{"id":"https://openalex.org/W4412349160","doi":"https://doi.org/10.1021/jacs.5c06039","title":"Engineered Nano-Micro Pyroptosis Generators: A Magnetic-Metallo-Immunotherapeutic Strategy to Reinforce Transarterial Embolization","display_name":"Engineered Nano-Micro Pyroptosis Generators: A Magnetic-Metallo-Immunotherapeutic Strategy to Reinforce Transarterial Embolization","publication_year":2025,"publication_date":"2025-07-11","ids":{"openalex":"https://openalex.org/W4412349160","doi":"https://doi.org/10.1021/jacs.5c06039","pmid":"https://pubmed.ncbi.nlm.nih.gov/40644662"},"language":"en","primary_location":{"id":"doi:10.1021/jacs.5c06039","doi":"https://doi.org/10.1021/jacs.5c06039","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jacs.5c06039","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040667277","display_name":"Di Wang","orcid":"https://orcid.org/0000-0002-0412-7813","observed_orcids":["https://orcid.org/0000-0002-0412-7813","https://orcid.org/0009-0003-9641-8179"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Di Wang","raw_affiliation_strings":["Department of Interventional Radiology","Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices","Soochow University","The Second Affiliated Hospital of Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Interventional Radiology","institution_ids":[]},{"raw_affiliation_string":"Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices","institution_ids":[]},{"raw_affiliation_string":"Soochow University","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"The Second Affiliated Hospital of Soochow University","institution_ids":["https://openalex.org/I4210124971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085282277","display_name":"Linzhu Zhang","orcid":"https://orcid.org/0000-0002-0142-7714","observed_orcids":["https://orcid.org/0000-0002-0142-7714"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]},{"id":"https://openalex.org/I4210105806","display_name":"Zhongda Hospital Southeast University","ror":"https://ror.org/01k3hq685","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105806"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linzhu Zhang","raw_affiliation_strings":["Center of Interventional Radiology & Vascular Surgery, Department of Radiology, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology (Southeast University), Basic Medicine Research and Innovation Center of Ministry of Education, Zhongda Hospital, Medical School, Southeast University, 87 Dingjiaqiao Road, Nanjing 210009, China","Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices","Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Interventional Radiology & Vascular Surgery, Department of Radiology, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology (Southeast University), Basic Medicine Research and Innovation Center of Ministry of Education, Zhongda Hospital, Medical School, Southeast University, 87 Dingjiaqiao Road, Nanjing 210009, China","institution_ids":["https://openalex.org/I4210105806","https://openalex.org/I76569877"]},{"raw_affiliation_string":"Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices","institution_ids":[]},{"raw_affiliation_string":"Soochow University","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104329938","display_name":"Jihu Nie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jihu Nie","raw_affiliation_strings":["Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices","Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices","institution_ids":[]},{"raw_affiliation_string":"Soochow University","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050967786","display_name":"Nailin Yang","orcid":"https://orcid.org/0000-0001-8825-2437","observed_orcids":["https://orcid.org/0000-0001-8825-2437"]},"institutions":[{"id":"https://openalex.org/I111950717","display_name":"Macau University of Science and Technology","ror":"https://ror.org/03jqs2n27","country_code":"MO","type":"education","lineage":["https://openalex.org/I111950717","https://openalex.org/I4391767947"]},{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN","MO"],"is_corresponding":true,"raw_author_name":"Nailin Yang","raw_affiliation_strings":["Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices","Macao Institute of Materials Science and Engineering","Macau University of Science and Technology","Soochow University"],"raw_orcid":"https://orcid.org/0000-0001-8825-2437","affiliations":[{"raw_affiliation_string":"Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices","institution_ids":[]},{"raw_affiliation_string":"Macao Institute of Materials Science and Engineering","institution_ids":["https://openalex.org/I111950717"]},{"raw_affiliation_string":"Macau University of Science and Technology","institution_ids":["https://openalex.org/I111950717"]},{"raw_affiliation_string":"Soochow University","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101066470","display_name":"Shumin Sun","orcid":"https://orcid.org/0009-0004-5449-0874","observed_orcids":["https://orcid.org/0009-0004-5449-0874"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shumin Sun","raw_affiliation_strings":["Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices","Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices","institution_ids":[]},{"raw_affiliation_string":"Soochow University","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100668510","display_name":"Chunjie Wang","orcid":"https://orcid.org/0000-0002-5001-0552","observed_orcids":["https://orcid.org/0000-0002-5001-0552"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunjie Wang","raw_affiliation_strings":["Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices","Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices","institution_ids":[]},{"raw_affiliation_string":"Soochow University","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zifan Pei","orcid":"https://orcid.org/0009-0001-6166-9678","observed_orcids":["https://orcid.org/0009-0001-6166-9678"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zifan Pei","raw_affiliation_strings":["Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices","Soochow University"],"raw_orcid":"https://orcid.org/0009-0001-6166-9678","affiliations":[{"raw_affiliation_string":"Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices","institution_ids":[]},{"raw_affiliation_string":"Soochow University","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059848031","display_name":"Fei Gong","orcid":"https://orcid.org/0000-0002-7603-8553","observed_orcids":["https://orcid.org/0000-0002-7603-8553"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Gong","raw_affiliation_strings":["Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices","Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices","institution_ids":[]},{"raw_affiliation_string":"Soochow University","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087330480","display_name":"Xingwei Sun","orcid":"https://orcid.org/0000-0002-6639-145X","observed_orcids":["https://orcid.org/0000-0002-6639-145X"]},"institutions":[{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xingwei Sun","raw_affiliation_strings":["Department of Interventional Radiology","The Second Affiliated Hospital of Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Interventional Radiology","institution_ids":[]},{"raw_affiliation_string":"The Second Affiliated Hospital of Soochow University","institution_ids":["https://openalex.org/I4210124971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036587412","display_name":"Yong Xun Jin","orcid":"https://orcid.org/0000-0003-2536-2270","observed_orcids":["https://orcid.org/0000-0003-2536-2270"]},"institutions":[{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yong Jin","raw_affiliation_strings":["Department of Interventional Radiology","The Second Affiliated Hospital of Soochow University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Interventional Radiology","institution_ids":[]},{"raw_affiliation_string":"The Second Affiliated Hospital of Soochow University","institution_ids":["https://openalex.org/I4210124971"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028364292","display_name":"Liang Cheng","orcid":"https://orcid.org/0000-0001-5324-9094","observed_orcids":["https://orcid.org/0000-0001-5324-9094"]},"institutions":[{"id":"https://openalex.org/I111950717","display_name":"Macau University of Science and Technology","ror":"https://ror.org/03jqs2n27","country_code":"MO","type":"education","lineage":["https://openalex.org/I111950717","https://openalex.org/I4391767947"]},{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN","MO"],"is_corresponding":true,"raw_author_name":"Liang Cheng","raw_affiliation_strings":["Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices","Macao Institute of Materials Science and Engineering","Macau University of Science and Technology","Soochow University"],"raw_orcid":"https://orcid.org/0000-0001-5324-9094","affiliations":[{"raw_affiliation_string":"Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices","institution_ids":[]},{"raw_affiliation_string":"Macao Institute of Materials Science and Engineering","institution_ids":["https://openalex.org/I111950717"]},{"raw_affiliation_string":"Macau University of Science and Technology","institution_ids":["https://openalex.org/I111950717"]},{"raw_affiliation_string":"Soochow University","institution_ids":["https://openalex.org/I3923682"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5028364292","https://openalex.org/A5036587412","https://openalex.org/A5050967786","https://openalex.org/A5087330480"],"corresponding_institution_ids":["https://openalex.org/I111950717","https://openalex.org/I3923682","https://openalex.org/I4210124971"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":9.0525,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.98990291,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"147","issue":"29","first_page":"25536","last_page":"25552"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyroptosis","display_name":"pyroptosis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/gasdermin","display_name":"gasdermin","score":0.8679999709129333},{"id":"https://openalex.org/keywords/magnetic-hyperthermia","display_name":"magnetic hyperthermia","score":0.9639999866485596},{"id":"https://openalex.org/keywords/transcatheter-arterial-embolization","display_name":"transcatheter arterial embolization","score":0.9240000247955322},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9459999799728394},{"id":"https://openalex.org/keywords/magnetic-beads","display_name":"magnetic beads","score":0.9259999990463257},{"id":"https://openalex.org/keywords/microfluidic-assembly","display_name":"microfluidic assembly","score":0.7210000157356262},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.8289999961853027},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.7229999899864197},{"id":"https://openalex.org/keywords/metal-ion-release","display_name":"metal ion release","score":0.4189999997615814}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9265594482421875},{"id":"https://openalex.org/C2780357685","wikidata":"https://www.wikidata.org/wiki/Q154357","display_name":"Nano-","level":2,"score":0.6758882999420166},{"id":"https://openalex.org/C17172800","wikidata":"https://www.wikidata.org/wiki/Q7263707","display_name":"Pyroptosis","level":4,"score":0.6213169693946838},{"id":"https://openalex.org/C2909913126","wikidata":"https://www.wikidata.org/wiki/Q221788","display_name":"Transarterial embolization","level":3,"score":0.5229395627975464},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5079227089881897},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.33118438720703125},{"id":"https://openalex.org/C2776035437","wikidata":"https://www.wikidata.org/wiki/Q1144114","display_name":"Embolization","level":2,"score":0.2594672441482544},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.22578465938568115},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09110599756240845},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.085563063621521},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.06546491384506226},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000069292","descriptor_name":"Pyroptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003035","descriptor_name":"Cobalt","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004621","descriptor_name":"Embolization, Therapeutic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006979","descriptor_name":"Hyperthermia, Induced","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jacs.5c06039","doi":"https://doi.org/10.1021/jacs.5c06039","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jacs.5c06039","pdf_url":null,"source":{"id":"https://openalex.org/S111155417","display_name":"Journal of the American Chemical Society","issn_l":"0002-7863","issn":["0002-7863","1520-5126","1943-2984"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"journal-article"},{"id":"pmid:40644662","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40644662","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Chemical Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1554548555","display_name":null,"funder_award_id":"2022YFB3804600","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"},{"id":"https://openalex.org/G3490241005","display_name":null,"funder_award_id":"ZD2022024","funder_id":"https://openalex.org/F4320321605","funder_display_name":"Government of Jiangsu Province"},{"id":"https://openalex.org/G5615360316","display_name":null,"funder_award_id":"52403386","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7921356028","display_name":null,"funder_award_id":"52472288","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321540","display_name":"Ministry of Science and Technology of the People's Republic of China","ror":"https://ror.org/027s68j25"},{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"},{"id":"https://openalex.org/F4320327610","display_name":"Collaborative Innovation Center of Suzhou Nano Science and Technology","ror":"https://ror.org/03h3fdc41"},{"id":"https://openalex.org/F4320327912","display_name":"Higher Education Discipline Innovation Project","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W2095520368","https://openalex.org/W2536322725","https://openalex.org/W2790388651","https://openalex.org/W3035149654","https://openalex.org/W3036239514","https://openalex.org/W3158770259","https://openalex.org/W3175722140","https://openalex.org/W3196303006","https://openalex.org/W3206266376","https://openalex.org/W4205989084","https://openalex.org/W4220733450","https://openalex.org/W4221075119","https://openalex.org/W4225002645","https://openalex.org/W4280583271","https://openalex.org/W4307501138","https://openalex.org/W4315620714","https://openalex.org/W4319060610","https://openalex.org/W4319335912","https://openalex.org/W4322487713","https://openalex.org/W4323321646","https://openalex.org/W4323350397","https://openalex.org/W4324020235","https://openalex.org/W4324046169","https://openalex.org/W4324329595","https://openalex.org/W4367310714","https://openalex.org/W4367367416","https://openalex.org/W4378211891","https://openalex.org/W4378978149","https://openalex.org/W4384830962","https://openalex.org/W4388213718","https://openalex.org/W4388767321","https://openalex.org/W4389372839","https://openalex.org/W4390946922","https://openalex.org/W4390972061","https://openalex.org/W4391027208","https://openalex.org/W4391141097","https://openalex.org/W4391221114","https://openalex.org/W4391917990","https://openalex.org/W4391942976","https://openalex.org/W4392938370","https://openalex.org/W4393029085","https://openalex.org/W4393155455","https://openalex.org/W4396683758","https://openalex.org/W4396802173","https://openalex.org/W4398163446","https://openalex.org/W4399756522","https://openalex.org/W4399916757","https://openalex.org/W4400692890","https://openalex.org/W4401327669","https://openalex.org/W4401632739","https://openalex.org/W4402567524","https://openalex.org/W4402710104","https://openalex.org/W4403609461","https://openalex.org/W4403895432","https://openalex.org/W4404258064","https://openalex.org/W4404876143","https://openalex.org/W4405997872","https://openalex.org/W4406188148","https://openalex.org/W4406534809","https://openalex.org/W4407131500","https://openalex.org/W4407331046","https://openalex.org/W4407634458","https://openalex.org/W4407738817","https://openalex.org/W4408772741"],"related_works":["https://openalex.org/W4399756522","https://openalex.org/W2947909393","https://openalex.org/W4386617976","https://openalex.org/W7132814619","https://openalex.org/W2999895618","https://openalex.org/W4416732885","https://openalex.org/W4220724859","https://openalex.org/W4319878069","https://openalex.org/W4388527659","https://openalex.org/W7127423901"],"abstract_inverted_index":{"Gasdermin-mediated":[0],"pyroptosis":[1,21,48,150],"represents":[2],"a":[3],"promising":[4],"immunotherapeutic":[5],"strategy,":[6],"yet":[7],"requires":[8],"precise":[9],"tumor-specific":[10],"activation.":[11],"Magnetic":[12],"hyperthermia":[13,132],"therapy":[14,177],"(MHT)":[15],"has":[16],"the":[17,107,120,156,162,189,210],"potential":[18],"to":[19,208],"induce":[20],"in":[22,151],"hepatocellular":[23],"carcinoma":[24],"(HCC),":[25],"while":[26,133,214],"its":[27],"efficacy":[28,163,186],"is":[29],"limited":[30],"by":[31,45],"suboptimal":[32],"heating":[33],"efficiency":[34],"and":[35,57,88,112,130,159,187,195],"tumor":[36,212],"resistance.":[37],"Herein,":[38],"we":[39],"developed":[40],"an":[41,115,205],"innovative":[42],"magnetic-metallo-immunotherapeutic":[43],"platform":[44,171],"engineering":[46],"nanomicro":[47],"generators,":[49],"thereby":[50,160],"enhancing":[51,161,184],"transarterial":[52],"embolization":[53],"(TAE).":[54],"Through":[55],"compositional":[56],"structural":[58],"optimization,":[59],"Zn\u2013Fe":[60],"3":[61,65,71,122,200],"O":[62,66,72,123,201],"4":[63,67,73,124,202],"@Co\u2013Fe":[64],"core\u2013shell":[68],"nanocubes":[69,92],"(ZnCo\u2013Fe":[70],"CSNCs)":[74],"with":[75,103,172],"enhanced":[76],"magnetothermal":[77],"properties":[78],"were":[79,93],"obtained,":[80],"which":[81],"exhibited":[82],"significantly":[83],"improved":[84],"saturation":[85],"magnetization":[86],"(Ms)":[87],"coercivity":[89],"(Hc).":[90],"These":[91],"further":[94],"assembled":[95],"via":[96],"microfluidic":[97],"technology":[98],"into":[99],"magnetic":[100,117],"microspheres":[101],"(MSs)":[102],"tunable":[104],"sizes,":[105],"integrating":[106],"therapeutic":[108,146],"functions":[109],"of":[110,164,169,191],"TAE":[111,217],"MHT.":[113],"Under":[114],"alternating":[116],"field":[118],"(AMF),":[119],"ZnCo\u2013Fe":[121,199],"MSs":[125,203],"demonstrated":[126,204],"temperature-dependent":[127],"ion":[128],"release":[129],"localized":[131],"simultaneously":[134],"inhibiting":[135],"heat":[136],"shock":[137],"protein":[138],"(HSP)":[139],"upregulation":[140],"through":[141,219],"metabolic":[142],"interference.":[143],"This":[144],"orchestrated":[145],"cascade":[147],"effectively":[148],"triggered":[149],"cancer":[152,236],"cells,":[153],"subsequently":[154],"activating":[155],"immune":[157,173,181],"response":[158],"magnetic-metallo-immunotherapy.":[165],"The":[166],"strategic":[167],"combination":[168],"this":[170,225],"checkpoint":[174],"blockade":[175],"(ICB)":[176],"provoked":[178],"comprehensive":[179],"systemic":[180],"activation,":[182],"markedly":[183],"treatment":[185],"suppressing":[188],"progression":[190],"both":[192],"primary":[193],"tumors":[194],"distant":[196],"tumors.":[197],"Notably,":[198],"exceptional":[206],"capacity":[207],"modulate":[209],"immunosuppressive":[211],"niche":[213],"substantially":[215],"improving":[216],"performance":[218],"their":[220],"unique":[221],"embolization-immunomodulation":[222],"functionality.":[223],"Overall,":[224],"study":[226],"highlights":[227],"new":[228],"avenues":[229],"for":[230,234],"exploring":[231],"pyroptosis-mediated":[232],"magnetic-metallo-immunotherapy":[233],"effective":[235],"therapy.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":35},{"year":2025,"cited_by_count":10}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2025-10-10T00:00:00"}
