{"id":"https://openalex.org/W4412372489","doi":"https://doi.org/10.1021/acs.jproteome.5c00285","title":"Data-Independent Acquisition Analysis to Identify Serum Biomarkers and Neoantigens for Differentiating Colorectal Cancer from Inflammatory Bowel Diseases","display_name":"Data-Independent Acquisition Analysis to Identify Serum Biomarkers and Neoantigens for Differentiating Colorectal Cancer from Inflammatory Bowel Diseases","publication_year":2025,"publication_date":"2025-07-13","ids":{"openalex":"https://openalex.org/W4412372489","doi":"https://doi.org/10.1021/acs.jproteome.5c00285","pmid":"https://pubmed.ncbi.nlm.nih.gov/40652393"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jproteome.5c00285","doi":"https://doi.org/10.1021/acs.jproteome.5c00285","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jproteome.5c00285","pdf_url":null,"source":{"id":"https://openalex.org/S74367812","display_name":"Journal of Proteome Research","issn_l":"1535-3893","issn":["1535-3893","1535-3907"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Proteome Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006059250","display_name":"Akhila Balakrishna Rai","orcid":"https://orcid.org/0000-0001-8064-1120","observed_orcids":["https://orcid.org/0000-0001-8064-1120"]},"institutions":[{"id":"https://openalex.org/I158688498","display_name":"Yenepoya University","ror":"https://ror.org/029zfa075","country_code":"IN","type":"education","lineage":["https://openalex.org/I158688498"]},{"id":"https://openalex.org/I4405268903","display_name":"Yenepoya Research Centre","ror":"https://ror.org/02ekn8f64","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4405268903"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Akhila Balakrishna Rai","raw_affiliation_strings":["Center for Systems Biology and Molecular Medicine [An ICMR-Collaborating Centre of Excellence 2024 (ICMR-CCoE 2024)], Yenepoya Research Centre","Yenepoya (Deemed to be University)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Systems Biology and Molecular Medicine [An ICMR-Collaborating Centre of Excellence 2024 (ICMR-CCoE 2024)], Yenepoya Research Centre","institution_ids":["https://openalex.org/I4405268903"]},{"raw_affiliation_string":"Yenepoya (Deemed to be University)","institution_ids":["https://openalex.org/I158688498"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085191691","display_name":"Jalaluddin Akbar Kandel Codi","orcid":"https://orcid.org/0000-0002-2490-3488","observed_orcids":["https://orcid.org/0000-0002-2490-3488"]},"institutions":[{"id":"https://openalex.org/I158688498","display_name":"Yenepoya University","ror":"https://ror.org/029zfa075","country_code":"IN","type":"education","lineage":["https://openalex.org/I158688498"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Jalaluddin Akbar Kandel Codi","raw_affiliation_strings":["Department of Surgical Oncology, Yenepoya Medical College and Hospital, Yenepoya (Deemed to be University), University Road, Deralakatte, Mangalore 575018, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Oncology, Yenepoya Medical College and Hospital, Yenepoya (Deemed to be University), University Road, Deralakatte, Mangalore 575018, India","institution_ids":["https://openalex.org/I158688498"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005367167","display_name":"Chinmaya Narayana Kotimoole","orcid":"https://orcid.org/0000-0002-8454-2450","observed_orcids":["https://orcid.org/0000-0002-8454-2450"]},"institutions":[{"id":"https://openalex.org/I158688498","display_name":"Yenepoya University","ror":"https://ror.org/029zfa075","country_code":"IN","type":"education","lineage":["https://openalex.org/I158688498"]},{"id":"https://openalex.org/I4405268903","display_name":"Yenepoya Research Centre","ror":"https://ror.org/02ekn8f64","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4405268903"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Chinmaya Narayana Kotimoole","raw_affiliation_strings":["Center for Systems Biology and Molecular Medicine [An ICMR-Collaborating Centre of Excellence 2024 (ICMR-CCoE 2024)], Yenepoya Research Centre","Yenepoya (Deemed to be University)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Systems Biology and Molecular Medicine [An ICMR-Collaborating Centre of Excellence 2024 (ICMR-CCoE 2024)], Yenepoya Research Centre","institution_ids":["https://openalex.org/I4405268903"]},{"raw_affiliation_string":"Yenepoya (Deemed to be University)","institution_ids":["https://openalex.org/I158688498"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042134574","display_name":"Poornima Ramesh","orcid":"https://orcid.org/0000-0001-5832-5631","observed_orcids":["https://orcid.org/0000-0001-5832-5631"]},"institutions":[{"id":"https://openalex.org/I158688498","display_name":"Yenepoya University","ror":"https://ror.org/029zfa075","country_code":"IN","type":"education","lineage":["https://openalex.org/I158688498"]},{"id":"https://openalex.org/I4405268903","display_name":"Yenepoya Research Centre","ror":"https://ror.org/02ekn8f64","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4405268903"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Poornima Ramesh","raw_affiliation_strings":["Center for Systems Biology and Molecular Medicine [An ICMR-Collaborating Centre of Excellence 2024 (ICMR-CCoE 2024)], Yenepoya Research Centre","Yenepoya (Deemed to be University)"],"raw_orcid":"https://orcid.org/0000-0001-5832-5631","affiliations":[{"raw_affiliation_string":"Center for Systems Biology and Molecular Medicine [An ICMR-Collaborating Centre of Excellence 2024 (ICMR-CCoE 2024)], Yenepoya Research Centre","institution_ids":["https://openalex.org/I4405268903"]},{"raw_affiliation_string":"Yenepoya (Deemed to be University)","institution_ids":["https://openalex.org/I158688498"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094010912","display_name":"Vanya Kadla Narayana","orcid":"https://orcid.org/0009-0007-8697-8278","observed_orcids":["https://orcid.org/0009-0007-8697-8278"]},"institutions":[{"id":"https://openalex.org/I158688498","display_name":"Yenepoya University","ror":"https://ror.org/029zfa075","country_code":"IN","type":"education","lineage":["https://openalex.org/I158688498"]},{"id":"https://openalex.org/I4405268903","display_name":"Yenepoya Research Centre","ror":"https://ror.org/02ekn8f64","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4405268903"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vanya Kadla Narayana","raw_affiliation_strings":["Center for Systems Biology and Molecular Medicine [An ICMR-Collaborating Centre of Excellence 2024 (ICMR-CCoE 2024)], Yenepoya Research Centre","Yenepoya (Deemed to be University)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Systems Biology and Molecular Medicine [An ICMR-Collaborating Centre of Excellence 2024 (ICMR-CCoE 2024)], Yenepoya Research Centre","institution_ids":["https://openalex.org/I4405268903"]},{"raw_affiliation_string":"Yenepoya (Deemed to be University)","institution_ids":["https://openalex.org/I158688498"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000951098","display_name":"Vineetha Shaji","orcid":"https://orcid.org/0000-0003-0038-5388","observed_orcids":["https://orcid.org/0000-0003-0038-5388"]},"institutions":[{"id":"https://openalex.org/I158688498","display_name":"Yenepoya University","ror":"https://ror.org/029zfa075","country_code":"IN","type":"education","lineage":["https://openalex.org/I158688498"]},{"id":"https://openalex.org/I4405268903","display_name":"Yenepoya Research Centre","ror":"https://ror.org/02ekn8f64","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4405268903"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vineetha Shaji","raw_affiliation_strings":["Center for Systems Biology and Molecular Medicine [An ICMR-Collaborating Centre of Excellence 2024 (ICMR-CCoE 2024)], Yenepoya Research Centre","Yenepoya (Deemed to be University)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Systems Biology and Molecular Medicine [An ICMR-Collaborating Centre of Excellence 2024 (ICMR-CCoE 2024)], Yenepoya Research Centre","institution_ids":["https://openalex.org/I4405268903"]},{"raw_affiliation_string":"Yenepoya (Deemed to be University)","institution_ids":["https://openalex.org/I158688498"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064765384","display_name":"Thottethodi Subrahmanya Keshava Prasad","orcid":"https://orcid.org/0000-0002-6206-2384","observed_orcids":["https://orcid.org/0000-0002-6206-2384"]},"institutions":[{"id":"https://openalex.org/I158688498","display_name":"Yenepoya University","ror":"https://ror.org/029zfa075","country_code":"IN","type":"education","lineage":["https://openalex.org/I158688498"]},{"id":"https://openalex.org/I4405268903","display_name":"Yenepoya Research Centre","ror":"https://ror.org/02ekn8f64","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4405268903"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Thottethodi Subrahmanya Keshava Prasad","raw_affiliation_strings":["Center for Systems Biology and Molecular Medicine [An ICMR-Collaborating Centre of Excellence 2024 (ICMR-CCoE 2024)], Yenepoya Research Centre","Yenepoya (Deemed to be University)"],"raw_orcid":"https://orcid.org/0000-0002-6206-2384","affiliations":[{"raw_affiliation_string":"Center for Systems Biology and Molecular Medicine [An ICMR-Collaborating Centre of Excellence 2024 (ICMR-CCoE 2024)], Yenepoya Research Centre","institution_ids":["https://openalex.org/I4405268903"]},{"raw_affiliation_string":"Yenepoya (Deemed to be University)","institution_ids":["https://openalex.org/I158688498"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5064765384","https://openalex.org/A5085191691"],"corresponding_institution_ids":["https://openalex.org/I158688498","https://openalex.org/I4405268903"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.2532,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.38425455,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"24","issue":"8","first_page":"4166","last_page":"4180"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.8935999870300293,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.8935999870300293,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.0414000004529953,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9850000143051147},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.9850000143051147},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.9900000095367432},{"id":"https://openalex.org/keywords/neoantigens","display_name":"neoantigens","score":0.8500000238418579},{"id":"https://openalex.org/keywords/data-independent-acquisition","display_name":"data-independent acquisition","score":0.6060000061988831},{"id":"https://openalex.org/keywords/carcinoembryonic-antigen","display_name":"carcinoembryonic antigen","score":0.906000018119812},{"id":"https://openalex.org/keywords/early-cancer-detection","display_name":"early cancer detection","score":0.7360000014305115},{"id":"https://openalex.org/keywords/colonoscopy","display_name":"colonoscopy","score":0.640999972820282},{"id":"https://openalex.org/keywords/serum-proteome","display_name":"serum proteome","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7627348899841309},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7360034584999084},{"id":"https://openalex.org/C2777387746","wikidata":"https://www.wikidata.org/wiki/Q769706","display_name":"Carcinoembryonic antigen","level":3,"score":0.7317787408828735},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6372450590133667},{"id":"https://openalex.org/C2778435480","wikidata":"https://www.wikidata.org/wiki/Q840387","display_name":"Colonoscopy","level":4,"score":0.6253100633621216},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6140550374984741},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.5280766487121582},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4984121322631836},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.4699414372444153},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4634515941143036},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4443078637123108},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.35419636964797974},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10238561034202576},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002272","descriptor_name":"Carcinoembryonic Antigen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002272","descriptor_name":"Carcinoembryonic Antigen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002272","descriptor_name":"Carcinoembryonic Antigen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003113","descriptor_name":"Colonoscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003113","descriptor_name":"Colonoscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003113","descriptor_name":"Colonoscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015212","descriptor_name":"Inflammatory Bowel Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055088","descriptor_name":"Early Detection of Cancer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055088","descriptor_name":"Early Detection of Cancer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055088","descriptor_name":"Early Detection of Cancer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.jproteome.5c00285","doi":"https://doi.org/10.1021/acs.jproteome.5c00285","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jproteome.5c00285","pdf_url":null,"source":{"id":"https://openalex.org/S74367812","display_name":"Journal of Proteome Research","issn_l":"1535-3893","issn":["1535-3893","1535-3907"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Proteome Research","raw_type":"journal-article"},{"id":"pmid:40652393","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40652393","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of proteome research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6800000071525574,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320720","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28"},{"id":"https://openalex.org/F6442310561","display_name":"Yenepoya University","ror":"https://ror.org/029zfa075"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W100382268","https://openalex.org/W1055665093","https://openalex.org/W1968164646","https://openalex.org/W1992183604","https://openalex.org/W2005723048","https://openalex.org/W2026884441","https://openalex.org/W2070830418","https://openalex.org/W2103912979","https://openalex.org/W2146888779","https://openalex.org/W2159675211","https://openalex.org/W2171426422","https://openalex.org/W2242659647","https://openalex.org/W2302244837","https://openalex.org/W2516573438","https://openalex.org/W2520028087","https://openalex.org/W2597634490","https://openalex.org/W2624943597","https://openalex.org/W2760137314","https://openalex.org/W2763195822","https://openalex.org/W2890085191","https://openalex.org/W2944545583","https://openalex.org/W2951132229","https://openalex.org/W2964906956","https://openalex.org/W2970644901","https://openalex.org/W2973108736","https://openalex.org/W2977233247","https://openalex.org/W2991106430","https://openalex.org/W3003028831","https://openalex.org/W3008682585","https://openalex.org/W3017030326","https://openalex.org/W3027028023","https://openalex.org/W3087768973","https://openalex.org/W3110648523","https://openalex.org/W3128646645","https://openalex.org/W3154423121","https://openalex.org/W3157152574","https://openalex.org/W3168675040","https://openalex.org/W3183885500","https://openalex.org/W3194810341","https://openalex.org/W3199626861","https://openalex.org/W3207910652","https://openalex.org/W3208691473","https://openalex.org/W4200527852","https://openalex.org/W4210631992","https://openalex.org/W4214528940","https://openalex.org/W4214769710","https://openalex.org/W4224323101","https://openalex.org/W4224998110","https://openalex.org/W4293999121","https://openalex.org/W4295096627","https://openalex.org/W4302424609","https://openalex.org/W4308834893","https://openalex.org/W4312222196","https://openalex.org/W4313547267","https://openalex.org/W4318473522","https://openalex.org/W4362668290","https://openalex.org/W4377138336","https://openalex.org/W4380538126","https://openalex.org/W4385497484","https://openalex.org/W4386212225","https://openalex.org/W4388522045","https://openalex.org/W4390621251","https://openalex.org/W4391811587","https://openalex.org/W4391847573","https://openalex.org/W4397293886","https://openalex.org/W4400531641","https://openalex.org/W4401793783","https://openalex.org/W4404209177","https://openalex.org/W4407005899"],"related_works":["https://openalex.org/W2280632276","https://openalex.org/W2053839600","https://openalex.org/W2422451333","https://openalex.org/W2443090837","https://openalex.org/W185860436","https://openalex.org/W2412064718","https://openalex.org/W2997642910","https://openalex.org/W2790182393","https://openalex.org/W4281696870","https://openalex.org/W1533674099"],"abstract_inverted_index":{"Early":[0],"colorectal":[1],"cancer":[2],"(CRC)":[3],"detection":[4],"among":[5],"inflammatory":[6],"bowel":[7,46],"disease":[8],"improves":[9],"treatment":[10],"outcomes":[11],"and":[12,16,27,42,145,171],"survival.":[13],"A":[14],"sensitive":[15],"specific":[17,113],"serum-based":[18,182],"tool":[19],"can":[20,102],"bridge":[21],"the":[22,76,115,142,177],"gap":[23],"between":[24],"patient":[25],"presentation":[26],"invasive":[28],"colonoscopy,":[29],"thereby":[30],"enhancing":[31],"early":[32],"diagnosis.":[33],"We":[34,82],"screened":[35],"serum":[36,86,117],"biomarkers":[37],"in":[38,52,75,98,123,196],"colonoscopy-positive":[39],"(CP,":[40],"cancer)":[41],"colonoscopy-negative":[43],"(CN,":[44],"other":[45],"diseases)":[47],"individuals,":[48],"as":[49,51,72],"well":[50],"healthy":[53],"controls":[54],"(":[55,129],"n":[56,130],"=":[57,131,164],"20":[58],"each),":[59],"to":[60,114,200],"identify":[61],"CRC-specific":[62],"markers.":[63],"Using":[64],"data-independent":[65],"acquisition-mass":[66],"spectrometry,":[67],"three":[68],"proteins":[69,149],"were":[70,119,150],"identified":[71],"uniquely":[73],"altered":[74],"CP":[77,104],"group":[78],"compared":[79],"with":[80,152],"CN.":[81],"found":[83],"that":[84],"a":[85,156,180,197],"protein":[87,93],"called":[88],"brain-specific":[89],"angiogenesis":[90],"inhibitor":[91],"I-associated":[92],"3":[94],"was":[95,139],"significantly":[96],"overexpressed":[97],"CRC":[99,116],"patients,":[100],"which":[101,159],"distinguish":[103],"patients":[105],"from":[106],"CN":[107],"patients.":[108],"Additionally,":[109],"19":[110],"neoantigen":[111,146],"peptides":[112],"proteome":[118],"identified.":[120,147],"Further":[121],"validation":[122],"an":[124],"independent":[125],"set":[126],"of":[127,179],"samples":[128],"10":[132],"per":[133],"group)":[134],"using":[135],"parallel":[136],"reaction":[137],"monitoring":[138],"performed":[140],"for":[141,184,188],"potential":[143,178],"biomarker":[144],"These":[148,174],"combined":[151],"carcinoembryonic":[153],"antigen":[154],"into":[155],"multiprotein":[157],"panel,":[158],"enhanced":[160],"diagnostic":[161],"performance":[162],"(AUC":[163],"0.758),":[165],"yielding":[166],"67%":[167],"sensitivity,":[168],"64%":[169],"specificity,":[170],"65%":[172],"accuracy.":[173],"findings":[175],"support":[176],"targeted":[181],"panel":[183],"preselecting":[185],"symptomatic":[186],"individuals":[187],"colonoscopic":[189],"evaluation.":[190],"However,":[191],"further":[192],"studies":[193],"are":[194],"needed":[195],"larger":[198],"cohort":[199],"evaluate":[201],"clinical":[202],"utility.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}
