{"id":"https://openalex.org/W4412371149","doi":"https://doi.org/10.48175/ijarsct-28320","title":"Rp-Hplc Method Development and Validation for Simultaneous Determination of Loteprednol Etabonate and Gatifloxacin in Bulk and its Pharmaceutical Dosage Form","display_name":"Rp-Hplc Method Development and Validation for Simultaneous Determination of Loteprednol Etabonate and Gatifloxacin in Bulk and its Pharmaceutical Dosage Form","publication_year":2025,"publication_date":"2025-07-13","ids":{"openalex":"https://openalex.org/W4412371149","doi":"https://doi.org/10.48175/ijarsct-28320"},"language":"en","primary_location":{"id":"doi:10.48175/ijarsct-28320","doi":"https://doi.org/10.48175/ijarsct-28320","is_oa":true,"landing_page_url":"https://doi.org/10.48175/ijarsct-28320","pdf_url":"https://doi.org/10.48175/ijarsct-28320","source":{"id":"https://openalex.org/S5407010211","display_name":"International Journal of Emerging Technologies and Innovative Research","issn_l":"2583-0554","issn":["2583-0554"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Emerging Technologies and Innovative Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.48175/ijarsct-28320","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5118966517","display_name":"Payal V Rathod","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Payal V Rathod","raw_affiliation_strings":["SGSPS Institute of Pharmacy, Akola, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SGSPS Institute of Pharmacy, Akola, Maharashtra, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088927968","display_name":"Lokesh R Gandhi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. R. Gandhi","raw_affiliation_strings":["SGSPS Institute of Pharmacy, Akola, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SGSPS Institute of Pharmacy, Akola, Maharashtra, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049401669","display_name":"N. S. Bhajipale","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. S. Bhajipale","raw_affiliation_strings":["SGSPS Institute of Pharmacy, Akola, Maharashtra, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SGSPS Institute of Pharmacy, Akola, Maharashtra, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10659129,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"210","last_page":"219"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/loteprednol-etabonate","display_name":"loteprednol etabonate","score":1.0},{"id":"https://openalex.org/keywords/gatifloxacin","display_name":"gatifloxacin","score":1.0},{"id":"https://openalex.org/keywords/simultaneous-determination","display_name":"simultaneous determination","score":0.8619999885559082},{"id":"https://openalex.org/keywords/rp-hplc-method-development","display_name":"RP-HPLC method development","score":0.8619999885559082},{"id":"https://openalex.org/keywords/method-validation","display_name":"method validation","score":0.9179999828338623},{"id":"https://openalex.org/keywords/ophthalmic-formulations","display_name":"ophthalmic preparations","score":0.7289999723434448},{"id":"https://openalex.org/keywords/combination-drug-formulation","display_name":"combination drug formulation","score":0.5519999861717224},{"id":"https://openalex.org/keywords/pharmaceutical-quality-control","display_name":"pharmaceutical quality control","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C2777653605","wikidata":"https://www.wikidata.org/wiki/Q2365016","display_name":"Gatifloxacin","level":4,"score":0.8457540273666382},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5408556461334229},{"id":"https://openalex.org/C178855305","wikidata":"https://www.wikidata.org/wiki/Q614304","display_name":"Pharmaceutical sciences","level":2,"score":0.4583719074726105},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.43477532267570496},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37496882677078247},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2722087502479553},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.24551209807395935},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2778512257","wikidata":"https://www.wikidata.org/wiki/Q256602","display_name":"Ciprofloxacin","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.48175/ijarsct-28320","doi":"https://doi.org/10.48175/ijarsct-28320","is_oa":true,"landing_page_url":"https://doi.org/10.48175/ijarsct-28320","pdf_url":"https://doi.org/10.48175/ijarsct-28320","source":{"id":"https://openalex.org/S5407010211","display_name":"International Journal of Emerging Technologies and Innovative Research","issn_l":"2583-0554","issn":["2583-0554"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Emerging Technologies and Innovative Research","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.48175/ijarsct-28320","doi":"https://doi.org/10.48175/ijarsct-28320","is_oa":true,"landing_page_url":"https://doi.org/10.48175/ijarsct-28320","pdf_url":"https://doi.org/10.48175/ijarsct-28320","source":{"id":"https://openalex.org/S5407010211","display_name":"International Journal of Emerging Technologies and Innovative Research","issn_l":"2583-0554","issn":["2583-0554"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Emerging Technologies and Innovative Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412371149.pdf","grobid_xml":"https://content.openalex.org/works/W4412371149.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W1986635081","https://openalex.org/W1992788348","https://openalex.org/W2017420343","https://openalex.org/W2033892059","https://openalex.org/W2145676971","https://openalex.org/W2168890940","https://openalex.org/W2910394867"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2899084033","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W4391375266","https://openalex.org/W3032801088","https://openalex.org/W1991230616","https://openalex.org/W2026391790"],"abstract_inverted_index":{"The":[0,75,123,148],"simultaneous":[1],"measurement":[2],"of":[3,23,77,130,136,174,196],"loteprednol":[4],"etabonate":[5],"(LOTE)":[6],"and":[7,12,21,28,53,66,91,95,112,125,133,139,142,145,153,176,184],"Gatifloxacin":[8],"(GATI)":[9],"in":[10,158,178],"bulk":[11],"pharmaceutical":[13],"dose":[14],"forms":[15],"was":[16,46,70,79,83],"accomplished":[17],"through":[18],"the":[19,49,62,67,86,107,197],"development":[20],"validation":[22],"a":[24],"straightforward,":[25],"quick,":[26],"accurate,":[27],"precise":[29],"reversed-phase":[30],"high-performance":[31],"liquid":[32],"chromatographic":[33,50],"(RP-HPLC)":[34],"method.":[35,199],"A":[36],"Grace":[37],"C18":[38],"column":[39],"(4.6":[40],"\u00d7":[41],"250":[42],"mm,":[43],"5":[44],"\u00b5m)":[45],"used":[47,60,168],"for":[48,89,169],"separation.":[51],"Acetonitrile":[52],"phosphate":[54],"buffer":[55],"(65:35,":[56],"pH":[57],"4)":[58],"were":[59,93],"as":[61],"isocratic":[63],"mobile":[64],"phase,":[65],"flow":[68],"rate":[69],"set":[71],"at":[72],"1.0":[73],"mL/min.":[74],"wavelength":[76],"detection":[78,131],"271":[80],"nm.":[81],"It":[82],"discovered":[84],"that":[85],"retention":[87],"durations":[88],"GATI":[90,126,177],"LOTE":[92,124,175],"4.21":[94],"7.13":[96],"minutes,":[97],"respectively.":[98],"With":[99],"recovery":[100],"percentages":[101],"ranging":[102],"from":[103,189],"98":[104],"to":[105],"102%,":[106],"approach":[108],"demonstrated":[109,150],"good":[110],"accuracy":[111],"high":[113],"precision,":[114],"with":[115,160],"relative":[116],"standard":[117],"deviation":[118],"(RSD)":[119],"values":[120],"<":[121],"2%.":[122],"had":[127],"respective":[128],"limits":[129],"(LOD)":[132],"quantification":[134],"(LOQ)":[135],"0.981":[137],"\u00b5g/mL":[138,141,144],"2.78":[140],"0.865":[143],"1.68":[146],"\u00b5g/mL.":[147],"technique":[149],"specificity,":[151],"robustness,":[152],"reproducibility":[154],"after":[155],"being":[156],"validated":[157],"accordance":[159],"ICH":[161],"criteria.":[162],"As":[163],"such,":[164],"it":[165],"can":[166],"be":[167],"routine":[170],"quality":[171],"control":[172],"analysis":[173,186],"combination":[179],"ophthalmic":[180],"formulations.":[181],"Simple,":[182],"economical,":[183],"quick":[185],"without":[187],"interference":[188],"excipients":[190],"or":[191],"degradation":[192],"products":[193],"are":[194],"benefits":[195],"developed":[198]},"counts_by_year":[],"updated_date":"2026-08-22T07:34:49.880490","created_date":"2025-10-10T00:00:00"}