{"id":"https://openalex.org/W4412442011","doi":"https://doi.org/10.1016/j.pathol.2025.05.008","title":"High-level STING expression in tumour and inflammatory cells is linked to microsatellite instability and favourable tumour parameters in a cohort of over 1,900 colorectal cancer patients","display_name":"High-level STING expression in tumour and inflammatory cells is linked to microsatellite instability and favourable tumour parameters in a cohort of over 1,900 colorectal cancer patients","publication_year":2025,"publication_date":"2025-07-15","ids":{"openalex":"https://openalex.org/W4412442011","doi":"https://doi.org/10.1016/j.pathol.2025.05.008","pmid":"https://pubmed.ncbi.nlm.nih.gov/40816937"},"language":"en","primary_location":{"id":"doi:10.1016/j.pathol.2025.05.008","doi":"https://doi.org/10.1016/j.pathol.2025.05.008","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.pathol.2025.05.008","pdf_url":null,"source":{"id":"https://openalex.org/S159118581","display_name":"Pathology","issn_l":"0031-3025","issn":["0031-3025","1465-3931"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.pathol.2025.05.008","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066249474","display_name":"Elena Bady","orcid":"https://orcid.org/0000-0002-8586-5200","observed_orcids":["https://orcid.org/0000-0002-8586-5200"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Elena Bady","raw_affiliation_strings":["Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-8586-5200","affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057028241","display_name":"Julia Ebner","orcid":"https://orcid.org/0000-0002-2829-8879","observed_orcids":["https://orcid.org/0000-0002-2829-8879"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julia Ebner","raw_affiliation_strings":["Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064279273","display_name":"Tim Mandelkow","orcid":"https://orcid.org/0000-0002-2562-3971","observed_orcids":["https://orcid.org/0000-0002-2562-3971"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tim Mandelkow","raw_affiliation_strings":["Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039532332","display_name":"Zhihao Huang","orcid":"https://orcid.org/0009-0003-6685-333X","observed_orcids":["https://orcid.org/0009-0003-6685-333X"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Zhihao Huang","raw_affiliation_strings":["Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025653427","display_name":"Michael Neipp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104827","display_name":"Klinikum Itzehoe","ror":"https://ror.org/01kkgy069","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210104827"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Neipp","raw_affiliation_strings":["General, Vascular and Visceral Surgery Clinic, Itzehoe Medical Center, Itzehoe, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General, Vascular and Visceral Surgery Clinic, Itzehoe Medical Center, Itzehoe, Germany","institution_ids":["https://openalex.org/I4210104827"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089321667","display_name":"Hamid Mofid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107688","display_name":"Regio Kliniken","ror":"https://ror.org/01prj4323","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210107688"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hamid Mofid","raw_affiliation_strings":["General, Visceral Thoracic and Vascular Surgery Clinic, Regio Clinic Pinneberg, Pinneberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General, Visceral Thoracic and Vascular Surgery Clinic, Regio Clinic Pinneberg, Pinneberg, Germany","institution_ids":["https://openalex.org/I4210107688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003117376","display_name":"Hannes L\u00e1russon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107688","display_name":"Regio Kliniken","ror":"https://ror.org/01prj4323","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210107688"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hannes L\u00e1russon","raw_affiliation_strings":["General, Visceral Thoracic and Vascular Surgery Clinic, Regio Clinic Pinneberg, Pinneberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General, Visceral Thoracic and Vascular Surgery Clinic, Regio Clinic Pinneberg, Pinneberg, Germany","institution_ids":["https://openalex.org/I4210107688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030303378","display_name":"Thies Daniels","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thies Daniels","raw_affiliation_strings":["General, Visceral and Tumor Surgery Clinic, Albertinen Hospital, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General, Visceral and Tumor Surgery Clinic, Albertinen Hospital, Hamburg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046077722","display_name":"Christoph M. Isbert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christoph Isbert","raw_affiliation_strings":["Department of General, Gastrointestinal and Colorectal Surgery, Amalie Sieveking Hospital, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General, Gastrointestinal and Colorectal Surgery, Amalie Sieveking Hospital, Hamburg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051509734","display_name":"Stephan Coerper","orcid":"https://orcid.org/0000-0002-0197-0995","observed_orcids":["https://orcid.org/0000-0002-0197-0995"]},"institutions":[{"id":"https://openalex.org/I4210142939","display_name":"Martha-Maria Hospital","ror":"https://ror.org/053darw66","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210142939"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stephan Coerper","raw_affiliation_strings":["Department of Surgery, General Hospital Martha-Maria Hospital Nuernberg, Nuernberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, General Hospital Martha-Maria Hospital Nuernberg, Nuernberg, Germany","institution_ids":["https://openalex.org/I4210142939"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035554695","display_name":"Daniel Ditterich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127969","display_name":"Sch\u00f6n Klinik Neustadt","ror":"https://ror.org/02devh349","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210088209","https://openalex.org/I4210127969"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Daniel Ditterich","raw_affiliation_strings":["Department of Surgery, General Hospital Neustadt/Aisch, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, General Hospital Neustadt/Aisch, Germany","institution_ids":["https://openalex.org/I4210127969"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062960007","display_name":"Holger Rupprecht","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Holger Rupprecht","raw_affiliation_strings":["Department of Thoracic Surgery, Academic Hospital Neumarkt, Neumarkt/Oberpfalz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Academic Hospital Neumarkt, Neumarkt/Oberpfalz, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Albert Goetz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Albert Goetz","raw_affiliation_strings":["Department of Surgery, General Hospital Roth, Roth, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, General Hospital Roth, Roth, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083166298","display_name":"Christian Bernreuther","orcid":"https://orcid.org/0000-0003-3939-322X","observed_orcids":["https://orcid.org/0000-0003-3939-322X"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Bernreuther","raw_affiliation_strings":["Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021421424","display_name":"Guido Sauter","orcid":"https://orcid.org/0000-0002-9024-4978","observed_orcids":["https://orcid.org/0000-0002-9024-4978"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Guido Sauter","raw_affiliation_strings":["Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008273506","display_name":"Ria Uhlig","orcid":"https://orcid.org/0000-0002-4880-6519","observed_orcids":["https://orcid.org/0000-0002-4880-6519"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ria Uhlig","raw_affiliation_strings":["Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072001228","display_name":"Waldemar Wilczak","orcid":"https://orcid.org/0009-0000-8438-9110","observed_orcids":["https://orcid.org/0009-0000-8438-9110"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Waldemar Wilczak","raw_affiliation_strings":["Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086499788","display_name":"Ronald Simon","orcid":"https://orcid.org/0000-0003-0158-4258","observed_orcids":["https://orcid.org/0000-0003-0158-4258"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ronald Simon","raw_affiliation_strings":["Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049914905","display_name":"Stefan A. Steurer","orcid":"https://orcid.org/0000-0002-7199-3615","observed_orcids":["https://orcid.org/0000-0002-7199-3615","https://orcid.org/0000-0003-3313-0453"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Steurer","raw_affiliation_strings":["Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060519896","display_name":"Sarah Jane Pauline Minner","orcid":"https://orcid.org/0000-0003-0765-3568","observed_orcids":["https://orcid.org/0000-0003-0765-3568"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sarah Minner","raw_affiliation_strings":["Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034204447","display_name":"Eike Burandt","orcid":"https://orcid.org/0000-0002-5705-9084","observed_orcids":["https://orcid.org/0000-0002-5705-9084"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eike Burandt","raw_affiliation_strings":["Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-5705-9084","affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053478291","display_name":"Till Krech","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Till Krech","raw_affiliation_strings":["Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Institute of Pathology, Clinical Center Osnabrueck, Osnabrueck, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Institute of Pathology, Clinical Center Osnabrueck, Osnabrueck, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000483058","display_name":"Thilo Hackert","orcid":"https://orcid.org/0000-0002-7012-1196","observed_orcids":["https://orcid.org/0000-0002-7012-1196"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thilo Hackert","raw_affiliation_strings":["General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110354181","display_name":"Nathaniel Melling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nathaniel Melling","raw_affiliation_strings":["General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106797922","display_name":"Nina Schraps","orcid":"https://orcid.org/0009-0001-3056-2974","observed_orcids":["https://orcid.org/0009-0001-3056-2974"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nina Schraps","raw_affiliation_strings":["General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":"https://orcid.org/0009-0001-3056-2974","affiliations":[{"raw_affiliation_string":"General, Visceral and Thoracic Surgery Department and Clinic, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079884607","display_name":"Till Sebastian Clauditz","orcid":"https://orcid.org/0000-0002-4257-856X","observed_orcids":["https://orcid.org/0000-0002-4257-856X"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Till S. Clauditz","raw_affiliation_strings":["Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035525469","display_name":"Andreas Marx","orcid":"https://orcid.org/0000-0002-6471-3689","observed_orcids":["https://orcid.org/0000-0002-6471-3689"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andreas H. Marx","raw_affiliation_strings":["Department of Pathology, Academic Hospital Fuerth, Fuerth, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Academic Hospital Fuerth, Fuerth, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070425304","display_name":"Jan H. M\u00fcller","orcid":"https://orcid.org/0009-0001-4367-7033","observed_orcids":["https://orcid.org/0009-0001-4367-7033"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Jan H. M\u00fcller","raw_affiliation_strings":["Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address: janh.mueller@uke.de"],"raw_orcid":"https://orcid.org/0009-0001-4367-7033","affiliations":[{"raw_affiliation_string":"Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address: janh.mueller@uke.de","institution_ids":["https://openalex.org/I4210108711"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5070425304"],"corresponding_institution_ids":["https://openalex.org/I4210108711"],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":{"value":3600,"currency":"USD","value_usd":3600},"fwci":0.8179,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.72975099,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"57","issue":"7","first_page":"843","last_page":"854"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5195000171661377,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5195000171661377,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.29269999265670776,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.09839999675750732,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sting","display_name":"STING","score":0.9829999804496765},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9269999861717224},{"id":"https://openalex.org/keywords/microsatellite-instability","display_name":"microsatellite instability","score":0.996999979019165},{"id":"https://openalex.org/keywords/tumour-associated-macrophages","display_name":"tumour-associated macrophages","score":0.9599999785423279},{"id":"https://openalex.org/keywords/tumour-associated-inflammation","display_name":"tumour-associated inflammation","score":0.8889999985694885},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.9229999780654907},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.8970000147819519},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.7289999723434448},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C2779767149","wikidata":"https://www.wikidata.org/wiki/Q488212","display_name":"Microsatellite instability","level":5,"score":0.9038165807723999},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7344323396682739},{"id":"https://openalex.org/C2779300339","wikidata":"https://www.wikidata.org/wiki/Q7617409","display_name":"Sting","level":2,"score":0.7115387916564941},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.6310895681381226},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.573101282119751},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5163118243217468},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5122401118278503},{"id":"https://openalex.org/C61320498","wikidata":"https://www.wikidata.org/wiki/Q265193","display_name":"Microsatellite","level":4,"score":0.4506162405014038},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4275628924369812},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4094077944755554},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2920411229133606},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23729810118675232},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14133960008621216},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.07359635829925537},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000099197","descriptor_name":"STING Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D053842","descriptor_name":"Microsatellite Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.pathol.2025.05.008","doi":"https://doi.org/10.1016/j.pathol.2025.05.008","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.pathol.2025.05.008","pdf_url":null,"source":{"id":"https://openalex.org/S159118581","display_name":"Pathology","issn_l":"0031-3025","issn":["0031-3025","1465-3931"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathology","raw_type":"journal-article"},{"id":"pmid:40816937","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40816937","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.pathol.2025.05.008","doi":"https://doi.org/10.1016/j.pathol.2025.05.008","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.pathol.2025.05.008","pdf_url":null,"source":{"id":"https://openalex.org/S159118581","display_name":"Pathology","issn_l":"0031-3025","issn":["0031-3025","1465-3931"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1967252809","https://openalex.org/W1987567569","https://openalex.org/W2008258524","https://openalex.org/W2041813750","https://openalex.org/W2049299149","https://openalex.org/W2050658928","https://openalex.org/W2060004514","https://openalex.org/W2064661384","https://openalex.org/W2066586758","https://openalex.org/W2070354264","https://openalex.org/W2087810003","https://openalex.org/W2094390470","https://openalex.org/W2162871269","https://openalex.org/W2171910021","https://openalex.org/W2296705508","https://openalex.org/W2395943362","https://openalex.org/W2525369565","https://openalex.org/W2613953650","https://openalex.org/W2733154631","https://openalex.org/W2807798312","https://openalex.org/W2917454657","https://openalex.org/W2963305393","https://openalex.org/W2973099721","https://openalex.org/W2982425966","https://openalex.org/W2990310466","https://openalex.org/W3004792237","https://openalex.org/W3111497885","https://openalex.org/W3128227583","https://openalex.org/W3128646645","https://openalex.org/W3140740477","https://openalex.org/W3156412144","https://openalex.org/W3168108992","https://openalex.org/W3168539558","https://openalex.org/W3174301328","https://openalex.org/W3192735673","https://openalex.org/W4211021377","https://openalex.org/W4214574231","https://openalex.org/W4223955386","https://openalex.org/W4248014834","https://openalex.org/W4281489683","https://openalex.org/W4293679385","https://openalex.org/W4307344795","https://openalex.org/W4313409632","https://openalex.org/W4317478289","https://openalex.org/W4327560957","https://openalex.org/W4361191210","https://openalex.org/W4391999307","https://openalex.org/W4397001662","https://openalex.org/W4400202096","https://openalex.org/W6774365918"],"related_works":["https://openalex.org/W4393095200","https://openalex.org/W4412179234","https://openalex.org/W2973099721","https://openalex.org/W2901731545","https://openalex.org/W2913705159","https://openalex.org/W7034174636","https://openalex.org/W4313409632","https://openalex.org/W4307878992","https://openalex.org/W4400202096","https://openalex.org/W7124157121"],"abstract_inverted_index":{"The":[0],"stimulator":[1],"of":[2,21,33,54,61,109,127,150,172,189,195,233],"interferon":[3],"genes":[4],"(STING)":[5],"is":[6,45,213,227],"expressed":[7],"on":[8,92,140,221],"various":[9],"cell":[10,59,87],"types":[11,60],"and":[12,25,115,130,143,154,175,186,223],"tumour":[13,27,37,93,103,116,141,211],"entities,":[14],"where":[15],"it":[16],"might":[17],"enhance":[18],"antitumoural":[19],"effects":[20],"the":[22,30,51,119,148,187,231],"immune":[23],"system":[24],"impact":[26],"angiogenesis.":[28],"However,":[29],"clinical":[31,52],"significance":[32,53],"STING":[34,55,90,138,208,219],"expression":[35,56,91,139,209,220],"in":[36,57,73,78,118,210,236],"cells":[38,44,142,212],"as":[39],"compared":[40],"to":[41,158,179,216,230],"tumour-associated":[42,234],"inflammatory":[43],"not":[46,134],"fully":[47],"resolved.":[48],"To":[49],"evaluate":[50],"different":[58],"colorectal":[62],"cancer":[63],"(CRC),":[64],"1,905":[65],"patients":[66],"were":[67,165],"analysed":[68],"by":[69],"multiplex":[70],"fluorescence":[71],"immunohistochemistry":[72],"a":[74,81,169,192],"tissue":[75],"microarray":[76],"format":[77],"combination":[79],"with":[80,96,129],"deep":[82],"learning":[83],"algorithm":[84],"for":[85,191],"automated":[86],"detection.":[88],"High":[89],"was":[94,156],"associated":[95],"microsatellite":[97],"instability":[98],"(MSI,":[99],"p":[100,106,113,123,183,199],"<0.0001),":[101],"low":[102,160,180],"stage":[104],"(pT,":[105],"=0.0013),":[107],"absence":[108,188],"nodal":[110],"metastasis":[111],"(pN,":[112],"=0.0003)":[114],"localisation":[117],"right":[120],"colon":[121],"(":[122,182,198],"<0.0001).":[124],"Subgroup":[125],"analysis":[126],"tumours":[128],"without":[131],"MSI":[132,217],"did":[133],"show":[135,205],"associations":[136,167],"between":[137,168],"pT":[144,161,181],"or":[145],"pN.":[146],"While":[147],"number":[149],"CD68":[151,176,224],"\u2013":[152,225],"leukocytes":[153,178,226],"macrophages":[155,174,197,222],"related":[157],"MSI,":[159],"\u200band":[162],"pN0,":[163],"there":[164],"significant":[166],"high":[170,193,207],"percentage":[171,194],"STING-positive":[173,196],"-":[177],"<0.0001":[184],"each)":[185],"metastases":[190],"=0.0033).":[200],"In":[201],"summary,":[202],"our":[203],"data":[204],"that":[206],"strongly":[214],"linked":[215,229],"while":[218],"tightly":[228],"extent":[232],"inflammation":[235],"CRC.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}