{"id":"https://openalex.org/W4412376461","doi":"https://doi.org/10.1101/2025.07.11.663676","title":"Multiplicative couplings facilitate rapid learning and information gating in recurrent neural networks","display_name":"Multiplicative couplings facilitate rapid learning and information gating in recurrent neural networks","publication_year":2025,"publication_date":"2025-07-12","ids":{"openalex":"https://openalex.org/W4412376461","doi":"https://doi.org/10.1101/2025.07.11.663676","pmid":"https://pubmed.ncbi.nlm.nih.gov/40672275"},"language":"en","primary_location":{"id":"doi:10.1101/2025.07.11.663676","doi":"https://doi.org/10.1101/2025.07.11.663676","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.07.11.663676","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/07/12/2025.07.11.663676.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2025/07/12/2025.07.11.663676.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100431077","display_name":"Xiaohan Zhang","orcid":"https://orcid.org/0000-0003-1522-4042","observed_orcids":["https://orcid.org/0000-0003-1522-4042","https://orcid.org/0000-0001-6305-2463","https://orcid.org/0009-0000-4673-4964","https://orcid.org/0009-0004-6120-4813","https://orcid.org/0000-0002-4758-8070"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaohan Zhang","raw_affiliation_strings":["New York University Grossman School of Medicine;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York University Grossman School of Medicine;","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118968887","display_name":"Mohamad Altrabulsi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohamad Altrabulsi","raw_affiliation_strings":["New York University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York University;","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017681571","display_name":"Wenqi Xu","orcid":"https://orcid.org/0000-0001-7876-1756","observed_orcids":["https://orcid.org/0000-0001-7876-1756"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenqi Xu","raw_affiliation_strings":["New York University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York University;","institution_ids":["https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ralf Wimmer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralf Wimmer","raw_affiliation_strings":["Tufts University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tufts University School of Medicine","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084779684","display_name":"Michael M. Halassa","orcid":"https://orcid.org/0000-0003-1386-0336","observed_orcids":["https://orcid.org/0000-0003-1386-0336"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael M. Halassa","raw_affiliation_strings":["Tufts University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tufts University School of Medicine","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100457703","display_name":"Zhe Sage Chen","orcid":"https://orcid.org/0000-0002-6483-6056","observed_orcids":["https://orcid.org/0000-0002-6483-6056","https://orcid.org/0000-0002-7106-5026"]},"institutions":[{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhe Sage Chen","raw_affiliation_strings":["New York University Grossman School of Medicine;"],"raw_orcid":"https://orcid.org/0000-0002-6483-6056","affiliations":[{"raw_affiliation_string":"New York University Grossman School of Medicine;","institution_ids":["https://openalex.org/I57206974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100457703"],"corresponding_institution_ids":["https://openalex.org/I57206974"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.6518999934196472,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.6518999934196472,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10320","display_name":"Neural Networks and Applications","score":0.27639999985694885,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.04470000043511391,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recurrent-neural-networks","display_name":"recurrent neural networks","score":0.9919999837875366},{"id":"https://openalex.org/keywords/feedforward-neural-networks","display_name":"feedforward neural networks","score":0.7900000214576721},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.8700000047683716},{"id":"https://openalex.org/keywords/hebbian-learning","display_name":"Hebbian learning","score":0.8980000019073486},{"id":"https://openalex.org/keywords/learning-speed","display_name":"learning speed","score":0.5960000157356262},{"id":"https://openalex.org/keywords/memory-capacity","display_name":"memory capacity","score":0.8320000171661377},{"id":"https://openalex.org/keywords/model-robustness","display_name":"model robustness","score":0.8240000009536743},{"id":"https://openalex.org/keywords/working-memory","display_name":"working memory","score":0.7710000276565552},{"id":"https://openalex.org/keywords/attention","display_name":"attention","score":0.9020000100135803},{"id":"https://openalex.org/keywords/attractor-dynamics","display_name":"attractor dynamics","score":0.8519999980926514},{"id":"https://openalex.org/keywords/reinforcement-learning","display_name":"reinforcement learning","score":0.7129999995231628},{"id":"https://openalex.org/keywords/unsupervised-learning","display_name":"unsupervised learning","score":0.8930000066757202},{"id":"https://openalex.org/keywords/supervised-learning","display_name":"supervised learning","score":0.6309999823570251},{"id":"https://openalex.org/keywords/biological-plausibility","display_name":"biological plausibility","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C194544171","wikidata":"https://www.wikidata.org/wiki/Q21105679","display_name":"Gating","level":2,"score":0.8060978651046753},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.583659291267395},{"id":"https://openalex.org/C42747912","wikidata":"https://www.wikidata.org/wiki/Q1048447","display_name":"Multiplicative function","level":2,"score":0.5686752200126648},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.5017290115356445},{"id":"https://openalex.org/C147168706","wikidata":"https://www.wikidata.org/wiki/Q1457734","display_name":"Recurrent neural network","level":3,"score":0.4298698902130127},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.38184744119644165},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3103838264942169},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2602675259113312},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.10849183797836304},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1101/2025.07.11.663676","doi":"https://doi.org/10.1101/2025.07.11.663676","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.07.11.663676","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/07/12/2025.07.11.663676.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:40672275","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40672275","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12265735","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12265735","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1101/2025.07.11.663676","doi":"https://doi.org/10.1101/2025.07.11.663676","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.07.11.663676","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/07/12/2025.07.11.663676.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.7599999904632568,"id":"https://metadata.un.org/sdg/16","display_name":"Peace, justice, and strong institutions"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1246091529","display_name":"Dissection of spatiotemporal activity from large-scale, multi-modal, multi-resolution hippocampal-neocortical recordings.","funder_award_id":"1rf1da056394-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3652761073","display_name":"CRCNS: Dissection and control of cognitive thalamocortical dynamics","funder_award_id":"1r01mh139352-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000865552","display_name":"Cognitive Thalamus","funder_award_id":"P50MH132642","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412376461.pdf","grobid_xml":"https://content.openalex.org/works/W4412376461.grobid-xml"},"referenced_works_count":92,"referenced_works":["https://openalex.org/W168968800","https://openalex.org/W196214544","https://openalex.org/W1525859397","https://openalex.org/W1570411240","https://openalex.org/W1583833196","https://openalex.org/W1677182931","https://openalex.org/W1874130433","https://openalex.org/W1971469299","https://openalex.org/W1973752972","https://openalex.org/W1975961509","https://openalex.org/W1976301604","https://openalex.org/W1989032589","https://openalex.org/W1999435425","https://openalex.org/W2015577212","https://openalex.org/W2041917456","https://openalex.org/W2047125104","https://openalex.org/W2064675550","https://openalex.org/W2072492557","https://openalex.org/W2089217417","https://openalex.org/W2095931805","https://openalex.org/W2096470434","https://openalex.org/W2099231026","https://openalex.org/W2105089471","https://openalex.org/W2111911706","https://openalex.org/W2112796928","https://openalex.org/W2115441154","https://openalex.org/W2126349398","https://openalex.org/W2148654448","https://openalex.org/W2149615516","https://openalex.org/W2153440713","https://openalex.org/W2155754335","https://openalex.org/W2171884247","https://openalex.org/W2230836247","https://openalex.org/W2261519444","https://openalex.org/W2280725856","https://openalex.org/W2536957931","https://openalex.org/W2538079766","https://openalex.org/W2593220908","https://openalex.org/W2594475619","https://openalex.org/W2611485120","https://openalex.org/W2626778328","https://openalex.org/W2738724892","https://openalex.org/W2751777443","https://openalex.org/W2767687421","https://openalex.org/W2785527097","https://openalex.org/W2791433556","https://openalex.org/W2794448029","https://openalex.org/W2800142021","https://openalex.org/W2899696887","https://openalex.org/W2908124316","https://openalex.org/W2923467929","https://openalex.org/W2952379393","https://openalex.org/W2971601581","https://openalex.org/W2981305449","https://openalex.org/W2994821360","https://openalex.org/W2995064991","https://openalex.org/W3037447448","https://openalex.org/W3043133474","https://openalex.org/W3046079479","https://openalex.org/W3047414922","https://openalex.org/W3048749966","https://openalex.org/W3140601242","https://openalex.org/W3161871721","https://openalex.org/W3163979969","https://openalex.org/W3202229880","https://openalex.org/W3215137167","https://openalex.org/W4200634264","https://openalex.org/W4225248781","https://openalex.org/W4225897269","https://openalex.org/W4281663412","https://openalex.org/W4285797023","https://openalex.org/W4307583652","https://openalex.org/W4311572328","https://openalex.org/W4321611635","https://openalex.org/W4353091694","https://openalex.org/W4360991386","https://openalex.org/W4362522955","https://openalex.org/W4380790388","https://openalex.org/W4381682834","https://openalex.org/W4385802664","https://openalex.org/W4390167859","https://openalex.org/W4391528527","https://openalex.org/W4393386271","https://openalex.org/W4396673704","https://openalex.org/W4399203401","https://openalex.org/W4399756299","https://openalex.org/W4400494507","https://openalex.org/W4404306027","https://openalex.org/W4408512753","https://openalex.org/W4409148785","https://openalex.org/W6604896550","https://openalex.org/W6830646645"],"related_works":["https://openalex.org/W2031449089","https://openalex.org/W2112596406","https://openalex.org/W2125499229","https://openalex.org/W2072696177","https://openalex.org/W4387096269","https://openalex.org/W4387096026","https://openalex.org/W2410610877","https://openalex.org/W2129483036","https://openalex.org/W2368671581","https://openalex.org/W1982291480"],"abstract_inverted_index":{"The":[0,71],"mammalian":[1],"forebrain":[2,39],"is":[3,44],"the":[4,18,26,38,119,165],"seat":[5],"of":[6,97,114,124],"higher":[7],"cognition":[8],"with":[9,40],"architectural":[10,35],"parallels":[11],"to":[12],"modern":[13],"machine":[14],"learning":[15,42,105],"systems.":[16],"Specifically,":[17],"cortex":[19],"resembles":[20,28],"recurrent":[21,179],"neural":[22,30,180],"networks":[23,31],"(RNNs)":[24],"while":[25],"thalamus":[27,135],"feedforward":[29],"(FNNs).":[32],"How":[33],"such":[34],"features":[36],"endow":[37],"its":[41],"capacity,":[43,109],"unknown.":[45],"Here":[46],"we":[47],"take":[48],"inspiration":[49],"from":[50],"empirical":[51],"thalamocortical":[52],"discovery":[53],"and":[54,69,84,103,112,121,147,149,157,176],"develop":[55],"a":[56,75,132,141],"multiplicative":[57,72,90,125],"coupling":[58],"mechanism":[59],"between":[60],"RNN-FNN":[61],"architectures":[62],"that":[63,89,171],"collectively":[64],"enhance":[65],"their":[66],"computational":[67],"strengths":[68],"learning.":[70],"interaction":[73],"imposes":[74],"Hebbian-weight":[76],"amplification":[77],"onto":[78],"synaptic-neuronal":[79],"coupling,":[80],"enabling":[81],"context-dependent":[82,138],"gating":[83,126],"rapid":[85],"switching.":[86],"We":[87,116],"demonstrate":[88,118,164],"feedback-driven":[91],"synaptic":[92],"plasticity":[93],"achieves":[94],"2-100":[95],"folds":[96],"speed":[98],"improvement":[99],"in":[100,127,178],"supervised,":[101],"reinforcement":[102],"unsupervised":[104],"settings,":[106],"boosting":[107],"memory":[108,146],"model":[110],"robustness":[111],"generalization":[113],"RNNs.":[115],"further":[117],"efficacy":[120],"biological":[122],"plausibility":[123],"modeling":[128],"multiregional":[129],"circuits,":[130],"including":[131],"prefrontal":[133],"cortex-mediodorsal":[134],"network":[136,143,153],"for":[137,144,154],"decision":[139],"making,":[140],"cortico-thalamic-cortical":[142],"working":[145],"attention,":[148],"an":[150],"entorhinal":[151],"cortex-hippocampus":[152],"visuospatial":[155],"navigation":[156],"sequence":[158],"replay.":[159],"Taken":[160],"together,":[161],"our":[162],"results":[163],"profound":[166],"insights":[167],"into":[168],"neuroscience-inspired":[169],"computation":[170,177],"enable":[172],"multi-plastic":[173],"attractor":[174],"dynamics":[175],"circuits.":[181]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
