{"id":"https://openalex.org/W4412378962","doi":"https://doi.org/10.1142/s2424835525500559","title":"The Relationship between Carpal Tunnel Syndrome and Wild-Type ATTR Amyloidosis","display_name":"The Relationship between Carpal Tunnel Syndrome and Wild-Type ATTR Amyloidosis","publication_year":2025,"publication_date":"2025-07-14","ids":{"openalex":"https://openalex.org/W4412378962","doi":"https://doi.org/10.1142/s2424835525500559","pmid":"https://pubmed.ncbi.nlm.nih.gov/40653641"},"language":"en","primary_location":{"id":"doi:10.1142/s2424835525500559","doi":"https://doi.org/10.1142/s2424835525500559","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s2424835525500559","pdf_url":null,"source":{"id":"https://openalex.org/S4210223129","display_name":"The Journal of Hand Surgery (Asian-Pacific Volume)","issn_l":"2424-8355","issn":["2424-8355","2424-8363"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Hand Surgery (Asian-Pacific Volume)","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101626043","display_name":"Kenji Goto","orcid":"https://orcid.org/0000-0003-4994-0602","observed_orcids":["https://orcid.org/0000-0003-4994-0602"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji GOTO","raw_affiliation_strings":["Department of Orthopaedic Surgery, Kyoto University, Kyoto City, Kyoto, Japan","Department of Orthopaedics, Juntendo University Faculty of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Kyoto University, Kyoto City, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"Department of Orthopaedics, Juntendo University Faculty of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I34077901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088763525","display_name":"Ryosuke Ikeguchi","orcid":"https://orcid.org/0000-0003-4525-7849","observed_orcids":["https://orcid.org/0000-0003-4525-7849"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryosuke IKEGUCHI","raw_affiliation_strings":["Department of Orthopaedic Surgery, Kyoto University, Kyoto City, Kyoto, Japan","Department of Rehabilitation Medicine, Kyoto University, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Kyoto University, Kyoto City, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"Department of Rehabilitation Medicine, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101521602","display_name":"Takashi Noguchi","orcid":"https://orcid.org/0000-0003-2965-4772","observed_orcids":["https://orcid.org/0000-0003-2965-4772"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi NOGUCHI","raw_affiliation_strings":["Department of Orthopaedic Surgery, Kyoto University, Kyoto City, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Kyoto University, Kyoto City, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102867436","display_name":"Kiyohito Naito","orcid":"https://orcid.org/0000-0001-7739-8334","observed_orcids":["https://orcid.org/0000-0001-7739-8334"]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyohito NAITO","raw_affiliation_strings":["Department of Orthopaedics, Juntendo University Faculty of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Juntendo University Faculty of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I34077901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001742512","display_name":"Muneaki Ishijima","orcid":"https://orcid.org/0000-0002-0920-0805","observed_orcids":["https://orcid.org/0000-0002-0920-0805"]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Muneaki ISHIJIMA","raw_affiliation_strings":["Department of Orthopaedics, Juntendo University Faculty of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Juntendo University Faculty of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I34077901"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103038675","display_name":"Shuichi Matsuda","orcid":"https://orcid.org/0000-0003-0802-1255","observed_orcids":["https://orcid.org/0000-0003-0802-1255"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuichi MATSUDA","raw_affiliation_strings":["Department of Orthopaedic Surgery, Kyoto University, Kyoto City, Kyoto, Japan","Department of Rehabilitation Medicine, Kyoto University, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Kyoto University, Kyoto City, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]},{"raw_affiliation_string":"Department of Rehabilitation Medicine, Kyoto University, Kyoto, Japan","institution_ids":["https://openalex.org/I22299242"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2611,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.45987286,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"30","issue":"5","first_page":"539","last_page":"544"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10954","display_name":"Peripheral Nerve Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carpal-tunnel-syndrome","display_name":"carpal tunnel syndrome","score":0.9869999885559082},{"id":"https://openalex.org/keywords/wild-type-transthyretin-amyloidosis","display_name":"wild-type transthyretin amyloidosis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.7509999871253967},{"id":"https://openalex.org/keywords/delayed-diagnosis","display_name":"delayed diagnosis","score":0.8230000138282776},{"id":"https://openalex.org/keywords/cardiology-referral","display_name":"cardiologist referral","score":0.8539999723434448},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.4880000054836273},{"id":"https://openalex.org/keywords/bilateral-carpal-tunnel-syndrome","display_name":"bilateral carpal tunnel syndrome","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6188985109329224},{"id":"https://openalex.org/C2779951007","wikidata":"https://www.wikidata.org/wiki/Q816798","display_name":"Amyloidosis","level":2,"score":0.5855254530906677},{"id":"https://openalex.org/C2779746960","wikidata":"https://www.wikidata.org/wiki/Q332293","display_name":"Carpal tunnel syndrome","level":2,"score":0.5425506234169006},{"id":"https://openalex.org/C121157162","wikidata":"https://www.wikidata.org/wiki/Q419999","display_name":"Transthyretin","level":2,"score":0.5242105722427368},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27753955125808716},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2132807970046997}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002349","descriptor_name":"Carpal Tunnel Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002349","descriptor_name":"Carpal Tunnel Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002349","descriptor_name":"Carpal Tunnel Syndrome","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D002349","descriptor_name":"Carpal Tunnel Syndrome","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D028227","descriptor_name":"Amyloid Neuropathies, Familial","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D028227","descriptor_name":"Amyloid Neuropathies, Familial","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D028227","descriptor_name":"Amyloid Neuropathies, Familial","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D028227","descriptor_name":"Amyloid Neuropathies, Familial","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D042241","descriptor_name":"Early Diagnosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042241","descriptor_name":"Early Diagnosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1142/s2424835525500559","doi":"https://doi.org/10.1142/s2424835525500559","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s2424835525500559","pdf_url":null,"source":{"id":"https://openalex.org/S4210223129","display_name":"The Journal of Hand Surgery (Asian-Pacific Volume)","issn_l":"2424-8355","issn":["2424-8355","2424-8363"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Hand Surgery (Asian-Pacific Volume)","raw_type":"journal-article"},{"id":"pmid:40653641","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40653641","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of hand surgery Asian-Pacific volume","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"No poverty","id":"https://metadata.un.org/sdg/1","score":0.6899999976158142}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4210472704","https://openalex.org/W2084731390","https://openalex.org/W2077316781","https://openalex.org/W2607140347","https://openalex.org/W2805908680","https://openalex.org/W2109513774","https://openalex.org/W4400599931","https://openalex.org/W270527095","https://openalex.org/W2333479840","https://openalex.org/W4221065483"],"abstract_inverted_index":{"Background:":[0],"Carpal":[1],"tunnel":[2],"syndrome":[3],"(CTS),":[4],"which":[5,31],"is":[6,12,178,207],"frequently":[7],"encountered":[8],"in":[9,32,38,124],"orthopaedic":[10,113,154,209,231],"practice,":[11],"an":[13],"early":[14,28,48,55],"symptom":[15],"of":[16,50,59,86,89,105,110,120,165,173,215,236],"wild-type":[17],"transthyretin":[18],"amyloidosis":[19],"(ATTRwt).":[20],"ATTRwt":[21,73,101,140,169,193],"has":[22],"a":[23,39,87,171,179,199],"high":[24],"misdiagnosis":[25],"rate,":[26],"making":[27],"detection":[29,56],"difficult,":[30],"turn":[33],"delays":[34],"treatment":[35,58],"and":[36,57,107,148,220],"results":[37,161],"poor":[40],"prognosis.":[41,64],"Therefore,":[42],"we":[43],"herein":[44],"investigated":[45,83],"whether":[46],"the":[47,54,84,91,94,97,103,108,136,185,189,216,225],"diagnosis":[49,99,138,191],"CTS":[51,98,121,137,177,190,219],"leads":[52],"to":[53,100,115,139,156,192,233],"ATTRwt,":[60,221],"ultimately":[61],"improving":[62],"its":[63],"Methods:":[65],"This":[66],"study":[67],"included":[68],"42":[69],"patients":[70,146,166],"diagnosed":[71,167],"with":[72,127,168],"(34":[74],"males,":[75],"8":[76],"females;":[77],"mean":[78],"age:":[79],"77.7":[80],"years).":[81],"We":[82],"presence":[85],"history":[88,119,172],"CTS,":[90,174],"affected":[92],"side,":[93],"duration":[95,134,187],"from":[96,112,135,153,188,230],"confirmation,":[102],"number":[104,109],"deaths":[106],"referrals":[111,152,229],"surgeons":[114,155,210,232],"cardiologists.":[116,157,234],"Results:":[117],"A":[118],"was":[122,142,195],"present":[123,160],"26":[125],"cases,":[126],"15":[128],"being":[129],"bilateral":[130],"CTS.":[131],"The":[132,159],"average":[133,186],"confirmation":[141,194],"6.4":[143,196],"years.":[144],"Four":[145],"died,":[147],"there":[149],"were":[150],"no":[151,228],"Conclusions:":[158],"showed":[162],"that":[163,176,208],"61.9%":[164],"had":[170],"suggesting":[175],"predictive":[180],"factor":[181],"for":[182,204],"ATTRwt.":[183],"However,":[184],"years,":[197],"indicating":[198],"significant":[200],"delay.":[201],"One":[202],"reason":[203],"this":[205],"delay":[206],"may":[211],"not":[212],"be":[213],"aware":[214],"relationship":[217],"between":[218],"as":[222],"suggested":[223],"by":[224],"result":[226],"showing":[227],"Level":[235,238],"Evidence:":[237],"IV":[239],"(Diagnostic)":[240]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}