{"id":"https://openalex.org/W4412178397","doi":"https://doi.org/10.3390/life15071081","title":"Centella asiatica: Advances in Extraction Technologies, Phytochemistry, and Therapeutic Applications","display_name":"Centella asiatica: Advances in Extraction Technologies, Phytochemistry, and Therapeutic Applications","publication_year":2025,"publication_date":"2025-07-09","ids":{"openalex":"https://openalex.org/W4412178397","doi":"https://doi.org/10.3390/life15071081","pmid":"https://pubmed.ncbi.nlm.nih.gov/40724583","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12298232"},"language":"en","primary_location":{"id":"doi:10.3390/life15071081","doi":"https://doi.org/10.3390/life15071081","is_oa":true,"landing_page_url":"https://doi.org/10.3390/life15071081","pdf_url":"https://www.mdpi.com/2075-1729/15/7/1081/pdf?version=1752045024","source":{"id":"https://openalex.org/S4210200765","display_name":"Life","issn_l":"2075-1729","issn":["2075-1729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2075-1729/15/7/1081/pdf?version=1752045024","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067353376","display_name":"Zaw Myo Hein","orcid":"https://orcid.org/0000-0001-7621-7132","observed_orcids":["https://orcid.org/0000-0001-7621-7132","https://orcid.org/0000-0002-6720-074X"]},"institutions":[{"id":"https://openalex.org/I182000528","display_name":"Ajman University","ror":"https://ror.org/01j1rma10","country_code":"AE","type":"education","lineage":["https://openalex.org/I182000528"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Zaw Myo Hein","raw_affiliation_strings":["Department of Basic Medical Sciences, College of Medicine, Ajman University, Ajman P.O. BOX 346, United Arab Emirates"],"raw_orcid":"https://orcid.org/0000-0001-7621-7132","affiliations":[{"raw_affiliation_string":"Department of Basic Medical Sciences, College of Medicine, Ajman University, Ajman P.O. BOX 346, United Arab Emirates","institution_ids":["https://openalex.org/I182000528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093411157","display_name":"Prarthana Kalerammana Gopalakrishna","orcid":"https://orcid.org/0000-0002-1428-5305","observed_orcids":["https://orcid.org/0000-0002-1428-5305"]},"institutions":[{"id":"https://openalex.org/I62370553","display_name":"IMU University","ror":"https://ror.org/04d4wjw61","country_code":"MY","type":"education","lineage":["https://openalex.org/I62370553"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Prarthana Kalerammana Gopalakrishna","raw_affiliation_strings":["Physiology Discipline, Human Biology Division, School of Medicine, IMU University, Kuala Lumpur 57000, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology Discipline, Human Biology Division, School of Medicine, IMU University, Kuala Lumpur 57000, Malaysia","institution_ids":["https://openalex.org/I62370553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116465364","display_name":"Anil Kumar Kanuri","orcid":"https://orcid.org/0000-0002-1350-7148","observed_orcids":["https://orcid.org/0000-0002-1350-7148"]},"institutions":[{"id":"https://openalex.org/I33849332","display_name":"University of Malaya","ror":"https://ror.org/00rzspn62","country_code":"MY","type":"education","lineage":["https://openalex.org/I33849332"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Anil Kumar Kanuri","raw_affiliation_strings":["Department of Pharmaceutical Technology, Faculty of Pharmacy, Universiti Malaya, Kuala Lumpur 50603, Malaysia"],"raw_orcid":"https://orcid.org/0000-0002-1350-7148","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Technology, Faculty of Pharmacy, Universiti Malaya, Kuala Lumpur 50603, Malaysia","institution_ids":["https://openalex.org/I33849332"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075802397","display_name":"Warren Thomas","orcid":"https://orcid.org/0000-0003-2706-1770","observed_orcids":["https://orcid.org/0000-0003-2706-1770"]},"institutions":[{"id":"https://openalex.org/I248769658","display_name":"Royal College of Surgeons in Ireland - Bahrain","ror":"https://ror.org/01h4bh480","country_code":"BH","type":"education","lineage":["https://openalex.org/I142762351","https://openalex.org/I248769658"]}],"countries":["BH"],"is_corresponding":false,"raw_author_name":"Warren Thomas","raw_affiliation_strings":["Department of Human Biology, Royal College of Surgeons in Ireland, Medical University of Bahrain, Al Sayh P.O. Box 15503, Bahrain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Biology, Royal College of Surgeons in Ireland, Medical University of Bahrain, Al Sayh P.O. Box 15503, Bahrain","institution_ids":["https://openalex.org/I248769658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045541640","display_name":"Farida Hussan","orcid":"https://orcid.org/0000-0002-0197-4646","observed_orcids":["https://orcid.org/0000-0002-0197-4646"]},"institutions":[{"id":"https://openalex.org/I62370553","display_name":"IMU University","ror":"https://ror.org/04d4wjw61","country_code":"MY","type":"education","lineage":["https://openalex.org/I62370553"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Farida Hussan","raw_affiliation_strings":["Anatomy Discipline, Human Biology Division, School of Medicine, IMU University, Kuala Lumpur 57000, Malaysia"],"raw_orcid":"https://orcid.org/0000-0002-0197-4646","affiliations":[{"raw_affiliation_string":"Anatomy Discipline, Human Biology Division, School of Medicine, IMU University, Kuala Lumpur 57000, Malaysia","institution_ids":["https://openalex.org/I62370553"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112091582","display_name":"V. R. Naik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405256456","display_name":"Universiti Tunku Abdul Rahman Sungai Long Campus","ror":"https://ror.org/046b54093","country_code":"MY","type":"education","lineage":["https://openalex.org/I4405256456","https://openalex.org/I931681460"]},{"id":"https://openalex.org/I931681460","display_name":"Universiti Tunku Abdul Rahman","ror":"https://ror.org/050pq4m56","country_code":"MY","type":"education","lineage":["https://openalex.org/I931681460"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Venkatesh R. Naik","raw_affiliation_strings":["Department of Preclinical Sciences, Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Kajang 43000, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preclinical Sciences, Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Kajang 43000, Malaysia","institution_ids":["https://openalex.org/I4405256456","https://openalex.org/I931681460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068341345","display_name":"Nisha Shantakumari","orcid":"https://orcid.org/0000-0002-1140-599X","observed_orcids":["https://orcid.org/0000-0002-1140-599X"]},"institutions":[{"id":"https://openalex.org/I182000528","display_name":"Ajman University","ror":"https://ror.org/01j1rma10","country_code":"AE","type":"education","lineage":["https://openalex.org/I182000528"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Nisha Shantakumari","raw_affiliation_strings":["Department of Basic Medical Sciences, College of Medicine, Ajman University, Ajman P.O. BOX 346, United Arab Emirates"],"raw_orcid":"https://orcid.org/0000-0002-1140-599X","affiliations":[{"raw_affiliation_string":"Department of Basic Medical Sciences, College of Medicine, Ajman University, Ajman P.O. BOX 346, United Arab Emirates","institution_ids":["https://openalex.org/I182000528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062351713","display_name":"Muhammad Danial Che Ramli","orcid":"https://orcid.org/0000-0002-5261-0391","observed_orcids":["https://orcid.org/0000-0002-5261-0391"]},"institutions":[{"id":"https://openalex.org/I1336834208","display_name":"Management and Science University","ror":"https://ror.org/027zr9y17","country_code":"MY","type":"education","lineage":["https://openalex.org/I1336834208"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Muhammad Danial Che Ramli","raw_affiliation_strings":["Department of Diagnostic and Allied Health Science, Faculty of Health and Life Sciences, Management and Science University, Shah Alam 40100, Malaysia"],"raw_orcid":"https://orcid.org/0000-0002-5261-0391","affiliations":[{"raw_affiliation_string":"Department of Diagnostic and Allied Health Science, Faculty of Health and Life Sciences, Management and Science University, Shah Alam 40100, Malaysia","institution_ids":["https://openalex.org/I1336834208"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053662595","display_name":"Mohamad Aris Mohd Moklas","orcid":"https://orcid.org/0000-0002-9282-129X","observed_orcids":["https://orcid.org/0000-0002-9282-129X"]},"institutions":[{"id":"https://openalex.org/I130343225","display_name":"Universiti Putra Malaysia","ror":"https://ror.org/02e91jd64","country_code":"MY","type":"education","lineage":["https://openalex.org/I130343225"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Mohamad Aris Mohd Moklas","raw_affiliation_strings":["Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia"],"raw_orcid":"https://orcid.org/0000-0002-9282-129X","affiliations":[{"raw_affiliation_string":"Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia","institution_ids":["https://openalex.org/I130343225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012216267","display_name":"Che Mohd Nasril Che Mohd Nassir","orcid":"https://orcid.org/0000-0002-2019-4565","observed_orcids":["https://orcid.org/0000-0002-2019-4565"]},"institutions":[{"id":"https://openalex.org/I51569856","display_name":"Sultan Zainal Abidin University","ror":"https://ror.org/00bnk2e50","country_code":"MY","type":"education","lineage":["https://openalex.org/I51569856"]}],"countries":["MY"],"is_corresponding":true,"raw_author_name":"Che Mohd Nasril Che Mohd Nassir","raw_affiliation_strings":["Department of Anatomy and Physiology, Faculty of Medicine, Universiti Sultan Zainal Abidin, Kuala Terengganu 20400, Malaysia"],"raw_orcid":"https://orcid.org/0000-0002-2019-4565","affiliations":[{"raw_affiliation_string":"Department of Anatomy and Physiology, Faculty of Medicine, Universiti Sultan Zainal Abidin, Kuala Terengganu 20400, Malaysia","institution_ids":["https://openalex.org/I51569856"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005174555","display_name":"Thirupathirao Vishnumukkala","orcid":"https://orcid.org/0000-0002-9517-3726","observed_orcids":["https://orcid.org/0000-0002-9517-3726"]},"institutions":[{"id":"https://openalex.org/I130343225","display_name":"Universiti Putra Malaysia","ror":"https://ror.org/02e91jd64","country_code":"MY","type":"education","lineage":["https://openalex.org/I130343225"]},{"id":"https://openalex.org/I62370553","display_name":"IMU University","ror":"https://ror.org/04d4wjw61","country_code":"MY","type":"education","lineage":["https://openalex.org/I62370553"]}],"countries":["MY"],"is_corresponding":true,"raw_author_name":"Thirupathirao Vishnumukkala","raw_affiliation_strings":["Anatomy Discipline, Human Biology Division, School of Medicine, IMU University, Kuala Lumpur 57000, Malaysia","Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anatomy Discipline, Human Biology Division, School of Medicine, IMU University, Kuala Lumpur 57000, Malaysia","institution_ids":["https://openalex.org/I62370553"]},{"raw_affiliation_string":"Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia","institution_ids":["https://openalex.org/I130343225"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5005174555","https://openalex.org/A5012216267"],"corresponding_institution_ids":["https://openalex.org/I130343225","https://openalex.org/I51569856","https://openalex.org/I62370553"],"apc_list":{"value":2600,"currency":"CHF","value_usd":3137},"apc_paid":{"value":2600,"currency":"CHF","value_usd":3137},"fwci":7.7089,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.99116608,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"15","issue":"7","first_page":"1081","last_page":"1081"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/centella-asiatica","display_name":"Centella asiatica","score":1.0},{"id":"https://openalex.org/keywords/extraction-methods","display_name":"extraction methods","score":0.8169999718666077},{"id":"https://openalex.org/keywords/supercritical-fluid-extraction","display_name":"supercritical fluid extraction","score":0.9850000143051147},{"id":"https://openalex.org/keywords/microwave-assisted-extraction","display_name":"microwave-assisted extraction","score":1.0},{"id":"https://openalex.org/keywords/phytochemicals","display_name":"phytochemicals","score":0.8320000171661377},{"id":"https://openalex.org/keywords/triterpenoids","display_name":"triterpenoids","score":0.9980000257492065},{"id":"https://openalex.org/keywords/saponins","display_name":"saponins","score":1.0},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":1.0},{"id":"https://openalex.org/keywords/nutraceuticals","display_name":"nutraceuticals","score":0.8149999976158142},{"id":"https://openalex.org/keywords/cosmeceuticals","display_name":"cosmeceuticals","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pharmaceutical-formulations","display_name":"drug formulation","score":0.5889999866485596},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.847000002861023},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":1.0},{"id":"https://openalex.org/keywords/skin-aging","display_name":"skin aging","score":0.9869999885559082},{"id":"https://openalex.org/keywords/stress-modulation","display_name":"stress modulation","score":0.9670000076293945},{"id":"https://openalex.org/keywords/quality-control","display_name":"quality control","score":0.925000011920929},{"id":"https://openalex.org/keywords/toxicological-evaluation","display_name":"toxicological evaluation","score":0.8640000224113464},{"id":"https://openalex.org/keywords/regulatory-standards","display_name":"regulatory standards","score":0.7429999709129333},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"traditional medicine","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C2779077069","wikidata":"https://www.wikidata.org/wiki/Q1348880","display_name":"Centella","level":2,"score":0.5047756433486938},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.4419615864753723},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3953327536582947},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.3398469090461731},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33226197957992554},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21694421768188477},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.15418437123298645}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/life15071081","doi":"https://doi.org/10.3390/life15071081","is_oa":true,"landing_page_url":"https://doi.org/10.3390/life15071081","pdf_url":"https://www.mdpi.com/2075-1729/15/7/1081/pdf?version=1752045024","source":{"id":"https://openalex.org/S4210200765","display_name":"Life","issn_l":"2075-1729","issn":["2075-1729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12298232","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12298232","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life (Basel)","raw_type":"Text"},{"id":"pmid:40724583","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40724583","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:512644c07e154802ac867e8287940c15","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/512644c07e154802ac867e8287940c15","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Life, Vol 15, Iss 7, p 1081 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/life15071081","doi":"https://doi.org/10.3390/life15071081","is_oa":true,"landing_page_url":"https://doi.org/10.3390/life15071081","pdf_url":"https://www.mdpi.com/2075-1729/15/7/1081/pdf?version=1752045024","source":{"id":"https://openalex.org/S4210200765","display_name":"Life","issn_l":"2075-1729","issn":["2075-1729"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320330328","display_name":"Ajman University","ror":"https://ror.org/01j1rma10"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412178397.pdf","grobid_xml":"https://content.openalex.org/works/W4412178397.grobid-xml"},"referenced_works_count":145,"referenced_works":["https://openalex.org/W976146978","https://openalex.org/W1521020595","https://openalex.org/W1961244152","https://openalex.org/W1965225492","https://openalex.org/W1968141753","https://openalex.org/W1976281831","https://openalex.org/W1976505302","https://openalex.org/W1978472019","https://openalex.org/W1996036468","https://openalex.org/W2007584755","https://openalex.org/W2012964177","https://openalex.org/W2013296220","https://openalex.org/W2016437402","https://openalex.org/W2030492279","https://openalex.org/W2046643614","https://openalex.org/W2063760395","https://openalex.org/W2066886841","https://openalex.org/W2068781678","https://openalex.org/W2069043685","https://openalex.org/W2071066258","https://openalex.org/W2072206209","https://openalex.org/W2083447663","https://openalex.org/W2100610591","https://openalex.org/W2124211842","https://openalex.org/W2143088276","https://openalex.org/W2191116581","https://openalex.org/W2303912721","https://openalex.org/W2339452491","https://openalex.org/W2413667177","https://openalex.org/W2417677658","https://openalex.org/W2477499505","https://openalex.org/W2480943605","https://openalex.org/W2510422951","https://openalex.org/W2518773180","https://openalex.org/W2528891811","https://openalex.org/W2564121620","https://openalex.org/W2580653411","https://openalex.org/W2590107239","https://openalex.org/W2600159981","https://openalex.org/W2734702968","https://openalex.org/W2752029125","https://openalex.org/W2756117995","https://openalex.org/W2757037296","https://openalex.org/W2770031589","https://openalex.org/W2782461457","https://openalex.org/W2787589347","https://openalex.org/W2793460794","https://openalex.org/W2795436466","https://openalex.org/W2885138958","https://openalex.org/W2886594044","https://openalex.org/W2938338269","https://openalex.org/W2949780892","https://openalex.org/W2956294126","https://openalex.org/W2964396604","https://openalex.org/W2973845216","https://openalex.org/W2981595503","https://openalex.org/W2997032704","https://openalex.org/W3006578543","https://openalex.org/W3010111911","https://openalex.org/W3021244210","https://openalex.org/W3037767298","https://openalex.org/W3080724744","https://openalex.org/W3081632915","https://openalex.org/W3083682345","https://openalex.org/W3092772705","https://openalex.org/W3096931499","https://openalex.org/W3097246647","https://openalex.org/W3100994999","https://openalex.org/W3114424208","https://openalex.org/W3131411982","https://openalex.org/W3135110362","https://openalex.org/W3135402364","https://openalex.org/W3139343485","https://openalex.org/W3154027813","https://openalex.org/W3157139940","https://openalex.org/W3164203269","https://openalex.org/W3184513121","https://openalex.org/W3198970443","https://openalex.org/W3211387350","https://openalex.org/W3212182879","https://openalex.org/W3212210189","https://openalex.org/W3214084733","https://openalex.org/W3215002667","https://openalex.org/W4200199049","https://openalex.org/W4205209788","https://openalex.org/W4206363393","https://openalex.org/W4206616511","https://openalex.org/W4210526461","https://openalex.org/W4210871777","https://openalex.org/W4212828208","https://openalex.org/W4213066779","https://openalex.org/W4214510073","https://openalex.org/W4220806549","https://openalex.org/W4220845813","https://openalex.org/W4220851662","https://openalex.org/W4221016197","https://openalex.org/W4223982589","https://openalex.org/W4283011042","https://openalex.org/W4288434000","https://openalex.org/W4307395593","https://openalex.org/W4307621430","https://openalex.org/W4308346873","https://openalex.org/W4309029198","https://openalex.org/W4310952744","https://openalex.org/W4316810601","https://openalex.org/W4319657069","https://openalex.org/W4320919855","https://openalex.org/W4321482446","https://openalex.org/W4322774929","https://openalex.org/W4327573035","https://openalex.org/W4383497729","https://openalex.org/W4383695129","https://openalex.org/W4385557213","https://openalex.org/W4385635786","https://openalex.org/W4385776111","https://openalex.org/W4387578380","https://openalex.org/W4388097680","https://openalex.org/W4389295115","https://openalex.org/W4390824874","https://openalex.org/W4391964233","https://openalex.org/W4392555286","https://openalex.org/W4393278811","https://openalex.org/W4394687219","https://openalex.org/W4394916629","https://openalex.org/W4395684365","https://openalex.org/W4399282513","https://openalex.org/W4399689886","https://openalex.org/W4401343661","https://openalex.org/W4401375816","https://openalex.org/W4402071700","https://openalex.org/W4402380816","https://openalex.org/W4402859964","https://openalex.org/W4403200031","https://openalex.org/W4405831062","https://openalex.org/W4406127510","https://openalex.org/W4406766128","https://openalex.org/W4407125132","https://openalex.org/W4407750210","https://openalex.org/W4407943655","https://openalex.org/W4408156386","https://openalex.org/W4410008325","https://openalex.org/W6731074480","https://openalex.org/W6750005870","https://openalex.org/W6839461889","https://openalex.org/W7160979775"],"related_works":["https://openalex.org/W7166837498","https://openalex.org/W6940778671","https://openalex.org/W3154027813","https://openalex.org/W7170088385","https://openalex.org/W3136454724","https://openalex.org/W3196290288","https://openalex.org/W4388097680","https://openalex.org/W7092356689","https://openalex.org/W4283258603","https://openalex.org/W7127350561"],"abstract_inverted_index":{"Centella":[0],"asiatica":[1,187],"(C.":[2],"asiatica)":[3],"has":[4,98],"attracted":[5],"significant":[6],"scientific":[7],"interest":[8],"due":[9],"to":[10,39,136,182],"its":[11],"extensive":[12],"medicinal":[13],"properties":[14],"and":[15,51,61,69,85,94,114,122,134,143,167,178,192],"long-established":[16],"use":[17,89],"in":[18,26],"traditional":[19,155],"medicine.":[20],"This":[21,149],"review":[22,150],"synthesizes":[23],"recent":[24],"advances":[25],"the":[27,34,58,88,100,141,152,161],"technological":[28],"exploitation":[29],"of":[30,36,63,90,102,145,154,163],"C.":[31,103,146,186],"asiatica,":[32],"covering":[33],"extraction":[35,43,49,53],"bioactive":[37],"constituents":[38],"product":[40,82],"development.":[41],"Modern":[42],"techniques":[44],"such":[45],"as":[46,171],"supercritical":[47],"fluid":[48],"(SFE)":[50],"microwave-assisted":[52],"(MAE)":[54],"have":[55],"substantially":[56],"improved":[57,190],"yield,":[59],"selectivity,":[60],"preservation":[62],"key":[64],"phytochemicals,":[65],"particularly":[66],"triterpenoids,":[67],"saponins,":[68],"flavonoids.":[70],"These":[71],"compounds":[72],"are":[73],"now":[74],"routinely":[75],"characterized":[76],"using":[77],"advanced":[78,95],"analytical":[79],"platforms,":[80],"ensuring":[81],"quality,":[83],"consistency,":[84],"standardization.":[86],"Moreover,":[87],"innovative":[91],"formulation":[92],"technologies":[93],"delivery":[96],"systems":[97],"facilitated":[99],"development":[101],"asiatica-based":[104],"products":[105,188],"tailored":[106],"for":[107,175],"various":[108],"therapeutic":[109,193],"areas,":[110],"including":[111],"pharmaceuticals,":[112],"nutraceuticals,":[113],"cosmeceuticals":[115],"targeting":[116],"neuroprotection,":[117],"wound":[118],"healing,":[119],"skin":[120],"aging,":[121],"stress":[123],"modulation.":[124],"Alongside":[125],"these":[126],"developments,":[127],"stringent":[128],"quality":[129],"control":[130],"protocols,":[131],"toxicological":[132],"evaluations,":[133],"adherence":[135],"evolving":[137],"regulatory":[138,179],"standards":[139],"enhance":[140],"safety":[142],"efficacy":[144],"asiatica-derived":[147],"interventions.":[148],"highlights":[151],"integration":[153],"knowledge":[156],"with":[157,189],"modern":[158],"science":[159],"across":[160],"domains":[162],"extraction,":[164],"analysis,":[165],"formulation,":[166],"regulation.":[168],"It":[169],"serves":[170],"a":[172],"comprehensive":[173],"resource":[174],"researchers,":[176],"formulators,":[177],"stakeholders":[180],"aiming":[181],"develop":[183],"high-quality,":[184],"evidence-based":[185],"bioavailability":[191],"value.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":38},{"year":2025,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-07-11T00:00:00"}