{"id":"https://openalex.org/W4412400830","doi":"https://doi.org/10.1093/ecco-jcc/jjag182","title":"B cell/adipocyte crosstalk amplifies MCP-1 secretion, M2-like macrophage accumulation, and polarization in gut-associated, inflamed adipose tissue","display_name":"B cell/adipocyte crosstalk amplifies MCP-1 secretion, M2-like macrophage accumulation, and polarization in gut-associated, inflamed adipose tissue","publication_year":2026,"publication_date":"2026-10-21","ids":{"openalex":"https://openalex.org/W4412400830","doi":"https://doi.org/10.1093/ecco-jcc/jjag182","pmid":"https://pubmed.ncbi.nlm.nih.gov/42998367"},"language":"en","primary_location":{"id":"doi:10.1093/ecco-jcc/jjag182","doi":"https://doi.org/10.1093/ecco-jcc/jjag182","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ecco-jcc/jjag182","pdf_url":"https://academic.oup.com/ecco-jcc/article-pdf/20/11/jjag182/73300289/jjag182.pdf","source":{"id":"https://openalex.org/S2735960814","display_name":"Journal of Crohn s and Colitis","issn_l":"1873-9946","issn":["1873-9946","1876-4479"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Crohn's and Colitis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/ecco-jcc/article-pdf/20/11/jjag182/73300289/jjag182.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007784510","display_name":"Marie Christine Goess","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I4405261557","display_name":"Institut f\u00fcr Laboratoriumsmedizin","ror":"https://ror.org/05g1y0660","country_code":"DE","type":"education","lineage":["https://openalex.org/I3018771216","https://openalex.org/I4405261557","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marie Christine Goess","raw_affiliation_strings":["Institute of Laboratory Medicine, School of Medicine and Health, TUM University Hospital , Munich,","TranslaTUM, Central Institute for Translational Cancer Research , Munich,","Institute for Clinical Chemistry and Pathobiochemistry, Technical University of Munich, School of Medicine and Health, Munich, Germany","TranslaTUM, Center for Translational Cancer Research, Technical University Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Laboratory Medicine, School of Medicine and Health, TUM University Hospital , Munich,","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I4405261557","https://openalex.org/I62916508"]},{"raw_affiliation_string":"TranslaTUM, Central Institute for Translational Cancer Research , Munich,","institution_ids":[]},{"raw_affiliation_string":"Institute for Clinical Chemistry and Pathobiochemistry, Technical University of Munich, School of Medicine and Health, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"TranslaTUM, Center for Translational Cancer Research, Technical University Munich, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059219550","display_name":"Julia M. Heinze","orcid":"https://orcid.org/0000-0002-1926-2524","observed_orcids":["https://orcid.org/0000-0002-1926-2524"]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I4405261557","display_name":"Institut f\u00fcr Laboratoriumsmedizin","ror":"https://ror.org/05g1y0660","country_code":"DE","type":"education","lineage":["https://openalex.org/I3018771216","https://openalex.org/I4405261557","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julia M Heinze","raw_affiliation_strings":["Institute of Laboratory Medicine, School of Medicine and Health, TUM University Hospital , Munich,","TranslaTUM, Central Institute for Translational Cancer Research , Munich,","Institute for Clinical Chemistry and Pathobiochemistry, Technical University of Munich, School of Medicine and Health, Munich, Germany","TranslaTUM, Center for Translational Cancer Research, Technical University Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Laboratory Medicine, School of Medicine and Health, TUM University Hospital , Munich,","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I4405261557","https://openalex.org/I62916508"]},{"raw_affiliation_string":"TranslaTUM, Central Institute for Translational Cancer Research , Munich,","institution_ids":[]},{"raw_affiliation_string":"Institute for Clinical Chemistry and Pathobiochemistry, Technical University of Munich, School of Medicine and Health, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"TranslaTUM, Center for Translational Cancer Research, Technical University Munich, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038537365","display_name":"Julian I. Hofmann","orcid":"https://orcid.org/0000-0002-4654-4121","observed_orcids":["https://orcid.org/0000-0002-4654-4121"]},"institutions":[{"id":"https://openalex.org/I130217899","display_name":"\u00c5bo Akademi University","ror":"https://ror.org/029pk6x14","country_code":"FI","type":"education","lineage":["https://openalex.org/I130217899"]},{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Julian Hofmann","raw_affiliation_strings":["Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University , Turku,","Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University, Turku, Finland"],"raw_orcid":"https://orcid.org/0000-0002-4654-4121","affiliations":[{"raw_affiliation_string":"Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University , Turku,","institution_ids":["https://openalex.org/I130217899","https://openalex.org/I155660961"]},{"raw_affiliation_string":"Turku Bioscience Centre, University of Turku and \u00c5bo Akademi University, Turku, Finland","institution_ids":["https://openalex.org/I130217899","https://openalex.org/I155660961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075019305","display_name":"Annalisa Buck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Annalisa Buck","raw_affiliation_strings":["Department of Surgery, Technical University of Munich, School of Medicine and Health , Munich,","Institute for Advanced Study, Technical University of Munich , Munich,","Department of Surgery, Technical University of Munich, School of Medicine and Health, Munich, Germany","Institute for Advanced Study, Technical University of Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Technical University of Munich, School of Medicine and Health , Munich,","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Institute for Advanced Study, Technical University of Munich , Munich,","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Department of Surgery, Technical University of Munich, School of Medicine and Health, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Institute for Advanced Study, Technical University of Munich, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024679902","display_name":"Iana Gadjalova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I4405261557","display_name":"Institut f\u00fcr Laboratoriumsmedizin","ror":"https://ror.org/05g1y0660","country_code":"DE","type":"education","lineage":["https://openalex.org/I3018771216","https://openalex.org/I4405261557","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Iana Gadjalova","raw_affiliation_strings":["Institute of Laboratory Medicine, School of Medicine and Health, TUM University Hospital , Munich,","TranslaTUM, Central Institute for Translational Cancer Research , Munich,","Institute for Clinical Chemistry and Pathobiochemistry, Technical University of Munich, School of Medicine and Health, Munich, Germany","TranslaTUM, Center for Translational Cancer Research, Technical University Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Laboratory Medicine, School of Medicine and Health, TUM University Hospital , Munich,","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I4405261557","https://openalex.org/I62916508"]},{"raw_affiliation_string":"TranslaTUM, Central Institute for Translational Cancer Research , Munich,","institution_ids":[]},{"raw_affiliation_string":"Institute for Clinical Chemistry and Pathobiochemistry, Technical University of Munich, School of Medicine and Health, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"TranslaTUM, Center for Translational Cancer Research, Technical University Munich, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064197587","display_name":"Marie-Christin Weber","orcid":"https://orcid.org/0000-0002-3188-2160","observed_orcids":["https://orcid.org/0000-0002-3188-2160"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marie-Christin Weber","raw_affiliation_strings":["Department of Surgery, Technical University of Munich, School of Medicine and Health , Munich,","Department of Surgery, Technical University of Munich, School of Medicine and Health, Munich, Germany"],"raw_orcid":"https://orcid.org/0000-0002-3188-2160","affiliations":[{"raw_affiliation_string":"Department of Surgery, Technical University of Munich, School of Medicine and Health , Munich,","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Department of Surgery, Technical University of Munich, School of Medicine and Health, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027395430","display_name":"Sandra Stephanie Ring","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I4405261557","display_name":"Institut f\u00fcr Laboratoriumsmedizin","ror":"https://ror.org/05g1y0660","country_code":"DE","type":"education","lineage":["https://openalex.org/I3018771216","https://openalex.org/I4405261557","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sandra Ring","raw_affiliation_strings":["Institute of Laboratory Medicine, School of Medicine and Health, TUM University Hospital , Munich,","TranslaTUM, Central Institute for Translational Cancer Research , Munich,","Institute for Clinical Chemistry and Pathobiochemistry, Technical University of Munich, School of Medicine and Health, Munich, Germany","TranslaTUM, Center for Translational Cancer Research, Technical University Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Laboratory Medicine, School of Medicine and Health, TUM University Hospital , Munich,","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I4405261557","https://openalex.org/I62916508"]},{"raw_affiliation_string":"TranslaTUM, Central Institute for Translational Cancer Research , Munich,","institution_ids":[]},{"raw_affiliation_string":"Institute for Clinical Chemistry and Pathobiochemistry, Technical University of Munich, School of Medicine and Health, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"TranslaTUM, Center for Translational Cancer Research, Technical University Munich, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074062353","display_name":"Joerg Martin Buescher","orcid":"https://orcid.org/0000-0002-6547-0076","observed_orcids":["https://orcid.org/0000-0002-6547-0076"]},"institutions":[{"id":"https://openalex.org/I4210164321","display_name":"Max Planck Institute of Immunobiology and Epigenetics","ror":"https://ror.org/058xzat49","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210164321"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Joerg M Buescher","raw_affiliation_strings":["Max Planck Institute for Immunobiology and Epigenetics , Freiburg 79108,","Max Planck Institute for Immunobiology and Epigenetics, 79108, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Immunobiology and Epigenetics , Freiburg 79108,","institution_ids":["https://openalex.org/I4210164321"]},{"raw_affiliation_string":"Max Planck Institute for Immunobiology and Epigenetics, 79108, Freiburg, Germany","institution_ids":["https://openalex.org/I4210164321"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064617779","display_name":"Matteo Villa","orcid":"https://orcid.org/0000-0003-2684-0596","observed_orcids":["https://orcid.org/0000-0003-2684-0596"]},"institutions":[{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Matteo Villa","raw_affiliation_strings":["Division of Rheumatology and Immunology, Medical University Graz , Graz,","Division of Rheumatology and Immunology, Medical University Graz, Graz, Austria"],"raw_orcid":"https://orcid.org/0000-0003-2684-0596","affiliations":[{"raw_affiliation_string":"Division of Rheumatology and Immunology, Medical University Graz , Graz,","institution_ids":["https://openalex.org/I202276237"]},{"raw_affiliation_string":"Division of Rheumatology and Immunology, Medical University Graz, Graz, Austria","institution_ids":["https://openalex.org/I202276237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068327315","display_name":"Philipp\u2010Alexander Neumann","orcid":"https://orcid.org/0000-0001-8361-3934","observed_orcids":["https://orcid.org/0000-0001-8361-3934"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Philipp-Alexander Neumann","raw_affiliation_strings":["Department of Surgery, Technical University of Munich, School of Medicine and Health , Munich,","Institute for Advanced Study, Technical University of Munich , Munich,","Department of Surgery, Technical University of Munich, School of Medicine and Health, Munich, Germany","Institute for Advanced Study, Technical University of Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Technical University of Munich, School of Medicine and Health , Munich,","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Institute for Advanced Study, Technical University of Munich , Munich,","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Department of Surgery, Technical University of Munich, School of Medicine and Health, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Institute for Advanced Study, Technical University of Munich, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068920358","display_name":"J\u00fcrgen Ruland","orcid":"https://orcid.org/0000-0002-8381-3597","observed_orcids":["https://orcid.org/0000-0002-8381-3597"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I4210115305","display_name":"German Center for Infection Research","ror":"https://ror.org/028s4q594","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210115305","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4391767962","display_name":"Deutsches Konsortium f\u00fcr Translationale Krebsforschung","ror":"https://ror.org/02pqn3g31","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4391767962","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4405261557","display_name":"Institut f\u00fcr Laboratoriumsmedizin","ror":"https://ror.org/05g1y0660","country_code":"DE","type":"education","lineage":["https://openalex.org/I3018771216","https://openalex.org/I4405261557","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00fcrgen Ruland","raw_affiliation_strings":["German Cancer Consortium (DKTK), partner site Munich, a partnership between DKFZ, TUM University Hospital , Munich,","German Center for Child and Adolescent Health (DZKJ), partner side Munich , Munich,","German Center for Infection Research (DZIF), partner side Munich , Munich,","Institute of Laboratory Medicine, School of Medicine and Health, TUM University Hospital , Munich,","TranslaTUM, Central Institute for Translational Cancer Research , Munich,","German Cancer Consortium (DKTK), partner site Munich, a partnership between DKFZ and TUM University Hospital, Germany","German Center for Infection Research (DZIF), partner side Munich, Germany","Institute for Clinical Chemistry and Pathobiochemistry, Technical University of Munich, School of Medicine and Health, Munich, Germany","TranslaTUM, Center for Translational Cancer Research, Technical University Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Cancer Consortium (DKTK), partner site Munich, a partnership between DKFZ, TUM University Hospital , Munich,","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"raw_affiliation_string":"German Center for Child and Adolescent Health (DZKJ), partner side Munich , Munich,","institution_ids":[]},{"raw_affiliation_string":"German Center for Infection Research (DZIF), partner side Munich , Munich,","institution_ids":["https://openalex.org/I4210115305"]},{"raw_affiliation_string":"Institute of Laboratory Medicine, School of Medicine and Health, TUM University Hospital , Munich,","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I4405261557","https://openalex.org/I62916508"]},{"raw_affiliation_string":"TranslaTUM, Central Institute for Translational Cancer Research , Munich,","institution_ids":[]},{"raw_affiliation_string":"German Cancer Consortium (DKTK), partner site Munich, a partnership between DKFZ and TUM University Hospital, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I4391767962"]},{"raw_affiliation_string":"German Center for Infection Research (DZIF), partner side Munich, Germany","institution_ids":["https://openalex.org/I4210115305"]},{"raw_affiliation_string":"Institute for Clinical Chemistry and Pathobiochemistry, Technical University of Munich, School of Medicine and Health, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"TranslaTUM, Center for Translational Cancer Research, Technical University Munich, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024154122","display_name":"Selina Jessica Keppler","orcid":"https://orcid.org/0000-0002-9010-8044","observed_orcids":["https://orcid.org/0000-0002-9010-8044"]},"institutions":[{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]},{"id":"https://openalex.org/I2802619606","display_name":"TUM Klinikum","ror":"https://ror.org/04jc43x05","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802619606","https://openalex.org/I62916508"]},{"id":"https://openalex.org/I4405261557","display_name":"Institut f\u00fcr Laboratoriumsmedizin","ror":"https://ror.org/05g1y0660","country_code":"DE","type":"education","lineage":["https://openalex.org/I3018771216","https://openalex.org/I4405261557","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["AT","DE"],"is_corresponding":true,"raw_author_name":"Selina J Keppler","raw_affiliation_strings":["Division of Rheumatology and Immunology, Medical University Graz , Graz,","Institute of Laboratory Medicine, School of Medicine and Health, TUM University Hospital , Munich,","TranslaTUM, Central Institute for Translational Cancer Research , Munich,","Division of Rheumatology and Immunology, Medical University Graz, Graz, Austria","Institute for Clinical Chemistry and Pathobiochemistry, Technical University of Munich, School of Medicine and Health, Munich, Germany","TranslaTUM, Center for Translational Cancer Research, Technical University Munich, Munich, Germany"],"raw_orcid":"https://orcid.org/0000-0002-9010-8044","affiliations":[{"raw_affiliation_string":"Division of Rheumatology and Immunology, Medical University Graz , Graz,","institution_ids":["https://openalex.org/I202276237"]},{"raw_affiliation_string":"Institute of Laboratory Medicine, School of Medicine and Health, TUM University Hospital , Munich,","institution_ids":["https://openalex.org/I2802619606","https://openalex.org/I4405261557","https://openalex.org/I62916508"]},{"raw_affiliation_string":"TranslaTUM, Central Institute for Translational Cancer Research , Munich,","institution_ids":[]},{"raw_affiliation_string":"Division of Rheumatology and Immunology, Medical University Graz, Graz, Austria","institution_ids":["https://openalex.org/I202276237"]},{"raw_affiliation_string":"Institute for Clinical Chemistry and Pathobiochemistry, Technical University of Munich, School of Medicine and Health, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"TranslaTUM, Center for Translational Cancer Research, Technical University Munich, Munich, Germany","institution_ids":["https://openalex.org/I62916508"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5024154122"],"corresponding_institution_ids":["https://openalex.org/I202276237","https://openalex.org/I2802619606","https://openalex.org/I4405261557","https://openalex.org/I62916508"],"apc_list":{"value":4238,"currency":"EUR","value_usd":4790},"apc_paid":{"value":4238,"currency":"EUR","value_usd":4790},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00136693,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"11","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.551800012588501,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.551800012588501,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.3310999870300293,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.062300000339746475,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.9269999861717224}],"concepts":[{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.7940506339073181},{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.7769029140472412},{"id":"https://openalex.org/C2776175234","wikidata":"https://www.wikidata.org/wiki/Q357519","display_name":"Adipocyte","level":3,"score":0.6879889369010925},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.6237952709197998},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5179694890975952},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4587959945201874},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44658568501472473},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.43860578536987305},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.43693995475769043},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.397513747215271},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3474687933921814},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33375340700149536},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26820307970046997},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10438063740730286},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D052436","descriptor_name":"Adipose Tissue, White","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/ecco-jcc/jjag182","doi":"https://doi.org/10.1093/ecco-jcc/jjag182","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ecco-jcc/jjag182","pdf_url":"https://academic.oup.com/ecco-jcc/article-pdf/20/11/jjag182/73300289/jjag182.pdf","source":{"id":"https://openalex.org/S2735960814","display_name":"Journal of Crohn s and Colitis","issn_l":"1873-9946","issn":["1873-9946","1876-4479"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Crohn's and Colitis","raw_type":"journal-article"},{"id":"doi:10.1101/2025.07.11.664132","doi":"https://doi.org/10.1101/2025.07.11.664132","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.07.11.664132","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/07/14/2025.07.11.664132.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:42998367","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42998367","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Crohn's & colitis","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/ecco-jcc/jjag182","doi":"https://doi.org/10.1093/ecco-jcc/jjag182","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ecco-jcc/jjag182","pdf_url":"https://academic.oup.com/ecco-jcc/article-pdf/20/11/jjag182/73300289/jjag182.pdf","source":{"id":"https://openalex.org/S2735960814","display_name":"Journal of Crohn s and Colitis","issn_l":"1873-9946","issn":["1873-9946","1876-4479"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Crohn's and Colitis","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2089512281","display_name":"TRR 338: LETSIMMUN  Lymphozyten Engineering f\u00fcr Therapeutische Synthetische Immunit\u00e4t","funder_award_id":"452881907","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2165549784","display_name":null,"funder_award_id":"Ke1737/2-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G2936650315","display_name":"TRR 237: Nukleins\u00e4ureImmunit\u00e4t","funder_award_id":"369799452","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3935353383","display_name":null,"funder_award_id":"RU 695/9-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G531439712","display_name":null,"funder_award_id":"2019_A105","funder_id":"https://openalex.org/F4320321672","funder_display_name":"Else Kr\u00f6ner-Fresenius-Stiftung"},{"id":"https://openalex.org/G7372146711","display_name":null,"funder_award_id":"695/13-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G8235906861","display_name":"SFB 1371: Microbiome Signatures  Funktionelle Relevanz des Mikrobioms im Verdauungstrakt","funder_award_id":"395357507","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321672","display_name":"Else Kr\u00f6ner-Fresenius-Stiftung","ror":"https://ror.org/03zcxha54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412400830.pdf","grobid_xml":"https://content.openalex.org/works/W4412400830.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1891721342","https://openalex.org/W1966241241","https://openalex.org/W2005276831","https://openalex.org/W2007146069","https://openalex.org/W2014440579","https://openalex.org/W2021924408","https://openalex.org/W2023012759","https://openalex.org/W2023289992","https://openalex.org/W2063632665","https://openalex.org/W2076817774","https://openalex.org/W2079214938","https://openalex.org/W2099317105","https://openalex.org/W2106172084","https://openalex.org/W2110827592","https://openalex.org/W2122992780","https://openalex.org/W2129319296","https://openalex.org/W2142327347","https://openalex.org/W2144821774","https://openalex.org/W2146957741","https://openalex.org/W2152024122","https://openalex.org/W2165202791","https://openalex.org/W2166626624","https://openalex.org/W2184578345","https://openalex.org/W2329468673","https://openalex.org/W2343116742","https://openalex.org/W2587579012","https://openalex.org/W2800392236","https://openalex.org/W2885063966","https://openalex.org/W2901677030","https://openalex.org/W2926781175","https://openalex.org/W2984169107","https://openalex.org/W2985753680","https://openalex.org/W3006789218","https://openalex.org/W3088648928","https://openalex.org/W3108476343","https://openalex.org/W3120724236","https://openalex.org/W3123526575","https://openalex.org/W3214672543","https://openalex.org/W4214876469","https://openalex.org/W4282979924","https://openalex.org/W4286515932","https://openalex.org/W4295929648","https://openalex.org/W4323530524","https://openalex.org/W4362521490","https://openalex.org/W4386890353","https://openalex.org/W4388036555","https://openalex.org/W4389398753","https://openalex.org/W4389506454","https://openalex.org/W4391934156","https://openalex.org/W4391990146","https://openalex.org/W4398223156","https://openalex.org/W4401982610","https://openalex.org/W4404172162","https://openalex.org/W4408249595","https://openalex.org/W4408310291","https://openalex.org/W4412929255","https://openalex.org/W4414463953"],"related_works":["https://openalex.org/W7208563234","https://openalex.org/W2122992780","https://openalex.org/W4406705066","https://openalex.org/W4389302656","https://openalex.org/W2892849721","https://openalex.org/W2069407327","https://openalex.org/W4391163109","https://openalex.org/W2152024122","https://openalex.org/W2005276831","https://openalex.org/W2328917577"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"AIMS:":[2],"During":[3],"Crohn's":[4],"disease":[5],"(CD),":[6],"hyperplasia":[7],"of":[8,24,32,59,63,72,88,139,146,150,157,167,177,235],"the":[9,22,30,86,204],"mesenteric":[10],"white":[11],"adipose":[12,46,224],"tissue":[13,225],"(WAT),":[14],"called":[15],"creeping":[16],"fat":[17],"(CrF),":[18],"is":[19],"associated":[20],"with":[21,180],"accumulation":[23,156,190],"immune":[25,37],"cells.":[26,159],"Here":[27],"we":[28,110,153],"investigated":[29],"impact":[31,87],"B":[33,89,158,160,178,205,218],"cell/adipocyte":[34,90,161,206,219],"crosstalk":[35,207],"on":[36,92],"cell":[38,185],"recruitment":[39,231],"and":[40,53,80,98,105,187,197,228,232],"inflammation":[41],"within":[42],"inflammatory":[43,120],"bowel":[44],"disease-related":[45],"tissue.":[47],"METHODS:":[48],"We":[49],"used":[50],"flow":[51],"cytometry":[52],"in":[54,75,126,191,221],"vitro":[55,76],"3D":[56,107],"culture":[57],"systems":[58],"biopsies":[60],"from":[61,114],"CrF":[62,138],"CD":[64,115,140],"patients":[65,116,141],"as":[66,68,142,144],"well":[67,143],"a":[69,118,128,147,209],"mouse":[70,106,148,193],"model":[71,149],"intestinal":[73,151],"inflammation,":[74,152],"co-cultures,":[77],"mass":[78],"spectrometry,":[79],"single-cell":[81,198],"RNA":[82,199],"sequencing":[83,200],"to":[84,164],"evaluate":[85],"interplay":[91],"monocyte":[93],"chemoattractant":[94],"protein-1":[95],"(MCP-1)":[96],"production":[97],"macrophage":[99,173,189,215],"polarization.":[100,216],"RESULTS:":[101],"Employing":[102],"primary":[103,170],"human":[104],"adipocyte":[108],"cultures,":[109],"observed":[111],"that":[112,203,211],"adipocytes":[113],"displayed":[117],"persistent":[119],"phenotype":[121],"even":[122],"after":[123],"prolonged":[124],"time":[125],"culture,":[127],"cytokine":[129],"secretion":[130,166],"profile":[131],"also":[132],"recapitulated":[133],"via":[134],"lipopolysaccharide":[135],"stimulation.":[136],"Analyzing":[137],"WAT":[145,240],"found":[154],"an":[155],"co-cultures":[162],"led":[163],"elevated":[165],"MCP-1":[168,227],"by":[169],"adipocytes,":[171],"facilitating":[172],"migration.":[174],"Consequently,":[175],"co-transfer":[176],"cells":[179,182],"T":[181,184],"increased":[183],"activation":[186],"M2-like":[188,214,233],"inflamed":[192,223],"WAT.":[194],"Mass":[195],"spectrometry":[196],"analyses":[201],"suggested":[202],"establishes":[208],"microenvironment":[210],"may":[212],"promote":[213],"CONCLUSION:":[217],"interactions":[220],"CD-associated":[222],"increase":[226],"lactate,":[229],"promoting":[230],"polarization":[234],"macrophages,":[236],"likely":[237],"amplifying":[238],"local":[239],"inflammation.":[241]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2025-10-10T00:00:00"}
