{"id":"https://openalex.org/W4412466610","doi":"https://doi.org/10.1016/j.tins.2025.06.004","title":"Untangling the multifaceted VTA responses to stress","display_name":"Untangling the multifaceted VTA responses to stress","publication_year":2025,"publication_date":"2025-07-16","ids":{"openalex":"https://openalex.org/W4412466610","doi":"https://doi.org/10.1016/j.tins.2025.06.004","pmid":"https://pubmed.ncbi.nlm.nih.gov/40675841","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12308838"},"language":"en","primary_location":{"id":"doi:10.1016/j.tins.2025.06.004","doi":"https://doi.org/10.1016/j.tins.2025.06.004","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tins.2025.06.004","pdf_url":null,"source":{"id":"https://openalex.org/S114966740","display_name":"Trends in Neurosciences","issn_l":"0166-2236","issn":["0166-2236","1878-108X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Trends in Neurosciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.tins.2025.06.004","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062480067","display_name":"Urszula Skupio","orcid":"https://orcid.org/0000-0003-3072-976X","observed_orcids":["https://orcid.org/0000-0003-3072-976X"]},"institutions":[{"id":"https://openalex.org/I4388891851","display_name":"New York State Psychiatric Institute","ror":"https://ror.org/04aqjf708","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4388891851"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Urszula Skupio","raw_affiliation_strings":["Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY, USA; Area Neuroscience, New York State Psychiatric Institute, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY, USA; Area Neuroscience, New York State Psychiatric Institute, New York, NY, USA","institution_ids":["https://openalex.org/I4388891851","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012194117","display_name":"Alexander Z. Harris","orcid":"https://orcid.org/0000-0001-9089-0366","observed_orcids":["https://orcid.org/0000-0001-9089-0366"]},"institutions":[{"id":"https://openalex.org/I4388891851","display_name":"New York State Psychiatric Institute","ror":"https://ror.org/04aqjf708","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4388891851"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alexander Z. Harris","raw_affiliation_strings":["Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY, USA; Area Neuroscience, New York State Psychiatric Institute, New York, NY, USA. Electronic address: ah2835@cumc.columbia.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY, USA; Area Neuroscience, New York State Psychiatric Institute, New York, NY, USA. Electronic address: ah2835@cumc.columbia.edu","institution_ids":["https://openalex.org/I4388891851","https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052959924","display_name":"Abigail M. Polter","orcid":"https://orcid.org/0000-0003-0151-0996","observed_orcids":["https://orcid.org/0000-0003-0151-0996"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Abigail M. Polter","raw_affiliation_strings":["Department of Pharmacology and Physiology, George Washington University, Washington, DC, USA. Electronic address: ampolter@gwu.edu"],"raw_orcid":"https://orcid.org/0000-0003-0151-0996","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Physiology, George Washington University, Washington, DC, USA. Electronic address: ampolter@gwu.edu","institution_ids":["https://openalex.org/I193531525"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5012194117","https://openalex.org/A5052959924"],"corresponding_institution_ids":["https://openalex.org/I193531525","https://openalex.org/I4388891851","https://openalex.org/I78577930"],"apc_list":{"value":7030,"currency":"USD","value_usd":7030},"apc_paid":null,"fwci":0.4648,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.43690249,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"48","issue":"8","first_page":"582","last_page":"593"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.031599998474121094,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ventral-tegmental-area","display_name":"ventral tegmental area","score":1.0},{"id":"https://openalex.org/keywords/stress","display_name":"stress","score":0.6970000267028809},{"id":"https://openalex.org/keywords/acute-stress","display_name":"acute stress","score":0.8330000042915344},{"id":"https://openalex.org/keywords/chronic-stress","display_name":"chronic stress","score":1.0},{"id":"https://openalex.org/keywords/stress-adaptation","display_name":"stress adaptation","score":0.640999972820282},{"id":"https://openalex.org/keywords/neuronal-heterogeneity","display_name":"neuronal heterogeneity","score":0.7850000262260437},{"id":"https://openalex.org/keywords/cumulative-stressors","display_name":"cumulative stressors","score":0.7879999876022339},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":0.7329999804496765},{"id":"https://openalex.org/keywords/behavioral-adaptation","display_name":"behavioral adaptation","score":0.6990000009536743},{"id":"https://openalex.org/keywords/reward-systems","display_name":"reward systems","score":0.5120000243186951}],"concepts":[{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6367849111557007},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4956873655319214},{"id":"https://openalex.org/C21036866","wikidata":"https://www.wikidata.org/wiki/Q181767","display_name":"Stress (linguistics)","level":2,"score":0.49097684025764465},{"id":"https://openalex.org/C180747234","wikidata":"https://www.wikidata.org/wiki/Q23373","display_name":"Cognitive psychology","level":1,"score":0.32190823554992676},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D017557","descriptor_name":"Ventral Tegmental Area","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017557","descriptor_name":"Ventral Tegmental Area","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.tins.2025.06.004","doi":"https://doi.org/10.1016/j.tins.2025.06.004","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tins.2025.06.004","pdf_url":null,"source":{"id":"https://openalex.org/S114966740","display_name":"Trends in Neurosciences","issn_l":"0166-2236","issn":["0166-2236","1878-108X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Trends in Neurosciences","raw_type":"journal-article"},{"id":"pmid:40675841","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40675841","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in neurosciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12308838","doi":null,"is_oa":true,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40675841/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends Neurosci","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.tins.2025.06.004","doi":"https://doi.org/10.1016/j.tins.2025.06.004","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tins.2025.06.004","pdf_url":null,"source":{"id":"https://openalex.org/S114966740","display_name":"Trends in Neurosciences","issn_l":"0166-2236","issn":["0166-2236","1878-108X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Trends in Neurosciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46810001134872437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7801923684","display_name":"VTA microcircuit dynamics during chronic stress","funder_award_id":"R01MH122712","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G9000904818","display_name":"VTA-NAc GABAergic communication underlying stress-induced reward deficits","funder_award_id":"R01MH124998","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320306147","display_name":"Brain and Behavior Research Foundation","ror":"https://ror.org/03a63f080"},{"id":"https://openalex.org/F4320311440","display_name":"National Alliance for Research on Schizophrenia and Depression","ror":"https://ror.org/03a63f080"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":125,"referenced_works":["https://openalex.org/W1409281047","https://openalex.org/W1870304014","https://openalex.org/W1970226919","https://openalex.org/W1970586330","https://openalex.org/W1972883529","https://openalex.org/W1977514547","https://openalex.org/W1981654563","https://openalex.org/W1982068079","https://openalex.org/W1990046088","https://openalex.org/W1997089027","https://openalex.org/W1998033984","https://openalex.org/W1999394080","https://openalex.org/W2007816528","https://openalex.org/W2014095642","https://openalex.org/W2022220403","https://openalex.org/W2022561563","https://openalex.org/W2024680557","https://openalex.org/W2031926980","https://openalex.org/W2043292527","https://openalex.org/W2043346837","https://openalex.org/W2055686502","https://openalex.org/W2055716589","https://openalex.org/W2058867280","https://openalex.org/W2059326607","https://openalex.org/W2062186304","https://openalex.org/W2067203693","https://openalex.org/W2072531628","https://openalex.org/W2074102542","https://openalex.org/W2078550466","https://openalex.org/W2081697362","https://openalex.org/W2095088925","https://openalex.org/W2112054094","https://openalex.org/W2117782909","https://openalex.org/W2139495058","https://openalex.org/W2140986639","https://openalex.org/W2146291241","https://openalex.org/W2147755305","https://openalex.org/W2157815289","https://openalex.org/W2164154357","https://openalex.org/W2165743581","https://openalex.org/W2239601698","https://openalex.org/W2252270618","https://openalex.org/W2277222849","https://openalex.org/W2408529313","https://openalex.org/W2511946169","https://openalex.org/W2528045595","https://openalex.org/W2547816908","https://openalex.org/W2559760094","https://openalex.org/W2567343056","https://openalex.org/W2569240731","https://openalex.org/W2592677663","https://openalex.org/W2624113673","https://openalex.org/W2724120353","https://openalex.org/W2736847196","https://openalex.org/W2761181514","https://openalex.org/W2766051881","https://openalex.org/W2772053941","https://openalex.org/W2778812358","https://openalex.org/W2890059556","https://openalex.org/W2891460750","https://openalex.org/W2896041157","https://openalex.org/W2900447114","https://openalex.org/W2902477192","https://openalex.org/W2905176374","https://openalex.org/W2906804217","https://openalex.org/W2912468739","https://openalex.org/W2917554513","https://openalex.org/W2949379349","https://openalex.org/W2964024465","https://openalex.org/W2971142169","https://openalex.org/W2972596869","https://openalex.org/W2981585873","https://openalex.org/W2981981976","https://openalex.org/W2993168892","https://openalex.org/W3010748436","https://openalex.org/W3014758815","https://openalex.org/W3022110985","https://openalex.org/W3026330748","https://openalex.org/W3027412899","https://openalex.org/W3030279718","https://openalex.org/W3040191515","https://openalex.org/W3082054200","https://openalex.org/W3093551035","https://openalex.org/W3104118617","https://openalex.org/W3164359378","https://openalex.org/W3173051232","https://openalex.org/W3199237971","https://openalex.org/W3207876808","https://openalex.org/W4210502342","https://openalex.org/W4210748072","https://openalex.org/W4220728520","https://openalex.org/W4220983882","https://openalex.org/W4224302426","https://openalex.org/W4233093883","https://openalex.org/W4283736479","https://openalex.org/W4284899630","https://openalex.org/W4285083709","https://openalex.org/W4285742712","https://openalex.org/W4289780969","https://openalex.org/W4291183952","https://openalex.org/W4292756010","https://openalex.org/W4309076182","https://openalex.org/W4310276869","https://openalex.org/W4317802131","https://openalex.org/W4367180556","https://openalex.org/W4378953487","https://openalex.org/W4383265040","https://openalex.org/W4386003650","https://openalex.org/W4386886562","https://openalex.org/W4387208645","https://openalex.org/W4391160376","https://openalex.org/W4391264708","https://openalex.org/W4391843646","https://openalex.org/W4392471559","https://openalex.org/W4400745096","https://openalex.org/W4401325095","https://openalex.org/W4402218007","https://openalex.org/W4404643261","https://openalex.org/W4405530572","https://openalex.org/W4408195055","https://openalex.org/W4409148745","https://openalex.org/W4409186868","https://openalex.org/W4409666938","https://openalex.org/W4409872485","https://openalex.org/W6746756519"],"related_works":["https://openalex.org/W2981585873","https://openalex.org/W2917554513","https://openalex.org/W4409148745","https://openalex.org/W4297237569","https://openalex.org/W7167589589","https://openalex.org/W7125524705","https://openalex.org/W1972601515","https://openalex.org/W2762773899","https://openalex.org/W7001207962","https://openalex.org/W6981463375"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}
