{"id":"https://openalex.org/W4412359554","doi":"https://doi.org/10.21608/edj.2025.382689.3467","title":"The Antimicrobial Efficacy of Modified Salt Solutions Against E. faecalis Biofilms: An Ex-Vivo Study","display_name":"The Antimicrobial Efficacy of Modified Salt Solutions Against E. faecalis Biofilms: An Ex-Vivo Study","publication_year":2025,"publication_date":"2025-07-01","ids":{"openalex":"https://openalex.org/W4412359554","doi":"https://doi.org/10.21608/edj.2025.382689.3467"},"language":"en","primary_location":{"id":"doi:10.21608/edj.2025.382689.3467","doi":"https://doi.org/10.21608/edj.2025.382689.3467","is_oa":false,"landing_page_url":"https://doi.org/10.21608/edj.2025.382689.3467","pdf_url":null,"source":{"id":"https://openalex.org/S2754641887","display_name":"Egyptian Dental Journal /Egyptian Dental Journal","issn_l":"0070-9484","issn":["0070-9484","2090-2360"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4324001494","host_organization_name":"The Egyptian Dental Association","host_organization_lineage":["https://openalex.org/P4324001494"],"host_organization_lineage_names":["The Egyptian Dental Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Egyptian Dental Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069435620","display_name":"Sherif Heidar","orcid":"https://orcid.org/0000-0002-7198-9595","observed_orcids":["https://orcid.org/0000-0002-7198-9595"]},"institutions":[{"id":"https://openalex.org/I130009713","display_name":"Suez University","ror":"https://ror.org/00ndhrx30","country_code":"EG","type":"education","lineage":["https://openalex.org/I130009713"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Sherif Heidar","raw_affiliation_strings":["Lecturer, Endodontics Department, Faculty of Dentistry, Suez University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lecturer, Endodontics Department, Faculty of Dentistry, Suez University","institution_ids":["https://openalex.org/I130009713"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080585535","display_name":"Iman Fathy","orcid":"https://orcid.org/0000-0002-5219-2740","observed_orcids":["https://orcid.org/0000-0002-5219-2740"]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Iman Ahmed Fathy","raw_affiliation_strings":["Associate Professor, Oral Biology Department (Stem Cells Research Unit), Faculty of Dentistry, Ain Shams University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Associate Professor, Oral Biology Department (Stem Cells Research Unit), Faculty of Dentistry, Ain Shams University","institution_ids":["https://openalex.org/I107720978"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111581119","display_name":"Samia Elsherief","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]},{"id":"https://openalex.org/I199693650","display_name":"Umm al-Qura University","ror":"https://ror.org/01xjqrm90","country_code":"SA","type":"education","lineage":["https://openalex.org/I199693650"]}],"countries":["EG","SA"],"is_corresponding":false,"raw_author_name":"Samia Mohamed Elsherief","raw_affiliation_strings":["Professor, Endodontics Department, Faculty of Dentistry, Umm Al-Qura University; Cairo University","Cairo University","Professor, Endodontics Department, Faculty of Dentistry, Umm Al-Qura University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor, Endodontics Department, Faculty of Dentistry, Umm Al-Qura University; Cairo University","institution_ids":["https://openalex.org/I145487455","https://openalex.org/I199693650"]},{"raw_affiliation_string":"Cairo University","institution_ids":["https://openalex.org/I145487455"]},{"raw_affiliation_string":"Professor, Endodontics Department, Faculty of Dentistry, Umm Al-Qura University","institution_ids":["https://openalex.org/I199693650"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7093,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.62468115,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"71","issue":"3","first_page":"2725","last_page":"2733"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10536","display_name":"Endodontics and Root Canal Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10536","display_name":"Endodontics and Root Canal Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12744","display_name":"Medical Device Sterilization and Disinfection","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10113","display_name":"Dental materials and restorations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enterococcus-faecalis","display_name":"Enterococcus faecalis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/bacterial-biofilms","display_name":"bacterial biofilms","score":0.7390000224113464},{"id":"https://openalex.org/keywords/root-canal-irrigation","display_name":"root canal irrigation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/sodium-hypochlorite","display_name":"sodium hypochlorite","score":0.9869999885559082},{"id":"https://openalex.org/keywords/endodontic-disinfection","display_name":"endodontic disinfection","score":0.699999988079071},{"id":"https://openalex.org/keywords/dentin","display_name":"dentin","score":0.7059999704360962},{"id":"https://openalex.org/keywords/antimicrobial-efficacy","display_name":"antimicrobial efficacy","score":0.7689999938011169},{"id":"https://openalex.org/keywords/live-dead-staining","display_name":"live/dead staining","score":0.6539999842643738},{"id":"https://openalex.org/keywords/confocal-laser-scanning-microscopy","display_name":"confocal laser scanning microscopy","score":0.9190000295639038}],"concepts":[{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.8968710899353027},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.6942002177238464},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.6746203303337097},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5781325697898865},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48815423250198364},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.19553706049919128},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17880487442016602},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.15147295594215393},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09489652514457703},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21608/edj.2025.382689.3467","doi":"https://doi.org/10.21608/edj.2025.382689.3467","is_oa":false,"landing_page_url":"https://doi.org/10.21608/edj.2025.382689.3467","pdf_url":null,"source":{"id":"https://openalex.org/S2754641887","display_name":"Egyptian Dental Journal /Egyptian Dental Journal","issn_l":"0070-9484","issn":["0070-9484","2090-2360"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4324001494","host_organization_name":"The Egyptian Dental Association","host_organization_lineage":["https://openalex.org/P4324001494"],"host_organization_lineage_names":["The Egyptian Dental Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Egyptian Dental Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2066475248","https://openalex.org/W1486215602","https://openalex.org/W1991447132","https://openalex.org/W2389826445","https://openalex.org/W1128257185","https://openalex.org/W7119324836","https://openalex.org/W1539798223","https://openalex.org/W2594342543","https://openalex.org/W2004300076","https://openalex.org/W3201542761"],"abstract_inverted_index":{"Objectives:":[0],"The":[1,133],"aim":[2],"of":[3,12,94,101],"this":[4],"study":[5],"was":[6,67,152],"to":[7,40,56,148,183],"investigate":[8],"the":[9,46,149],"disinfecting":[10],"effect":[11],"a":[13],"modified":[14,75],"salt":[15,76],"solution":[16,77],"(MSS)":[17,78],"on":[18],"Enterococcus":[19],"faecalis":[20,34,145,164,176],"biofilms":[21],"in":[22,45,161,166,178],"ex-vivo":[23],"model.Methods:":[24],"Eighteen":[25],"human":[26],"dentine":[27,62,87],"sections":[28,63,88],"were":[29,89,105,116],"standardized,":[30],"inoculated":[31],"with":[32,69,74,81,91,180],"E.":[33,102,144,163,175],"and":[35,79,104,140,159],"incubated":[36],"for":[37,98,129],"three":[38],"weeks":[39],"ensure":[41],"bacterial":[42],"biofilm":[43,177],"maturation":[44],"root":[47],"canal":[48],"space.":[49],"Then":[50],"samples":[51],"will":[52],"be":[53],"allocated":[54],"according":[55],"irrigation":[57],"into":[58],"3":[59],"groups":[60,115],"(6":[61],"each):":[64],"GI":[65],"(Control)":[66],"irrigated":[68,73],"distilled":[70],"water,":[71],"GII":[72],"GIII":[80],"sodium":[82],"hypochlorite":[83],"(NaOCl)":[84],"irrigation.":[85],"Afterwards":[86],"stained":[90],"1:1":[92],"mixture":[93],"Syto":[95],"9/propidium":[96],"iodide":[97],"LIVE/DEAD":[99],"staining":[100],"faecalis,":[103],"analyzed":[106],"under":[107],"conofocal":[108],"laser":[109],"scanning":[110],"microscopy":[111],"(CLSM).":[112],"Comparisons":[113],"between":[114,157],"done":[117],"by":[118,124],"One":[119],"Way":[120],"ANOVA":[121],"test":[122,128],"followed":[123],"Tukey\u2019s":[125],"post":[126],"hoc":[127],"multiple":[130],"comparisons.":[131],"Results:":[132],"results":[134],"showed":[135],"that":[136],"both":[137],"irrigants":[138],"NaOCL":[139],"MSS":[141,158,170],"dramatically":[142],"increased":[143],"death":[146],"compared":[147],"control.":[150],"There":[151],"no":[153],"statistically":[154],"significant":[155],"difference":[156],"NaOCl":[160],"dead":[162],"detected":[165],"CLSM":[167],"images.":[168],"Conclusion:":[169],"is":[171],"potent":[172],"antimicrobial":[173],"against":[174],"dentine,":[179],"efficacy":[181],"comparable":[182],"NaOCl.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-10-10T00:00:00"}