{"id":"https://openalex.org/W4412440887","doi":"https://doi.org/10.1016/j.csbj.2025.07.022","title":"Towards predicting implant-induced fibrosis: A standardized network model of macrophage-fibroblast interactions","display_name":"Towards predicting implant-induced fibrosis: A standardized network model of macrophage-fibroblast interactions","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4412440887","doi":"https://doi.org/10.1016/j.csbj.2025.07.022","pmid":"https://pubmed.ncbi.nlm.nih.gov/40746411"},"language":"en","primary_location":{"id":"doi:10.1016/j.csbj.2025.07.022","doi":"https://doi.org/10.1016/j.csbj.2025.07.022","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.csbj.2025.07.022","pdf_url":"https://www.csbj.org/article/S2001-0370(25)00285-5/pdf","source":{"id":"https://openalex.org/S2764539591","display_name":"Computational and Structural Biotechnology Journal","issn_l":"2001-0370","issn":["2001-0370"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Structural Biotechnology Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.csbj.org/article/S2001-0370(25)00285-5/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5118993825","display_name":"Matilde Marradi","orcid":"https://orcid.org/0009-0000-2445-6967","observed_orcids":["https://orcid.org/0009-0000-2445-6967"]},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Matilde Marradi","raw_affiliation_strings":["Department of Cell Biology\u2013Inspired Tissue Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, P.O. Box 616, Maastricht, MD 6200, the Netherlands","Department of Cell Biology-Inspired Tissue Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, P.O. Box 616, Maastricht, MD 6200, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology\u2013Inspired Tissue Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, P.O. Box 616, Maastricht, MD 6200, the Netherlands","institution_ids":["https://openalex.org/I34352273"]},{"raw_affiliation_string":"Department of Cell Biology-Inspired Tissue Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, P.O. Box 616, Maastricht, MD 6200, the Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039164555","display_name":"Martijn van Griensven","orcid":"https://orcid.org/0000-0001-5104-9881","observed_orcids":["https://orcid.org/0000-0001-5104-9881"]},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Martijn van Griensven","raw_affiliation_strings":["Department of Cell Biology\u2013Inspired Tissue Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, P.O. Box 616, Maastricht, MD 6200, the Netherlands","Department of Cell Biology-Inspired Tissue Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, P.O. Box 616, Maastricht, MD 6200, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology\u2013Inspired Tissue Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, P.O. Box 616, Maastricht, MD 6200, the Netherlands","institution_ids":["https://openalex.org/I34352273"]},{"raw_affiliation_string":"Department of Cell Biology-Inspired Tissue Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, P.O. Box 616, Maastricht, MD 6200, the Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080383386","display_name":"Nick R. M. Beijer","orcid":"https://orcid.org/0000-0002-0915-8969","observed_orcids":["https://orcid.org/0000-0002-0915-8969"]},"institutions":[{"id":"https://openalex.org/I4210104433","display_name":"National Institute for Public Health and the Environment","ror":"https://ror.org/01cesdt21","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210104433"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Nick R.M. Beijer","raw_affiliation_strings":["National Institute of Public Health and Environment, Centre for Health Protection, Antonie van Leeuwenhoeklaan 9, Bilthoven, MA 3721, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute of Public Health and Environment, Centre for Health Protection, Antonie van Leeuwenhoeklaan 9, Bilthoven, MA 3721, the Netherlands","institution_ids":["https://openalex.org/I4210104433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058224640","display_name":"Jan de Boer","orcid":"https://orcid.org/0000-0001-9188-9324","observed_orcids":["https://orcid.org/0000-0001-9188-9324","https://orcid.org/0000-0002-7748-1231"]},"institutions":[{"id":"https://openalex.org/I83019370","display_name":"Eindhoven University of Technology","ror":"https://ror.org/02c2kyt77","country_code":"NL","type":"education","lineage":["https://openalex.org/I83019370"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jan de Boer","raw_affiliation_strings":["Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, the Netherlands","institution_ids":["https://openalex.org/I83019370"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032492321","display_name":"Aur\u00e9lie Carlier","orcid":"https://orcid.org/0000-0002-2305-5667","observed_orcids":["https://orcid.org/0000-0002-2305-5667"]},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Aur\u00e9lie Carlier","raw_affiliation_strings":["Department of Cell Biology\u2013Inspired Tissue Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, P.O. Box 616, Maastricht, MD 6200, the Netherlands","Department of Cell Biology-Inspired Tissue Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, P.O. Box 616, Maastricht, MD 6200, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology\u2013Inspired Tissue Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, P.O. Box 616, Maastricht, MD 6200, the Netherlands","institution_ids":["https://openalex.org/I34352273"]},{"raw_affiliation_string":"Department of Cell Biology-Inspired Tissue Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, P.O. Box 616, Maastricht, MD 6200, the Netherlands","institution_ids":["https://openalex.org/I34352273"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5032492321"],"corresponding_institution_ids":["https://openalex.org/I34352273"],"apc_list":{"value":3230,"currency":"USD","value_usd":3230},"apc_paid":{"value":3230,"currency":"USD","value_usd":3230},"fwci":3.4741,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.92733421,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"27","issue":null,"first_page":"3251","last_page":"3263"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":0.6714000105857849,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10512","display_name":"Orthopaedic implants and arthroplasty","score":0.6714000105857849,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.19979999959468842,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.023000000044703484,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/foreign-body-reaction","display_name":"foreign body reaction","score":0.9900000095367432},{"id":"https://openalex.org/keywords/macrophage-fibroblast-interaction","display_name":"macrophage-fibroblast interaction","score":0.9909999966621399},{"id":"https://openalex.org/keywords/in-silico-modeling","display_name":"in silico modeling","score":0.7369999885559082},{"id":"https://openalex.org/keywords/network-models","display_name":"network models","score":0.6919999718666077},{"id":"https://openalex.org/keywords/material-stiffness","display_name":"material stiffness","score":0.753000020980835},{"id":"https://openalex.org/keywords/extracellular-matrix-deposition","display_name":"extracellular matrix deposition","score":0.9010000228881836},{"id":"https://openalex.org/keywords/tissue-stiffening","display_name":"tissue stiffening","score":0.718999981880188},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.7049999833106995},{"id":"https://openalex.org/keywords/mechanical-mismatch","display_name":"mechanical mismatch","score":0.8849999904632568},{"id":"https://openalex.org/keywords/medical-device-integration","display_name":"medical device integration","score":0.7120000123977661},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.3199999928474426}],"concepts":[{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.6331606507301331},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.6289147734642029},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5542082190513611},{"id":"https://openalex.org/C2781411149","wikidata":"https://www.wikidata.org/wiki/Q486975","display_name":"Implant","level":2,"score":0.466838002204895},{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.4606040120124817},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3538116216659546},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3502464294433594},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32662561535835266},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32100337743759155},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3070988357067108},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2484971582889557},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.19123634696006775},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.15346193313598633},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.14379659295082092},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12499317526817322},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1016/j.csbj.2025.07.022","doi":"https://doi.org/10.1016/j.csbj.2025.07.022","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.csbj.2025.07.022","pdf_url":"https://www.csbj.org/article/S2001-0370(25)00285-5/pdf","source":{"id":"https://openalex.org/S2764539591","display_name":"Computational and Structural Biotechnology Journal","issn_l":"2001-0370","issn":["2001-0370"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Structural Biotechnology Journal","raw_type":"journal-article"},{"id":"pmid:40746411","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40746411","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and structural biotechnology journal","raw_type":"Journal Article"},{"id":"pmh:oai:cris.maastrichtuniversity.nl:openaire/4bcb0584-1c67-466b-96a3-b75d12c1cebc","doi":null,"is_oa":true,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/4bcb0584-1c67-466b-96a3-b75d12c1cebc","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marradi, M, van Griensven, M, Beijer, N R M, de Boer, J & Carlier, A 2025, 'Towards predicting implant-induced fibrosis : A standardized network model of macrophage-fibroblast interactions', Computational and Structural Biotechnology Journal, vol. 27, pp. 3251-3263. https://doi.org/10.1016/j.csbj.2025.07.022","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.tue.nl:openaire/a32b37e7-0e8b-4879-a233-8018d0d3448b","doi":null,"is_oa":true,"landing_page_url":"https://research.tue.nl/en/publications/a32b37e7-0e8b-4879-a233-8018d0d3448b","pdf_url":null,"source":{"id":"https://openalex.org/S4406922641","display_name":"TU/e Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marradi, M, van Griensven, M, Beijer, N R M, de Boer, J & Carlier, A 2025, 'Towards predicting implant-induced fibrosis : A standardized network model of macrophage-fibroblast interactions', Computational and Structural Biotechnology Journal, vol. 27, pp. 3251-3263. https://doi.org/10.1016/j.csbj.2025.07.022","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:europepmc.org:11124711","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12312070","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12312070","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12312070","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Comput Struct Biotechnol J","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:6358091dbb1c41e8b5041911a284431e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6358091dbb1c41e8b5041911a284431e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computational and Structural Biotechnology Journal, Vol 27, Iss , Pp 3251-3263 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.csbj.2025.07.022","doi":"https://doi.org/10.1016/j.csbj.2025.07.022","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.csbj.2025.07.022","pdf_url":"https://www.csbj.org/article/S2001-0370(25)00285-5/pdf","source":{"id":"https://openalex.org/S2764539591","display_name":"Computational and Structural Biotechnology Journal","issn_l":"2001-0370","issn":["2001-0370"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Structural Biotechnology Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1164323722","display_name":"Materials-driven regeneration: Regenerating tissue and organ function with intelligent, life-like materials","funder_award_id":"024.003.013","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G420050720","display_name":null,"funder_award_id":"024.003","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"}],"funders":[{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412440887.pdf","grobid_xml":"https://content.openalex.org/works/W4412440887.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W1482515349","https://openalex.org/W1581914145","https://openalex.org/W1830091241","https://openalex.org/W1995063875","https://openalex.org/W1995592152","https://openalex.org/W1998406475","https://openalex.org/W2019641554","https://openalex.org/W2021663737","https://openalex.org/W2051082996","https://openalex.org/W2051124211","https://openalex.org/W2105124776","https://openalex.org/W2126324756","https://openalex.org/W2127236332","https://openalex.org/W2301044272","https://openalex.org/W2519835472","https://openalex.org/W2531256915","https://openalex.org/W2554019942","https://openalex.org/W2579268339","https://openalex.org/W2607022689","https://openalex.org/W2728064785","https://openalex.org/W2734365706","https://openalex.org/W2767519788","https://openalex.org/W2781527068","https://openalex.org/W2785854718","https://openalex.org/W2793777720","https://openalex.org/W2799932713","https://openalex.org/W2802761207","https://openalex.org/W2890878628","https://openalex.org/W2909659447","https://openalex.org/W2915555769","https://openalex.org/W2916642185","https://openalex.org/W2932028486","https://openalex.org/W2957779183","https://openalex.org/W2970695199","https://openalex.org/W2980058036","https://openalex.org/W3023142428","https://openalex.org/W3096035829","https://openalex.org/W3115923263","https://openalex.org/W3164721819","https://openalex.org/W3168981793","https://openalex.org/W3178890732","https://openalex.org/W3206669073","https://openalex.org/W3209588035","https://openalex.org/W3210640813","https://openalex.org/W4210940352","https://openalex.org/W4212927278","https://openalex.org/W4220675016","https://openalex.org/W4280579224","https://openalex.org/W4289793055","https://openalex.org/W4313279766","https://openalex.org/W4317868879","https://openalex.org/W4384198853","https://openalex.org/W4386945353","https://openalex.org/W4388665786","https://openalex.org/W4388914200","https://openalex.org/W4389573054","https://openalex.org/W4389674370","https://openalex.org/W4391322019","https://openalex.org/W4392286802","https://openalex.org/W4392918291","https://openalex.org/W4393902108","https://openalex.org/W4394581121","https://openalex.org/W4401056004","https://openalex.org/W4401620590","https://openalex.org/W4405113568","https://openalex.org/W4406556064","https://openalex.org/W4407366901","https://openalex.org/W4411730984"],"related_works":["https://openalex.org/W2233208243","https://openalex.org/W2550398695","https://openalex.org/W2038201261","https://openalex.org/W2793287449","https://openalex.org/W3031359994","https://openalex.org/W2081464723","https://openalex.org/W2016016160","https://openalex.org/W2096084828","https://openalex.org/W4366191696","https://openalex.org/W4383499408"],"abstract_inverted_index":{"The":[0,47,112],"foreign":[1],"body":[2],"response":[3],"(FBR)":[4],"is":[5,144],"a":[6,28,38,130],"complex":[7],"and":[8,34,59,67,81,94,150,157,172,176],"multifaceted":[9],"process":[10],"that":[11,78,95],"remains":[12],"incompletely":[13],"understood,":[14],"often":[15],"leading":[16],"to":[17,42,86],"complications":[18],"in":[19,48,136,165,174,177],"medical":[20],"device":[21,142],"integration.":[22],"In":[23],"this":[24],"study,":[25],"we":[26],"constructed":[27],"literature-based":[29],"network":[30],"of":[31,119,123,141,162],"the":[32,92,100,108,137,163],"FBR":[33,50,93],"developed":[35],"it":[36],"into":[37],"semi-quantitative":[39],"predictive":[40,131],"model":[41,51,113],"better":[43],"understand":[44],"its":[45,127],"dynamics.":[46],"silico":[49,166],"incorporates":[52],"key":[53],"material-related":[54],"factors,":[55],"including":[56],"immunogenic":[57],"properties":[58],"mechanical":[60],"mismatch,":[61],"which":[62],"influence":[63],"immune":[64],"cell":[65],"activation":[66],"extracellular":[68],"matrix":[69],"(ECM)":[70],"deposition.":[71],"Predictions":[72],"align":[73],"with":[74],"existing":[75],"knowledge,":[76],"showing":[77],"material":[79],"stiffness":[80],"tissue":[82],"progressive":[83],"stiffening":[84],"due":[85],"increased":[87],"ECM":[88],"deposition":[89],"can":[90,98,168],"exacerbate":[91],"feedback":[96],"interactions":[97],"protect":[99],"system":[101],"from":[102],"pathological":[103],"outcome":[104],"by":[105],"gradually":[106],"reducing":[107,151],"initial":[109],"inflammatory":[110],"input.":[111],"also":[114],"successfully":[115],"replicated":[116],"six":[117],"out":[118],"eight":[120],"experimental":[121],"cases":[122],"anti-fibrotic":[124],"interventions,":[125],"demonstrating":[126],"potential":[128],"as":[129],"tool.":[132],"Assessing":[133],"implant":[134,182],"safety":[135,183],"early":[138],"pre-clinical":[139],"stages":[140],"development":[143],"critical":[145],"for":[146,180],"ensuring":[147],"long-term":[148],"functionality":[149],"adverse":[152],"reactions.":[153],"By":[154],"systematically":[155],"analyzing":[156],"integrating":[158],"all":[159],"interacting":[160],"aspects":[161],"FBR,":[164],"modeling":[167],"provide":[169],"valuable":[170],"insights":[171],"complement":[173],"vitro":[175],"vivo":[178],"studies":[179],"improved":[181],"assessment.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":4}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}