{"id":"https://openalex.org/W4412377977","doi":"https://doi.org/10.1186/s13046-025-03460-1","title":"m5C-modified circRREB1 promotes lung cancer progression by inducing mitophagy","display_name":"m5C-modified circRREB1 promotes lung cancer progression by inducing mitophagy","publication_year":2025,"publication_date":"2025-07-14","ids":{"openalex":"https://openalex.org/W4412377977","doi":"https://doi.org/10.1186/s13046-025-03460-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/40653497"},"language":"en","primary_location":{"id":"doi:10.1186/s13046-025-03460-1","doi":"https://doi.org/10.1186/s13046-025-03460-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13046-025-03460-1","pdf_url":null,"source":{"id":"https://openalex.org/S33781645","display_name":"Journal of Experimental & Clinical Cancer Research","issn_l":"0392-9078","issn":["0392-9078","1756-9966"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental &amp; Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s13046-025-03460-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113262234","display_name":"Dunyu Cai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dunyu Cai","raw_affiliation_strings":["Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, 530021, China","School of Public Health, Guangxi Medical University, Nanning, 530021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, 530021, China","institution_ids":["https://openalex.org/I160354086"]},{"raw_affiliation_string":"School of Public Health, Guangxi Medical University, Nanning, 530021, China","institution_ids":["https://openalex.org/I160354086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083396458","display_name":"Xingcai Chen","orcid":"https://orcid.org/0000-0002-9489-5014","observed_orcids":["https://orcid.org/0000-0002-9489-5014"]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xingcai Chen","raw_affiliation_strings":["Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, 530021, China","School of Public Health, Guangxi Medical University, Nanning, 530021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, 530021, China","institution_ids":["https://openalex.org/I160354086"]},{"raw_affiliation_string":"School of Public Health, Guangxi Medical University, Nanning, 530021, China","institution_ids":["https://openalex.org/I160354086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061108078","display_name":"Haotian Xu","orcid":"https://orcid.org/0000-0003-1673-6779","observed_orcids":["https://orcid.org/0000-0003-1673-6779","https://orcid.org/0009-0001-1565-8521"]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haotian Xu","raw_affiliation_strings":["Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, 530021, China","School of Public Health, Guangxi Medical University, Nanning, 530021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, 530021, China","institution_ids":["https://openalex.org/I160354086"]},{"raw_affiliation_string":"School of Public Health, Guangxi Medical University, Nanning, 530021, China","institution_ids":["https://openalex.org/I160354086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104689366","display_name":"Qingyun Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingyun Zhao","raw_affiliation_strings":["Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, 530021, China","School of Public Health, Guangxi Medical University, Nanning, 530021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, 530021, China","institution_ids":["https://openalex.org/I160354086"]},{"raw_affiliation_string":"School of Public Health, Guangxi Medical University, Nanning, 530021, China","institution_ids":["https://openalex.org/I160354086"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiaodong Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaodong Zhou","raw_affiliation_strings":["Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, 530021, China","School of Public Health, Guangxi Medical University, Nanning, 530021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, 530021, China","institution_ids":["https://openalex.org/I160354086"]},{"raw_affiliation_string":"School of Public Health, Guangxi Medical University, Nanning, 530021, China","institution_ids":["https://openalex.org/I160354086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101202378","display_name":"Jiaxi Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaxi Wu","raw_affiliation_strings":["Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, 530021, China","School of Public Health, Guangxi Medical University, Nanning, 530021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, 530021, China","institution_ids":["https://openalex.org/I160354086"]},{"raw_affiliation_string":"School of Public Health, Guangxi Medical University, Nanning, 530021, China","institution_ids":["https://openalex.org/I160354086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108991075","display_name":"Shengyi Yuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shengyi Yuan","raw_affiliation_strings":["Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, 530021, China","School of Public Health, Guangxi Medical University, Nanning, 530021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, 530021, China","institution_ids":["https://openalex.org/I160354086"]},{"raw_affiliation_string":"School of Public Health, Guangxi Medical University, Nanning, 530021, China","institution_ids":["https://openalex.org/I160354086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068572096","display_name":"Yihong Gao","orcid":"https://orcid.org/0000-0002-9293-4075","observed_orcids":["https://orcid.org/0000-0002-9293-4075"]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yihong Gao","raw_affiliation_strings":["Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, 530021, China","School of Public Health, Guangxi Medical University, Nanning, 530021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, 530021, China","institution_ids":["https://openalex.org/I160354086"]},{"raw_affiliation_string":"School of Public Health, Guangxi Medical University, Nanning, 530021, China","institution_ids":["https://openalex.org/I160354086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053160046","display_name":"Deqing Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Deqing Li","raw_affiliation_strings":["Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, 530021, China","School of Public Health, Guangxi Medical University, Nanning, 530021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, 530021, China","institution_ids":["https://openalex.org/I160354086"]},{"raw_affiliation_string":"School of Public Health, Guangxi Medical University, Nanning, 530021, China","institution_ids":["https://openalex.org/I160354086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100441988","display_name":"Ruirui Zhang","orcid":"https://orcid.org/0000-0003-1898-1487","observed_orcids":["https://orcid.org/0000-0003-1898-1487"]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruirui Zhang","raw_affiliation_strings":["Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, 530021, China","School of Public Health, Guangxi Medical University, Nanning, 530021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, 530021, China","institution_ids":["https://openalex.org/I160354086"]},{"raw_affiliation_string":"School of Public Health, Guangxi Medical University, Nanning, 530021, China","institution_ids":["https://openalex.org/I160354086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049649274","display_name":"Wenyi Peng","orcid":"https://orcid.org/0000-0001-7699-6850","observed_orcids":["https://orcid.org/0000-0001-7699-6850"]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenyi Peng","raw_affiliation_strings":["Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, 530021, China","School of Public Health, Guangxi Medical University, Nanning, 530021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, 530021, China","institution_ids":["https://openalex.org/I160354086"]},{"raw_affiliation_string":"School of Public Health, Guangxi Medical University, Nanning, 530021, China","institution_ids":["https://openalex.org/I160354086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100352875","display_name":"Gang Li","orcid":"https://orcid.org/0000-0003-3184-1032","observed_orcids":["https://orcid.org/0000-0003-3184-1032"]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gang Li","raw_affiliation_strings":["Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, 530021, China","School of Public Health, Guangxi Medical University, Nanning, 530021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, 530021, China","institution_ids":["https://openalex.org/I160354086"]},{"raw_affiliation_string":"School of Public Health, Guangxi Medical University, Nanning, 530021, China","institution_ids":["https://openalex.org/I160354086"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001013290","display_name":"Aruo Nan","orcid":"https://orcid.org/0000-0003-0351-8561","observed_orcids":["https://orcid.org/0000-0003-0351-8561"]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Aruo Nan","raw_affiliation_strings":["Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, 530021, China. nanaruo@163.com","School of Public Health, Guangxi Medical University, Nanning, 530021, China. nanaruo@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, 530021, China. nanaruo@163.com","institution_ids":["https://openalex.org/I160354086"]},{"raw_affiliation_string":"School of Public Health, Guangxi Medical University, Nanning, 530021, China. nanaruo@163.com","institution_ids":["https://openalex.org/I160354086"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001013290"],"corresponding_institution_ids":["https://openalex.org/I160354086"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":3.3941,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.93724452,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"44","issue":"1","first_page":"203","last_page":"203"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.6859999895095825},{"id":"https://openalex.org/keywords/mitophagy","display_name":"mitophagy","score":0.9070000052452087},{"id":"https://openalex.org/keywords/nsun2","display_name":"NSUN2","score":0.8510000109672546},{"id":"https://openalex.org/keywords/alyref","display_name":"ALYREF","score":0.9559999704360962},{"id":"https://openalex.org/keywords/hsc70","display_name":"Hsc70","score":0.8659999966621399},{"id":"https://openalex.org/keywords/circular-rna","display_name":"circular RNA","score":0.6710000038146973},{"id":"https://openalex.org/keywords/rna-stability","display_name":"RNA stability","score":0.7129999995231628},{"id":"https://openalex.org/keywords/ubiquitin-mediated-degradation","display_name":"ubiquitin-mediated proteolysis","score":0.7889999747276306},{"id":"https://openalex.org/keywords/nuclear-export","display_name":"nuclear export","score":0.6010000109672546},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.859000027179718}],"concepts":[{"id":"https://openalex.org/C71829478","wikidata":"https://www.wikidata.org/wiki/Q901305","display_name":"Immunoprecipitation","level":3,"score":0.6852607727050781},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.6531994938850403},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5995045900344849},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4822562336921692},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44995787739753723},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4250161945819855},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.42454737424850464},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3323969542980194},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25378894805908203},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1473202109336853},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1068209707736969},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0986289381980896}],"mesh":[{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044503","descriptor_name":"5-Methylcytosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044503","descriptor_name":"5-Methylcytosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044503","descriptor_name":"5-Methylcytosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063306","descriptor_name":"Mitophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D063306","descriptor_name":"Mitophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D063306","descriptor_name":"Mitophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/s13046-025-03460-1","doi":"https://doi.org/10.1186/s13046-025-03460-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13046-025-03460-1","pdf_url":null,"source":{"id":"https://openalex.org/S33781645","display_name":"Journal of Experimental & Clinical Cancer Research","issn_l":"0392-9078","issn":["0392-9078","1756-9966"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental &amp; Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:40653497","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40653497","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of experimental & clinical cancer research : CR","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11063011","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12257754","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12257754","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12257754","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Exp Clin Cancer Res","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:b1e6e076a2914dc5afadd5e7e650fb14","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b1e6e076a2914dc5afadd5e7e650fb14","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Experimental & Clinical Cancer Research, Vol 44, Iss 1, Pp 1-22 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13046-025-03460-1","doi":"https://doi.org/10.1186/s13046-025-03460-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13046-025-03460-1","pdf_url":null,"source":{"id":"https://openalex.org/S33781645","display_name":"Journal of Experimental & Clinical Cancer Research","issn_l":"0392-9078","issn":["0392-9078","1756-9966"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental &amp; Clinical Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.800000011920929,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5258317929","display_name":null,"funder_award_id":"NSFC82260652","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1770535374","https://openalex.org/W2007360321","https://openalex.org/W2032474599","https://openalex.org/W2034087770","https://openalex.org/W2047242847","https://openalex.org/W2060902122","https://openalex.org/W2064165694","https://openalex.org/W2073642561","https://openalex.org/W2085398950","https://openalex.org/W2157096314","https://openalex.org/W2164945122","https://openalex.org/W2166262263","https://openalex.org/W2167616678","https://openalex.org/W2167867141","https://openalex.org/W2172336833","https://openalex.org/W2551880155","https://openalex.org/W2606518593","https://openalex.org/W2736275121","https://openalex.org/W2755721896","https://openalex.org/W2803721679","https://openalex.org/W2963850569","https://openalex.org/W2964438344","https://openalex.org/W2967043226","https://openalex.org/W3006786463","https://openalex.org/W3011350719","https://openalex.org/W3120908027","https://openalex.org/W3123218478","https://openalex.org/W3128646645","https://openalex.org/W3158403563","https://openalex.org/W3163570813","https://openalex.org/W3203777534","https://openalex.org/W4220891964","https://openalex.org/W4221129315","https://openalex.org/W4292966970","https://openalex.org/W4295346352","https://openalex.org/W4311589889","https://openalex.org/W4317659818","https://openalex.org/W4381435898","https://openalex.org/W4388616649","https://openalex.org/W4388731367","https://openalex.org/W4389166615","https://openalex.org/W4390946922","https://openalex.org/W4391172254","https://openalex.org/W4391809302","https://openalex.org/W4393935425","https://openalex.org/W4395114650","https://openalex.org/W4401410804","https://openalex.org/W4407228673"],"related_works":["https://openalex.org/W1976739589","https://openalex.org/W7949606","https://openalex.org/W2526890363","https://openalex.org/W121381176","https://openalex.org/W2000239818","https://openalex.org/W626095004","https://openalex.org/W2081832690","https://openalex.org/W150314098","https://openalex.org/W4388866360","https://openalex.org/W2148507644"],"abstract_inverted_index":{"BACKGROUND:":[0],"Lung":[1],"cancer":[2,161,207,283,291],"is":[3,156],"the":[4,10,36,55,92,95,103,122,143,181,186,196,232,239,248,279],"most":[5],"common":[6],"malignant":[7],"tumour":[8,28],"and":[9,23,42,73,84,105,111,114,135,163,165,212,221,236,255],"leading":[11],"cause":[12],"of":[13,39,59,64,94,107,125,146,241,250,278],"cancer-related":[14],"death.":[15],"circular":[16],"RNAs":[17],"(circRNAs)":[18],"have":[19,172],"important":[20],"biological":[21,123],"functions":[22,124],"are":[24],"closely":[25],"related":[26],"to":[27,53,90,120,141,219],"development.":[29,46],"The":[30,61],"5-methylcytosine":[31],"(m5C)":[32],"modification":[33,63,97,183,190],"can":[34,260],"regulate":[35],"molecular":[37,144],"fate":[38],"RNA":[40,49,70,76,128,132],"molecules":[41],"thus":[43],"influence":[44],"disease":[45],"METHODS:":[47],"High-throughput":[48],"sequencing":[50],"was":[51,66,109],"used":[52],"construct":[54],"differential":[56],"expression":[57,171],"profiles":[58],"circRNAs.":[60],"m5C":[62,96,182,197,251],"circRREB1":[65,108,155,170,179,204,216,254,259],"explored":[67],"through":[68,231],"methylated":[69],"immunoprecipitation":[71,133],"(MeRIP)":[72],"crosslinking-immunoprecipitation":[74],"(CLIP).":[75],"stability":[77],"experiments,":[78],"fluorescence":[79],"in":[80,112,115,159,210,213],"situ":[81],"hybridization":[82],"(FISH),":[83],"nuclear-cytoplasmic":[85],"fractionation":[86],"experiments":[87,117,138],"were":[88,118,139],"performed":[89],"explore":[91],"effects":[93],"on":[98,253],"circRREB1.":[99,126,147],"A":[100],"system":[101],"for":[102,275,289],"silencing":[104],"overexpression":[106],"established,":[110],"vitro":[113,211],"vivo":[116],"conducted":[119,140],"study":[121,246],"Tagged":[127],"affinity":[129],"purification":[130],"(TRAP),":[131],"(RIP),":[134],"coimmunoprecipitation":[136],"(Co-IP)":[137],"reveal":[142],"mechanisms":[145,280],"RESULTS:":[148],"In":[149],"this":[150],"study,":[151],"we":[152],"found":[153],"that":[154,166,178,203,257],"highly":[157],"expressed":[158],"lung":[160,206,242,265,282,290],"tissues":[162],"cells":[164],"patients":[167],"with":[168],"high":[169],"a":[173,272],"poor":[174],"prognosis.":[175],"We":[176],"discovered":[177],"undergoes":[180],"mediated":[184],"by":[185,224],"methyltransferase":[187],"NSUN2.":[188],"This":[189,245],"facilitates":[191],"its":[192],"nuclear":[193],"export":[194],"via":[195],"reader":[198],"ALYREF.":[199],"Functional":[200],"studies":[201],"demonstrated":[202],"promotes":[205],"progression":[208],"both":[209],"vivo.":[214],"Mechanistically,":[215],"directly":[217],"binds":[218],"HSPA8":[220],"stabilizes":[222],"it":[223],"inhibiting":[225],"ubiquitin-dependent":[226],"degradation,":[227],"thereby":[228],"inducing":[229],"mitophagy":[230],"HSPA8/PINK1/Parkin":[233],"signalling":[234],"axis":[235],"ultimately":[237,263],"promoting":[238,264],"development":[240,284],"cancer.":[243,266],"CONCLUSIONS:":[244],"revealed":[247],"presence":[249],"modifications":[252],"showed":[256],"m5C-modified":[258],"induce":[261],"mitophagy,":[262],"These":[267],"findings":[268],"provide":[269],"not":[270],"only":[271],"theoretical":[273],"basis":[274],"further":[276],"exploration":[277],"underlying":[281],"but":[285],"also":[286],"potential":[287],"targets":[288],"therapy.":[292]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-06T10:28:23.643775","created_date":"2025-10-10T00:00:00"}
