{"id":"https://openalex.org/W4412449333","doi":"https://doi.org/10.1134/s0026261725600648","title":"Effect of Biogenic Polyamines on Rifampicin Accumulation in Escherichia coli Cells","display_name":"Effect of Biogenic Polyamines on Rifampicin Accumulation in Escherichia coli Cells","publication_year":2025,"publication_date":"2025-07-15","ids":{"openalex":"https://openalex.org/W4412449333","doi":"https://doi.org/10.1134/s0026261725600648"},"language":"en","primary_location":{"id":"doi:10.1134/s0026261725600648","doi":"https://doi.org/10.1134/s0026261725600648","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s0026261725600648","pdf_url":null,"source":{"id":"https://openalex.org/S4210199608","display_name":"Microbiology","issn_l":"0026-2617","issn":["0026-2617","1608-3237","3034-5464"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080672541","display_name":"\u0410. \u0412. \u0410\u0445\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0002-3477-750X","observed_orcids":["https://orcid.org/0000-0002-3477-750X"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210144800","display_name":"Institute of Ecology and Genetics of Microorganisms","ror":"https://ror.org/04e09qg36","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690","https://openalex.org/I4210144800"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"A. V. Akhova","raw_affiliation_strings":["Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, 614081, Perm, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, 614081, Perm, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210144800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062321477","display_name":"Larisa Yu. Nesterova","orcid":"https://orcid.org/0000-0003-2885-2777","observed_orcids":["https://orcid.org/0000-0003-2885-2777"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210144800","display_name":"Institute of Ecology and Genetics of Microorganisms","ror":"https://ror.org/04e09qg36","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690","https://openalex.org/I4210144800"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"L. Y. Nesterova","raw_affiliation_strings":["Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, 614081, Perm, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, 614081, Perm, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210144800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075961947","display_name":"\u0410. \u0413. \u0422\u043a\u0430\u0447\u0435\u043d\u043a\u043e","orcid":"https://orcid.org/0000-0002-8631-8583","observed_orcids":["https://orcid.org/0000-0002-8631-8583"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210144800","display_name":"Institute of Ecology and Genetics of Microorganisms","ror":"https://ror.org/04e09qg36","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690","https://openalex.org/I4210144800"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. G. Tkachenko","raw_affiliation_strings":["Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, 614081, Perm, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, 614081, Perm, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210144800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5080672541"],"corresponding_institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210144800"],"apc_list":null,"apc_paid":null,"fwci":0.2208,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.34208554,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"94","issue":"4","first_page":"515","last_page":"523"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.8105000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.8105000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.1736000031232834,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cadaverine","display_name":"cadaverine","score":0.8690000176429749},{"id":"https://openalex.org/keywords/putrescine","display_name":"putrescine","score":0.9919999837875366},{"id":"https://openalex.org/keywords/spermidine","display_name":"spermidine","score":1.0},{"id":"https://openalex.org/keywords/cell-surface-hydrophobicity","display_name":"cell surface hydrophobicity","score":0.8690000176429749},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.5979999899864197},{"id":"https://openalex.org/keywords/polyamine-biosynthesis","display_name":"polyamine biosynthesis","score":0.8360000252723694},{"id":"https://openalex.org/keywords/bacterial-susceptibility","display_name":"bacterial susceptibility","score":0.3790000081062317}],"concepts":[{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.8452794551849365},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6120107769966125},{"id":"https://openalex.org/C2778607973","wikidata":"https://www.wikidata.org/wiki/Q422652","display_name":"Rifampicin","level":3,"score":0.560914158821106},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5161870121955872},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.3947852849960327},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36146247386932373},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30670568346977234},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1485775113105774}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1134/s0026261725600648","doi":"https://doi.org/10.1134/s0026261725600648","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s0026261725600648","pdf_url":null,"source":{"id":"https://openalex.org/S4210199608","display_name":"Microbiology","issn_l":"0026-2617","issn":["0026-2617","1608-3237","3034-5464"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbiology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46810001134872437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W76076646","https://openalex.org/W1546783991","https://openalex.org/W1572779399","https://openalex.org/W1593363062","https://openalex.org/W1981267913","https://openalex.org/W1981366496","https://openalex.org/W1986711364","https://openalex.org/W1999979510","https://openalex.org/W2075487534","https://openalex.org/W2076093949","https://openalex.org/W2107423955","https://openalex.org/W2116879945","https://openalex.org/W2120061656","https://openalex.org/W2131217069","https://openalex.org/W2155543154","https://openalex.org/W2218403659","https://openalex.org/W2735401266","https://openalex.org/W3040512497","https://openalex.org/W3045897352","https://openalex.org/W3149919171","https://openalex.org/W3199162226","https://openalex.org/W4309831925","https://openalex.org/W4318482194","https://openalex.org/W4387799217"],"related_works":["https://openalex.org/W3166349191","https://openalex.org/W1985778379","https://openalex.org/W3045897352","https://openalex.org/W2076093949","https://openalex.org/W2116879945","https://openalex.org/W2138931089","https://openalex.org/W7216640661","https://openalex.org/W7095824837","https://openalex.org/W4214949297","https://openalex.org/W1590759449"],"abstract_inverted_index":{"Abstract\u2014":[0],"The":[1,19,129],"biogenic":[2],"polyamines":[3,22,72,86],"are":[4],"well":[5,67],"known":[6],"to":[7,58,126,196,202,234],"regulate":[8],"cell":[9,16,64,97,147],"wall":[10],"permeability":[11],"for":[12],"antibiotics":[13,25],"permeating":[14],"the":[15,24,28,41,50,55,60,63,69,74,77,84,90,96,99,146,151,161,164,180,199,213,224],"via":[17],"porins.":[18],"effect":[20,70,111],"of":[21,43,52,62,71,76,83,92,112,118,131,153,163,226],"on":[23,49,73],"transported":[26],"by":[27,172],"non-porin":[29],"route,":[30],"such":[31],"as":[32,66,68,198],"rifampicin,":[33,59,197],"has":[34],"not":[35,159],"been":[36],"studied.":[37],"In":[38],"this":[39],"work,":[40],"effects":[42,225],"intracellular":[44,229],"putrescine,":[45],"spermidine,":[46],"and":[47,150,183,207],"cadaverine":[48,113,132,184,204],"efficiency":[51,152],"rifampicin":[53,93,119,154],"accumulation,":[54],"bacterial":[56,194,232],"susceptibility":[57,233],"hydrophobicity":[61,149],"surface,":[65],"expression":[75,162,170,181],"marRAB":[78,165],"operon":[79],"were":[80,209],"tested.":[81],"None":[82],"three":[85],"under":[87],"study":[88],"affected":[89],"rate":[91],"transport":[94],"into":[95],"at":[98],"early":[100],"stages":[101],"(2":[102],"min).":[103],"Under":[104],"longer":[105],"exposure":[106],"(60":[107],"min),":[108],"a":[109,142,191,218],"protective":[110],"was":[114,123,141],"observed,":[115],"since":[116],"accumulation":[117],"in":[120,133,193,221],"cadaverine-free":[121],"cells":[122,136],"higher":[124],"compared":[125],"cadaverine-proficient":[127],"ones.":[128],"absence":[130],"Escherichia":[134],"coli":[135],"increased":[137,185],"their":[138],"hydrophobicity.":[139],"There":[140],"direct":[143],"relationship":[144],"between":[145],"surface":[148],"accumulation.":[155],"Polyamines":[156],"themselves":[157],"did":[158],"affect":[160],"operon,":[166],"but":[167],"modulated":[168],"its":[169,228],"induced":[171],"salicylate.":[173],"Putrescine":[174],"had":[175],"no":[176],"effect,":[177],"spermidine":[178,208],"decreased":[179],"level,":[182],"it.":[186],"Overall,":[187],"polyamine":[188],"biosynthesis":[189],"plays":[190,217],"role":[192,220],"adaptation":[195],"strains":[200],"unable":[201],"synthesize":[203],"or":[205],"putrescine":[206],"more":[210],"sensitive":[211],"than":[212],"wild-type":[214],"strains.":[215],"Cadaverine":[216],"special":[219],"protecting":[222],"against":[223],"rifampicin;":[227],"concentration":[230],"affects":[231],"rifampicin.":[235]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2025-10-10T00:00:00"}