{"id":"https://openalex.org/W4412374918","doi":"https://doi.org/10.1038/s41598-025-10143-6","title":"TGF\u03b21 accelerated the progression of diabetic nephropathy via up-regulating BRD4/Notch1/YAP signaling induced fibrosis and proliferation in fibroblasts","display_name":"TGF\u03b21 accelerated the progression of diabetic nephropathy via up-regulating BRD4/Notch1/YAP signaling induced fibrosis and proliferation in fibroblasts","publication_year":2025,"publication_date":"2025-07-13","ids":{"openalex":"https://openalex.org/W4412374918","doi":"https://doi.org/10.1038/s41598-025-10143-6","pmid":"https://pubmed.ncbi.nlm.nih.gov/40653516"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-025-10143-6","doi":"https://doi.org/10.1038/s41598-025-10143-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-025-10143-6","pdf_url":"https://www.nature.com/articles/s41598-025-10143-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-025-10143-6.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100412891","display_name":"Lin Li","orcid":"https://orcid.org/0000-0002-5958-0666","observed_orcids":["https://orcid.org/0000-0002-5958-0666"]},"institutions":[{"id":"https://openalex.org/I4210140680","display_name":"Affiliated Hospital of Hebei University","ror":"https://ror.org/049vsq398","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140680"]},{"id":"https://openalex.org/I43337087","display_name":"Hebei University","ror":"https://ror.org/01p884a79","country_code":"CN","type":"education","lineage":["https://openalex.org/I43337087"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Li","raw_affiliation_strings":["Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province, Affiliated Hospital of Hebei University, No. 212 Yuhua East Road, Baoding, 071000, Hebei, China","Nephrology Department, Affiliated Hospital of Hebei University, No. 212 Yuhua East Road, Baoding, 071000, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province, Affiliated Hospital of Hebei University, No. 212 Yuhua East Road, Baoding, 071000, Hebei, China","institution_ids":["https://openalex.org/I4210140680","https://openalex.org/I43337087"]},{"raw_affiliation_string":"Nephrology Department, Affiliated Hospital of Hebei University, No. 212 Yuhua East Road, Baoding, 071000, Hebei, China","institution_ids":["https://openalex.org/I4210140680"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100406732","display_name":"Limin Zhang","orcid":"https://orcid.org/0000-0001-5689-948X","observed_orcids":["https://orcid.org/0000-0001-5689-948X","https://orcid.org/0009-0000-7360-8162"]},"institutions":[{"id":"https://openalex.org/I4210140680","display_name":"Affiliated Hospital of Hebei University","ror":"https://ror.org/049vsq398","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140680"]},{"id":"https://openalex.org/I43337087","display_name":"Hebei University","ror":"https://ror.org/01p884a79","country_code":"CN","type":"education","lineage":["https://openalex.org/I43337087"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Limin Zhang","raw_affiliation_strings":["Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province, Affiliated Hospital of Hebei University, No. 212 Yuhua East Road, Baoding, 071000, Hebei, China","Nephrology Department, Affiliated Hospital of Hebei University, No. 212 Yuhua East Road, Baoding, 071000, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province, Affiliated Hospital of Hebei University, No. 212 Yuhua East Road, Baoding, 071000, Hebei, China","institution_ids":["https://openalex.org/I4210140680","https://openalex.org/I43337087"]},{"raw_affiliation_string":"Nephrology Department, Affiliated Hospital of Hebei University, No. 212 Yuhua East Road, Baoding, 071000, Hebei, China","institution_ids":["https://openalex.org/I4210140680"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhe Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140680","display_name":"Affiliated Hospital of Hebei University","ror":"https://ror.org/049vsq398","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140680"]},{"id":"https://openalex.org/I43337087","display_name":"Hebei University","ror":"https://ror.org/01p884a79","country_code":"CN","type":"education","lineage":["https://openalex.org/I43337087"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhe Li","raw_affiliation_strings":["Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province, Affiliated Hospital of Hebei University, No. 212 Yuhua East Road, Baoding, 071000, Hebei, China","Nephrology Department, Affiliated Hospital of Hebei University, No. 212 Yuhua East Road, Baoding, 071000, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province, Affiliated Hospital of Hebei University, No. 212 Yuhua East Road, Baoding, 071000, Hebei, China","institution_ids":["https://openalex.org/I4210140680","https://openalex.org/I43337087"]},{"raw_affiliation_string":"Nephrology Department, Affiliated Hospital of Hebei University, No. 212 Yuhua East Road, Baoding, 071000, Hebei, China","institution_ids":["https://openalex.org/I4210140680"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100390999","display_name":"Qian Wang","orcid":"https://orcid.org/0000-0001-6823-7897","observed_orcids":["https://orcid.org/0000-0001-6823-7897"]},"institutions":[{"id":"https://openalex.org/I4210140680","display_name":"Affiliated Hospital of Hebei University","ror":"https://ror.org/049vsq398","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140680"]},{"id":"https://openalex.org/I43337087","display_name":"Hebei University","ror":"https://ror.org/01p884a79","country_code":"CN","type":"education","lineage":["https://openalex.org/I43337087"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Wang","raw_affiliation_strings":["Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province, Affiliated Hospital of Hebei University, No. 212 Yuhua East Road, Baoding, 071000, Hebei, China","Nephrology Department, Affiliated Hospital of Hebei University, No. 212 Yuhua East Road, Baoding, 071000, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province, Affiliated Hospital of Hebei University, No. 212 Yuhua East Road, Baoding, 071000, Hebei, China","institution_ids":["https://openalex.org/I4210140680","https://openalex.org/I43337087"]},{"raw_affiliation_string":"Nephrology Department, Affiliated Hospital of Hebei University, No. 212 Yuhua East Road, Baoding, 071000, Hebei, China","institution_ids":["https://openalex.org/I4210140680"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100401687","display_name":"Qian Zhang","orcid":"https://orcid.org/0000-0002-9187-4277","observed_orcids":["https://orcid.org/0000-0002-9187-4277"]},"institutions":[{"id":"https://openalex.org/I4210140680","display_name":"Affiliated Hospital of Hebei University","ror":"https://ror.org/049vsq398","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140680"]},{"id":"https://openalex.org/I43337087","display_name":"Hebei University","ror":"https://ror.org/01p884a79","country_code":"CN","type":"education","lineage":["https://openalex.org/I43337087"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Zhang","raw_affiliation_strings":["Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province, Affiliated Hospital of Hebei University, No. 212 Yuhua East Road, Baoding, 071000, Hebei, China","Nephrology Department, Affiliated Hospital of Hebei University, No. 212 Yuhua East Road, Baoding, 071000, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province, Affiliated Hospital of Hebei University, No. 212 Yuhua East Road, Baoding, 071000, Hebei, China","institution_ids":["https://openalex.org/I4210140680","https://openalex.org/I43337087"]},{"raw_affiliation_string":"Nephrology Department, Affiliated Hospital of Hebei University, No. 212 Yuhua East Road, Baoding, 071000, Hebei, China","institution_ids":["https://openalex.org/I4210140680"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Song Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140680","display_name":"Affiliated Hospital of Hebei University","ror":"https://ror.org/049vsq398","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140680"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Song Li","raw_affiliation_strings":["Department of Urology, Affiliated Hospital of Hebei University, No. 212 Yuhua East Road, Baoding, 071000, Hebei, China. 15830201177@sina.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Affiliated Hospital of Hebei University, No. 212 Yuhua East Road, Baoding, 071000, Hebei, China. 15830201177@sina.com","institution_ids":["https://openalex.org/I4210140680"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001620035","display_name":"Juan Ji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140680","display_name":"Affiliated Hospital of Hebei University","ror":"https://ror.org/049vsq398","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210140680"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Juan Ji","raw_affiliation_strings":["Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province, Affiliated Hospital of Hebei University, No. 212 Yuhua East Road, Baoding, 071000, Hebei, China. 15830201177@163.com","Nephrology Department, Affiliated Hospital of Hebei University, No. 212 Yuhua East Road, Baoding, 071000, Hebei, China. 15830201177@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province, Affiliated Hospital of Hebei University, No. 212 Yuhua East Road, Baoding, 071000, Hebei, China. 15830201177@163.com","institution_ids":["https://openalex.org/I4210140680"]},{"raw_affiliation_string":"Nephrology Department, Affiliated Hospital of Hebei University, No. 212 Yuhua East Road, Baoding, 071000, Hebei, China. 15830201177@163.com","institution_ids":["https://openalex.org/I4210140680"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001620035"],"corresponding_institution_ids":["https://openalex.org/I4210140680"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":1.2162,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.79305884,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"15","issue":"1","first_page":"25338","last_page":"25338"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.9829999804496765},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9769999980926514},{"id":"https://openalex.org/keywords/brd4","display_name":"BRD4","score":0.9210000038146973},{"id":"https://openalex.org/keywords/notch1","display_name":"Notch1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.9399999976158142},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9390000104904175},{"id":"https://openalex.org/keywords/high-fat-diet-streptozotocin-model","display_name":"high-fat diet streptozotocin model","score":0.765999972820282},{"id":"https://openalex.org/keywords/renal-tubular-cell-apoptosis","display_name":"renal tubular cell apoptosis","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.7557690143585205},{"id":"https://openalex.org/C2779922275","wikidata":"https://www.wikidata.org/wiki/Q1129105","display_name":"Diabetic nephropathy","level":3,"score":0.6682291626930237},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.643866777420044},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.6306222677230835},{"id":"https://openalex.org/C2777420927","wikidata":"https://www.wikidata.org/wiki/Q5038318","display_name":"Cardiac fibrosis","level":3,"score":0.6069057583808899},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5469532012939453},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47999757528305054},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.4688400328159332},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4297357499599457},{"id":"https://openalex.org/C2778229498","wikidata":"https://www.wikidata.org/wiki/Q24785672","display_name":"Transforming growth factor beta","level":3,"score":0.42835551500320435},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3348051905632019},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31579533219337463},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26794975996017456},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2542821168899536}],"mesh":[{"descriptor_ui":"D000091102","descriptor_name":"YAP-Signaling Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000091102","descriptor_name":"YAP-Signaling Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000091102","descriptor_name":"YAP-Signaling Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000091102","descriptor_name":"YAP-Signaling Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003928","descriptor_name":"Diabetic Nephropathies","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051881","descriptor_name":"Receptor, Notch1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051881","descriptor_name":"Receptor, Notch1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051881","descriptor_name":"Receptor, Notch1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051881","descriptor_name":"Receptor, Notch1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051881","descriptor_name":"Receptor, Notch1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051881","descriptor_name":"Receptor, Notch1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051881","descriptor_name":"Receptor, Notch1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051881","descriptor_name":"Receptor, Notch1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-025-10143-6","doi":"https://doi.org/10.1038/s41598-025-10143-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-025-10143-6","pdf_url":"https://www.nature.com/articles/s41598-025-10143-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:40653516","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40653516","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11062051","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12256632","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:12256632","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12256632","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:1e398469ba964b7294750653ba9af375","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1e398469ba964b7294750653ba9af375","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 15, Iss 1, Pp 1-13 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-025-10143-6","doi":"https://doi.org/10.1038/s41598-025-10143-6","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-025-10143-6","pdf_url":"https://www.nature.com/articles/s41598-025-10143-6.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.4399999976158142}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412374918.pdf","grobid_xml":"https://content.openalex.org/works/W4412374918.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W2105478161","https://openalex.org/W2256103742","https://openalex.org/W2770331207","https://openalex.org/W2881438881","https://openalex.org/W2900679912","https://openalex.org/W2967233606","https://openalex.org/W2983335475","https://openalex.org/W3016976461","https://openalex.org/W3030510106","https://openalex.org/W3034168062","https://openalex.org/W3048419072","https://openalex.org/W3083268343","https://openalex.org/W3087315461","https://openalex.org/W3127843453","https://openalex.org/W3129183670","https://openalex.org/W3162961592","https://openalex.org/W3176922160","https://openalex.org/W3202929439","https://openalex.org/W3207692850","https://openalex.org/W4210824172","https://openalex.org/W4221041782","https://openalex.org/W4282937719","https://openalex.org/W4283756029","https://openalex.org/W4295222671","https://openalex.org/W4310954200","https://openalex.org/W4318982560","https://openalex.org/W4323036808","https://openalex.org/W4323066924","https://openalex.org/W4376605060","https://openalex.org/W4384299922","https://openalex.org/W4385680719","https://openalex.org/W4386160916","https://openalex.org/W4390542937","https://openalex.org/W4391032147","https://openalex.org/W4404436536"],"related_works":["https://openalex.org/W1974938188","https://openalex.org/W3117797797","https://openalex.org/W2020479094","https://openalex.org/W2068883101","https://openalex.org/W2355360993","https://openalex.org/W2308616550","https://openalex.org/W2155558762","https://openalex.org/W2331390067","https://openalex.org/W2366835330","https://openalex.org/W2329414425"],"abstract_inverted_index":{"Mounting":[0],"evidence":[1],"implicates":[2],"transforming":[3],"growth":[4],"factor-\u03b21":[5],"(TGF-\u03b21)-mediated":[6],"renal":[7,38,126,140,177,186],"tubular":[8],"cell":[9,56,65],"apoptosis":[10],"in":[11,31,69,107,139,144,161,189],"the":[12,22,26,55,68,123,136,143,155,160,185,198,210,213],"pathogenesis":[13],"of":[14,29,125,200,212],"diabetic":[15,32,168,190,201],"nephropathy.":[16],"This":[17],"investigation":[18],"sought":[19],"to":[20,53,63,121,134],"elucidate":[21],"molecular":[23],"mechanisms":[24],"governing":[25],"pathogenic":[27],"role":[28],"TGF-\u03b21":[30],"nephropathy":[33,169,191,202],"progression.":[34],"In":[35,67,142,159],"vitro,":[36],"human":[37],"fibroblasts":[39],"purchased":[40],"were":[41,76],"divided":[42,78],"into":[43,79],"six":[44],"groups":[45],"after":[46],"different":[47],"stimuli.":[48],"Western":[49,130],"blot":[50,131],"was":[51,61,98,119,132,165,182,193],"used":[52,62,120,133],"observe":[54,64,122,135],"protein":[57,137],"expression,":[58],"and":[59,88,95,129,150,206],"CCK-8":[60],"proliferation.":[66],"vivo":[70,162],"experiment,":[71,146,163],"32":[72],"SD":[73],"male":[74],"rats":[75,170,192],"randomly":[77],"Control":[80],"group,":[81,83,87,94],"Model":[82,84,89,96],"+":[85,90,92],"TGF\u03b21":[86,91,147,173,196],"Notch1-KD":[93],"group":[97],"experimentally":[99],"induced":[100,148],"by":[101,153,203],"a":[102],"high-fat":[103],"diet":[104],"(HFD)/streptozocin(STZ)":[105],"regimen":[106],"type":[108],"2":[109],"diabetes":[110],"mellitus":[111],"(":[112],"T2DM":[113],")":[114],"mouse":[115],"model.":[116],"HE":[117],"staining":[118],"degree":[124],"tissue":[127,178,187],"fibrosis,":[128],"expression":[138],"tissues.":[141],"vitro":[145],"fibrosis":[149,188,205],"fibroblast":[151,207],"proliferation":[152,208],"regulating":[154],"BRD4/Notch1/YAP":[156,214],"signaling":[157,215],"pathway.":[158,216],"it":[164],"found":[166],"that":[167],"treated":[171],"with":[172],"showed":[174],"significantly":[175,194],"increased":[176],"fibrosis;":[179],"when":[180],"Notch1":[181],"knocked":[183],"down,":[184],"reduced.":[195],"accelerates":[197],"progression":[199],"inducing":[204],"through":[209],"regulation":[211]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
