{"id":"https://openalex.org/W4412467775","doi":"https://doi.org/10.15829/1728-8800-2025-4318","title":"Vulnerable plaques and lipid changes over statin therapy in patients with acute coronary syndrome. Initial data from the Combi-LLT ACS trial","display_name":"Vulnerable plaques and lipid changes over statin therapy in patients with acute coronary syndrome. Initial data from the Combi-LLT ACS trial","publication_year":2025,"publication_date":"2025-07-15","ids":{"openalex":"https://openalex.org/W4412467775","doi":"https://doi.org/10.15829/1728-8800-2025-4318"},"language":"en","primary_location":{"id":"doi:10.15829/1728-8800-2025-4318","doi":"https://doi.org/10.15829/1728-8800-2025-4318","is_oa":true,"landing_page_url":"https://doi.org/10.15829/1728-8800-2025-4318","pdf_url":null,"source":{"id":"https://openalex.org/S143907125","display_name":"CARDIOVASCULAR THERAPY AND PREVENTION","issn_l":"1728-8800","issn":["1728-8800","2619-0125"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","jufo-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312795","host_organization_name":"\u00abSILICEA-POLIGRAF\u00bb LLC","host_organization_lineage":["https://openalex.org/P4310312795"],"host_organization_lineage_names":["\u00abSILICEA-POLIGRAF\u00bb LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Therapy and Prevention","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.15829/1728-8800-2025-4318","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021598753","display_name":"\u0413. \u0420. \u0411\u0438\u043a\u0431\u0430\u0435\u0432\u0430","orcid":"https://orcid.org/0000-0002-6725-7180","observed_orcids":["https://orcid.org/0000-0002-6725-7180"]},"institutions":[{"id":"https://openalex.org/I4210127240","display_name":"Samara State Medical University","ror":"https://ror.org/02z5czc07","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210127240"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"G. R. Bikbaeva","raw_affiliation_strings":["Samara State Medical University;\r\nPolyakov Samara Regional Clinical Cardiology Dispensary"],"raw_orcid":"https://orcid.org/0000-0002-6725-7180","affiliations":[{"raw_affiliation_string":"Samara State Medical University;\r\nPolyakov Samara Regional Clinical Cardiology Dispensary","institution_ids":["https://openalex.org/I4210127240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018989882","display_name":"A. N. Kovalskaya","orcid":"https://orcid.org/0000-0003-4526-8003","observed_orcids":["https://orcid.org/0000-0003-4526-8003"]},"institutions":[{"id":"https://openalex.org/I4210127240","display_name":"Samara State Medical University","ror":"https://ror.org/02z5czc07","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210127240"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. N. Kovalskaya","raw_affiliation_strings":["Samara State Medical University"],"raw_orcid":"https://orcid.org/0000-0003-4526-8003","affiliations":[{"raw_affiliation_string":"Samara State Medical University","institution_ids":["https://openalex.org/I4210127240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022589773","display_name":"Kseniya Vyacheslavovna Kuznetsova","orcid":"https://orcid.org/0000-0002-0211-2108","observed_orcids":["https://orcid.org/0000-0002-0211-2108"]},"institutions":[{"id":"https://openalex.org/I4210127240","display_name":"Samara State Medical University","ror":"https://ror.org/02z5czc07","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210127240"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"K. V. Kuznetsova","raw_affiliation_strings":["Samara State Medical University;\r\nPolyakov Samara Regional Clinical Cardiology Dispensary"],"raw_orcid":"https://orcid.org/0000-0002-0211-2108","affiliations":[{"raw_affiliation_string":"Samara State Medical University;\r\nPolyakov Samara Regional Clinical Cardiology Dispensary","institution_ids":["https://openalex.org/I4210127240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068190562","display_name":"\u0414\u0443\u043f\u043b\u044f\u043a\u043e\u0432\u0430 \u041f\u043e\u043b\u0438\u043d\u0430 \u0414\u043c\u0438\u0442\u0440\u0438\u0435\u0432\u043d\u0430","orcid":"https://orcid.org/0000-0003-2773-1682","observed_orcids":["https://orcid.org/0000-0003-2773-1682"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. D. Duplyakova","raw_affiliation_strings":["Polyakov Samara Regional Clinical Cardiology Dispensary"],"raw_orcid":"https://orcid.org/0000-0003-2773-1682","affiliations":[{"raw_affiliation_string":"Polyakov Samara Regional Clinical Cardiology Dispensary","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029239691","display_name":"Aliya V. Tukhbatova","orcid":"https://orcid.org/0000-0002-1088-0641","observed_orcids":["https://orcid.org/0000-0002-1088-0641"]},"institutions":[{"id":"https://openalex.org/I4210127240","display_name":"Samara State Medical University","ror":"https://ror.org/02z5czc07","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210127240"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. A. Tukhbatova","raw_affiliation_strings":["Samara State Medical University;\r\nPolyakov Samara Regional Clinical Cardiology Dispensary"],"raw_orcid":"https://orcid.org/0000-0002-1088-0641","affiliations":[{"raw_affiliation_string":"Samara State Medical University;\r\nPolyakov Samara Regional Clinical Cardiology Dispensary","institution_ids":["https://openalex.org/I4210127240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002449921","display_name":"E. M. Sukhinina","orcid":"https://orcid.org/0000-0001-6398-9598","observed_orcids":["https://orcid.org/0000-0001-6398-9598"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. M. Sukhinina","raw_affiliation_strings":["Polyakov Samara Regional Clinical Cardiology Dispensary"],"raw_orcid":"https://orcid.org/0000-0001-6398-9598","affiliations":[{"raw_affiliation_string":"Polyakov Samara Regional Clinical Cardiology Dispensary","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082084901","display_name":"Tatyana V. Pavlova","orcid":"https://orcid.org/0000-0003-3301-1577","observed_orcids":["https://orcid.org/0000-0003-3301-1577"]},"institutions":[{"id":"https://openalex.org/I4210127240","display_name":"Samara State Medical University","ror":"https://ror.org/02z5czc07","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210127240"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"T. V. Pavlova","raw_affiliation_strings":["Samara State Medical University;\r\nPolyakov Samara Regional Clinical Cardiology Dispensary"],"raw_orcid":"https://orcid.org/0000-0003-3301-1577","affiliations":[{"raw_affiliation_string":"Samara State Medical University;\r\nPolyakov Samara Regional Clinical Cardiology Dispensary","institution_ids":["https://openalex.org/I4210127240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059294927","display_name":"Dmitry Viktorovich Duplyakov","orcid":"https://orcid.org/0000-0002-6453-2976","observed_orcids":["https://orcid.org/0000-0002-6453-2976","https://orcid.org/0000-0003-2773-1682"]},"institutions":[{"id":"https://openalex.org/I4210127240","display_name":"Samara State Medical University","ror":"https://ror.org/02z5czc07","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210127240"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"D. V. Duplyakov","raw_affiliation_strings":["Samara State Medical University;\r\nPolyakov Samara Regional Clinical Cardiology Dispensary"],"raw_orcid":"https://orcid.org/0000-0002-6453-2976","affiliations":[{"raw_affiliation_string":"Samara State Medical University;\r\nPolyakov Samara Regional Clinical Cardiology Dispensary","institution_ids":["https://openalex.org/I4210127240"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5116385616","display_name":"E. V. Savinova","orcid":"https://orcid.org/0009-0007-1015-3878","observed_orcids":["https://orcid.org/0009-0007-1015-3878"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. V. Savinova","raw_affiliation_strings":["Polyakov Samara Regional Clinical Cardiology Dispensary"],"raw_orcid":"https://orcid.org/0009-0007-1015-3878","affiliations":[{"raw_affiliation_string":"Polyakov Samara Regional Clinical Cardiology Dispensary","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5306,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.6198877,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"24","issue":"5","first_page":"4318","last_page":"4318"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.6815999746322632,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.6815999746322632,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.15080000460147858,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.14749999344348907,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vulnerable-plaque","display_name":"vulnerable plaque","score":0.847000002861023},{"id":"https://openalex.org/keywords/acute-coronary-syndrome","display_name":"acute coronary syndrome","score":0.9929999709129333},{"id":"https://openalex.org/keywords/percutaneous-coronary-intervention","display_name":"percutaneous coronary intervention","score":0.9100000262260437},{"id":"https://openalex.org/keywords/statin-therapy","display_name":"statin therapy","score":0.828000009059906},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.7540000081062317},{"id":"https://openalex.org/keywords/coronary-computed-tomography","display_name":"coronary computed tomography","score":0.8080000281333923},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9340475797653198},{"id":"https://openalex.org/C2777698277","wikidata":"https://www.wikidata.org/wiki/Q266018","display_name":"Acute coronary syndrome","level":3,"score":0.7888718843460083},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6735318899154663},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.6672635078430176},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6283773183822632},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.08637633919715881}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.15829/1728-8800-2025-4318","doi":"https://doi.org/10.15829/1728-8800-2025-4318","is_oa":true,"landing_page_url":"https://doi.org/10.15829/1728-8800-2025-4318","pdf_url":null,"source":{"id":"https://openalex.org/S143907125","display_name":"CARDIOVASCULAR THERAPY AND PREVENTION","issn_l":"1728-8800","issn":["1728-8800","2619-0125"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","jufo-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312795","host_organization_name":"\u00abSILICEA-POLIGRAF\u00bb LLC","host_organization_lineage":["https://openalex.org/P4310312795"],"host_organization_lineage_names":["\u00abSILICEA-POLIGRAF\u00bb LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Therapy and Prevention","raw_type":"journal-article"},{"id":"doi:10.15829/1728-8800-20254318","doi":"https://doi.org/10.15829/1728-8800-20254318","is_oa":true,"landing_page_url":"https://doi.org/10.15829/1728-8800-20254318","pdf_url":"https://cardiovascular.elpub.ru/jour/article/download/4318/3341","source":{"id":"https://openalex.org/S143907125","display_name":"CARDIOVASCULAR THERAPY AND PREVENTION","issn_l":"1728-8800","issn":["1728-8800","2619-0125"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","jufo-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312795","host_organization_name":"\u00abSILICEA-POLIGRAF\u00bb LLC","host_organization_lineage":["https://openalex.org/P4310312795"],"host_organization_lineage_names":["\u00abSILICEA-POLIGRAF\u00bb LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Therapy and Prevention","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:1f497ec302a9417bbc6456c697b3bcc6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1f497ec302a9417bbc6456c697b3bcc6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u041a\u0430\u0440\u0434\u0438\u043e\u0432\u0430\u0441\u043a\u0443\u043b\u044f\u0440\u043d\u0430\u044f \u0442\u0435\u0440\u0430\u043f\u0438\u044f \u0438 \u043f\u0440\u043e\u0444\u0438\u043b\u0430\u043a\u0442\u0438\u043a\u0430, Vol 24, Iss 5 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.15829/1728-8800-2025-4318","doi":"https://doi.org/10.15829/1728-8800-2025-4318","is_oa":true,"landing_page_url":"https://doi.org/10.15829/1728-8800-2025-4318","pdf_url":null,"source":{"id":"https://openalex.org/S143907125","display_name":"CARDIOVASCULAR THERAPY AND PREVENTION","issn_l":"1728-8800","issn":["1728-8800","2619-0125"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","jufo-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312795","host_organization_name":"\u00abSILICEA-POLIGRAF\u00bb LLC","host_organization_lineage":["https://openalex.org/P4310312795"],"host_organization_lineage_names":["\u00abSILICEA-POLIGRAF\u00bb LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Therapy and Prevention","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1969678022","https://openalex.org/W2075793605","https://openalex.org/W2104420864","https://openalex.org/W2134343469","https://openalex.org/W2161682643","https://openalex.org/W2342699081","https://openalex.org/W2532776499","https://openalex.org/W2612137454","https://openalex.org/W2806294808","https://openalex.org/W2865964443","https://openalex.org/W2884694793","https://openalex.org/W2889356366","https://openalex.org/W2922980060","https://openalex.org/W2942743512","https://openalex.org/W2974451321","https://openalex.org/W3112780954","https://openalex.org/W3120916025","https://openalex.org/W3135220323","https://openalex.org/W3164547182","https://openalex.org/W3210672698","https://openalex.org/W4230114742","https://openalex.org/W4311835428","https://openalex.org/W4386153206","https://openalex.org/W4388466960","https://openalex.org/W4399982637","https://openalex.org/W4403473988","https://openalex.org/W4407370798"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W3183948672","https://openalex.org/W3173606202","https://openalex.org/W3110381201","https://openalex.org/W2948807893","https://openalex.org/W2899084033","https://openalex.org/W2778153218","https://openalex.org/W2758277628","https://openalex.org/W2748952813","https://openalex.org/W1531601525"],"abstract_inverted_index":{"Aim.":[0],"To":[1],"assess":[2],"the":[3,48,68,177],"detection":[4,199],"rate":[5,200],"of":[6,70,166,201],"vulnerable":[7,71,97,142,151,167,195,202,224],"plaques":[8,72,79,98,152,168,203,225],"using":[9,86],"computed":[10],"tomography":[11],"(CT)":[12],"in":[13,82,148,204],"patients":[14,32,51,85,140,149,193,205],"after":[15,47,206],"acute":[16],"coronary":[17,22,105,145,172,232],"syndrome":[18],"(ACS)":[19],"and":[20,26,180,208,234],"percutaneous":[21],"intervention":[23],"(PCI).":[24],"Material":[25],"methods.":[27],"The":[28,144,198],"study":[29],"included":[30],"125":[31],"with":[33,96,150,164,223],"ACS":[34,207],"who":[35,52],"underwent":[36],"PCI":[37,209],"(men,":[38],"68%;":[39],"median":[40,90],"age,":[41],"59":[42],"(51-66)":[43],"years).":[44,94],"One":[45],"month":[46],"index":[49,147],"event,":[50],"did":[53],"not":[54,210],"achieve":[55],"target":[56,212],"low-density":[57],"lipoprotein":[58],"cholesterol":[59],"values":[60,214],"were":[61,80,99,226],"divided":[62],"into":[63],"two":[64],"groups":[65],"depending":[66],"on":[67],"signs":[69,165],"according":[73,175],"to":[74,102,139,176,192],"CT":[75,87],"data.":[76],"Results.":[77],"Vulnerable":[78],"detected":[81],"56":[83],"(44,8%)":[84],"(69,6%":[88],"men,":[89],"age":[91],"60":[92],"(51-63)":[93],"Patients":[95,163,222],"more":[100,170,229],"likely":[101],"have":[103],"right":[104],"artery":[106,125,132,173],"(CA)":[107],"involvement":[108,233],"\u2014":[109,117,126,133,156,184],"53,6":[110],"vs":[111,119,128,135,159,187],"11,6%":[112],"(p<0,001);":[113,121,130],"left":[114,122],"main":[115],"CA":[116],"33,9":[118],"5,8%":[120],"anterior":[123],"descending":[124],"76,8":[127],"15,9%":[129],"circumflex":[131],"48,2":[134],"18,8%":[136],"(p<0,001)":[137,190],"compared":[138,191],"without":[141,194],"plaques.":[143,196],"calcium":[146,237],"was":[153,220],"significantly":[154],"higher":[155],"111":[157],"(29-247)":[158],"35":[160],"(1-138)":[161],"(p=0,003).":[162],"had":[169],"severe":[171],"disease":[174],"segment-stenosis":[178],"(SSS)":[179],"segment-involvement":[181],"(SIS)":[182],"scores":[183],"3":[185],"(1-4)":[186],"0":[188],"(0-1)":[189],"Conclusion.":[197],"achieved":[211],"LDL":[213],"while":[215],"receiving":[216],"highdose":[217],"statin":[218],"therapy":[219],"44,8%.":[221],"characterized":[227],"by":[228],"spread":[230],"atherosclerotic":[231],"a":[235],"high":[236],"index.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-07-16T00:00:00"}
