{"id":"https://openalex.org/W4412379983","doi":"https://doi.org/10.3389/fcvm.2025.1631992","title":"A \u201cgiant bomb\u201d in acute myocardial infarction due to coronary artery aneurysm: a case report","display_name":"A \u201cgiant bomb\u201d in acute myocardial infarction due to coronary artery aneurysm: a case report","publication_year":2025,"publication_date":"2025-07-14","ids":{"openalex":"https://openalex.org/W4412379983","doi":"https://doi.org/10.3389/fcvm.2025.1631992","pmid":"https://pubmed.ncbi.nlm.nih.gov/40727575"},"language":"en","primary_location":{"id":"doi:10.3389/fcvm.2025.1631992","doi":"https://doi.org/10.3389/fcvm.2025.1631992","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2025.1631992","pdf_url":"https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1631992/pdf","source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1631992/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jin Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin Chen","raw_affiliation_strings":["Department of Cardiology, Zhangjiagang Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Traditional Chinese Medicine, Zhangjiagang, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Zhangjiagang Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Traditional Chinese Medicine, Zhangjiagang, Jiangsu, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086354656","display_name":"Wei Du","orcid":"https://orcid.org/0000-0003-4694-7649","observed_orcids":["https://orcid.org/0000-0003-4694-7649"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Du","raw_affiliation_strings":["Department of Cardiology, Zhangjiagang Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Traditional Chinese Medicine, Zhangjiagang, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Zhangjiagang Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Traditional Chinese Medicine, Zhangjiagang, Jiangsu, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jianyu Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianyu Jiang","raw_affiliation_strings":["Department of Cardiology, Zhangjiagang Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Traditional Chinese Medicine, Zhangjiagang, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Zhangjiagang Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Traditional Chinese Medicine, Zhangjiagang, Jiangsu, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062144400","display_name":"Liugang Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Liugang Xu","raw_affiliation_strings":["Department of Cardiology, Zhangjiagang City Hospital of Traditional Chinese Medicine Attached to Jiangsu Institute of Vocational Medicine, Zhangjiagang, Jiangsu, China","Department of Cardiology, Zhangjiagang Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Traditional Chinese Medicine, Zhangjiagang, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Zhangjiagang City Hospital of Traditional Chinese Medicine Attached to Jiangsu Institute of Vocational Medicine, Zhangjiagang, Jiangsu, China","institution_ids":[]},{"raw_affiliation_string":"Department of Cardiology, Zhangjiagang Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Traditional Chinese Medicine, Zhangjiagang, Jiangsu, China","institution_ids":["https://openalex.org/I131434179"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5062144400"],"corresponding_institution_ids":["https://openalex.org/I131434179"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.20954227,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":null,"first_page":"1631992","last_page":"1631992"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12018","display_name":"Coronary Artery Anomalies","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12018","display_name":"Coronary Artery Anomalies","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10292","display_name":"Acute Myocardial Infarction Research","score":0.01769999973475933,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coronary-artery-aneurysm","display_name":"coronary artery aneurysm","score":0.9990000128746033},{"id":"https://openalex.org/keywords/st-elevation-myocardial-infarction","display_name":"ST-elevation myocardial infarction","score":0.9190000295639038},{"id":"https://openalex.org/keywords/acute-coronary-syndrome","display_name":"acute coronary syndrome","score":0.8690000176429749},{"id":"https://openalex.org/keywords/aspiration-thrombectomy","display_name":"thrombus aspiration","score":0.8029999732971191},{"id":"https://openalex.org/keywords/dual-antiplatelet-therapy","display_name":"dual antiplatelet therapy","score":1.0},{"id":"https://openalex.org/keywords/endothelial-shear-stress","display_name":"endothelial shear stress","score":0.7680000066757202},{"id":"https://openalex.org/keywords/blood-stasis","display_name":"blood stasis","score":0.7789999842643738},{"id":"https://openalex.org/keywords/right-coronary-artery","display_name":"right coronary artery","score":0.6959999799728394},{"id":"https://openalex.org/keywords/treatment-algorithm","display_name":"treatment algorithm","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.934272050857544},{"id":"https://openalex.org/C2781362458","wikidata":"https://www.wikidata.org/wiki/Q1588755","display_name":"Thrombus","level":2,"score":0.6970217227935791},{"id":"https://openalex.org/C2776098176","wikidata":"https://www.wikidata.org/wiki/Q189389","display_name":"Aneurysm","level":2,"score":0.6833924055099487},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6716747879981995},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.6557897329330444},{"id":"https://openalex.org/C2777995511","wikidata":"https://www.wikidata.org/wiki/Q2897649","display_name":"TIMI","level":4,"score":0.6263299584388733},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5953524112701416},{"id":"https://openalex.org/C2780400711","wikidata":"https://www.wikidata.org/wiki/Q2008344","display_name":"Percutaneous coronary intervention","level":3,"score":0.5711493492126465},{"id":"https://openalex.org/C2776055304","wikidata":"https://www.wikidata.org/wiki/Q5172183","display_name":"Coronary artery aneurysm","level":4,"score":0.5299720764160156},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.487037718296051},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.4370340406894684},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.414112389087677},{"id":"https://openalex.org/C3019004856","wikidata":"https://www.wikidata.org/wiki/Q42297149","display_name":"Coronary angiography","level":3,"score":0.09835872054100037}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fcvm.2025.1631992","doi":"https://doi.org/10.3389/fcvm.2025.1631992","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2025.1631992","pdf_url":"https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1631992/pdf","source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},{"id":"pmid:40727575","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40727575","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cardiovascular medicine","raw_type":"Case Reports"},{"id":"pmh:oai:pubmedcentral.nih.gov:12301389","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12301389","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Cardiovasc Med","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:ecc75f4902c6444c83f8f0ec20f815c5","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ecc75f4902c6444c83f8f0ec20f815c5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cardiovascular Medicine, Vol 12 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcvm.2025.1631992","doi":"https://doi.org/10.3389/fcvm.2025.1631992","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcvm.2025.1631992","pdf_url":"https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1631992/pdf","source":{"id":"https://openalex.org/S2595413687","display_name":"Frontiers in Cardiovascular Medicine","issn_l":"2297-055X","issn":["2297-055X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cardiovascular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8500000238418579,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412379983.pdf","grobid_xml":"https://content.openalex.org/works/W4412379983.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W2001395014","https://openalex.org/W2015217324","https://openalex.org/W2128341391","https://openalex.org/W2140758224","https://openalex.org/W2765289951","https://openalex.org/W2783936617","https://openalex.org/W2799782428","https://openalex.org/W2809996878","https://openalex.org/W2958174632","https://openalex.org/W2994710872","https://openalex.org/W3021386420","https://openalex.org/W3035162280","https://openalex.org/W3084957133","https://openalex.org/W3138708800","https://openalex.org/W4210610619","https://openalex.org/W4223604938","https://openalex.org/W4324335438","https://openalex.org/W4394713387"],"related_works":["https://openalex.org/W2034570615","https://openalex.org/W2002059153","https://openalex.org/W1975484197","https://openalex.org/W2077300746","https://openalex.org/W2029556496","https://openalex.org/W12058249","https://openalex.org/W2010954547","https://openalex.org/W2348831066","https://openalex.org/W2218936584","https://openalex.org/W2025945167"],"abstract_inverted_index":{"Background:":[0],"Coronary":[1],"artery":[2,62,103,194,249],"aneurysm":[3,63,104,250],"associated":[4,251],"with":[5,17,88,105,133,209,247,252],"acute":[6,89,253],"coronary":[7,61,96,102,171,193,248,254],"syndromes":[8],"represents":[9],"a":[10,99,182,192,214],"rare":[11,183],"clinical":[12],"entity,":[13],"particularly":[14],"in":[15,60,75,200,224,227],"cases":[16],"persistent":[18,119],"significant":[19,106,225],"thrombus":[20,108,112,121],"burden":[21],"following":[22],"aspiration":[23,113],"therapy.":[24],"The":[25],"novel":[26],"pathomechanism":[27],"of":[28,53,129,157,164,176,185,220],"intra-aneurysmal":[29,107,166],"thrombosis":[30],"secondary":[31],"to":[32,240],"pathological":[33],"flow":[34,172],"dynamics-characterized":[35],"by":[36,169,191],"endothelial":[37],"shear":[38],"stress":[39],"perturbation":[40],"and":[41,58,173],"blood":[42],"stasis-has":[43],"been":[44,69],"rarely":[45],"documented.":[46],"While":[47,205],"existing":[48],"literature":[49],"describes":[50],"therapeutic":[51,142,198],"applications":[52],"surgical":[54],"repair,":[55],"percutaneous":[56,138],"intervention,":[57],"pharmacotherapy":[59],"management,":[64],"no":[65,174],"consensus-driven":[66],"protocol":[67],"has":[68],"established,":[70],"reflecting":[71],"critical":[72],"knowledge":[73],"gaps":[74],"risk-stratified":[76],"treatment":[77,228],"algorithms":[78],"for":[79,236,245],"thrombus-laden":[80],"aneurysms.":[81],"Case":[82],"outline:":[83],"A":[84],"51-year-old":[85],"female":[86],"presenting":[87],"ST-segment":[90,186],"elevation":[91,187],"myocardial":[92,188],"infarction":[93,189],"underwent":[94],"emergency":[95],"angiography,":[97],"revealing":[98],"large":[100],"right":[101],"burden.":[109],"Despite":[110],"successful":[111],"restoring":[114],"distal":[115,177],"TIMI":[116],"3":[117],"flow,":[118],"residual":[120],"within":[122],"the":[123,127,141,144,165,197,218,233],"aneurysmal":[124],"segment":[125],"prompted":[126],"selection":[128],"intensified":[130,206],"anticoagulation":[131,207],"combined":[132,208],"dual":[134,210],"antiplatelet":[135,211],"therapy":[136,160,212],"over":[137],"intervention.":[139],"Throughout":[140],"course,":[143],"patient":[145],"remained":[146],"asymptomatic":[147],"without":[148],"recurrent":[149],"angina.":[150],"Follow-up":[151],"angiography":[152],"performed":[153],"after":[154],"7":[155],"days":[156],"targeted":[158],"antithrombotic":[159],"demonstrated":[161],"near-complete":[162],"resolution":[163],"thrombus,":[167],"accompanied":[168],"preserved":[170],"evidence":[175],"embolization.":[178],"Conclusion:":[179],"We":[180],"present":[181],"case":[184,231],"complicated":[190],"aneurysm,":[195],"highlighting":[196],"challenges":[199],"managing":[201],"such":[202],"complex":[203],"pathologies.":[204],"constitutes":[213],"clinically":[215],"valid":[216],"approach,":[217],"absence":[219],"consensus":[221],"guidelines":[222],"results":[223],"variability":[226],"protocols.":[229],"This":[230],"underscores":[232],"urgent":[234],"need":[235],"large-scale":[237],"multicenter":[238],"studies":[239],"establish":[241],"evidence-based":[242],"management":[243],"strategies":[244],"patients":[246],"syndromes.":[255]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
