{"id":"https://openalex.org/W4412463585","doi":"https://doi.org/10.3389/fgene.2025.1605055","title":"Characterization of lactylation modification subtypes and the promoting role of CCL20 in hepatocellular carcinoma progression","display_name":"Characterization of lactylation modification subtypes and the promoting role of CCL20 in hepatocellular carcinoma progression","publication_year":2025,"publication_date":"2025-07-16","ids":{"openalex":"https://openalex.org/W4412463585","doi":"https://doi.org/10.3389/fgene.2025.1605055","pmid":"https://pubmed.ncbi.nlm.nih.gov/40741410"},"language":"en","primary_location":{"id":"doi:10.3389/fgene.2025.1605055","doi":"https://doi.org/10.3389/fgene.2025.1605055","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2025.1605055","pdf_url":"https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2025.1605055/pdf","source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2025.1605055/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038226931","display_name":"Lihong Wu","orcid":"https://orcid.org/0000-0002-1903-6981","observed_orcids":["https://orcid.org/0000-0002-1903-6981"]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li-Hong Wu","raw_affiliation_strings":["Department of Gastroenterology, Xijing 986 Hospital, Fourth Military Medical University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Xijing 986 Hospital, Fourth Military Medical University, Xi'an, China","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100739478","display_name":"Yang Liu","orcid":"https://orcid.org/0000-0001-7714-9194","observed_orcids":["https://orcid.org/0000-0001-7714-9194"]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liu Yang","raw_affiliation_strings":["Department of Gastroenterology, Xijing 986 Hospital, Fourth Military Medical University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Xijing 986 Hospital, Fourth Military Medical University, Xi'an, China","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025849812","display_name":"Xiang-Xu Wang","orcid":"https://orcid.org/0000-0002-1658-953X","observed_orcids":["https://orcid.org/0000-0002-1658-953X"]},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiang-Xu Wang","raw_affiliation_strings":["Department of Clinical Oncology, Xijing Hospital, Fourth Military Medical University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Oncology, Xijing Hospital, Fourth Military Medical University, Xi'an, China","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shuang Bai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shuang Bai","raw_affiliation_strings":["Department of Oncology, Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000736025","display_name":"Xi Yan","orcid":"https://orcid.org/0000-0002-8048-9461","observed_orcids":["https://orcid.org/0000-0002-8048-9461"]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi Yan","raw_affiliation_strings":["Department of Gastroenterology, Xijing 986 Hospital, Fourth Military Medical University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Xijing 986 Hospital, Fourth Military Medical University, Xi'an, China","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055587105","display_name":"Jing Wei","orcid":"https://orcid.org/0000-0002-2371-6111","observed_orcids":["https://orcid.org/0000-0002-2371-6111"]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Wei","raw_affiliation_strings":["Department of Gastroenterology, Xijing 986 Hospital, Fourth Military Medical University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Xijing 986 Hospital, Fourth Military Medical University, Xi'an, China","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100384592","display_name":"Jun Wang","orcid":"https://orcid.org/0000-0001-5895-1333","observed_orcids":["https://orcid.org/0000-0001-5895-1333"]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jun Wang","raw_affiliation_strings":["Department of Gastroenterology, Xijing 986 Hospital, Fourth Military Medical University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Xijing 986 Hospital, Fourth Military Medical University, Xi'an, China","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101886126","display_name":"Fei Tian","orcid":"https://orcid.org/0000-0003-4106-2841","observed_orcids":["https://orcid.org/0000-0003-4106-2841"]},"institutions":[{"id":"https://openalex.org/I4210158926","display_name":"Xijing Hospital","ror":"https://ror.org/05cqe9350","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158926"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fei Tian","raw_affiliation_strings":["Department of Clinical Oncology, Xijing Hospital, Fourth Military Medical University, Xi'an, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Oncology, Xijing Hospital, Fourth Military Medical University, Xi'an, China","institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100384592","https://openalex.org/A5101886126"],"corresponding_institution_ids":["https://openalex.org/I4210158926","https://openalex.org/I9916479"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":1.4899,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.83047252,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"16","issue":null,"first_page":"1605055","last_page":"1605055"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.5708000063896179,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.5708000063896179,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.149399995803833,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.06870000064373016,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9480000138282776},{"id":"https://openalex.org/keywords/ccl20","display_name":"CCL20","score":0.9729999899864197},{"id":"https://openalex.org/keywords/prognostic-model","display_name":"prognostic model","score":0.8650000095367432},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.625},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.8799999952316284},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.8149999976158142},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.7379999756813049},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6759999990463257},{"id":"https://openalex.org/keywords/cell-proliferation-and-migration","display_name":"cell proliferation and migration","score":0.8820000290870667},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7889999747276306},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.7228904962539673},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5820027589797974},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5510448217391968},{"id":"https://openalex.org/C83360876","wikidata":"https://www.wikidata.org/wiki/Q5009615","display_name":"CCL20","level":5,"score":0.5228859782218933},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5069006085395813},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4785478711128235},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.456880658864975},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4085387587547302},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4046073853969574},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3252827525138855},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31426650285720825},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30761370062828064},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.3024071753025055},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13861289620399475},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.09448257088661194}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fgene.2025.1605055","doi":"https://doi.org/10.3389/fgene.2025.1605055","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2025.1605055","pdf_url":"https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2025.1605055/pdf","source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},{"id":"pmid:40741410","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40741410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in genetics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12307209","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12307209","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Genet","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:3137181d2dc746a899fc159102a659e0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3137181d2dc746a899fc159102a659e0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Genetics, Vol 16 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fgene.2025.1605055","doi":"https://doi.org/10.3389/fgene.2025.1605055","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fgene.2025.1605055","pdf_url":"https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2025.1605055/pdf","source":{"id":"https://openalex.org/S2597340651","display_name":"Frontiers in Genetics","issn_l":"1664-8021","issn":["1664-8021"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7900000214576721,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412463585.pdf","grobid_xml":"https://content.openalex.org/works/W4412463585.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1985987855","https://openalex.org/W2123060376","https://openalex.org/W2982216374","https://openalex.org/W2998854007","https://openalex.org/W3047612202","https://openalex.org/W3204325474","https://openalex.org/W4290988347","https://openalex.org/W4308891835","https://openalex.org/W4311159672","https://openalex.org/W4313454211","https://openalex.org/W4317477706","https://openalex.org/W4318814864","https://openalex.org/W4327571871","https://openalex.org/W4360600440","https://openalex.org/W4367054767","https://openalex.org/W4387964910","https://openalex.org/W4391743535","https://openalex.org/W4392465141","https://openalex.org/W4393935425","https://openalex.org/W4399269139","https://openalex.org/W4401841913","https://openalex.org/W4403287642","https://openalex.org/W4403793920","https://openalex.org/W4404929291","https://openalex.org/W4405201554","https://openalex.org/W4405527140","https://openalex.org/W4406816431","https://openalex.org/W4407592556","https://openalex.org/W4408241219","https://openalex.org/W4408905764"],"related_works":["https://openalex.org/W4379599675","https://openalex.org/W2089734783","https://openalex.org/W2417822880","https://openalex.org/W2091286425","https://openalex.org/W628600844","https://openalex.org/W2336496693","https://openalex.org/W2027336565","https://openalex.org/W1992840590","https://openalex.org/W4313359034","https://openalex.org/W3159092249"],"abstract_inverted_index":{"Background":[0],"Hepatocellular":[1],"carcinoma":[2],"(HCC)":[3],"is":[4,17],"a":[5,30,206,220,259,271,287,314,319],"highly":[6],"aggressive":[7],"and":[8,23,39,69,112,178,182,225,233,255,293,308,318],"deadly":[9],"malignancy.":[10],"Early":[11],"identification":[12],"of":[13,42,129,210,215,229,246],"prognostic":[14,40,105,169,274,316],"risk":[15,284],"factors":[16],"crucial":[18],"for":[19,54,262,322],"guiding":[20],"clinical":[21],"management":[22],"improving":[24],"patient":[25],"outcomes.":[26],"Lactylation":[27],"modification":[28,80,152,157,238],"plays":[29],"pivotal":[31],"role":[32,261],"in":[33,45,134,139,163,189,248,264,280],"tumorigenesis,":[34],"yet":[35],"the":[36,86,93,130,190,196,226,241],"regulatory":[37],"mechanisms":[38],"significance":[41],"lactylation-related":[43,131],"genes":[44,59,91],"HCC":[46,72,135,143,249,265,281,305],"remain":[47],"insufficiently":[48],"understood.":[49],"Methods":[50],"This":[51,268,283],"study":[52,269],"screened":[53],"prognostically":[55],"significant":[56,221,288],"lactylation":[57,79,103,151,156,167,237,272],"modification-related":[58,104],"based":[60],"on":[61],"their":[62,253],"expression":[63],"levels,":[64],"integrated":[65],"with":[66,154,160,290],"DFS,":[67],"PFS,":[68],"OS":[70],"data.":[71],"patients":[73],"were":[74,96],"stratified":[75],"into":[76],"three":[77,94,149],"distinct":[78,150],"subtypes":[81,95],"(C1,":[82],"C2,":[83],"C3)":[84],"using":[85,110,142],"NMF":[87],"algorithm.":[88],"Differentially":[89],"expressed":[90],"across":[92],"identified":[97,148],"through":[98,138],"an":[99],"intersection":[100],"analysis.":[101],"A":[102,165],"model":[106,170,275,301],"was":[107,120,136,180,186],"subsequently":[108],"constructed":[109,181],"LASSO-Cox":[111],"multivariate":[113],"Cox":[114],"regression":[115],"analyses.":[116],"The":[117,200,299],"CIBERSORT":[118],"algorithm":[119],"utilized":[121],"to":[122,195],"analyze":[123],"immune":[124,216,243,295],"cell":[125,144,217,296,306],"infiltration.":[126],"Functional":[127],"validation":[128],"gene":[132],"CCL20":[133,247,263],"conducted":[137],"vitro":[140],"experiments":[141],"lines.":[145],"Results":[146],"We":[147],"patterns,":[153],"higher":[155,208],"levels":[158],"correlating":[159],"worse":[161],"prognosis":[162],"HCC.":[164,323],"six-gene":[166],"modification-based":[168,273],"(LRPS),":[171],"including":[172],"FAM83D,":[173],"ENO1,":[174],"PFN2,":[175],"LCAT,":[176],"PTGR1,":[177],"CCL20,":[179,303],"validated.":[183],"Overall":[184],"survival":[185],"markedly":[187],"reduced":[188],"high":[191,201],"LRPS":[192,198,202,224],"group":[193,203],"relative":[194],"low":[197],"group.":[199],"also":[204],"showed":[205,286],"significantly":[207,251],"frequency":[209],"TP53":[211],"mutations.":[212],"Correlation":[213],"analysis":[214],"infiltration":[218,227,297],"revealed":[219],"association":[222],"between":[223],"abundance":[228],"M0":[230],"macrophages,":[231],"Tregs,":[232],"neutrophils,":[234],"suggesting":[235],"that":[236,276],"may":[239],"influence":[240],"tumor":[242],"microenvironment.":[244],"Overexpression":[245],"cells":[250],"enhanced":[252],"proliferative":[254],"migratory":[256],"capacities,":[257],"indicating":[258],"key":[260],"progression.":[266],"Conclusion":[267],"established":[270],"accurately":[277],"forecasts":[278],"outcomes":[279],"patients.":[282],"score":[285],"correlation":[289],"glucose":[291],"metabolism":[292],"reflected":[294],"patterns.":[298],"core":[300],"gene,":[302],"promotes":[304],"proliferation":[307],"migration,":[309],"supporting":[310],"its":[311],"potential":[312],"as":[313],"valuable":[315],"biomarker":[317],"therapeutic":[320],"target":[321]},"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}