{"id":"https://openalex.org/W4412379636","doi":"https://doi.org/10.1021/acsomega.5c01614","title":"Synthetic Aminochalcone Prevents Hyperglycemia-Induced Anxiety and Delays Pentylenetetrazole-Induced Epileptic Crisis in Adult Zebrafish","display_name":"Synthetic Aminochalcone Prevents Hyperglycemia-Induced Anxiety and Delays Pentylenetetrazole-Induced Epileptic Crisis in Adult Zebrafish","publication_year":2025,"publication_date":"2025-07-14","ids":{"openalex":"https://openalex.org/W4412379636","doi":"https://doi.org/10.1021/acsomega.5c01614","pmid":"https://pubmed.ncbi.nlm.nih.gov/40727737"},"language":"en","primary_location":{"id":"doi:10.1021/acsomega.5c01614","doi":"https://doi.org/10.1021/acsomega.5c01614","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.5c01614","pdf_url":null,"source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1021/acsomega.5c01614","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014064907","display_name":"Arnaldo Solheiro Bezerra","orcid":"https://orcid.org/0000-0001-7912-7394","observed_orcids":["https://orcid.org/0000-0001-7912-7394"]},"institutions":[{"id":"https://openalex.org/I102939073","display_name":"Universidade Estadual do Cear\u00e1","ror":"https://ror.org/00sec1m50","country_code":"BR","type":"education","lineage":["https://openalex.org/I102939073"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Arnaldo\nSolheiro Bezerra","raw_affiliation_strings":["State University of Ceara , , , ,","Laboratory of Biotechnology and Molecular Biology","State University of Ceara"],"raw_orcid":"https://orcid.org/0000-0001-7912-7394","affiliations":[{"raw_affiliation_string":"State University of Ceara , , , ,","institution_ids":["https://openalex.org/I102939073"]},{"raw_affiliation_string":"Laboratory of Biotechnology and Molecular Biology","institution_ids":[]},{"raw_affiliation_string":"State University of Ceara","institution_ids":["https://openalex.org/I102939073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086138604","display_name":"Amauri Barbosa da Silva-Junior","orcid":"https://orcid.org/0000-0002-1647-2331","observed_orcids":["https://orcid.org/0000-0002-1647-2331"]},"institutions":[{"id":"https://openalex.org/I102939073","display_name":"Universidade Estadual do Cear\u00e1","ror":"https://ror.org/00sec1m50","country_code":"BR","type":"education","lineage":["https://openalex.org/I102939073"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Amauri Barbosa da Silva Junior","raw_affiliation_strings":["Chemical-pharmacological and Environmental Bioassay Laboratory - LABQFAM , , ,","State University of Ceara , , , ,","Laboratory of Biotechnology and Molecular Biology","State University of Ceara"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical-pharmacological and Environmental Bioassay Laboratory - LABQFAM , , ,","institution_ids":[]},{"raw_affiliation_string":"State University of Ceara , , , ,","institution_ids":["https://openalex.org/I102939073"]},{"raw_affiliation_string":"Laboratory of Biotechnology and Molecular Biology","institution_ids":[]},{"raw_affiliation_string":"State University of Ceara","institution_ids":["https://openalex.org/I102939073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031779477","display_name":"Ant\u00f4nio Wlisses da Silva","orcid":"https://orcid.org/0000-0002-1686-1644","observed_orcids":["https://orcid.org/0000-0002-1686-1644"]},"institutions":[{"id":"https://openalex.org/I102939073","display_name":"Universidade Estadual do Cear\u00e1","ror":"https://ror.org/00sec1m50","country_code":"BR","type":"education","lineage":["https://openalex.org/I102939073"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Antonio Wlisses da Silva","raw_affiliation_strings":["Chemical-pharmacological and Environmental Bioassay Laboratory - LABQFAM , , ,","State University of Ceara , , , ,","Chemical-pharmacological and Environmental Bioassay Laboratory - LABQFAM","Chemical-pharmacological and Environmental Bioassay Laboratory - LABQFAM, Fortaleza, Ceara 60714-903, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical-pharmacological and Environmental Bioassay Laboratory - LABQFAM , , ,","institution_ids":[]},{"raw_affiliation_string":"State University of Ceara , , , ,","institution_ids":["https://openalex.org/I102939073"]},{"raw_affiliation_string":"Chemical-pharmacological and Environmental Bioassay Laboratory - LABQFAM","institution_ids":[]},{"raw_affiliation_string":"Chemical-pharmacological and Environmental Bioassay Laboratory - LABQFAM, Fortaleza, Ceara 60714-903, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Emanuela de Lima Rebouc\u0327as Borges","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102939073","display_name":"Universidade Estadual do Cear\u00e1","ror":"https://ror.org/00sec1m50","country_code":"BR","type":"education","lineage":["https://openalex.org/I102939073"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Emanuela de Lima Rebouc\u0327as Borges","raw_affiliation_strings":["State University of Ceara , , , ,","Graduate Program in Natural Sciences","State University of Ceara"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State University of Ceara , , , ,","institution_ids":["https://openalex.org/I102939073"]},{"raw_affiliation_string":"Graduate Program in Natural Sciences","institution_ids":[]},{"raw_affiliation_string":"State University of Ceara","institution_ids":["https://openalex.org/I102939073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080067711","display_name":"Levi Magalh\u00e3es Gurgel Mac\u00eado","orcid":"https://orcid.org/0000-0002-7930-0238","observed_orcids":["https://orcid.org/0000-0002-7930-0238"]},"institutions":[{"id":"https://openalex.org/I102939073","display_name":"Universidade Estadual do Cear\u00e1","ror":"https://ror.org/00sec1m50","country_code":"BR","type":"education","lineage":["https://openalex.org/I102939073"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Levi Magalha\u0303es Gurgel Mace\u0302do","raw_affiliation_strings":["State University of Ceara , , , ,","Laboratory of Biotechnology and Molecular Biology","State University of Ceara"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State University of Ceara , , , ,","institution_ids":["https://openalex.org/I102939073"]},{"raw_affiliation_string":"Laboratory of Biotechnology and Molecular Biology","institution_ids":[]},{"raw_affiliation_string":"State University of Ceara","institution_ids":["https://openalex.org/I102939073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021923492","display_name":"Yago Kayan de Souza Lima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102939073","display_name":"Universidade Estadual do Cear\u00e1","ror":"https://ror.org/00sec1m50","country_code":"BR","type":"education","lineage":["https://openalex.org/I102939073"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Yago Kayan de Souza Lima","raw_affiliation_strings":["State University of Ceara , , , ,","Laboratory of Biotechnology and Molecular Biology","State University of Ceara"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State University of Ceara , , , ,","institution_ids":["https://openalex.org/I102939073"]},{"raw_affiliation_string":"Laboratory of Biotechnology and Molecular Biology","institution_ids":[]},{"raw_affiliation_string":"State University of Ceara","institution_ids":["https://openalex.org/I102939073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052995431","display_name":"Camila Costa de Sousa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102939073","display_name":"Universidade Estadual do Cear\u00e1","ror":"https://ror.org/00sec1m50","country_code":"BR","type":"education","lineage":["https://openalex.org/I102939073"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Camila Costa de Sousa","raw_affiliation_strings":["State University of Ceara , , , ,","Laboratory of Biotechnology and Molecular Biology","State University of Ceara"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State University of Ceara , , , ,","institution_ids":["https://openalex.org/I102939073"]},{"raw_affiliation_string":"Laboratory of Biotechnology and Molecular Biology","institution_ids":[]},{"raw_affiliation_string":"State University of Ceara","institution_ids":["https://openalex.org/I102939073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106839637","display_name":"Beatriz Helena Gama Joca","orcid":"https://orcid.org/0009-0003-2014-2639","observed_orcids":["https://orcid.org/0009-0003-2014-2639"]},"institutions":[{"id":"https://openalex.org/I102939073","display_name":"Universidade Estadual do Cear\u00e1","ror":"https://ror.org/00sec1m50","country_code":"BR","type":"education","lineage":["https://openalex.org/I102939073"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Beatriz Helena Gama Joca","raw_affiliation_strings":["State University of Ceara , , , ,","Laboratory of Biotechnology and Molecular Biology","State University of Ceara"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State University of Ceara , , , ,","institution_ids":["https://openalex.org/I102939073"]},{"raw_affiliation_string":"Laboratory of Biotechnology and Molecular Biology","institution_ids":[]},{"raw_affiliation_string":"State University of Ceara","institution_ids":["https://openalex.org/I102939073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099086990","display_name":"Ana Lorena Pereira Bezerra","orcid":"https://orcid.org/0009-0000-0784-6904","observed_orcids":["https://orcid.org/0009-0000-0784-6904"]},"institutions":[{"id":"https://openalex.org/I102939073","display_name":"Universidade Estadual do Cear\u00e1","ror":"https://ror.org/00sec1m50","country_code":"BR","type":"education","lineage":["https://openalex.org/I102939073"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana Lorena Pereira Bezerra","raw_affiliation_strings":["State University of Ceara , , , ,","Laboratory of Biotechnology and Molecular Biology","State University of Ceara"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State University of Ceara , , , ,","institution_ids":["https://openalex.org/I102939073"]},{"raw_affiliation_string":"Laboratory of Biotechnology and Molecular Biology","institution_ids":[]},{"raw_affiliation_string":"State University of Ceara","institution_ids":["https://openalex.org/I102939073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016269814","display_name":"Erick Patrick Alves Moreira","orcid":"https://orcid.org/0000-0001-5709-7526","observed_orcids":["https://orcid.org/0000-0001-5709-7526"]},"institutions":[{"id":"https://openalex.org/I4210141362","display_name":"Centro Universit\u00e1rio Maur\u00edcio de Nassau","ror":"https://ror.org/051a88j84","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210141362"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Erick Patrick\nAlves Moreira","raw_affiliation_strings":["Mauricio de Nassau University Center , , ,","Mauricio de Nassau University Center, Fortaleza, Ceara 60714-903, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mauricio de Nassau University Center , , ,","institution_ids":["https://openalex.org/I4210141362"]},{"raw_affiliation_string":"Mauricio de Nassau University Center, Fortaleza, Ceara 60714-903, Brazil","institution_ids":["https://openalex.org/I4210141362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118970606","display_name":"L\u00facia de F\u00e1tima Mota Pernambuco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141362","display_name":"Centro Universit\u00e1rio Maur\u00edcio de Nassau","ror":"https://ror.org/051a88j84","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210141362"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Lu\u0301cia de Fa\u0301tima Mota Pernambuco","raw_affiliation_strings":["Mauricio de Nassau University Center , , ,","Mauricio de Nassau University Center, Fortaleza, Ceara 60714-903, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mauricio de Nassau University Center , , ,","institution_ids":["https://openalex.org/I4210141362"]},{"raw_affiliation_string":"Mauricio de Nassau University Center, Fortaleza, Ceara 60714-903, Brazil","institution_ids":["https://openalex.org/I4210141362"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ana Vito\u0301ria\nSantana Garcia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141362","display_name":"Centro Universit\u00e1rio Maur\u00edcio de Nassau","ror":"https://ror.org/051a88j84","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210141362"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ana Vito\u0301ria\nSantana Garcia","raw_affiliation_strings":["Mauricio de Nassau University Center , , ,","Mauricio de Nassau University Center, Fortaleza, Ceara 60714-903, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mauricio de Nassau University Center , , ,","institution_ids":["https://openalex.org/I4210141362"]},{"raw_affiliation_string":"Mauricio de Nassau University Center, Fortaleza, Ceara 60714-903, Brazil","institution_ids":["https://openalex.org/I4210141362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090259170","display_name":"M\u00e1rcia Machado Marinho","orcid":"https://orcid.org/0000-0002-7640-2220","observed_orcids":["https://orcid.org/0000-0002-7640-2220"]},"institutions":[{"id":"https://openalex.org/I330528248","display_name":"State University of Vale do Acara\u00fa","ror":"https://ror.org/038ddjp72","country_code":"BR","type":"education","lineage":["https://openalex.org/I330528248"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ma\u0301rcia Machado Marinho","raw_affiliation_strings":["State University of Acarau\u0301 Valley , , , ,","Chemistry Course","State University of Acara\u00fa Valley"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State University of Acarau\u0301 Valley , , , ,","institution_ids":["https://openalex.org/I330528248"]},{"raw_affiliation_string":"Chemistry Course","institution_ids":[]},{"raw_affiliation_string":"State University of Acara\u00fa Valley","institution_ids":["https://openalex.org/I330528248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072220387","display_name":"Emmanuel Silva Marinho","orcid":"https://orcid.org/0000-0002-4774-8775","observed_orcids":["https://orcid.org/0000-0002-4774-8775","https://orcid.org/0000-0001-5527-164X"]},"institutions":[{"id":"https://openalex.org/I102939073","display_name":"Universidade Estadual do Cear\u00e1","ror":"https://ror.org/00sec1m50","country_code":"BR","type":"education","lineage":["https://openalex.org/I102939073"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Emmanuel Silva Marinho","raw_affiliation_strings":["State University of Ceara , , , ,","Graduate Program in Natural Sciences","State University of Ceara"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State University of Ceara , , , ,","institution_ids":["https://openalex.org/I102939073"]},{"raw_affiliation_string":"Graduate Program in Natural Sciences","institution_ids":[]},{"raw_affiliation_string":"State University of Ceara","institution_ids":["https://openalex.org/I102939073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089263091","display_name":"Dami\u00e3o Sampaio de Sousa","orcid":"https://orcid.org/0000-0003-2425-8228","observed_orcids":["https://orcid.org/0000-0003-2425-8228"]},"institutions":[{"id":"https://openalex.org/I102939073","display_name":"Universidade Estadual do Cear\u00e1","ror":"https://ror.org/00sec1m50","country_code":"BR","type":"education","lineage":["https://openalex.org/I102939073"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Damia\u0303o\nSampaio de Sousa","raw_affiliation_strings":["State University of Ceara , , , ,","Graduate Program in Natural Sciences","State University of Ceara"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State University of Ceara , , , ,","institution_ids":["https://openalex.org/I102939073"]},{"raw_affiliation_string":"Graduate Program in Natural Sciences","institution_ids":[]},{"raw_affiliation_string":"State University of Ceara","institution_ids":["https://openalex.org/I102939073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030127568","display_name":"Paulo Nogueira Bandeira","orcid":"https://orcid.org/0000-0001-5374-1839","observed_orcids":["https://orcid.org/0000-0001-5374-1839"]},"institutions":[{"id":"https://openalex.org/I330528248","display_name":"State University of Vale do Acara\u00fa","ror":"https://ror.org/038ddjp72","country_code":"BR","type":"education","lineage":["https://openalex.org/I330528248"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Paulo Nogueira Bandeira","raw_affiliation_strings":["State University of Acarau\u0301 Valley , , , ,","Chemistry Course","State University of Acara\u00fa Valley"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State University of Acarau\u0301 Valley , , , ,","institution_ids":["https://openalex.org/I330528248"]},{"raw_affiliation_string":"Chemistry Course","institution_ids":[]},{"raw_affiliation_string":"State University of Acara\u00fa Valley","institution_ids":["https://openalex.org/I330528248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093811567","display_name":"Francisco Ferdinando Mesquita Cajazeiras","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I330528248","display_name":"State University of Vale do Acara\u00fa","ror":"https://ror.org/038ddjp72","country_code":"BR","type":"education","lineage":["https://openalex.org/I330528248"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Francisco Ferdinando\nMesquita Cajazeiras","raw_affiliation_strings":["State University of Acarau\u0301 Valley , , , ,","Chemistry Course","State University of Acara\u00fa Valley"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State University of Acarau\u0301 Valley , , , ,","institution_ids":["https://openalex.org/I330528248"]},{"raw_affiliation_string":"Chemistry Course","institution_ids":[]},{"raw_affiliation_string":"State University of Acara\u00fa Valley","institution_ids":["https://openalex.org/I330528248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031715759","display_name":"H\u00e9lcio Silva dos Santos","orcid":"https://orcid.org/0000-0001-5527-164X","observed_orcids":["https://orcid.org/0000-0001-5527-164X"]},"institutions":[{"id":"https://openalex.org/I102939073","display_name":"Universidade Estadual do Cear\u00e1","ror":"https://ror.org/00sec1m50","country_code":"BR","type":"education","lineage":["https://openalex.org/I102939073"]},{"id":"https://openalex.org/I243754102","display_name":"Universidade Federal do Cear\u00e1","ror":"https://ror.org/03srtnf24","country_code":"BR","type":"education","lineage":["https://openalex.org/I243754102"]},{"id":"https://openalex.org/I330528248","display_name":"State University of Vale do Acara\u00fa","ror":"https://ror.org/038ddjp72","country_code":"BR","type":"education","lineage":["https://openalex.org/I330528248"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"He\u0301lcio\nSilva dos Santos","raw_affiliation_strings":["Federal University of Ceara , , , ,","State University of Acarau\u0301 Valley , , , ,","State University of Ceara , , , ,","Chemistry Course","Department of Analytical and Physical Chemistry","Federal University of Ceara","Graduate Program in Natural Sciences","Graduate Program in Natural Sciences, State University of Ceara, Fortaleza, Ceara 60714-903, Brazil","Graduate Program of Biotechnology","State University of Acara\u00fa Valley"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Ceara , , , ,","institution_ids":["https://openalex.org/I243754102"]},{"raw_affiliation_string":"State University of Acarau\u0301 Valley , , , ,","institution_ids":["https://openalex.org/I330528248"]},{"raw_affiliation_string":"State University of Ceara , , , ,","institution_ids":["https://openalex.org/I102939073"]},{"raw_affiliation_string":"Chemistry Course","institution_ids":[]},{"raw_affiliation_string":"Department of Analytical and Physical Chemistry","institution_ids":[]},{"raw_affiliation_string":"Federal University of Ceara","institution_ids":["https://openalex.org/I243754102"]},{"raw_affiliation_string":"Graduate Program in Natural Sciences","institution_ids":[]},{"raw_affiliation_string":"Graduate Program in Natural Sciences, State University of Ceara, Fortaleza, Ceara 60714-903, Brazil","institution_ids":["https://openalex.org/I102939073"]},{"raw_affiliation_string":"Graduate Program of Biotechnology","institution_ids":[]},{"raw_affiliation_string":"State University of Acara\u00fa Valley","institution_ids":["https://openalex.org/I330528248"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073320176","display_name":"Maria Izabel Florindo Guedes","orcid":"https://orcid.org/0000-0002-4569-8663","observed_orcids":["https://orcid.org/0000-0002-4569-8663"]},"institutions":[{"id":"https://openalex.org/I102939073","display_name":"Universidade Estadual do Cear\u00e1","ror":"https://ror.org/00sec1m50","country_code":"BR","type":"education","lineage":["https://openalex.org/I102939073"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Maria Izabel Florindo Guedes","raw_affiliation_strings":["State University of Ceara , , , ,","Laboratory of Biotechnology and Molecular Biology","State University of Ceara"],"raw_orcid":"https://orcid.org/0000-0002-4569-8663","affiliations":[{"raw_affiliation_string":"State University of Ceara , , , ,","institution_ids":["https://openalex.org/I102939073"]},{"raw_affiliation_string":"Laboratory of Biotechnology and Molecular Biology","institution_ids":[]},{"raw_affiliation_string":"State University of Ceara","institution_ids":["https://openalex.org/I102939073"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5073320176"],"corresponding_institution_ids":["https://openalex.org/I102939073"],"apc_list":{"value":1935,"currency":"USD","value_usd":1935},"apc_paid":{"value":1935,"currency":"USD","value_usd":1935},"fwci":0.298,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.42947335,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"10","issue":"28","first_page":"30313","last_page":"30326"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.9053000211715698,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.9053000211715698,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.01759999990463257,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.01489999983459711,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chalcones","display_name":"chalcones","score":0.8410000205039978},{"id":"https://openalex.org/keywords/claisen-schmidt-condensation","display_name":"Claisen-Schmidt condensation","score":0.7870000004768372},{"id":"https://openalex.org/keywords/anxiolytic-effects","display_name":"anxiolytic effects","score":0.8349999785423279},{"id":"https://openalex.org/keywords/anticonvulsant-activity","display_name":"anticonvulsant activity","score":0.871999979019165},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.9279999732971191},{"id":"https://openalex.org/keywords/pentylenetetrazole-induced-seizures","display_name":"pentylenetetrazole-induced seizures","score":0.902999997138977},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.6850000023841858},{"id":"https://openalex.org/keywords/gabaergic-pathway","display_name":"GABAergic pathway","score":0.7310000061988831},{"id":"https://openalex.org/keywords/serotonergic-pathways","display_name":"serotonergic pathways","score":0.9789999723434448},{"id":"https://openalex.org/keywords/hypoglycemic-effect","display_name":"hypoglycemic effect","score":0.8479999899864197},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9340000152587891},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.6179999709129333},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.8550000190734863},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6169999837875366},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.7896789312362671},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.6696473360061646},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.4908457398414612},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.38055098056793213},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3692135810852051},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33610332012176514},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1946716010570526},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.19185233116149902},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05047914385795593},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1021/acsomega.5c01614","doi":"https://doi.org/10.1021/acsomega.5c01614","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.5c01614","pdf_url":null,"source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},{"id":"pmid:40727737","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40727737","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS omega","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12290938","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12290938","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ACS Omega","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:b082328f1f774441b7e0657b47f97c7f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b082328f1f774441b7e0657b47f97c7f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ACS Omega, Vol 10, Iss 28, Pp 30313-30326 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1021/acsomega.5c01614","doi":"https://doi.org/10.1021/acsomega.5c01614","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.5c01614","pdf_url":null,"source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2324973720","display_name":null,"funder_award_id":"306008/202) 2-0","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G559832745","display_name":null,"funder_award_id":"UNI\u20100210\u201000337.01.00/23","funder_id":"https://openalex.org/F4320323202","funder_display_name":"Funda\u00e7\u00e3o Cearense de Apoio ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G6111416821","display_name":null,"funder_award_id":"FPD\u20100213\u201000088.01.00/23","funder_id":"https://openalex.org/F4320323202","funder_display_name":"Funda\u00e7\u00e3o Cearense de Apoio ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G643726454","display_name":null,"funder_award_id":"ITR- 0214-00060.01.00/23","funder_id":"https://openalex.org/F4320323202","funder_display_name":"Funda\u00e7\u00e3o Cearense de Apoio ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"}],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320323202","display_name":"Funda\u00e7\u00e3o Cearense de Apoio ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/007pgtp80"},{"id":"https://openalex.org/F4320324351","display_name":"Universidade\u00a0Estadual do\u00a0Cear\u00e1","ror":"https://ror.org/00sec1m50"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":84,"referenced_works":["https://openalex.org/W1519606665","https://openalex.org/W1955247304","https://openalex.org/W1957176172","https://openalex.org/W1965164425","https://openalex.org/W1967722500","https://openalex.org/W1974918638","https://openalex.org/W1981239255","https://openalex.org/W1995952752","https://openalex.org/W2000104422","https://openalex.org/W2014747463","https://openalex.org/W2026858401","https://openalex.org/W2027655332","https://openalex.org/W2028046413","https://openalex.org/W2037030399","https://openalex.org/W2038355081","https://openalex.org/W2061657453","https://openalex.org/W2067902357","https://openalex.org/W2073028926","https://openalex.org/W2074990246","https://openalex.org/W2076124694","https://openalex.org/W2087411507","https://openalex.org/W2094235329","https://openalex.org/W2105668062","https://openalex.org/W2115011904","https://openalex.org/W2147421370","https://openalex.org/W2149106174","https://openalex.org/W2374483418","https://openalex.org/W2520366561","https://openalex.org/W2692744364","https://openalex.org/W2735367792","https://openalex.org/W2772522913","https://openalex.org/W2786822500","https://openalex.org/W2790144358","https://openalex.org/W2887972508","https://openalex.org/W2909903816","https://openalex.org/W2911542458","https://openalex.org/W2941911189","https://openalex.org/W2949984678","https://openalex.org/W2972046145","https://openalex.org/W2973805821","https://openalex.org/W2989228045","https://openalex.org/W3001541936","https://openalex.org/W3003919131","https://openalex.org/W3014610649","https://openalex.org/W3015022543","https://openalex.org/W3028540953","https://openalex.org/W3028870976","https://openalex.org/W3037950396","https://openalex.org/W3045089668","https://openalex.org/W3082533986","https://openalex.org/W3094381658","https://openalex.org/W3109408285","https://openalex.org/W3113094018","https://openalex.org/W3113730240","https://openalex.org/W3126878588","https://openalex.org/W3130441017","https://openalex.org/W3133927813","https://openalex.org/W3136109176","https://openalex.org/W3136931247","https://openalex.org/W3137471326","https://openalex.org/W3159085565","https://openalex.org/W3171325432","https://openalex.org/W3172747904","https://openalex.org/W3188304183","https://openalex.org/W3188442370","https://openalex.org/W3216523727","https://openalex.org/W4213187718","https://openalex.org/W4226480824","https://openalex.org/W4229978218","https://openalex.org/W4236001271","https://openalex.org/W4238293077","https://openalex.org/W4238610611","https://openalex.org/W4286268915","https://openalex.org/W4307943172","https://openalex.org/W4312212210","https://openalex.org/W4316464097","https://openalex.org/W4319656269","https://openalex.org/W4362506373","https://openalex.org/W4384283332","https://openalex.org/W4385230212","https://openalex.org/W4388016607","https://openalex.org/W4388440931","https://openalex.org/W4396220720","https://openalex.org/W4406778389"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W3129642199","https://openalex.org/W4256528904","https://openalex.org/W1597543017","https://openalex.org/W4293058866","https://openalex.org/W4245153001","https://openalex.org/W3147492987","https://openalex.org/W4243165149","https://openalex.org/W4283069614"],"abstract_inverted_index":{"Abstract":[0],"Neurological":[1],"disorders":[2],"are":[3,125],"a":[4,107,250],"major":[5],"contributor":[6],"to":[7,66,92,183,222,282,325],"disability-adjusted":[8],"life":[9],"years":[10,104],"(DALYs)":[11],"worldwide,":[12],"with":[13,113],"anxiety":[14,22,226],"and":[15,29,54,82,98,138,158,172,192,207,214,225,243,246,274,285,319],"epilepsy":[16],"being":[17,117],"particularly":[18],"prevalent.":[19],"Among":[20],"them,":[21],"is":[23],"among":[24],"the":[25,39,46,76,87,93,120,128,132,142,154,188,241,253,257,260,264,278,289,292],"top":[26],"ten":[27],"diseases":[28],"causes":[30,249],"an":[31,322],"annual":[32],"cost":[33],"of":[34,48,52,78,86,95,110,141,169,177,232,256,262,266],"42.3":[35],"billion":[36],"dollars":[37],"in":[38,71,102,119,145,187,252,277,280,301],"United":[40],"States.":[41],"It":[42],"can":[43,64],"also":[44,116],"increase":[45],"chance":[47],"developing":[49],"diabetes,":[50],"regardless":[51],"cardiometabolic":[53],"sociodemographic":[55],"factors.":[56],"Diabetes,":[57],"if":[58],"left":[59],"uncontrolled":[60],"for":[61,75,105,315],"long":[62],"periods,":[63],"lead":[65],"serious":[67],"health":[68],"problems":[69],"and,":[70],"2021,":[72],"was":[73,151,162,220],"responsible":[74],"deaths":[77],"1.6":[79],"million":[80],"people":[81],"affected":[83],"around":[84],"10.5%":[85],"world":[88],"population.":[89],"chalcones":[90,306],"belong":[91],"class":[94],"flavonoid":[96],"compounds":[97,124],"have":[99,307],"gained":[100],"prominence":[101],"recent":[103],"presenting":[106],"wide":[108],"range":[109],"physiological":[111,311],"effects,":[112],"similar":[114],"effects":[115,186],"found":[118],"literature":[121],"when":[122],"these":[123],"synthesized.":[126],"Therefore,":[127],"work":[129],"aimed":[130],"at":[131,167,230],"synthesis,":[133],"characterization,":[134],"toxicological,":[135],"anxiolytic,":[136],"hypoglycemic,":[137],"anticonvulsant":[139],"analysis":[140],"compound":[143,218],"4AAF":[144],"Danio":[146],"rerio.":[147],"Initially,":[148],"amino":[149],"chalcone":[150],"synthesized":[152],"employing":[153],"Claisen\u2013Schmidt":[155],"condensation":[156],"reaction,":[157],"then":[159],"its":[160],"toxicity":[161],"tested":[163],"over":[164],"96":[165],"h":[166],"concentrations":[168,231],"0.1,":[170],"0.5,":[171],"1.0":[173,293],"mg/mL.":[174],"Subsequently,":[175],"groups":[176],"6":[178],"treated":[179],"animals":[180],"were":[181,228],"formed":[182],"evaluate":[184],"their":[185,327],"following":[189],"tests:":[190],"light":[191],"dark,":[193],"novel":[194],"tank":[195],"test,":[196,199,291],"open":[197],"field":[198],"spinning":[200],"task,":[201],"anxiolytic":[202,284],"action":[203],"mechanism":[204],"via":[205],"GABA":[206,242],"serotonergic,":[208],"chronic":[209],"hyperglycemia,":[210,263],"reactive":[211],"oxygen":[212],"species,":[213],"pentylenetetrazol-induced":[215],"seizure.":[216],"The":[217],"produced":[219],"shown":[221],"be":[223],"nontoxic,":[224],"tests":[227],"promising":[229],"0.5":[233,267],"mg/mL,":[234],"showing":[235],"that":[236,247],"aminochalcone":[237],"acts":[238],"on":[239],"both":[240],"serotonergic":[244],"pathways":[245],"it":[248],"reduction":[251],"locomotor":[254],"pattern":[255],"animals.":[258],"In":[259,288],"context":[261],"concentration":[265,295],"mg/mL":[268,294],"significantly":[269],"reduced":[270],"blood":[271],"glucose":[272],"levels":[273],"oxidative":[275],"stress":[276],"liver,":[279],"addition":[281],"causing":[283],"sedative":[286],"behavior.":[287],"seizure":[290],"partially":[296],"reversed":[297],"PTZ-induced":[298],"convulsive":[299],"behavior":[300],"stage":[302],"three.":[303],"Finally,":[304],"synthetic":[305],"more":[308],"than":[309],"one":[310],"effect,":[312],"requiring":[313],"bioprospecting":[314],"other":[316],"possible":[317],"actions,":[318],"zebrafish":[320],"become":[321],"interesting":[323],"model":[324],"investigate":[326],"various":[328],"uses.":[329]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}
