{"id":"https://openalex.org/W4412376101","doi":"https://doi.org/10.1107/s1600576725004716","title":"Differentiating the solution structures and stability of transthyretin tetramer complexed with tolcapone and tafamidis using SEC-SWAXS and NMR","display_name":"Differentiating the solution structures and stability of transthyretin tetramer complexed with tolcapone and tafamidis using SEC-SWAXS and NMR","publication_year":2025,"publication_date":"2025-06-23","ids":{"openalex":"https://openalex.org/W4412376101","doi":"https://doi.org/10.1107/s1600576725004716","pmid":"https://pubmed.ncbi.nlm.nih.gov/40765976","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12321038"},"language":"en","primary_location":{"id":"doi:10.1107/s1600576725004716","doi":"https://doi.org/10.1107/s1600576725004716","is_oa":true,"landing_page_url":"https://doi.org/10.1107/s1600576725004716","pdf_url":"https://journals.iucr.org/j/issues/2025/04/00/vg5150/vg5150.pdf","source":{"id":"https://openalex.org/S79162954","display_name":"Journal of Applied Crystallography","issn_l":"0021-8898","issn":["0021-8898","1600-5767"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Crystallography","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4412376101"],"child_works_count":1,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://journals.iucr.org/j/issues/2025/04/00/vg5150/vg5150.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021963607","display_name":"Orion Shih","orcid":"https://orcid.org/0000-0002-0610-6856","observed_orcids":["https://orcid.org/0000-0002-0610-6856"]},"institutions":[{"id":"https://openalex.org/I4210094216","display_name":"National Synchrotron Radiation Research Center","ror":"https://ror.org/00k575643","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210094216","https://openalex.org/I4210128167"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Orion Shih","raw_affiliation_strings":["National Synchrotron Radiation Research Center Hsinchu300092 Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-0610-6856","affiliations":[{"raw_affiliation_string":"National Synchrotron Radiation Research Center Hsinchu300092 Taiwan","institution_ids":["https://openalex.org/I4210094216"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010347570","display_name":"Yu-Chen Feng","orcid":"https://orcid.org/0009-0004-0826-2686","observed_orcids":["https://orcid.org/0009-0004-0826-2686"]},"institutions":[{"id":"https://openalex.org/I134161618","display_name":"National Taiwan Normal University","ror":"https://ror.org/059dkdx38","country_code":"TW","type":"education","lineage":["https://openalex.org/I134161618"]},{"id":"https://openalex.org/I4210135784","display_name":"Institute of Atomic and Molecular Sciences, Academia Sinica","ror":"https://ror.org/03haqsp75","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210135784","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Chen Feng","raw_affiliation_strings":["Department of Chemistry National Taiwan Normal University Taipei11677 Taiwan","Institute of Atomic and Molecular Sciences Academia Sinica Taipei106319 Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry National Taiwan Normal University Taipei11677 Taiwan","institution_ids":["https://openalex.org/I134161618"]},{"raw_affiliation_string":"Institute of Atomic and Molecular Sciences Academia Sinica Taipei106319 Taiwan","institution_ids":["https://openalex.org/I4210135784"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038900481","display_name":"Sashank Agrawal","orcid":"https://orcid.org/0000-0001-8549-9602","observed_orcids":["https://orcid.org/0000-0001-8549-9602"]},"institutions":[{"id":"https://openalex.org/I4210135784","display_name":"Institute of Atomic and Molecular Sciences, Academia Sinica","ror":"https://ror.org/03haqsp75","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210135784","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Sashank Agrawal","raw_affiliation_strings":["Institute of Atomic and Molecular Sciences Academia Sinica Taipei106319 Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Atomic and Molecular Sciences Academia Sinica Taipei106319 Taiwan","institution_ids":["https://openalex.org/I4210135784"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070646075","display_name":"Kuei-Fen Liao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I134161618","display_name":"National Taiwan Normal University","ror":"https://ror.org/059dkdx38","country_code":"TW","type":"education","lineage":["https://openalex.org/I134161618"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kuei-Fen Liao","raw_affiliation_strings":["Department of Chemistry National Taiwan Normal University Taipei11677 Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry National Taiwan Normal University Taipei11677 Taiwan","institution_ids":["https://openalex.org/I134161618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045330527","display_name":"Yi\u2010Qi Yeh","orcid":"https://orcid.org/0000-0002-2387-3600","observed_orcids":["https://orcid.org/0000-0002-2387-3600"]},"institutions":[{"id":"https://openalex.org/I4210094216","display_name":"National Synchrotron Radiation Research Center","ror":"https://ror.org/00k575643","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210094216","https://openalex.org/I4210128167"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yi-Qi Yeh","raw_affiliation_strings":["National Synchrotron Radiation Research Center Hsinchu300092 Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-2387-3600","affiliations":[{"raw_affiliation_string":"National Synchrotron Radiation Research Center Hsinchu300092 Taiwan","institution_ids":["https://openalex.org/I4210094216"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Je-Wei Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094216","display_name":"National Synchrotron Radiation Research Center","ror":"https://ror.org/00k575643","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210094216","https://openalex.org/I4210128167"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Je-Wei Chang","raw_affiliation_strings":["National Synchrotron Radiation Research Center Hsinchu300092 Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Synchrotron Radiation Research Center Hsinchu300092 Taiwan","institution_ids":["https://openalex.org/I4210094216"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057468033","display_name":"Tsyr\u2010Yan Yu","orcid":"https://orcid.org/0000-0001-7051-4769","observed_orcids":["https://orcid.org/0000-0001-7051-4769"]},"institutions":[{"id":"https://openalex.org/I4210135784","display_name":"Institute of Atomic and Molecular Sciences, Academia Sinica","ror":"https://ror.org/03haqsp75","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210135784","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Tsyr-Yan Yu","raw_affiliation_strings":["Institute of Atomic and Molecular Sciences Academia Sinica Taipei106319 Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Atomic and Molecular Sciences Academia Sinica Taipei106319 Taiwan","institution_ids":["https://openalex.org/I4210135784"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003543477","display_name":"U\u2010Ser Jeng","orcid":"https://orcid.org/0000-0002-2247-5061","observed_orcids":["https://orcid.org/0000-0002-2247-5061"]},"institutions":[{"id":"https://openalex.org/I25846049","display_name":"National Tsing Hua University","ror":"https://ror.org/00zdnkx70","country_code":"TW","type":"education","lineage":["https://openalex.org/I25846049"]},{"id":"https://openalex.org/I4210094216","display_name":"National Synchrotron Radiation Research Center","ror":"https://ror.org/00k575643","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210094216","https://openalex.org/I4210128167"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"U-Ser Jeng","raw_affiliation_strings":["Department of Chemical Engineering and College of Semiconductor Research National Tsing Hua University Hsinchu300044 Taiwan","National Synchrotron Radiation Research Center Hsinchu300092 Taiwan"],"raw_orcid":"https://orcid.org/0000-0002-2247-5061","affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering and College of Semiconductor Research National Tsing Hua University Hsinchu300044 Taiwan","institution_ids":["https://openalex.org/I25846049"]},{"raw_affiliation_string":"National Synchrotron Radiation Research Center Hsinchu300092 Taiwan","institution_ids":["https://openalex.org/I4210094216"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5003543477","https://openalex.org/A5057468033"],"corresponding_institution_ids":["https://openalex.org/I25846049","https://openalex.org/I4210094216","https://openalex.org/I4210135784"],"apc_list":{"value":5110,"currency":"USD","value_usd":5110},"apc_paid":{"value":5110,"currency":"USD","value_usd":5110},"fwci":1.6199,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.80336658,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"58","issue":"4","first_page":"1373","last_page":"1383"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.9570000171661377,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.017400000244379044,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prealbumin","display_name":"prealbumin","score":0.9819999933242798},{"id":"https://openalex.org/keywords/tolcapone","display_name":"tolcapone","score":0.8920000195503235},{"id":"https://openalex.org/keywords/tafamidis","display_name":"tafamidis","score":1.0},{"id":"https://openalex.org/keywords/protein-drug-complexes","display_name":"protein-drug complexes","score":0.625},{"id":"https://openalex.org/keywords/radius-of-gyration","display_name":"radius of gyration","score":0.7630000114440918},{"id":"https://openalex.org/keywords/protein-denaturation","display_name":"protein denaturation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/urea-induced-unfolding","display_name":"urea-induced unfolding","score":0.640999972820282},{"id":"https://openalex.org/keywords/oligomerization","display_name":"oligomerization","score":0.7670000195503235},{"id":"https://openalex.org/keywords/protein-solution-structure","display_name":"protein solution structure","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C2778886173","wikidata":"https://www.wikidata.org/wiki/Q53832","display_name":"Tetramer","level":3,"score":0.9329136610031128},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7231091856956482},{"id":"https://openalex.org/C121157162","wikidata":"https://www.wikidata.org/wiki/Q419999","display_name":"Transthyretin","level":2,"score":0.6231498122215271},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.32810527086257935},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.17738446593284607},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15064913034439087},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07954210042953491},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1107/s1600576725004716","doi":"https://doi.org/10.1107/s1600576725004716","is_oa":true,"landing_page_url":"https://doi.org/10.1107/s1600576725004716","pdf_url":"https://journals.iucr.org/j/issues/2025/04/00/vg5150/vg5150.pdf","source":{"id":"https://openalex.org/S79162954","display_name":"Journal of Applied Crystallography","issn_l":"0021-8898","issn":["0021-8898","1600-5767"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Crystallography","raw_type":"journal-article"},{"id":"pmid:40765976","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40765976","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied crystallography","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12321038","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12321038/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Appl Crystallogr","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1107/s1600576725004716","doi":"https://doi.org/10.1107/s1600576725004716","is_oa":true,"landing_page_url":"https://doi.org/10.1107/s1600576725004716","pdf_url":"https://journals.iucr.org/j/issues/2025/04/00/vg5150/vg5150.pdf","source":{"id":"https://openalex.org/S79162954","display_name":"Journal of Applied Crystallography","issn_l":"0021-8898","issn":["0021-8898","1600-5767"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Crystallography","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1854414819","display_name":null,"funder_award_id":"111-2112-M213-014","funder_id":"https://openalex.org/F4320331164","funder_display_name":"National Science and Technology Council"},{"id":"https://openalex.org/G4719824547","display_name":null,"funder_award_id":"112DCA0100015","funder_id":"https://openalex.org/F4320321041","funder_display_name":"Academia Sinica"},{"id":"https://openalex.org/G7380309610","display_name":"Aggregation Behavior and Mechanism of the Type I Collagen in Solution Studied by X-Ray Scattering, Optical Spectroscopies, and Molecular Simulation","funder_award_id":"MOST111-2112-M213-014-MY3","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"}],"funders":[{"id":"https://openalex.org/F4320321041","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784"},{"id":"https://openalex.org/F4320322795","display_name":"Ministry of Science and Technology, Taiwan","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320331164","display_name":"National Science and Technology Council","ror":"https://ror.org/00wnb9798"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412376101.pdf","grobid_xml":"https://content.openalex.org/works/W4412376101.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1075695031","https://openalex.org/W1977038370","https://openalex.org/W1987870308","https://openalex.org/W2008351370","https://openalex.org/W2029694443","https://openalex.org/W2033650210","https://openalex.org/W2055218251","https://openalex.org/W2066088601","https://openalex.org/W2088769136","https://openalex.org/W2091506983","https://openalex.org/W2123454044","https://openalex.org/W2126991217","https://openalex.org/W2146134187","https://openalex.org/W2158907165","https://openalex.org/W2266690651","https://openalex.org/W2284643705","https://openalex.org/W2487638977","https://openalex.org/W2570141027","https://openalex.org/W2591961714","https://openalex.org/W2593931212","https://openalex.org/W2707646777","https://openalex.org/W2747992112","https://openalex.org/W2769378869","https://openalex.org/W2795163257","https://openalex.org/W2910869605","https://openalex.org/W2915131983","https://openalex.org/W2972379075","https://openalex.org/W2977501476","https://openalex.org/W3000178499","https://openalex.org/W3109413273","https://openalex.org/W3207472264","https://openalex.org/W4220715016","https://openalex.org/W4235939487","https://openalex.org/W4307584925","https://openalex.org/W4379508208","https://openalex.org/W4384944201","https://openalex.org/W4385248556","https://openalex.org/W4401443645","https://openalex.org/W4405383274","https://openalex.org/W4406010982","https://openalex.org/W4406706885","https://openalex.org/W4409472798"],"related_works":["https://openalex.org/W3044308886","https://openalex.org/W6987521866","https://openalex.org/W2284643705","https://openalex.org/W2019910913","https://openalex.org/W4406706885","https://openalex.org/W2158907165","https://openalex.org/W2342106571","https://openalex.org/W3085963987","https://openalex.org/W4402340886","https://openalex.org/W3087982963"],"abstract_inverted_index":{"Human":[0],"transthyretin":[1],"(TTR)":[2],"is":[3],"a":[4,38,49,117,171,196],"homotetrameric":[5],"protein":[6,14],"involved":[7],"in":[8,120],"transporting":[9],"thyroxine":[10],"(T4)":[11],"and":[12,17,52,72,92,97,146,161],"retinol-binding":[13],"within":[15],"serum":[16],"cerebrospinal":[18],"fluid.":[19],"The":[20],"disassociation":[21],"of":[22,31,90,113,123,176,223,235],"TTR's":[23],"tetrameric":[24,190],"structure":[25],"can":[26,105],"lead":[27],"to":[28,58,65,108,116,131,149,156,199,232],"the":[29,60,87,109,121,141,188,204,220,233],"formation":[30],"biologically":[32],"toxic":[33],"TTR":[34,50,67,93,142,189],"amyloid":[35],"fibrils.":[36],"Tolcapone,":[37],"small":[39,118],"molecule":[40],"currently":[41],"under":[42,170,226],"clinical":[43],"trial,":[44],"has":[45],"shown":[46],"potential":[47],"as":[48,55],"stabilizer":[51],"may":[53],"act":[54],"an":[56,211],"alternative":[57],"tafamidis,":[59],"conventional":[61],"therapeutic":[62,236],"agent":[63],"used":[64],"prevent":[66],"dissociation.":[68],"Using":[69],"size-exclusion-chromatography-based":[70],"small-":[71],"wide-angle":[73],"X-ray":[74],"scattering":[75],"(SEC-SWAXS)":[76],"complemented":[77],"by":[78,218],"nuclear":[79],"magnetic":[80],"resonance":[81],"(NMR)":[82],"spectroscopy,":[83],"this":[84,159],"study":[85],"reveals":[86],"solution":[88,221],"conformations":[89,222],"Apo-TTR":[91,154],"complexed":[94],"with":[95],"tolcapone":[96],"tafamidis.":[98],"Our":[99],"results":[100,209],"indicate":[101],"that":[102],"both":[103,137],"compounds":[104,138],"bind":[106],"similarly":[107],"two":[110],"T4":[111,182,206],"sites":[112],"TTR,":[114],"leading":[115],"increase":[119],"radius":[122],"gyration":[124],"from":[125],"24.3":[126],"\u00b1":[127,133],"0.1":[128,134],"\u00c5":[129],"(Apo-TTR)":[130],"25.8":[132],"\u00c5.":[135],"Consequently,":[136],"largely":[139],"stabilize":[140],"against":[143],"dissociation,":[144],"denaturation":[145],"oligomerization":[147],"up":[148],"8":[150,166,193],"M":[151,167,194],"urea,":[152,195],"whereas":[153],"starts":[155],"denature":[157],"at":[158,165,192],"concentration":[160],"forms":[162],"larger":[163],"oligomers":[164],"urea.":[168],"Additionally,":[169],"reduced":[172],"TTR\u2013drug":[173],"mixing":[174],"ratio":[175],"1:1,":[177],"which":[178],"targets":[179],"only":[180],"one":[181],"site,":[183],"tafamidis":[184],"more":[185],"effectively":[186],"stabilizes":[187],"conformation":[191],"difference":[197],"attributed":[198],"its":[200],"higher":[201],"affinity":[202],"for":[203,214],"first":[205],"site.":[207],"These":[208],"illustrate":[210],"effective":[212],"strategy":[213],"investigating":[215],"protein\u2013drug":[216,224],"interactions":[217],"examining":[219],"complexes":[225],"physiological":[227],"conditions,":[228],"providing":[229],"structural":[230],"hints":[231],"design":[234],"agents":[237],"targeting":[238],"TTR.":[239]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2025-10-10T00:00:00"}
