{"id":"https://openalex.org/W4412372231","doi":"https://doi.org/10.1177/19373341251359106","title":"Disc-Derived Induced Pluripotent Stem Cells and Environmental Cues for Nucleus Pulposus Regeneration","display_name":"Disc-Derived Induced Pluripotent Stem Cells and Environmental Cues for Nucleus Pulposus Regeneration","publication_year":2025,"publication_date":"2025-10-08","ids":{"openalex":"https://openalex.org/W4412372231","doi":"https://doi.org/10.1177/19373341251359106","pmid":"https://pubmed.ncbi.nlm.nih.gov/40644334"},"language":"en","primary_location":{"id":"doi:10.1177/19373341251359106","doi":"https://doi.org/10.1177/19373341251359106","is_oa":true,"landing_page_url":"https://doi.org/10.1177/19373341251359106","pdf_url":null,"source":{"id":"https://openalex.org/S19081469","display_name":"Tissue Engineering Part A","issn_l":"1937-3341","issn":["1937-3341","1937-335X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Engineering Part A","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1177/19373341251359106","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002522621","display_name":"Lisanne T. Laagland","orcid":"https://orcid.org/0000-0002-4456-6167","observed_orcids":["https://orcid.org/0000-0002-4456-6167"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Lisanne T. Laagland","raw_affiliation_strings":["Faculty of Veterinary Medicine, Department of Clinical Sciences, Utrecht University, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Veterinary Medicine, Department of Clinical Sciences, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091799602","display_name":"Deepani W. Poramba\u2010Liyanage","orcid":"https://orcid.org/0000-0003-3717-4787","observed_orcids":["https://orcid.org/0000-0003-3717-4787"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Deepani W.L. Poramba Liyanage","raw_affiliation_strings":["Faculty of Veterinary Medicine, Department of Clinical Sciences, Utrecht University, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Veterinary Medicine, Department of Clinical Sciences, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012337436","display_name":"Romain Desprat","orcid":"https://orcid.org/0000-0002-8310-7318","observed_orcids":["https://orcid.org/0000-0002-8310-7318"]},"institutions":[{"id":"https://openalex.org/I4210143740","display_name":"H\u00f4pital Saint Eloi","ror":"https://ror.org/04pwyfk22","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210093292","https://openalex.org/I4210143740"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Romain Desprat","raw_affiliation_strings":["Plateforme de Reprogrammation Cellulaire (SAFE-iPSC) Stem Cell Core Facility, Centres Hospitaliers Universitaires de Montpellier, H\u00f4pital Saint Eloi, Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Plateforme de Reprogrammation Cellulaire (SAFE-iPSC) Stem Cell Core Facility, Centres Hospitaliers Universitaires de Montpellier, H\u00f4pital Saint Eloi, Montpellier, France","institution_ids":["https://openalex.org/I4210143740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074117570","display_name":"Frank M. Riemers","orcid":"https://orcid.org/0000-0003-4732-9447","observed_orcids":["https://orcid.org/0000-0003-4732-9447"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Frank M. Riemers","raw_affiliation_strings":["Faculty of Veterinary Medicine, Department of Clinical Sciences, Utrecht University, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Veterinary Medicine, Department of Clinical Sciences, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118967156","display_name":"Corinde C. Warmerdam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Corinde C. Warmerdam","raw_affiliation_strings":["Faculty of Veterinary Medicine, Department of Clinical Sciences, Utrecht University, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Veterinary Medicine, Department of Clinical Sciences, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058830302","display_name":"Mathis Soubeyrand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210095750","display_name":"Institute for Regenerative Medicine & Biotherapy","ror":"https://ror.org/00b8mh310","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210095750"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mathis Soubeyrand","raw_affiliation_strings":["IRMB, University of Montpellier, INSERM, Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRMB, University of Montpellier, INSERM, Montpellier, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210095750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043570716","display_name":"Paul Bensadoun","orcid":"https://orcid.org/0000-0001-5966-3560","observed_orcids":["https://orcid.org/0000-0001-5966-3560"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210095750","display_name":"Institute for Regenerative Medicine & Biotherapy","ror":"https://ror.org/00b8mh310","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210095750"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Paul Bensadoun","raw_affiliation_strings":["IRMB, University of Montpellier, INSERM, Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRMB, University of Montpellier, INSERM, Montpellier, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210095750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085927001","display_name":"Keita Ito","orcid":"https://orcid.org/0000-0002-7372-4072","observed_orcids":["https://orcid.org/0000-0002-7372-4072","https://orcid.org/0000-0002-3682-8614","https://orcid.org/0000-0003-0531-3578"]},"institutions":[{"id":"https://openalex.org/I83019370","display_name":"Eindhoven University of Technology","ror":"https://ror.org/02c2kyt77","country_code":"NL","type":"education","lineage":["https://openalex.org/I83019370"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Keita Ito","raw_affiliation_strings":["Eindhoven University of Technology, Eindhoven, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eindhoven University of Technology, Eindhoven, The Netherlands","institution_ids":["https://openalex.org/I83019370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062891938","display_name":"Ollivier Milhavet","orcid":"https://orcid.org/0000-0001-6236-0499","observed_orcids":["https://orcid.org/0000-0001-6236-0499"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210095750","display_name":"Institute for Regenerative Medicine & Biotherapy","ror":"https://ror.org/00b8mh310","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210095750"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ollivier Milhavet","raw_affiliation_strings":["IRMB, University of Montpellier, INSERM, CNRS, Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRMB, University of Montpellier, INSERM, CNRS, Montpellier, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210095750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023619509","display_name":"Anne Camus","orcid":"https://orcid.org/0000-0002-8820-0407","observed_orcids":["https://orcid.org/0000-0002-8820-0407","https://orcid.org/0000-0002-1397-6411"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I3019204325","display_name":"Centre Hospitalier Universitaire de Nantes","ror":"https://ror.org/05c1qsg97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019204325"]},{"id":"https://openalex.org/I4210157468","display_name":"Oniris","ror":"https://ror.org/05q0ncs32","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210157468"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anne Camus","raw_affiliation_strings":["Nantes University, Oniris, CHU Nantes, Inserm, Regenerative Medicine and Skeleton, RMeS, UMR 1229, Nantes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nantes University, Oniris, CHU Nantes, Inserm, Regenerative Medicine and Skeleton, RMeS, UMR 1229, Nantes, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I3019204325","https://openalex.org/I4210157468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022889910","display_name":"Benjamin Gantenbein","orcid":"https://orcid.org/0000-0002-9005-0655","observed_orcids":["https://orcid.org/0000-0002-9005-0655"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I2801112126","display_name":"University Hospital of Bern","ror":"https://ror.org/01q9sj412","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2801112126"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Benjamin Gantenbein","raw_affiliation_strings":["Faculty of Medicine, Department of Orthopedic Surgery &amp; Traumatology, Inselpital, Bern University Hospital, University of Bern, Bern, Switzerland","Medical Faculty, Tissue Engineering for Orthopaedics and Mechanobiology, Bone &amp; Joint Program, Department for BioMedical Research (DBMR), University of Bern, Switzerland","Faculty of Medicine, Department of Orthopedic Surgery & Traumatology, Inselpital, Bern University Hospital, University of Bern, Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Department of Orthopedic Surgery &amp; Traumatology, Inselpital, Bern University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]},{"raw_affiliation_string":"Medical Faculty, Tissue Engineering for Orthopaedics and Mechanobiology, Bone &amp; Joint Program, Department for BioMedical Research (DBMR), University of Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Faculty of Medicine, Department of Orthopedic Surgery & Traumatology, Inselpital, Bern University Hospital, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535","https://openalex.org/I2801112126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051212502","display_name":"Jean-Marc Lema\u0131\u0302tre","orcid":"https://orcid.org/0000-0002-6492-5219","observed_orcids":["https://orcid.org/0000-0002-6492-5219"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4210095750","display_name":"Institute for Regenerative Medicine & Biotherapy","ror":"https://ror.org/00b8mh310","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210095750"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Marc Lemaitre","raw_affiliation_strings":["IRMB, University of Montpellier, INSERM, Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRMB, University of Montpellier, INSERM, Montpellier, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I19894307","https://openalex.org/I4210095750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073803993","display_name":"Marianna A. Tryfonidou","orcid":"https://orcid.org/0000-0002-2333-7162","observed_orcids":["https://orcid.org/0000-0002-2333-7162"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marianna A. Tryfonidou","raw_affiliation_strings":["Faculty of Veterinary Medicine, Department of Clinical Sciences, Utrecht University, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Veterinary Medicine, Department of Clinical Sciences, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":11,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.9403,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.90928899,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"32","issue":"1-2","first_page":"54","last_page":"67"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.8119999766349792,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.8119999766349792,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.1387999951839447,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.019500000402331352,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nucleus-pulposus-regeneration","display_name":"nucleus pulposus regeneration","score":0.8339999914169312},{"id":"https://openalex.org/keywords/intervertebral-disc-regeneration","display_name":"intervertebral disc regeneration","score":0.8119999766349792},{"id":"https://openalex.org/keywords/notochordal-cells","display_name":"notochordal cells","score":0.8790000081062317},{"id":"https://openalex.org/keywords/epigenetic-memory","display_name":"epigenetic memory","score":0.8880000114440918},{"id":"https://openalex.org/keywords/microenvironmental-cues","display_name":"microenvironmental cues","score":0.8360000252723694},{"id":"https://openalex.org/keywords/hematopoietic-differentiation","display_name":"hematopoietic differentiation","score":0.7760000228881836},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.9380000233650208}],"concepts":[{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.7262856960296631},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.6843412518501282},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.635172963142395},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5168195366859436},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.5088134407997131},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3930214047431946},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3526540696620941},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3464389443397522},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.32346901297569275},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.1992974877357483},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000070614","descriptor_name":"Nucleus Pulposus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D000070614","descriptor_name":"Nucleus Pulposus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D000070614","descriptor_name":"Nucleus Pulposus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000070614","descriptor_name":"Nucleus Pulposus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1177/19373341251359106","doi":"https://doi.org/10.1177/19373341251359106","is_oa":true,"landing_page_url":"https://doi.org/10.1177/19373341251359106","pdf_url":null,"source":{"id":"https://openalex.org/S19081469","display_name":"Tissue Engineering Part A","issn_l":"1937-3341","issn":["1937-3341","1937-335X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Engineering Part A","raw_type":"journal-article"},{"id":"pmid:40644334","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40644334","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue engineering. Part A","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-05346429v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.umontpellier.fr/hal-05346429v1/document","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tissue Engineering: Parts A, B, and C, 2025, &#x27E8;10.1177/19373341251359106&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dspace.library.uu.nl:1874/477698","doi":null,"is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/477698","pdf_url":null,"source":{"id":"https://openalex.org/S4306401649","display_name":"Utrecht University Repository (Utrecht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I193662353","host_organization_name":"Utrecht University","host_organization_lineage":["https://openalex.org/I193662353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"doi:10.48620/89493","doi":"https://doi.org/10.48620/89493","is_oa":true,"landing_page_url":"https://doi.org/10.48620/89493","pdf_url":null,"source":{"id":"https://openalex.org/S7407053152","display_name":"Open Access CRIS of the University of Bern","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1177/19373341251359106","doi":"https://doi.org/10.1177/19373341251359106","is_oa":true,"landing_page_url":"https://doi.org/10.1177/19373341251359106","pdf_url":null,"source":{"id":"https://openalex.org/S19081469","display_name":"Tissue Engineering Part A","issn_l":"1937-3341","issn":["1937-3341","1937-335X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Engineering Part A","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6000000238418579,"display_name":"Life on land","id":"https://metadata.un.org/sdg/15"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1584623062","https://openalex.org/W1805858026","https://openalex.org/W1817479092","https://openalex.org/W1958596468","https://openalex.org/W1982678468","https://openalex.org/W1989077880","https://openalex.org/W1993554607","https://openalex.org/W2027507811","https://openalex.org/W2032255522","https://openalex.org/W2038206131","https://openalex.org/W2056840798","https://openalex.org/W2060610551","https://openalex.org/W2081331532","https://openalex.org/W2081628067","https://openalex.org/W2082223061","https://openalex.org/W2095546080","https://openalex.org/W2102560467","https://openalex.org/W2131495509","https://openalex.org/W2179438025","https://openalex.org/W2181131337","https://openalex.org/W2275040537","https://openalex.org/W2343910187","https://openalex.org/W2403913767","https://openalex.org/W2410134334","https://openalex.org/W2510668402","https://openalex.org/W2564933932","https://openalex.org/W2586239032","https://openalex.org/W2622297493","https://openalex.org/W2755622569","https://openalex.org/W2793940073","https://openalex.org/W2808218792","https://openalex.org/W2828050787","https://openalex.org/W2886269413","https://openalex.org/W2981254954","https://openalex.org/W3001803099","https://openalex.org/W3003583234","https://openalex.org/W3008650073","https://openalex.org/W3008897414","https://openalex.org/W3010467346","https://openalex.org/W3027554203","https://openalex.org/W3091350374","https://openalex.org/W3112034430","https://openalex.org/W3166417300","https://openalex.org/W3201326993","https://openalex.org/W3207974949","https://openalex.org/W4221036123","https://openalex.org/W4281622425","https://openalex.org/W4290761515","https://openalex.org/W4309246465","https://openalex.org/W4313909511","https://openalex.org/W4383819959","https://openalex.org/W4388539829","https://openalex.org/W4390498783","https://openalex.org/W4391256719","https://openalex.org/W4391813433","https://openalex.org/W4394894573"],"related_works":["https://openalex.org/W2126478593","https://openalex.org/W2036028623","https://openalex.org/W3127850750","https://openalex.org/W4295681237","https://openalex.org/W2998117225","https://openalex.org/W4313335506","https://openalex.org/W2981369774","https://openalex.org/W4327680022","https://openalex.org/W4254937032","https://openalex.org/W2418603484"],"abstract_inverted_index":{"Notochordal":[0],"cells":[1,56,64,70,135,160],"(NCs),":[2],"abundantly":[3],"found":[4],"in":[5,31,36,86,192,206,238],"the":[6,53,58,83,87,91,109,123,219,239,244,248],"developing":[7],"nucleus":[8],"pulposus":[9],"(NP),":[10],"show":[11,179],"potential":[12,245],"for":[13,78,161],"intervertebral":[14],"disc":[15],"regeneration":[16],"because":[17,41],"of":[18,55,60,99,115,126,140,147,196,210,241,247],"their":[19,44],"unique":[20],"instructive":[21,113],"and":[22,33,94,112,137,150,199,221],"healthy":[23,61,116,158,197],"matrix-producing":[24,62,101,159],"capacity.":[25],"However,":[26],"NCs":[27],"are":[28,73],"lost":[29],"early":[30],"life,":[32],"attempts":[34],"at":[35],"vitro":[37,207],"expansion":[38],"have":[39],"failed":[40],"they":[42],"lose":[43],"specific":[45],"phenotype.":[46],"Therefore,":[47],"much":[48],"effort":[49],"is":[50],"focused":[51],"on":[52,108],"generation":[54],"resembling":[57],"properties":[59],"NP-like":[63],"from":[65,130,232],"human":[66],"induced":[67],"pluripotent":[68],"stem":[69],"(hiPSCs).":[71],"They":[72],"considered":[74],"a":[75,96,165],"promising":[76],"alternative":[77],"employing":[79,181],"native":[80],"NCs.":[81],"Given":[82],"ongoing":[84],"challenges":[85],"field":[88],"to":[89,106,153,215],"fine-tune":[90],"differentiation":[92,209,217,236],"protocol":[93],"obtain":[95],"high":[97],"yield":[98],"mature":[100],"cells,":[102],"this":[103,205],"study":[104],"aims":[105],"build":[107],"epigenetic":[110,124,249],"memory":[111,125],"capacity":[114],"NP":[117,133,162,201],"tissue.":[118],"For":[119],"this,":[120],"we":[121,227],"employed":[122],"tissue-specific":[127],"hiPSCs":[128,174,183,230],"derived":[129,231],"TIE2":[131],"+":[132],"progenitor":[134],"(NPPCs)":[136],"microenvironmental":[138],"cues":[139,187],"decellularized":[141],"porcine":[142],"NC-derived":[143],"matrix":[144,148],"(dNCM),":[145],"consisting":[146],"components":[149],"bioactive":[151],"factors":[152],"differentiate":[154],"hiPSC":[155,212],"into":[156,218],"mature,":[157],"repair.":[163],"As":[164],"comparison,":[166],"donor-matched":[167],"minimally":[168],"invasive":[169],"peripheral":[170],"blood":[171],"mononuclear":[172],"cell-derived":[173],"were":[175],"used.":[176],"The":[177],"results":[178],"that":[180,229],"NPPC-derived":[182],"instructed":[184],"by":[185,189],"natural":[186],"provided":[188],"dNCM":[190],"resulted":[191],"an":[193],"increased":[194],"expression":[195],"phenotypic":[198],"matrisome-related":[200],"markers.":[202],"Furthermore,":[203],"within":[204],"environment,":[208],"blood-derived":[211],"lines":[213],"led":[214],"augmented":[216],"hematopoietic":[220],"neural":[222],"cell":[223],"lineage.":[224],"In":[225],"conclusion,":[226],"demonstrate":[228],"NPPCs":[233],"achieve":[234],"enhanced":[235],"outcomes":[237],"presence":[240],"dNCM,":[242],"highlighting":[243],"impact":[246],"memory.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}
