{"id":"https://openalex.org/W4412379854","doi":"https://doi.org/10.5021/ad.25.063","title":"Botulinum Toxin A Modulates Keratinocyte Proliferation and Inflammatory and Pruritic Mediators in Wound Healing","display_name":"Botulinum Toxin A Modulates Keratinocyte Proliferation and Inflammatory and Pruritic Mediators in Wound Healing","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4412379854","doi":"https://doi.org/10.5021/ad.25.063","pmid":"https://pubmed.ncbi.nlm.nih.gov/41044806"},"language":"en","primary_location":{"id":"doi:10.5021/ad.25.063","doi":"https://doi.org/10.5021/ad.25.063","is_oa":true,"landing_page_url":"https://doi.org/10.5021/ad.25.063","pdf_url":"http://anndermatol.org/Synapse/Data/PDFData/0140AD/ad-37-e24.pdf","source":{"id":"https://openalex.org/S182931825","display_name":"Annals of Dermatology","issn_l":"1013-9087","issn":["1013-9087","2005-3894"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","kci-registered","ki-jl-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4324001547","host_organization_name":"Korean Dermatological Association","host_organization_lineage":["https://openalex.org/P4324001547"],"host_organization_lineage_names":["Korean Dermatological Association"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://anndermatol.org/Synapse/Data/PDFData/0140AD/ad-37-e24.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110668185","display_name":"Dayeon Jung","orcid":"https://orcid.org/0000-0003-3431-9397","observed_orcids":["https://orcid.org/0000-0003-3431-9397"]},"institutions":[{"id":"https://openalex.org/I146824383","display_name":"Hallym University","ror":"https://ror.org/03sbhge02","country_code":"KR","type":"education","lineage":["https://openalex.org/I146824383"]},{"id":"https://openalex.org/I4210159787","display_name":"Hallym University Sacred Heart Hospital","ror":"https://ror.org/04ngysf93","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210159787","https://openalex.org/I4210167048"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dayeon Jung","raw_affiliation_strings":["Department of Dermatology, College of Medicine, Hallym University, Chuncheon, Korea","Department of Dermatology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea"],"raw_orcid":"https://orcid.org/0000-0003-3431-9397","affiliations":[{"raw_affiliation_string":"Department of Dermatology, College of Medicine, Hallym University, Chuncheon, Korea","institution_ids":["https://openalex.org/I146824383"]},{"raw_affiliation_string":"Department of Dermatology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea","institution_ids":["https://openalex.org/I4210159787"]}]},{"author_position":"middle","author":{"id":null,"display_name":"SunMee Shin","orcid":"https://orcid.org/0000-0002-7903-6879","observed_orcids":["https://orcid.org/0000-0002-7903-6879"]},"institutions":[{"id":"https://openalex.org/I4210167048","display_name":"Hallym University Medical Center","ror":"https://ror.org/05ydxj072","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210167048"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"SunMee Shin","raw_affiliation_strings":["Department of Dermatology, Hallym Institute for Translational Medicine, Anyang, Korea"],"raw_orcid":"https://orcid.org/0000-0002-7903-6879","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Hallym Institute for Translational Medicine, Anyang, Korea","institution_ids":["https://openalex.org/I4210167048"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100708405","display_name":"Kwang Ho Kim","orcid":"https://orcid.org/0000-0001-5315-6031","observed_orcids":["https://orcid.org/0000-0001-5315-6031"]},"institutions":[{"id":"https://openalex.org/I146824383","display_name":"Hallym University","ror":"https://ror.org/03sbhge02","country_code":"KR","type":"education","lineage":["https://openalex.org/I146824383"]},{"id":"https://openalex.org/I4210159787","display_name":"Hallym University Sacred Heart Hospital","ror":"https://ror.org/04ngysf93","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210159787","https://openalex.org/I4210167048"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kwang Ho Kim","raw_affiliation_strings":["Department of Dermatology, College of Medicine, Hallym University, Chuncheon, Korea","Department of Dermatology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea"],"raw_orcid":"https://orcid.org/0000-0001-5315-6031","affiliations":[{"raw_affiliation_string":"Department of Dermatology, College of Medicine, Hallym University, Chuncheon, Korea","institution_ids":["https://openalex.org/I146824383"]},{"raw_affiliation_string":"Department of Dermatology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea","institution_ids":["https://openalex.org/I4210159787"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005234873","display_name":"Kwang Joong Kim","orcid":"https://orcid.org/0000-0003-4158-6100","observed_orcids":["https://orcid.org/0000-0003-4158-6100"]},"institutions":[{"id":"https://openalex.org/I146824383","display_name":"Hallym University","ror":"https://ror.org/03sbhge02","country_code":"KR","type":"education","lineage":["https://openalex.org/I146824383"]},{"id":"https://openalex.org/I4210159787","display_name":"Hallym University Sacred Heart Hospital","ror":"https://ror.org/04ngysf93","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210159787","https://openalex.org/I4210167048"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kwang Joong Kim","raw_affiliation_strings":["Department of Dermatology, College of Medicine, Hallym University, Chuncheon, Korea","Department of Dermatology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea"],"raw_orcid":"https://orcid.org/0000-0003-4158-6100","affiliations":[{"raw_affiliation_string":"Department of Dermatology, College of Medicine, Hallym University, Chuncheon, Korea","institution_ids":["https://openalex.org/I146824383"]},{"raw_affiliation_string":"Department of Dermatology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea","institution_ids":["https://openalex.org/I4210159787"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102004697","display_name":"Eun Joo Park","orcid":"https://orcid.org/0000-0002-9924-515X","observed_orcids":["https://orcid.org/0000-0002-9924-515X"]},"institutions":[{"id":"https://openalex.org/I146824383","display_name":"Hallym University","ror":"https://ror.org/03sbhge02","country_code":"KR","type":"education","lineage":["https://openalex.org/I146824383"]},{"id":"https://openalex.org/I4210159787","display_name":"Hallym University Sacred Heart Hospital","ror":"https://ror.org/04ngysf93","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210159787","https://openalex.org/I4210167048"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eun Joo Park","raw_affiliation_strings":["Department of Dermatology, College of Medicine, Hallym University, Chuncheon, Korea","Department of Dermatology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea"],"raw_orcid":"https://orcid.org/0000-0002-9924-515X","affiliations":[{"raw_affiliation_string":"Department of Dermatology, College of Medicine, Hallym University, Chuncheon, Korea","institution_ids":["https://openalex.org/I146824383"]},{"raw_affiliation_string":"Department of Dermatology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea","institution_ids":["https://openalex.org/I4210159787"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1500403,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"37","issue":"5","first_page":"269","last_page":"269"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.7929999828338623,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.7929999828338623,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":0.12540000677108765,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.02630000002682209,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/botulinum-toxin-type-a","display_name":"botulinum toxin type A","score":0.9860000014305115},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.8650000095367432},{"id":"https://openalex.org/keywords/keratinocyte-proliferation","display_name":"keratinocyte proliferation","score":0.9739999771118164},{"id":"https://openalex.org/keywords/keratinocyte-migration","display_name":"keratinocyte migration","score":0.996999979019165},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.8370000123977661},{"id":"https://openalex.org/keywords/smad2-3-phosphorylation","display_name":"Smad2/3 phosphorylation","score":0.9399999976158142},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.75},{"id":"https://openalex.org/keywords/pruritus","display_name":"pruritus","score":0.9480000138282776},{"id":"https://openalex.org/keywords/il-31","display_name":"IL-31","score":0.7590000033378601},{"id":"https://openalex.org/keywords/il-33","display_name":"IL-33","score":0.9520000219345093},{"id":"https://openalex.org/keywords/substance-p","display_name":"substance P","score":0.7269999980926514},{"id":"https://openalex.org/keywords/calcitonin-gene-related-peptide","display_name":"calcitonin gene-related peptide","score":0.9200000166893005},{"id":"https://openalex.org/keywords/cathepsin-s","display_name":"cathepsin S","score":0.8799999952316284},{"id":"https://openalex.org/keywords/prostaglandin-e-synthase","display_name":"prostaglandin E synthase","score":0.8029999732971191},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.7509999871253967},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.48100000619888306}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9416941404342651},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.6916893720626831},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.6360560059547424},{"id":"https://openalex.org/C2777478456","wikidata":"https://www.wikidata.org/wiki/Q208413","display_name":"Botulinum toxin","level":2,"score":0.5083975195884705},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.447611927986145},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.41490763425827026},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33100128173828125},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31469643115997314},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.2045162320137024},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.16345810890197754},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.08535271883010864},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.5021/ad.25.063","doi":"https://doi.org/10.5021/ad.25.063","is_oa":true,"landing_page_url":"https://doi.org/10.5021/ad.25.063","pdf_url":"http://anndermatol.org/Synapse/Data/PDFData/0140AD/ad-37-e24.pdf","source":{"id":"https://openalex.org/S182931825","display_name":"Annals of Dermatology","issn_l":"1013-9087","issn":["1013-9087","2005-3894"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","kci-registered","ki-jl-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4324001547","host_organization_name":"Korean Dermatological Association","host_organization_lineage":["https://openalex.org/P4324001547"],"host_organization_lineage_names":["Korean Dermatological Association"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Dermatology","raw_type":"journal-article"},{"id":"pmid:41044806","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41044806","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of dermatology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11313311","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12505372","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12505372","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12505372/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Ann Dermatol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.5021/ad.25.063","doi":"https://doi.org/10.5021/ad.25.063","is_oa":true,"landing_page_url":"https://doi.org/10.5021/ad.25.063","pdf_url":"http://anndermatol.org/Synapse/Data/PDFData/0140AD/ad-37-e24.pdf","source":{"id":"https://openalex.org/S182931825","display_name":"Annals of Dermatology","issn_l":"1013-9087","issn":["1013-9087","2005-3894"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","kci-registered","ki-jl-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4324001547","host_organization_name":"Korean Dermatological Association","host_organization_lineage":["https://openalex.org/P4324001547"],"host_organization_lineage_names":["Korean Dermatological Association"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Dermatology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.6899999976158142}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3752584820","display_name":null,"funder_award_id":"RS202300248787","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320321367","display_name":"Hallym University","ror":"https://ror.org/03sbhge02"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412379854.pdf","grobid_xml":"https://content.openalex.org/works/W4412379854.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1023732356","https://openalex.org/W1547736903","https://openalex.org/W1745952739","https://openalex.org/W1981764249","https://openalex.org/W2035031081","https://openalex.org/W2046304513","https://openalex.org/W2063140011","https://openalex.org/W2087554786","https://openalex.org/W2089740159","https://openalex.org/W2102565647","https://openalex.org/W2140137404","https://openalex.org/W2158259619","https://openalex.org/W2461451462","https://openalex.org/W2511250646","https://openalex.org/W2548516545","https://openalex.org/W2606918428","https://openalex.org/W2785747601","https://openalex.org/W2804259135","https://openalex.org/W2943490940","https://openalex.org/W2963025783","https://openalex.org/W2969247772","https://openalex.org/W2972983540","https://openalex.org/W3035991748","https://openalex.org/W3042768509","https://openalex.org/W3092754589","https://openalex.org/W3103671200","https://openalex.org/W3149296709","https://openalex.org/W3160758742","https://openalex.org/W4210355395","https://openalex.org/W4221085542","https://openalex.org/W4281664222","https://openalex.org/W4381433115","https://openalex.org/W4383955720","https://openalex.org/W4393052013"],"related_works":["https://openalex.org/W2389805019","https://openalex.org/W2044188579","https://openalex.org/W1919163543","https://openalex.org/W2349215575","https://openalex.org/W2786432207","https://openalex.org/W2393575317","https://openalex.org/W2069859312","https://openalex.org/W2188921905","https://openalex.org/W4213437920","https://openalex.org/W2594436424"],"abstract_inverted_index":{"BACKGROUND:":[0],"Botulinum":[1],"toxin":[2],"type":[3],"A":[4],"(BTA)":[5],"is":[6],"widely":[7],"used":[8,101],"in":[9,23],"dermatologic":[10],"procedures.":[11],"While":[12],"its":[13,21],"anti-fibrotic":[14],"effects":[15,37],"on":[16,40],"fibroblasts":[17],"are":[18],"well":[19],"established,":[20],"role":[22],"keratinocyte-driven":[24],"inflammation":[25,188],"and":[26,44,52,73,82,89,106,124,144,156,165,169,189],"pruritus":[27],"during":[28],"wound":[29,65,179],"healing":[30,180],"remains":[31],"underexplored.":[32],"OBJECTIVE:":[33],"To":[34],"evaluate":[35],"the":[36],"of":[38,50,122],"BTA":[39,69,110,126,161,176],"keratinocyte":[41,113,163,183],"proliferation,":[42],"migration,":[43],"transforming":[45],"growth":[46],"factor-beta":[47],"(TGF-\u03b2)-induced":[48],"expression":[49],"inflammatory":[51,104,168],"pruritus-associated":[53,170],"mediator.":[54],"METHODS:":[55],"Human":[56],"epidermal":[57],"keratinocytes":[58],"were":[59,75],"stimulated":[60],"with":[61],"TGF-\u03b2":[62],"to":[63,102],"mimic":[64],"conditions,":[66],"followed":[67],"by":[68,181],"co-treatment.":[70],"Cell":[71],"proliferation":[72,114,164,184],"migration":[74],"assessed":[76],"using":[77],"water":[78],"soluble":[79],"tetrazolium":[80],"salt-8":[81],"scratch":[83],"assays.":[84],"Western":[85],"blotting":[86],"evaluated":[87],"Smad2/3":[88,123],"extracellular":[90],"signal-regulated":[91],"kinase":[92],"(ERK)1/2":[93],"phosphorylation.":[94],"Reverse":[95],"transcription-quantitative":[96],"polymerase":[97],"chain":[98],"reaction":[99],"was":[100],"quantify":[103],"cytokines":[105,130],"itch-related":[107],"mediators.":[108,171],"RESULTS:":[109],"significantly":[111],"enhanced":[112],"without":[115],"affecting":[116],"migration.":[117],"It":[118],"inhibited":[119],"TGF-\u03b2-induced":[120,167],"phosphorylation":[121],"ERK1/2.":[125],"also":[127],"downregulated":[128],"pro-inflammatory":[129],"(interleukin":[131],"[IL]-1\u03b2,":[132],"IL-6,":[133],"tumor":[134],"necrosis":[135],"factor-\u03b1,":[136],"monocyte":[137],"chemotactic":[138],"protein":[139],"1,":[140],"prostaglandin":[141],"E":[142],"synthase)":[143],"pruritus-related":[145],"mediators":[146],"(IL-31,":[147],"IL-33,":[148],"cathepsin":[149],"S,":[150],"calcitonin":[151],"gene-related":[152],"peptide,":[153],"substance":[154],"P,":[155],"thymic":[157],"stromal":[158],"lymphopoietin).":[159],"CONCLUSION:":[160],"promotes":[162],"reduces":[166],"These":[172],"findings":[173],"suggest":[174],"that":[175],"may":[177],"facilitate":[178],"promoting":[182],"while":[185],"simultaneously":[186],"modulating":[187],"pruritic":[190],"responses.":[191]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
