{"id":"https://openalex.org/W4412371306","doi":"https://doi.org/10.54117/ijddrr.v3i1.28","title":"Helicobacter pylori Inhibition by Medicinal Plant Extracts: An In Vitro Assessment","display_name":"Helicobacter pylori Inhibition by Medicinal Plant Extracts: An In Vitro Assessment","publication_year":2025,"publication_date":"2025-05-25","ids":{"openalex":"https://openalex.org/W4412371306","doi":"https://doi.org/10.54117/ijddrr.v3i1.28"},"language":"en","primary_location":{"id":"doi:10.54117/ijddrr.v3i1.28","doi":"https://doi.org/10.54117/ijddrr.v3i1.28","is_oa":true,"landing_page_url":"https://doi.org/10.54117/ijddrr.v3i1.28","pdf_url":"https://journals.ipsintelligentsia.com/drugdiscoveryupdate/index.php/JDDRR/article/download/28/17","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IPS Journal of Drug Discovery Research and Reviews","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.ipsintelligentsia.com/drugdiscoveryupdate/index.php/JDDRR/article/download/28/17","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5117015422","display_name":"Patricia Amaka Egbe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121708413","display_name":"Chukwuemeka Odumegwu Ojukwu University","ror":"https://ror.org/018ze3r73","country_code":"NG","type":"education","lineage":["https://openalex.org/I121708413"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"P. A. Egbe","raw_affiliation_strings":["Department of Microbiology, Faculty of Natural Sciences, Chukwuemeka Odumegwu Ojukwu University, Anambra State, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Faculty of Natural Sciences, Chukwuemeka Odumegwu Ojukwu University, Anambra State, Nigeria","institution_ids":["https://openalex.org/I121708413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112896964","display_name":"Chinyelu Nkiruka Umeaku","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121708413","display_name":"Chukwuemeka Odumegwu Ojukwu University","ror":"https://ror.org/018ze3r73","country_code":"NG","type":"education","lineage":["https://openalex.org/I121708413"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"C. N. Umeaku","raw_affiliation_strings":["Department of Microbiology, Faculty of Natural Sciences, Chukwuemeka Odumegwu Ojukwu University, Anambra State, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Faculty of Natural Sciences, Chukwuemeka Odumegwu Ojukwu University, Anambra State, Nigeria","institution_ids":["https://openalex.org/I121708413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010235243","display_name":"Ikechukwu Harmony Iheukwumere","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121708413","display_name":"Chukwuemeka Odumegwu Ojukwu University","ror":"https://ror.org/018ze3r73","country_code":"NG","type":"education","lineage":["https://openalex.org/I121708413"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"I. H. Iheukwumere","raw_affiliation_strings":["Department of Microbiology, Faculty of Natural Sciences, Chukwuemeka Odumegwu Ojukwu University, Anambra State, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Faculty of Natural Sciences, Chukwuemeka Odumegwu Ojukwu University, Anambra State, Nigeria","institution_ids":["https://openalex.org/I121708413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041342751","display_name":"C. M. Iheukwumere","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I207227095","display_name":"Nnamdi Azikiwe University","ror":"https://ror.org/02r6pfc06","country_code":"NG","type":"education","lineage":["https://openalex.org/I207227095"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"C. M. Iheukwumere","raw_affiliation_strings":["Department of Applied Microbiology & Brewing, Faculty of Biosciences, Nnamdi Azikiwe University Awka, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Microbiology & Brewing, Faculty of Biosciences, Nnamdi Azikiwe University Awka, Nigeria","institution_ids":["https://openalex.org/I207227095"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118945123","display_name":"Uche F. Onwuasoanya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I207227095","display_name":"Nnamdi Azikiwe University","ror":"https://ror.org/02r6pfc06","country_code":"NG","type":"education","lineage":["https://openalex.org/I207227095"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"U. F. Onwuasoanya","raw_affiliation_strings":["Department of Medical Microbiology and Public Health, Faculty of Medical Laboratory Science, College of Health Sciences, Nnamdi Azikiwe University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Microbiology and Public Health, Faculty of Medical Laboratory Science, College of Health Sciences, Nnamdi Azikiwe University","institution_ids":["https://openalex.org/I207227095"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050466444","display_name":"Ifeoma Susan Ezenwata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121708413","display_name":"Chukwuemeka Odumegwu Ojukwu University","ror":"https://ror.org/018ze3r73","country_code":"NG","type":"education","lineage":["https://openalex.org/I121708413"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"I. S. Ezenwata","raw_affiliation_strings":["Department of Biological Sciences, Faculty of Natural Sciences, Chukwuemeka Odumegwu Ojukwu University, Anambra State, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Faculty of Natural Sciences, Chukwuemeka Odumegwu Ojukwu University, Anambra State, Nigeria","institution_ids":["https://openalex.org/I121708413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039379708","display_name":"Stella Chinyere Afulukwe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121708413","display_name":"Chukwuemeka Odumegwu Ojukwu University","ror":"https://ror.org/018ze3r73","country_code":"NG","type":"education","lineage":["https://openalex.org/I121708413"]},{"id":"https://openalex.org/I4405259477","display_name":"Chukwuemeka Odumegwu Ojukwu University, Igbariam Campus","ror":"https://ror.org/029x2tx62","country_code":"NG","type":"education","lineage":["https://openalex.org/I121708413","https://openalex.org/I4405259477"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"S. C. Afulukwe","raw_affiliation_strings":["Department of Medical Laboratory Science, Chukwuemeka Odumegwu Ojukwu University, Anambra State, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory Science, Chukwuemeka Odumegwu Ojukwu University, Anambra State, Nigeria","institution_ids":["https://openalex.org/I121708413","https://openalex.org/I4405259477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116669866","display_name":"Victor Echezona Ike","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405256953","display_name":"University of Agriculture and Environmental Sciences, Umuagwo","ror":"https://ror.org/04qagr784","country_code":"NG","type":"education","lineage":["https://openalex.org/I4405256953"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"V. E. Ike","raw_affiliation_strings":["Department of Biology, University of Agriculture and Environmental Sciences Umuagwo, Imo State"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Agriculture and Environmental Sciences Umuagwo, Imo State","institution_ids":["https://openalex.org/I4405256953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035927270","display_name":"Eucharia Nkiruka Ezeumeh","orcid":"https://orcid.org/0009-0002-0175-3218","observed_orcids":["https://orcid.org/0009-0002-0175-3218"]},"institutions":[{"id":"https://openalex.org/I121708413","display_name":"Chukwuemeka Odumegwu Ojukwu University","ror":"https://ror.org/018ze3r73","country_code":"NG","type":"education","lineage":["https://openalex.org/I121708413"]},{"id":"https://openalex.org/I4405259477","display_name":"Chukwuemeka Odumegwu Ojukwu University, Igbariam Campus","ror":"https://ror.org/029x2tx62","country_code":"NG","type":"education","lineage":["https://openalex.org/I121708413","https://openalex.org/I4405259477"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"E. N. Ezeumeh","raw_affiliation_strings":["Department of Medical Laboratory Science, Chukwuemeka Odumegwu Ojukwu University, Anambra State, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory Science, Chukwuemeka Odumegwu Ojukwu University, Anambra State, Nigeria","institution_ids":["https://openalex.org/I121708413","https://openalex.org/I4405259477"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060315553","display_name":"Chukwuebuka Egbuna","orcid":"https://orcid.org/0000-0001-8382-0693","observed_orcids":["https://orcid.org/0000-0001-8382-0693"]},"institutions":[{"id":"https://openalex.org/I100116408","display_name":"University of Port Harcourt","ror":"https://ror.org/005bw2d06","country_code":"NG","type":"education","lineage":["https://openalex.org/I100116408"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"C. Egbuna","raw_affiliation_strings":["Africa Centre of Excellence for Public Health and Toxicological Research, University of Port Harcourt, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Africa Centre of Excellence for Public Health and Toxicological Research, University of Port Harcourt, Nigeria","institution_ids":["https://openalex.org/I100116408"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8653,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.73178344,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"3","issue":"1","first_page":"32","last_page":"37"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.0421999990940094,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/helicobacter-pylori","display_name":"Helicobacter pylori","score":1.0},{"id":"https://openalex.org/keywords/medicinal-plant-extracts","display_name":"medicinal plant extracts","score":0.9700000286102295},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.9039999842643738},{"id":"https://openalex.org/keywords/ginger","display_name":"ginger","score":0.9480000138282776},{"id":"https://openalex.org/keywords/hunteria-umbellata","display_name":"Hunteria umbellata","score":0.9829999804496765},{"id":"https://openalex.org/keywords/phytochemical-screening","display_name":"phytochemical screening","score":0.9710000157356262},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.6439999938011169},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C2776409635","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori","level":2,"score":0.8626833558082581},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6975382566452026},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.45712465047836304},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45400333404541016},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.35617345571517944},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30631786584854126},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05738607048988342},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.54117/ijddrr.v3i1.28","doi":"https://doi.org/10.54117/ijddrr.v3i1.28","is_oa":true,"landing_page_url":"https://doi.org/10.54117/ijddrr.v3i1.28","pdf_url":"https://journals.ipsintelligentsia.com/drugdiscoveryupdate/index.php/JDDRR/article/download/28/17","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IPS Journal of Drug Discovery Research and Reviews","raw_type":"journal-article"},{"id":"pmh:oai:ojs2.journals.ipsintelligentsia.com:article/28","doi":null,"is_oa":true,"landing_page_url":"https://journals.ipsintelligentsia.com/drugdiscoveryupdate/index.php/JDDTR/article/view/28","pdf_url":"https://journals.ipsintelligentsia.com/drugdiscoveryupdate/index.php/JDDTR/article/download/28/17","source":{"id":"https://openalex.org/S7407059055","display_name":"Journal of Drug Discovery and Translational Research","issn_l":"3141-5784","issn":["3141-5784"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"3141-5784","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.54117/ijddrr.v3i1.28","doi":"https://doi.org/10.54117/ijddrr.v3i1.28","is_oa":true,"landing_page_url":"https://doi.org/10.54117/ijddrr.v3i1.28","pdf_url":"https://journals.ipsintelligentsia.com/drugdiscoveryupdate/index.php/JDDRR/article/download/28/17","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IPS Journal of Drug Discovery Research and Reviews","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412371306.pdf","grobid_xml":"https://content.openalex.org/works/W4412371306.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W2013243191","https://openalex.org/W1971568933"],"abstract_inverted_index":{"In":[0],"Nigeria,":[1],"the":[2,13,26,105,126,130,161,171,178,183,187,193],"increase":[3],"in":[4,98,160,177],"antibiotic-resistant":[5],"strains":[6],"associated":[7],"with":[8,58],"H.":[9,36,137,142,147,153],"pylori":[10,138,143,148,154],"has":[11],"necessitated":[12],"search":[14],"for":[15,52],"alternative":[16],"therapeutic":[17],"agents":[18],"from":[19,129],"botanical":[20],"sources.":[21],"This":[22],"study":[23,131],"focused":[24],"on":[25],"assessment":[27],"of":[28,30,40,43,75,101,115],"inhibition":[29,185,224],"some":[31],"selected":[32],"medicinal":[33,102],"plants":[34,103],"against":[35,104,225],"pylori.":[37],"A":[38],"total":[39],"186":[41],"each":[42],"stool":[44],"and":[45,50,69,84,94,118,152,168,204,214,220,227],"blood":[46],"samples":[47],"were":[48,63,90,107,122,158,170],"collected":[49],"screened":[51],"HP":[53],"using":[54,65,92,110],"Columbia":[55],"agar":[56],"supplemented":[57],"minor":[59],"nutrients.":[60],"The":[61,72,97],"isolates":[62,106],"characterized":[64],"their":[66],"morphological,":[67],"biochemical":[68],"molecular":[70],"properties.":[71],"phytochemical":[73],"content":[74],"Zingiber":[76],"officinale":[77],"(ZO)":[78],"rhizome,":[79],"Hunteria":[80],"umbellate":[81],"(HU)":[82],"leaves":[83,88],"Neubouda":[85],"laevis":[86],"(NL)":[87],"extracts":[89],"determined":[91],"gravimetric":[93],"spectrophotometric":[95],"methods.":[96],"vitro":[99],"activities":[100],"carried":[108],"out":[109],"agar-well":[111],"diffusion":[112],"method.":[113],"Analysis":[114],"variance":[116],"(ANOVA)":[117],"student":[119],"\u201ct\u201d":[120],"test":[121],"used":[123],"to":[124,202,212],"analyze":[125],"data":[127],"generated":[128],"at":[132,186],"95":[133],"%":[134],"confidence":[135],"level.":[136],"strain":[139,144,149,155],"K154":[140],"(HPK154),":[141],"BS07":[145],"(HPBS07),":[146],"K93":[150],"(HPK93)":[151],"K115":[156],"(HPK115)":[157],"encountered":[159],"study.":[162],"Alkaloids,":[163],"saponins,":[164],"phenolics,":[165],"flavonoids,":[166],"tannins,":[167],"glycosides":[169],"major":[172],"phytochemicals":[173],"significantly":[174],"(P<0.05)":[175],"detected":[176],"plant":[179],"extracts.":[180],"ZO":[181],"showed":[182,222],"highest":[184],"optimal":[188],"concentration":[189],"(250":[190],"mg/ml),":[191],"but":[192],"activity":[194],"was":[195,207,229],"statistically":[196],"non-":[197],"significant":[198,223],"(p\u22650.05)":[199],"when":[200,210],"compared":[201,211],"HU":[203,219],"NL.":[205],"NL+HU+ZO":[206],"most":[208,230],"effective":[209],"single":[213],"double":[215],"combination.":[216],"Therefore,":[217],"ZO,":[218],"NL":[221],"HP,":[226],"ZO+HU+NL":[228],"effective.":[231]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2025-07-13T00:00:00"}