215630","https://openalex.org/W2242976516","https://openalex.org/W2275108065","https://openalex.org/W2400303083","https://openalex.org/W2510973425","https://openalex.org/W2591058303","https://openalex.org/W2617812311","https://openalex.org/W2740057279","https://openalex.org/W2922090728","https://openalex.org/W2982511147","https://openalex.org/W3049666243","https://openalex.org/W3138700587","https://openalex.org/W3203889005","https://openalex.org/W3216529606","https://openalex.org/W4206139296","https://openalex.org/W4206248777","https://openalex.org/W4283651323","https://openalex.org/W4403552922"],"related_works":["https://openalex.org/W4399483420","https://openalex.org/W1990622566","https://openalex.org/W4403552922","https://openalex.org/W4411295781","https://openalex.org/W2519219914","https://openalex.org/W4396936255","https://openalex.org/W1585213087","https://openalex.org/W4401886971","https://openalex.org/W2160661739","https://openalex.org/W7219800618"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-10-10T00:00:00"}
