{"id":"https://openalex.org/W4412374130","doi":"https://doi.org/10.1111/febs.70191","title":"Overcoming BET \u2010inhibitor JQ1 resistance in aggressive non\u2010small cell lung cancer by inducing ferroptosis via inhibition of the BRD2 \u2013 FTH1 axis","display_name":"Overcoming BET \u2010inhibitor JQ1 resistance in aggressive non\u2010small cell lung cancer by inducing ferroptosis via inhibition of the BRD2 \u2013 FTH1 axis","publication_year":2025,"publication_date":"2025-07-13","ids":{"openalex":"https://openalex.org/W4412374130","doi":"https://doi.org/10.1111/febs.70191","pmid":"https://pubmed.ncbi.nlm.nih.gov/40652527"},"language":"en","primary_location":{"id":"doi:10.1111/febs.70191","doi":"https://doi.org/10.1111/febs.70191","is_oa":true,"landing_page_url":"https://doi.org/10.1111/febs.70191","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/febs.70191","source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/febs.70191","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000228198","display_name":"Stefania Scicchitano","orcid":"https://orcid.org/0000-0002-3566-7214","observed_orcids":["https://orcid.org/0000-0002-3566-7214"]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefania Scicchitano","raw_affiliation_strings":["Department of Experimental and Clinical Medicine Magna Graecia University of Catanzaro  Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine Magna Graecia University of Catanzaro  Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022893813","display_name":"Cinzia Garofalo","orcid":"https://orcid.org/0000-0003-0317-7840","observed_orcids":["https://orcid.org/0000-0003-0317-7840"]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cinzia Garofalo","raw_affiliation_strings":["Department of Experimental and Clinical Medicine Magna Graecia University of Catanzaro  Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine Magna Graecia University of Catanzaro  Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Beatrice Stella","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Beatrice Stella","raw_affiliation_strings":["Department of Experimental and Clinical Medicine Magna Graecia University of Catanzaro  Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine Magna Graecia University of Catanzaro  Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030552101","display_name":"Gianluca Santamaria","orcid":"https://orcid.org/0000-0001-9284-7492","observed_orcids":["https://orcid.org/0000-0001-9284-7492"]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gianluca Santamaria","raw_affiliation_strings":["Department of Experimental and Clinical Medicine Magna Graecia University of Catanzaro  Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine Magna Graecia University of Catanzaro  Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082317631","display_name":"Flora Cozzolino","orcid":"https://orcid.org/0000-0002-4648-8107","observed_orcids":["https://orcid.org/0000-0002-4648-8107"]},"institutions":[{"id":"https://openalex.org/I4210128854","display_name":"CEINGE Biotecnologie Avanzate Franco Salvatore (Italy)","ror":"https://ror.org/033pa2k60","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210128854"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Flora Cozzolino","raw_affiliation_strings":["Department of Chemical Sciences Federico II University of Naples and CEINGE Advanced Biotechnologies Franco Salvatore  Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Sciences Federico II University of Naples and CEINGE Advanced Biotechnologies Franco Salvatore  Italy","institution_ids":["https://openalex.org/I4210128854","https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043926201","display_name":"Vittoria Monaco","orcid":"https://orcid.org/0000-0002-7459-8733","observed_orcids":["https://orcid.org/0000-0002-7459-8733"]},"institutions":[{"id":"https://openalex.org/I4210128854","display_name":"CEINGE Biotecnologie Avanzate Franco Salvatore (Italy)","ror":"https://ror.org/033pa2k60","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210128854"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vittoria Monaco","raw_affiliation_strings":["Department of Chemical Sciences Federico II University of Naples and CEINGE Advanced Biotechnologies Franco Salvatore  Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Sciences Federico II University of Naples and CEINGE Advanced Biotechnologies Franco Salvatore  Italy","institution_ids":["https://openalex.org/I4210128854","https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020289893","display_name":"Flavia Biamonte","orcid":"https://orcid.org/0000-0003-3248-3863","observed_orcids":["https://orcid.org/0000-0003-3248-3863"]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Flavia Biamonte","raw_affiliation_strings":["Department of Experimental and Clinical Medicine Magna Graecia University of Catanzaro  Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine Magna Graecia University of Catanzaro  Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089383490","display_name":"Maria Monti","orcid":"https://orcid.org/0000-0002-7775-7154","observed_orcids":["https://orcid.org/0000-0002-7775-7154"]},"institutions":[{"id":"https://openalex.org/I4210128854","display_name":"CEINGE Biotecnologie Avanzate Franco Salvatore (Italy)","ror":"https://ror.org/033pa2k60","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210128854"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Monti","raw_affiliation_strings":["Department of Chemical Sciences Federico II University of Naples and CEINGE Advanced Biotechnologies Franco Salvatore  Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Sciences Federico II University of Naples and CEINGE Advanced Biotechnologies Franco Salvatore  Italy","institution_ids":["https://openalex.org/I4210128854","https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036489838","display_name":"Eleonora Vecchio","orcid":"https://orcid.org/0000-0001-8422-2679","observed_orcids":["https://orcid.org/0000-0001-8422-2679"]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Eleonora Vecchio","raw_affiliation_strings":["Department of Experimental and Clinical Medicine Magna Graecia University of Catanzaro  Italy"],"raw_orcid":"https://orcid.org/0000-0001-8422-2679","affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine Magna Graecia University of Catanzaro  Italy","institution_ids":["https://openalex.org/I36443711"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034855794","display_name":"Maria Concetta Faniello","orcid":"https://orcid.org/0000-0001-6938-2754","observed_orcids":["https://orcid.org/0000-0001-6938-2754"]},"institutions":[{"id":"https://openalex.org/I36443711","display_name":"Magna Graecia University","ror":"https://ror.org/0530bdk91","country_code":"IT","type":"education","lineage":["https://openalex.org/I36443711"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Maria Concetta Faniello","raw_affiliation_strings":["Department of Experimental and Clinical Medicine Magna Graecia University of Catanzaro  Italy"],"raw_orcid":"https://orcid.org/0000-0001-6938-2754","affiliations":[{"raw_affiliation_string":"Department of Experimental and Clinical Medicine Magna Graecia University of Catanzaro  Italy","institution_ids":["https://openalex.org/I36443711"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5034855794","https://openalex.org/A5036489838"],"corresponding_institution_ids":["https://openalex.org/I36443711"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":{"value":5000,"currency":"USD","value_usd":5000},"fwci":1.5224,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.82079305,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"292","issue":"23","first_page":"6345","last_page":"6364"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.8485999703407288,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.8485999703407288,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.13760000467300415,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bet-inhibitors","display_name":"BET inhibitors","score":0.5680000185966492},{"id":"https://openalex.org/keywords/jq1","display_name":"JQ1","score":0.8389999866485596},{"id":"https://openalex.org/keywords/brd2","display_name":"BRD2","score":0.8840000033378601},{"id":"https://openalex.org/keywords/fth1","display_name":"FTH1","score":0.949999988079071},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9549999833106995},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.8240000009536743},{"id":"https://openalex.org/keywords/gpx4","display_name":"GPX4","score":0.8980000019073486},{"id":"https://openalex.org/keywords/slc7a11","display_name":"SLC7A11","score":0.9860000014305115},{"id":"https://openalex.org/keywords/slc3a2","display_name":"SLC3A2","score":0.9940000176429749},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6470000147819519},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C74401373","wikidata":"https://www.wikidata.org/wiki/Q1829843","display_name":"Bromodomain","level":4,"score":0.7668631076812744},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.5430731773376465},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4906531870365143},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4858855605125427},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2978106737136841},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.26299044489860535},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17774349451065063},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08686837553977966}],"mesh":[{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000079403","descriptor_name":"Ferroptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000092468","descriptor_name":"Bromodomain Containing Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000092468","descriptor_name":"Bromodomain Containing Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000092468","descriptor_name":"Bromodomain Containing Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001381","descriptor_name":"Azepines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001381","descriptor_name":"Azepines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001381","descriptor_name":"Azepines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005293","descriptor_name":"Ferritins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005293","descriptor_name":"Ferritins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005293","descriptor_name":"Ferritins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/febs.70191","doi":"https://doi.org/10.1111/febs.70191","is_oa":true,"landing_page_url":"https://doi.org/10.1111/febs.70191","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/febs.70191","source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},{"id":"pmid:40652527","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40652527","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12699187","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12699187/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"FEBS J","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1111/febs.70191","doi":"https://doi.org/10.1111/febs.70191","is_oa":true,"landing_page_url":"https://doi.org/10.1111/febs.70191","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/febs.70191","source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8700000047683716,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412374130.pdf","grobid_xml":"https://content.openalex.org/works/W4412374130.grobid-xml"},"referenced_works_count":103,"referenced_works":["https://openalex.org/W39436661","https://openalex.org/W1961554656","https://openalex.org/W1966248579","https://openalex.org/W1970527559","https://openalex.org/W1975603630","https://openalex.org/W1982308118","https://openalex.org/W1987119816","https://openalex.org/W1988930647","https://openalex.org/W1997183854","https://openalex.org/W1997753515","https://openalex.org/W2006325248","https://openalex.org/W2009949436","https://openalex.org/W2016326408","https://openalex.org/W2016988770","https://openalex.org/W2020536005","https://openalex.org/W2023241927","https://openalex.org/W2038840747","https://openalex.org/W2040932281","https://openalex.org/W2041535798","https://openalex.org/W2045925217","https://openalex.org/W2051161713","https://openalex.org/W2051504691","https://openalex.org/W2052787205","https://openalex.org/W2057460011","https://openalex.org/W2062220603","https://openalex.org/W2067851902","https://openalex.org/W2073119030","https://openalex.org/W2084049152","https://openalex.org/W2087670043","https://openalex.org/W2088055025","https://openalex.org/W2091618472","https://openalex.org/W2094834269","https://openalex.org/W2109378990","https://openalex.org/W2113399114","https://openalex.org/W2117559539","https://openalex.org/W2118428599","https://openalex.org/W2119605126","https://openalex.org/W2120572492","https://openalex.org/W2129129812","https://openalex.org/W2134964552","https://openalex.org/W2138428661","https://openalex.org/W2145411470","https://openalex.org/W2148746663","https://openalex.org/W2150469988","https://openalex.org/W2164805147","https://openalex.org/W2183670742","https://openalex.org/W2205700110","https://openalex.org/W2222339288","https://openalex.org/W2226721679","https://openalex.org/W2234023838","https://openalex.org/W2237475663","https://openalex.org/W2265062179","https://openalex.org/W2293393098","https://openalex.org/W2329674354","https://openalex.org/W2345014259","https://openalex.org/W2511100615","https://openalex.org/W2513196336","https://openalex.org/W2518233756","https://openalex.org/W2604817993","https://openalex.org/W2743505659","https://openalex.org/W2767769619","https://openalex.org/W2771430225","https://openalex.org/W2779743226","https://openalex.org/W2787134758","https://openalex.org/W2790987002","https://openalex.org/W2794303722","https://openalex.org/W2799731732","https://openalex.org/W2805978167","https://openalex.org/W2915478882","https://openalex.org/W2916290398","https://openalex.org/W2939427895","https://openalex.org/W2939496493","https://openalex.org/W2969290849","https://openalex.org/W2972260742","https://openalex.org/W2999078431","https://openalex.org/W3000918873","https://openalex.org/W3003254681","https://openalex.org/W3045896836","https://openalex.org/W3123922203","https://openalex.org/W3124897936","https://openalex.org/W3135213615","https://openalex.org/W3136300158","https://openalex.org/W3156823137","https://openalex.org/W3199502312","https://openalex.org/W3209636004","https://openalex.org/W4200502803","https://openalex.org/W4213309506","https://openalex.org/W4220843620","https://openalex.org/W4223436519","https://openalex.org/W4296467035","https://openalex.org/W4307358434","https://openalex.org/W4313583836","https://openalex.org/W4377015501","https://openalex.org/W4378714142","https://openalex.org/W4387230878","https://openalex.org/W4388657570","https://openalex.org/W4391480941","https://openalex.org/W4392897031","https://openalex.org/W4393900204","https://openalex.org/W4396863974","https://openalex.org/W4398223119","https://openalex.org/W4401052507","https://openalex.org/W4402243335"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2899084033","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W4391375266","https://openalex.org/W2078814861","https://openalex.org/W2439473447","https://openalex.org/W2527526854"],"abstract_inverted_index":{"Recent":[0],"studies":[1],"emphasize":[2],"the":[3,6,42,58,77,118,151,156,176,189,224,229,233,241,259,266],"involvement":[4],"of":[5,44,61,80,99,113,121,158,179,191,235,261],"nuclear":[7,81],"H":[8],"ferritin":[9,15],"subunit":[10],"(FTH1;":[11],"also":[12],"known":[13],"as":[14,34,252],"heavy":[16],"chain)":[17],"in":[18,49,96,109,125,141,148,175,185,269],"DNA":[19],"protection":[20],"from":[21],"oxidative":[22],"damage":[23],"and":[24,28,103,205],"transcriptional":[25,38],"regulation.":[26,39],"Bromodomain":[27],"extra-terminal":[29],"domain":[30],"(BET)":[31],"proteins":[32],"act":[33],"epigenome":[35],"readers":[36],"for":[37,240],"Among":[40],"them,":[41],"role":[43],"bromodomain-containing":[45,92],"protein":[46,93,106],"2":[47,211],"(BRD2)":[48],"non-small":[50],"cell":[51,101,164],"lung":[52],"carcinoma":[53],"(NSCLC)":[54],"remains":[55],"unclear.":[56],"Moreover,":[57,188],"clinical":[59],"utilization":[60],"BET":[62,133],"bromodomain":[63,134],"inhibition":[64,226],"is":[65,87,173],"severely":[66],"limited":[67],"by":[68,154],"different":[69],"sensitivities":[70],"among":[71],"NSCLC":[72,100,114],"subtypes.":[73],"This":[74],"study":[75],"provides":[76],"first":[78,242],"evidence":[79],"BRD2-FTH1":[82],"functional":[83],"interplay.":[84],"Nuclear":[85],"FTH1":[86,122,161,182,220,248],"associated":[88],"with":[89,160],"BRD2,":[90],"not":[91,140],"4":[94,196],"(BRD4),":[95],"a":[97],"panel":[98],"lines":[102],"affects":[104],"BRD2":[105,225],"stability":[107],"only":[108,184,218],"more":[110,270],"aggressive":[111,271],"types":[112],"cells.":[115,187],"In":[116,238],"addition,":[117],"protective":[119],"function":[120],"was":[123,166,213],"abrogated":[124],"FTH1-silenced":[126],"cells":[127],"that":[128,171,223,247],"are":[129],"resistant":[130],"to":[131,145,228,257,264],"synthetic":[132],"inhibitor":[135],"JQ1":[136,159,180,216],"(a":[137],"thieno-triazolo-1,4-diazepine)":[138],"but":[139],"JQ1-sensitive":[142],"cells,":[143],"leading":[144],"an":[146,253],"increase":[147],"mortality.":[149],"Then,":[150],"potential":[152],"mechanism":[153],"which":[155],"combination":[157],"silencing":[162,183,249],"induces":[163],"death":[165],"explored.":[167],"The":[168],"results":[169],"show":[170],"ferroptosis":[172],"involved":[174],"anticancer":[177],"effect":[178],"upon":[181],"JQ1-insensitive":[186],"expression":[190,234],"ferroptosis-associated":[192,236],"genes":[193],"glutathione":[194],"peroxidase":[195],"(GPX4),":[197],"solute":[198,206],"carrier":[199,207],"family":[200,208],"7":[201],"member":[202,210],"11":[203],"(SLC7A11)":[204],"3":[209],"(SLC3A2)":[212],"downregulated":[214],"under":[215],"treatment":[217],"after":[219],"silencing,":[221],"indicating":[222],"due":[227],"co-treatment":[230],"could":[231],"regulate":[232],"genes.":[237],"summary,":[239],"time,":[243],"our":[244],"data":[245],"suggest":[246],"may":[250],"serve":[251],"effective":[254],"anti-tumor":[255],"strategy":[256],"enhance":[258],"activity":[260],"JQ1,":[262],"acting":[263],"overcome":[265],"chemotherapy":[267],"resistance":[268],"NSCLCs.":[272]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-07-13T00:00:00"}
