{"id":"https://openalex.org/W4412379734","doi":"https://doi.org/10.3389/fimmu.2025.1474447","title":"IDO1-AhR axis increases T regulatory cells in Plasmodium vivax malaria infection","display_name":"IDO1-AhR axis increases T regulatory cells in Plasmodium vivax malaria infection","publication_year":2025,"publication_date":"2025-07-14","ids":{"openalex":"https://openalex.org/W4412379734","doi":"https://doi.org/10.3389/fimmu.2025.1474447","pmid":"https://pubmed.ncbi.nlm.nih.gov/40726977"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2025.1474447","doi":"https://doi.org/10.3389/fimmu.2025.1474447","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2025.1474447","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1474447/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1474447/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063025857","display_name":"Rafaella Oliveira dos Santos","orcid":"https://orcid.org/0009-0006-8201-495X","observed_orcids":["https://orcid.org/0009-0006-8201-495X","https://orcid.org/0000-0003-4446-9663"]},"institutions":[{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rafaella Oliveira dos Santos","raw_affiliation_strings":["Instituto Le\u00f4nidas e Maria Deane (ILMD), Fiocruz Amaz\u00f4nia, Manaus, Amazonas,\u00a0Brazil","Laboratory of Infectious Diseases and Immunology, Instituto Le\u00f4nidas e Maria Deane, Fiocruz Amaz\u00f4nia and Programa de P\u00f3s-Gradua\u00e7\u00e3o Stricto Sensu em Imunologia B\u00e1sica e Aplicada, Manaus,\u00a0Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Le\u00f4nidas e Maria Deane (ILMD), Fiocruz Amaz\u00f4nia, Manaus, Amazonas,\u00a0Brazil","institution_ids":["https://openalex.org/I52325"]},{"raw_affiliation_string":"Laboratory of Infectious Diseases and Immunology, Instituto Le\u00f4nidas e Maria Deane, Fiocruz Amaz\u00f4nia and Programa de P\u00f3s-Gradua\u00e7\u00e3o Stricto Sensu em Imunologia B\u00e1sica e Aplicada, Manaus,\u00a0Brazil","institution_ids":["https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073977051","display_name":"Nani Oliveira Carvalho","orcid":"https://orcid.org/0000-0002-5859-728X","observed_orcids":["https://orcid.org/0000-0002-5859-728X"]},"institutions":[{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Nani Oliveira Carvalho","raw_affiliation_strings":["Instituto Le\u00f4nidas e Maria Deane (ILMD), Fiocruz Amaz\u00f4nia, Manaus, Amazonas,\u00a0Brazil","Laboratory of Infectious Diseases and Immunology, Instituto Le\u00f4nidas e Maria Deane, Fiocruz Amaz\u00f4nia and Programa de P\u00f3s-Gradua\u00e7\u00e3o Stricto Sensu em Imunologia B\u00e1sica e Aplicada, Manaus,\u00a0Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Le\u00f4nidas e Maria Deane (ILMD), Fiocruz Amaz\u00f4nia, Manaus, Amazonas,\u00a0Brazil","institution_ids":["https://openalex.org/I52325"]},{"raw_affiliation_string":"Laboratory of Infectious Diseases and Immunology, Instituto Le\u00f4nidas e Maria Deane, Fiocruz Amaz\u00f4nia and Programa de P\u00f3s-Gradua\u00e7\u00e3o Stricto Sensu em Imunologia B\u00e1sica e Aplicada, Manaus,\u00a0Brazil","institution_ids":["https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022144054","display_name":"Thiago Barros do Nascimento de Morais","orcid":"https://orcid.org/0000-0002-3174-1288","observed_orcids":["https://orcid.org/0000-0002-3174-1288"]},"institutions":[{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Thiago Barros do Nascimento de Morais","raw_affiliation_strings":["Instituto Le\u00f4nidas e Maria Deane (ILMD), Fiocruz Amaz\u00f4nia, Manaus, Amazonas,\u00a0Brazil","Laboratory of Infectious Diseases and Immunology, Instituto Le\u00f4nidas e Maria Deane, Fiocruz Amaz\u00f4nia and Programa de P\u00f3s-Gradua\u00e7\u00e3o Stricto Sensu em Imunologia B\u00e1sica e Aplicada, Manaus,\u00a0Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Le\u00f4nidas e Maria Deane (ILMD), Fiocruz Amaz\u00f4nia, Manaus, Amazonas,\u00a0Brazil","institution_ids":["https://openalex.org/I52325"]},{"raw_affiliation_string":"Laboratory of Infectious Diseases and Immunology, Instituto Le\u00f4nidas e Maria Deane, Fiocruz Amaz\u00f4nia and Programa de P\u00f3s-Gradua\u00e7\u00e3o Stricto Sensu em Imunologia B\u00e1sica e Aplicada, Manaus,\u00a0Brazil","institution_ids":["https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086957343","display_name":"Wlademir Braga Salgado Sobrinho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Wlademir Braga Salgado Sobrinho","raw_affiliation_strings":["Instituto Le\u00f4nidas e Maria Deane (ILMD), Fiocruz Amaz\u00f4nia, Manaus, Amazonas,\u00a0Brazil","Laboratory of Infectious Diseases and Immunology, Instituto Le\u00f4nidas e Maria Deane, Fiocruz Amaz\u00f4nia and Programa de P\u00f3s-Gradua\u00e7\u00e3o Stricto Sensu em Imunologia B\u00e1sica e Aplicada, Manaus,\u00a0Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Le\u00f4nidas e Maria Deane (ILMD), Fiocruz Amaz\u00f4nia, Manaus, Amazonas,\u00a0Brazil","institution_ids":["https://openalex.org/I52325"]},{"raw_affiliation_string":"Laboratory of Infectious Diseases and Immunology, Instituto Le\u00f4nidas e Maria Deane, Fiocruz Amaz\u00f4nia and Programa de P\u00f3s-Gradua\u00e7\u00e3o Stricto Sensu em Imunologia B\u00e1sica e Aplicada, Manaus,\u00a0Brazil","institution_ids":["https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071894885","display_name":"Maria Geuziane Soares da Cruz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria Geuziane Soares da Cruz","raw_affiliation_strings":["Instituto Le\u00f4nidas e Maria Deane (ILMD), Fiocruz Amaz\u00f4nia, Manaus, Amazonas,\u00a0Brazil","Laboratory of Infectious Diseases and Immunology, Instituto Le\u00f4nidas e Maria Deane, Fiocruz Amaz\u00f4nia and Programa de P\u00f3s-Gradua\u00e7\u00e3o Stricto Sensu em Imunologia B\u00e1sica e Aplicada, Manaus,\u00a0Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Le\u00f4nidas e Maria Deane (ILMD), Fiocruz Amaz\u00f4nia, Manaus, Amazonas,\u00a0Brazil","institution_ids":["https://openalex.org/I52325"]},{"raw_affiliation_string":"Laboratory of Infectious Diseases and Immunology, Instituto Le\u00f4nidas e Maria Deane, Fiocruz Amaz\u00f4nia and Programa de P\u00f3s-Gradua\u00e7\u00e3o Stricto Sensu em Imunologia B\u00e1sica e Aplicada, Manaus,\u00a0Brazil","institution_ids":["https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056363419","display_name":"Elaine Speziali de Faria","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Elaine Speziali de Faria","raw_affiliation_strings":["Instituto Ren\u00e9 Rachou (IRR), Fiocruz Minas Gerais, Belo Horizonte, Minas Gerais,\u00a0Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Ren\u00e9 Rachou (IRR), Fiocruz Minas Gerais, Belo Horizonte, Minas Gerais,\u00a0Brazil","institution_ids":["https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015527050","display_name":"Fernanda Fortes de Ara\u00fajo","orcid":"https://orcid.org/0000-0002-8066-3677","observed_orcids":["https://orcid.org/0000-0002-8066-3677"]},"institutions":[{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fernanda Fortes de Ara\u00fajo","raw_affiliation_strings":["Instituto Ren\u00e9 Rachou (IRR), Fiocruz Minas Gerais, Belo Horizonte, Minas Gerais,\u00a0Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Ren\u00e9 Rachou (IRR), Fiocruz Minas Gerais, Belo Horizonte, Minas Gerais,\u00a0Brazil","institution_ids":["https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102832789","display_name":"Vanessa Peruhype-Magalh\u00e3es","orcid":"https://orcid.org/0000-0002-2907-2724","observed_orcids":["https://orcid.org/0000-0002-2907-2724"]},"institutions":[{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Vanessa Peruhype Magalh\u00e3es","raw_affiliation_strings":["Instituto Ren\u00e9 Rachou (IRR), Fiocruz Minas Gerais, Belo Horizonte, Minas Gerais,\u00a0Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Ren\u00e9 Rachou (IRR), Fiocruz Minas Gerais, Belo Horizonte, Minas Gerais,\u00a0Brazil","institution_ids":["https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016817608","display_name":"Stefanie Costa Pinto Lopes","orcid":"https://orcid.org/0000-0002-6981-2192","observed_orcids":["https://orcid.org/0000-0002-6981-2192"]},"institutions":[{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Stefanie Costa Pinto Lopes","raw_affiliation_strings":["Instituto Le\u00f4nidas e Maria Deane (ILMD), Fiocruz Amaz\u00f4nia, Manaus, Amazonas,\u00a0Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Le\u00f4nidas e Maria Deane (ILMD), Fiocruz Amaz\u00f4nia, Manaus, Amazonas,\u00a0Brazil","institution_ids":["https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017388328","display_name":"Adriana Malheiros","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62885914","display_name":"Universidade Federal do Amazonas","ror":"https://ror.org/02263ky35","country_code":"BR","type":"education","lineage":["https://openalex.org/I62885914"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Adriana Malheiros","raw_affiliation_strings":["Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Amazonas (UFAM), Manaus, Amazonas,\u00a0Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Amazonas (UFAM), Manaus, Amazonas,\u00a0Brazil","institution_ids":["https://openalex.org/I62885914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010024602","display_name":"Adolfo Jos\u00e9 da Mota","orcid":"https://orcid.org/0000-0002-9745-1128","observed_orcids":["https://orcid.org/0000-0002-9745-1128"]},"institutions":[{"id":"https://openalex.org/I62885914","display_name":"Universidade Federal do Amazonas","ror":"https://ror.org/02263ky35","country_code":"BR","type":"education","lineage":["https://openalex.org/I62885914"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Adolfo Jos\u00e9 da Mota","raw_affiliation_strings":["Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Amazonas (UFAM), Manaus, Amazonas,\u00a0Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal do Amazonas (UFAM), Manaus, Amazonas,\u00a0Brazil","institution_ids":["https://openalex.org/I62885914"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072210483","display_name":"Helton C. Santiago","orcid":"https://orcid.org/0000-0002-5695-8256","observed_orcids":["https://orcid.org/0000-0002-5695-8256"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Helton da Costa Santiago","raw_affiliation_strings":["Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais,\u00a0Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais,\u00a0Brazil","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045907511","display_name":"Paulo Afonso Nogueira","orcid":"https://orcid.org/0000-0001-9677-7225","observed_orcids":["https://orcid.org/0000-0001-9677-7225","https://orcid.org/0000-0003-3015-1021"]},"institutions":[{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Paulo Afonso Nogueira","raw_affiliation_strings":["Instituto Le\u00f4nidas e Maria Deane (ILMD), Fiocruz Amaz\u00f4nia, Manaus, Amazonas,\u00a0Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Le\u00f4nidas e Maria Deane (ILMD), Fiocruz Amaz\u00f4nia, Manaus, Amazonas,\u00a0Brazil","institution_ids":["https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022976564","display_name":"Andr\u00e9a Teixeira\u2010Carvalho","orcid":"https://orcid.org/0000-0003-2814-5183","observed_orcids":["https://orcid.org/0000-0003-2814-5183"]},"institutions":[{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Andr\u00e9a Teixeira de Carvalho","raw_affiliation_strings":["Instituto Ren\u00e9 Rachou (IRR), Fiocruz Minas Gerais, Belo Horizonte, Minas Gerais,\u00a0Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Ren\u00e9 Rachou (IRR), Fiocruz Minas Gerais, Belo Horizonte, Minas Gerais,\u00a0Brazil","institution_ids":["https://openalex.org/I52325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001446475","display_name":"Marcus Lacerda","orcid":"https://orcid.org/0000-0003-3374-9985","observed_orcids":["https://orcid.org/0000-0003-3374-9985","https://orcid.org/0000-0003-4690-4841"]},"institutions":[{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marcus Vin\u00edcius Guimar\u00e3es de Lacerda","raw_affiliation_strings":["Instituto Le\u00f4nidas e Maria Deane (ILMD), Fiocruz Amaz\u00f4nia, Manaus, Amazonas,\u00a0Brazil","Laboratory of Infectious Diseases and Immunology, Instituto Le\u00f4nidas e Maria Deane, Fiocruz Amaz\u00f4nia and Programa de P\u00f3s-Gradua\u00e7\u00e3o Stricto Sensu em Imunologia B\u00e1sica e Aplicada, Manaus,\u00a0Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Le\u00f4nidas e Maria Deane (ILMD), Fiocruz Amaz\u00f4nia, Manaus, Amazonas,\u00a0Brazil","institution_ids":["https://openalex.org/I52325"]},{"raw_affiliation_string":"Laboratory of Infectious Diseases and Immunology, Instituto Le\u00f4nidas e Maria Deane, Fiocruz Amaz\u00f4nia and Programa de P\u00f3s-Gradua\u00e7\u00e3o Stricto Sensu em Imunologia B\u00e1sica e Aplicada, Manaus,\u00a0Brazil","institution_ids":["https://openalex.org/I52325"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054155351","display_name":"Pritesh Jaychand Lalwani","orcid":"https://orcid.org/0000-0003-2996-0446","observed_orcids":["https://orcid.org/0000-0003-2996-0446"]},"institutions":[{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Pritesh Lalwani","raw_affiliation_strings":["Instituto Le\u00f4nidas e Maria Deane (ILMD), Fiocruz Amaz\u00f4nia, Manaus, Amazonas,\u00a0Brazil","Laboratory of Infectious Diseases and Immunology, Instituto Le\u00f4nidas e Maria Deane, Fiocruz Amaz\u00f4nia and Programa de P\u00f3s-Gradua\u00e7\u00e3o Stricto Sensu em Imunologia B\u00e1sica e Aplicada, Manaus,\u00a0Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Le\u00f4nidas e Maria Deane (ILMD), Fiocruz Amaz\u00f4nia, Manaus, Amazonas,\u00a0Brazil","institution_ids":["https://openalex.org/I52325"]},{"raw_affiliation_string":"Laboratory of Infectious Diseases and Immunology, Instituto Le\u00f4nidas e Maria Deane, Fiocruz Amaz\u00f4nia and Programa de P\u00f3s-Gradua\u00e7\u00e3o Stricto Sensu em Imunologia B\u00e1sica e Aplicada, Manaus,\u00a0Brazil","institution_ids":["https://openalex.org/I52325"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5054155351"],"corresponding_institution_ids":["https://openalex.org/I52325"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":3.3975,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.92380069,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"16","issue":null,"first_page":"1474447","last_page":"1474447"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmodium-vivax","display_name":"Plasmodium vivax","score":0.9309999942779541},{"id":"https://openalex.org/keywords/malaria","display_name":"malaria","score":0.7409999966621399},{"id":"https://openalex.org/keywords/indoleamine-2-3-dioxygenase","display_name":"indoleamine 2,3-dioxygenase","score":0.9559999704360962},{"id":"https://openalex.org/keywords/aryl-hydrocarbon-receptor","display_name":"aryl hydrocarbon receptor","score":0.9480000138282776},{"id":"https://openalex.org/keywords/tryptophan-catabolism","display_name":"tryptophan catabolism","score":0.902999997138977},{"id":"https://openalex.org/keywords/kynurenine","display_name":"kynurenine","score":0.9340000152587891},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9800000190734863},{"id":"https://openalex.org/keywords/myd88","display_name":"MyD88","score":0.7429999709129333},{"id":"https://openalex.org/keywords/immune-tolerance","display_name":"immune tolerance","score":0.6589999794960022},{"id":"https://openalex.org/keywords/cd4-t-cell-proliferation","display_name":"CD4+ T cell proliferation","score":0.7310000061988831},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7829999923706055},{"id":"https://openalex.org/keywords/chronic-inflammation","display_name":"chronic inflammation","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C2777503454","wikidata":"https://www.wikidata.org/wiki/Q415768","display_name":"Kynurenine","level":4,"score":0.7713170647621155},{"id":"https://openalex.org/C2779997623","wikidata":"https://www.wikidata.org/wiki/Q311376","display_name":"Plasmodium vivax","level":4,"score":0.6641896367073059},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6028534770011902},{"id":"https://openalex.org/C33594762","wikidata":"https://www.wikidata.org/wiki/Q155750","display_name":"Aryl hydrocarbon receptor","level":4,"score":0.5906684994697571},{"id":"https://openalex.org/C83478079","wikidata":"https://www.wikidata.org/wiki/Q908221","display_name":"Indoleamine 2,3-dioxygenase","level":4,"score":0.5845069885253906},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5819206237792969},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5056309700012207},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.4618789851665497},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.45927247405052185},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45879504084587097},{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.10325497388839722},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.059224724769592285},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007737","descriptor_name":"Kynurenine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007737","descriptor_name":"Kynurenine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007737","descriptor_name":"Kynurenine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010966","descriptor_name":"Plasmodium vivax","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010966","descriptor_name":"Plasmodium vivax","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010966","descriptor_name":"Plasmodium vivax","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016780","descriptor_name":"Malaria, Vivax","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016780","descriptor_name":"Malaria, Vivax","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016780","descriptor_name":"Malaria, Vivax","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016780","descriptor_name":"Malaria, Vivax","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016780","descriptor_name":"Malaria, Vivax","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016780","descriptor_name":"Malaria, Vivax","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016780","descriptor_name":"Malaria, Vivax","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":true},{"descriptor_ui":"D016780","descriptor_name":"Malaria, Vivax","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":true},{"descriptor_ui":"D016780","descriptor_name":"Malaria, Vivax","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":true},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050503","descriptor_name":"Indoleamine-Pyrrole 2,3,-Dioxygenase","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050503","descriptor_name":"Indoleamine-Pyrrole 2,3,-Dioxygenase","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050503","descriptor_name":"Indoleamine-Pyrrole 2,3,-Dioxygenase","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050503","descriptor_name":"Indoleamine-Pyrrole 2,3,-Dioxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050503","descriptor_name":"Indoleamine-Pyrrole 2,3,-Dioxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050503","descriptor_name":"Indoleamine-Pyrrole 2,3,-Dioxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053594","descriptor_name":"Myeloid Differentiation Factor 88","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053594","descriptor_name":"Myeloid Differentiation Factor 88","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053594","descriptor_name":"Myeloid Differentiation Factor 88","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3389/fimmu.2025.1474447","doi":"https://doi.org/10.3389/fimmu.2025.1474447","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2025.1474447","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1474447/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmid:40726977","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40726977","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:arca.fiocruz.br:icict/71637","doi":null,"is_oa":true,"landing_page_url":"https://arca.fiocruz.br/handle/icict/71637","pdf_url":"https://arca.fiocruz.br/bitstreams/6a102982-095f-49c7-b44d-09e4a4932d29/download","source":{"id":"https://openalex.org/S7407055450","display_name":"Arca - Reposit\u00f3rio Institucional da Fiocruz","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12301311","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12301311","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:d403082ee77f443798509cf7b0f123ad","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d403082ee77f443798509cf7b0f123ad","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 16 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2025.1474447","doi":"https://doi.org/10.3389/fimmu.2025.1474447","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2025.1474447","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1474447/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8100000023841858,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1124425307","display_name":null,"funder_award_id":"436097/2018\u20104","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G4146792895","display_name":null,"funder_award_id":"ERC-CONFAP-CNPq , Universal Amazonas, INICIATIVA AMAZ\u00d4NIA +10, CT&I \u00c1REAS PRIORIT\u00c1RIAS, PEX-CT&I/FAPEAM, POSGRAD","funder_id":"https://openalex.org/F4320322994","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Amazonas"},{"id":"https://openalex.org/G4806177968","display_name":null,"funder_award_id":"Funding 001","funder_id":"https://openalex.org/F4320321091","funder_display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior"},{"id":"https://openalex.org/G8462984973","display_name":null,"funder_award_id":"INICIATIVA AMAZ\u00d4NIA +10","funder_id":"https://openalex.org/F4320322994","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Amazonas"}],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322994","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Amazonas","ror":"https://ror.org/026d6ma13"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412379734.pdf","grobid_xml":"https://content.openalex.org/works/W4412379734.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1176648364","https://openalex.org/W1603640418","https://openalex.org/W1901555156","https://openalex.org/W1975929837","https://openalex.org/W2008789929","https://openalex.org/W2008878335","https://openalex.org/W2014781888","https://openalex.org/W2018271895","https://openalex.org/W2023592375","https://openalex.org/W2034531211","https://openalex.org/W2077857097","https://openalex.org/W2102404632","https://openalex.org/W2112265988","https://openalex.org/W2113341236","https://openalex.org/W2115552466","https://openalex.org/W2117293621","https://openalex.org/W2125972672","https://openalex.org/W2140132924","https://openalex.org/W2150168591","https://openalex.org/W2152636972","https://openalex.org/W2168079915","https://openalex.org/W2217324544","https://openalex.org/W2259556556","https://openalex.org/W2599882981","https://openalex.org/W2782774905","https://openalex.org/W2890859804","https://openalex.org/W2900194457","https://openalex.org/W2991744173","https://openalex.org/W3011751699","https://openalex.org/W3090429581"],"related_works":["https://openalex.org/W3173019255","https://openalex.org/W4247638686","https://openalex.org/W2990281329","https://openalex.org/W2008878335","https://openalex.org/W2041221972","https://openalex.org/W2036520747","https://openalex.org/W2180521141","https://openalex.org/W1989044153","https://openalex.org/W2076454822","https://openalex.org/W2516877445"],"abstract_inverted_index":{"Introduction":[0],"Malaria":[1],"remains":[2],"a":[3,206,248],"significant":[4],"public":[5],"health":[6],"challenge":[7],"in":[8,43,73,119,148,246],"Brazil,":[9],"where":[10],"Plasmodium":[11],"vivax":[12,63,124,195,253],"(P.":[13],"vivax)":[14],"is":[15],"the":[16,31,51,236],"predominant":[17],"species.":[18],"Dysregulated":[19],"immune":[20,44,244,266],"responses":[21],"contribute":[22,264],"substantially":[23],"to":[24,49,81,227,265],"malaria":[25,133,196,215],"pathogenesis.":[26],"Indoleamine":[27],"2,3-dioxygenase":[28],"(IDO)":[29],"mediates":[30],"catabolism":[32,55,241],"of":[33,53,94,97,238],"tryptophan":[34],"(TRP)":[35],"into":[36,260],"kynurenine":[37],"(KYN),":[38],"an":[39],"immunosuppressive":[40],"metabolite":[41],"implicated":[42],"tolerance.":[45],"This":[46],"study":[47,256],"aimed":[48],"investigate":[50],"role":[52,237],"TRP":[54,240],"and":[56,89,100,114,126,135,154,164,176,180,186,201,223,242,270],"regulatory":[57],"T":[58,188],"cells":[59,69],"(Tregs)":[60],"during":[61,251,272],"P.":[62,76,123,194,252],"infection.":[64,254],"Methods":[65],"Peripheral":[66],"blood":[67],"mononuclear":[68],"(PBMCs)":[70],"were":[71,106,117],"stimulated":[72],"vitro":[74],"with":[75,121,137,142,192,205,213,229,274],"vivax-infected":[77],"erythrocyte":[78],"(Pv-iE)":[79],"lysate":[80,144],"assess":[82],"IDO-1":[83,146,174],"expression,":[84],"KYN/TRP":[85,110,152,162,177,199,224],"ratio,":[86,111,153],"cytokine":[87,115,157],"production,":[88],"Treg":[90,112,165,184,203,219],"frequency.":[91],"The":[92,255],"effects":[93],"pharmacological":[95],"inhibition":[96,160,171,182],"IDO,":[98],"MyD88,":[99],"aryl":[101],"hydrocarbon":[102],"receptor":[103],"(AhR)":[104],"pathways":[105],"evaluated.":[107],"Additionally,":[108],"plasma":[109,221],"frequencies,":[113,204,220],"levels":[116],"measured":[118],"patients":[120],"acute":[122,193],"infection":[125],"compared":[127,226],"between":[128,209],"individuals":[129],"experiencing":[130],"their":[131],"first":[132],"episode":[134],"those":[136,228],"previous":[138],"infections.":[139,231],"Results":[140],"Stimulation":[141],"Pv-iE":[143,168],"increased":[145,202],"expression":[147,175],"CD14+":[149],"cells,":[150],"elevated":[151,198],"induced":[155],"pro-inflammatory":[156],"production.":[158],"IDO":[159,179],"reduced":[161,183],"ratio":[163],"frequencies":[166,185],"upon":[167],"stimulation.":[169],"MyD88":[170],"decreased":[172],"both":[173],"ratio.":[178],"AhR":[181],"CD4+":[187],"cell":[189],"proliferation.":[190],"Patients":[191],"exhibited":[197],"ratios":[200,225],"positive":[207],"correlation":[208],"these":[210],"parameters.":[211],"Individuals":[212],"prior":[214],"episodes":[216],"showed":[217],"lower":[218],"IFN-\u03b3,":[222],"primary":[230],"Discussion":[232],"These":[233],"findings":[234],"highlight":[235],"IDO-mediated":[239],"innate":[243],"signaling":[245],"promoting":[247],"tolerogenic":[249],"phenotype":[250],"provides":[257],"novel":[258],"insights":[259],"mechanisms":[261],"that":[262],"may":[263],"regulation,":[267],"chronic":[268],"inflammation,":[269],"tolerance":[271],"malaria,":[273],"potential":[275],"implications":[276],"for":[277],"therapeutic":[278],"interventions.":[279]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1}],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2025-07-14T00:00:00"}