{"id":"https://openalex.org/W4412388399","doi":"https://doi.org/10.7759/cureus.87879","title":"Cardiomyopathy in the Shadow of Fibrillary Glomerulonephritis: An Unusual Indirect Association","display_name":"Cardiomyopathy in the Shadow of Fibrillary Glomerulonephritis: An Unusual Indirect Association","publication_year":2025,"publication_date":"2025-07-14","ids":{"openalex":"https://openalex.org/W4412388399","doi":"https://doi.org/10.7759/cureus.87879","pmid":"https://pubmed.ncbi.nlm.nih.gov/40821257"},"language":"en","primary_location":{"id":"doi:10.7759/cureus.87879","doi":"https://doi.org/10.7759/cureus.87879","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.87879","pdf_url":"https://www.cureus.com/articles/360172-cardiomyopathy-in-the-shadow-of-fibrillary-glomerulonephritis-an-unusual-indirect-association.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.cureus.com/articles/360172-cardiomyopathy-in-the-shadow-of-fibrillary-glomerulonephritis-an-unusual-indirect-association.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Satya Rijal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I2800531617","display_name":"Sparrow Hospital","ror":"https://ror.org/018dx8725","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800531617"]},{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Satya Rijal","raw_affiliation_strings":["Internal Medicine, Michigan State University College of Human Medicine, East Lansing, USA","Internal Medicine, University of Michigan Health-Sparrow Hospital, East Lansing, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Michigan State University College of Human Medicine, East Lansing, USA","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Internal Medicine, University of Michigan Health-Sparrow Hospital, East Lansing, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I2800531617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081847838","display_name":"Maitri P Shah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I2800531617","display_name":"Sparrow Hospital","ror":"https://ror.org/018dx8725","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800531617"]},{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maitri P Shah","raw_affiliation_strings":["Internal Medicine, Michigan State University College of Human Medicine, East Lansing, USA","Internal Medicine, University of Michigan Health-Sparrow Hospital, East Lansing, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Michigan State University College of Human Medicine, East Lansing, USA","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Internal Medicine, University of Michigan Health-Sparrow Hospital, East Lansing, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I2800531617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093258528","display_name":"Sai Sushrutha Mudupula Vemula","orcid":"https://orcid.org/0009-0003-1250-5532","observed_orcids":["https://orcid.org/0009-0003-1250-5532"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I2800531617","display_name":"Sparrow Hospital","ror":"https://ror.org/018dx8725","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800531617"]},{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sai Sushrutha Mudupula Vemula","raw_affiliation_strings":["Internal Medicine, Michigan State University College of Human Medicine, East Lansing, USA","Internal Medicine, University of Michigan Health-Sparrow Hospital, East Lansing, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Michigan State University College of Human Medicine, East Lansing, USA","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Internal Medicine, University of Michigan Health-Sparrow Hospital, East Lansing, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I2800531617"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102933305","display_name":"Prakash Khanal","orcid":"https://orcid.org/0000-0002-7862-6869","observed_orcids":["https://orcid.org/0000-0002-7862-6869"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I2800531617","display_name":"Sparrow Hospital","ror":"https://ror.org/018dx8725","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800531617"]},{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prakash Khanal","raw_affiliation_strings":["Internal Medicine, Michigan State University College of Human Medicine, East Lansing, USA","Internal Medicine, University of Michigan Health-Sparrow Hospital, East Lansing, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Michigan State University College of Human Medicine, East Lansing, USA","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Internal Medicine, University of Michigan Health-Sparrow Hospital, East Lansing, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I2800531617"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066387016","display_name":"Ayushma Duwadi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I2800531617","display_name":"Sparrow Hospital","ror":"https://ror.org/018dx8725","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800531617"]},{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ayushma Duwadi","raw_affiliation_strings":["Internal Medicine, Michigan State University College of Human Medicine, East Lansing, USA","Internal Medicine, University of Michigan Health-Sparrow Hospital, East Lansing, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine, Michigan State University College of Human Medicine, East Lansing, USA","institution_ids":["https://openalex.org/I87216513"]},{"raw_affiliation_string":"Internal Medicine, University of Michigan Health-Sparrow Hospital, East Lansing, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I2800531617"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1722548,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"7","first_page":"e87879","last_page":"e87879"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fibrillary-glomerulonephritis","display_name":"fibrillary glomerulonephritis","score":0.996999979019165},{"id":"https://openalex.org/keywords/secondary-cardiomyopathy","display_name":"secondary cardiomyopathy","score":0.8769999742507935},{"id":"https://openalex.org/keywords/left-ventricular-hypertrophy","display_name":"left ventricular hypertrophy","score":0.7390000224113464},{"id":"https://openalex.org/keywords/systolic-dysfunction","display_name":"systolic dysfunction","score":0.8579999804496765},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.8140000104904175},{"id":"https://openalex.org/keywords/nephrotic-syndrome","display_name":"nephrotic syndrome","score":0.8999999761581421},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.8880000114440918},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.6809999942779541},{"id":"https://openalex.org/keywords/left-ventricular-remodeling","display_name":"left ventricular remodeling","score":0.7070000171661377},{"id":"https://openalex.org/keywords/rituximab","display_name":"rituximab","score":0.8579999804496765},{"id":"https://openalex.org/keywords/prednisone","display_name":"prednisone","score":0.9430000185966492},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.48899999260902405},{"id":"https://openalex.org/keywords/ventricular-ejection-fraction","display_name":"ventricular ejection fraction","score":0.7239999771118164},{"id":"https://openalex.org/keywords/brain-natriuretic-peptide","display_name":"brain natriuretic peptide","score":0.7200000286102295},{"id":"https://openalex.org/keywords/fluid-overload","display_name":"fluid overload","score":0.38999998569488525}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.969011664390564},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.6278745532035828},{"id":"https://openalex.org/C117797892","wikidata":"https://www.wikidata.org/wiki/Q286363","display_name":"Shadow (psychology)","level":2,"score":0.5208247900009155},{"id":"https://openalex.org/C2780368995","wikidata":"https://www.wikidata.org/wiki/Q605006","display_name":"Glomerulonephritis","level":3,"score":0.5034543871879578},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.42058658599853516},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34358108043670654},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33883732557296753},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3336471915245056},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.3261576294898987},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.23029795289039612},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.08301529288291931},{"id":"https://openalex.org/C11171543","wikidata":"https://www.wikidata.org/wiki/Q41630","display_name":"Psychoanalysis","level":1,"score":0.061460673809051514},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.7759/cureus.87879","doi":"https://doi.org/10.7759/cureus.87879","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.87879","pdf_url":"https://www.cureus.com/articles/360172-cardiomyopathy-in-the-shadow-of-fibrillary-glomerulonephritis-an-unusual-indirect-association.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},{"id":"pmid:40821257","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40821257","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"Case Reports"},{"id":"pmh:oai:pubmedcentral.nih.gov:12351503","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12351503","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cureus","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.7759/cureus.87879","doi":"https://doi.org/10.7759/cureus.87879","is_oa":true,"landing_page_url":"https://doi.org/10.7759/cureus.87879","pdf_url":"https://www.cureus.com/articles/360172-cardiomyopathy-in-the-shadow-of-fibrillary-glomerulonephritis-an-unusual-indirect-association.pdf","source":{"id":"https://openalex.org/S2738950867","display_name":"Cureus","issn_l":"2168-8184","issn":["2168-8184"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310316779","host_organization_name":"Cureus, Inc.","host_organization_lineage":["https://openalex.org/P4310316779"],"host_organization_lineage_names":["Cureus, Inc."],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cureus","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/5","display_name":"Gender equality","score":0.4300000071525574}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412388399.pdf","grobid_xml":"https://content.openalex.org/works/W4412388399.grobid-xml"},"referenced_works_count":10,"referenced_works":["https://openalex.org/W2078572625","https://openalex.org/W2116275357","https://openalex.org/W2281776699","https://openalex.org/W2936540719","https://openalex.org/W2943231095","https://openalex.org/W2985727417","https://openalex.org/W4281477959","https://openalex.org/W4317616742","https://openalex.org/W4400235023","https://openalex.org/W4401090958"],"related_works":["https://openalex.org/W2893218741","https://openalex.org/W4392589133","https://openalex.org/W2558319350","https://openalex.org/W1492594177","https://openalex.org/W1842742976","https://openalex.org/W2803235238","https://openalex.org/W3112085556","https://openalex.org/W399661440","https://openalex.org/W4392585872","https://openalex.org/W410356389"],"abstract_inverted_index":{"Fibrillary":[0],"glomerulonephritis":[1],"(FGN)":[2],"is":[3,45,310,315,336],"a":[4,119,122,128,173,180,212,226,254,318],"rare":[5,213],"and":[6,24,30,43,63,75,96,104,137,152,169,202,241,247,258,265,290,305,342],"complex":[7],"renal":[8,138,161,167,189,200,249],"disease":[9],"where":[10],"the":[11,22,34,84,170,184,205,261,327,340],"accumulation":[12],"of":[13,17,121,131,154,172,176,186,207,260,292,344],"non-amyloid":[14],"microfibrils":[15],"composed":[16],"polyclonal":[18],"immunoglobulin":[19],"G":[20],"within":[21],"mesangium":[23],"glomerular":[25],"capillaries":[26],"results":[27],"in":[28,33,90,256,321,347],"structural":[29,95],"functional":[31,97],"abnormalities":[32],"kidney's":[35],"filtering":[36],"units.":[37],"The":[38,209,237],"direct":[39,109],"link":[40],"between":[41],"FGN":[42,91,324,348],"cardiomyopathy":[44,136,304],"not":[46,222],"well":[47],"established.":[48],"However,":[49],"it":[50,68],"may":[51],"be":[52,72,223],"caused":[53],"secondarily":[54],"by":[55,77,114],"systemic":[56],"inflammation,":[57],"uremia,":[58],"or":[59,112],"other":[60],"overlapping":[61],"factors":[62],"comorbidities.":[64],"In":[65],"our":[66],"case,":[67],"was":[69],"believed":[70],"to":[71,94,158,165,179,194,217,232,338],"significantly":[73],"influenced":[74],"worsened":[76],"various":[78],"comorbid":[79],"conditions,":[80],"with":[81,127,134,146,239,278,317],"hypertension":[82],"being":[83],"most":[85],"common":[86],"cardiovascular":[87],"risk":[88],"factor":[89],"itself,":[92],"contributing":[93],"cardiac":[98,214,227,330,345],"impairment,":[99],"including":[100,141],"left":[101,285],"ventricular":[102,286,293],"hypertrophy":[103],"systolic":[105],"dysfunction,":[106],"rather":[107],"than":[108],"myocardial":[110],"infiltration":[111],"damage":[113],"fibrillary":[115],"deposit.":[116],"We":[117],"have":[118],"case":[120],"60-year-old":[123],"female":[124],"who":[125],"presented":[126],"severe":[129],"manifestation":[130],"FGN,":[132,219,244],"associated":[133,316],"secondary":[135],"failure":[139],"complications,":[140],"hypertension-related":[142],"issues,":[143],"nephrotic":[144,174],"syndrome":[145],"significant":[147],"proteinuria,":[148],"peripheral":[149],"edema,":[150],"anasarca,":[151],"shortness":[153],"breath,":[155],"initially":[156],"leading":[157],"hospitalization.":[159],"Her":[160,188],"insufficiency":[162],"subsequently":[163],"progressed":[164],"end-stage":[166],"disease,":[168],"discovery":[171],"range":[175],"proteinuria":[177,246],"led":[178],"kidney":[181],"biopsy,":[182],"confirming":[183],"diagnosis":[185],"FGN.":[187],"recovery":[190,201],"remained":[191],"poor":[192],"due":[193],"persistent":[195],"volume":[196],"overload,":[197],"which":[198,203,220,251],"impeded":[199],"required":[204],"initiation":[206],"dialysis.":[208],"patient":[210],"experienced":[211],"involvement":[215,346],"related":[216],"underlying":[218],"could":[221],"confirmed":[224],"through":[225],"biopsy":[228],"because":[229],"she":[230],"chose":[231],"refuse":[233],"this":[234],"invasive":[235],"test.":[236],"treatment":[238],"prednisone":[240],"rituximab":[242],"targeted":[243,351],"reducing":[245],"improving":[248],"function,":[250],"allowed":[252],"for":[253,349],"decrease":[255],"hemodialysis":[257],"normalization":[259],"erythrocyte":[262],"sedimentation":[263],"rate":[264],"C-reactive":[266],"protein":[267],"at":[268],"12":[269],"months.":[270],"Cardiac":[271],"function":[272],"also":[273],"improved":[274,313],"after":[275],"six":[276],"months,":[277],"lower":[279],"brain":[280],"natriuretic":[281],"peptide":[282],"levels,":[283],"increased":[284],"ejection":[287],"fraction":[288],"(LVEF),":[289],"reversal":[291],"remodeling":[294],"on":[295],"echocardiogram,":[296],"suggesting":[297],"that":[298],"early":[299],"immunologic":[300],"intervention":[301],"can":[302],"reverse":[303],"prevent":[306],"progression.":[307],"Longer":[308],"follow-up":[309],"recommended,":[311],"as":[312],"LVEF":[314],"better":[319],"prognosis":[320],"heart":[322],"failure.":[323],"typically":[325],"affects":[326],"kidneys,":[328],"making":[329],"issues":[331],"uncommon.":[332],"Therefore,":[333],"further":[334],"research":[335],"needed":[337],"understand":[339],"prevalence":[341],"mechanisms":[343],"developing":[350],"therapies.":[352]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}