{"id":"https://openalex.org/W4412178262","doi":"https://doi.org/10.1186/s13075-025-03609-5","title":"Receptor activator of nuclear factor-kappa B ligand-derived microglia healing peptide 1-AcN inhibits osteoarthritis progression in mice","display_name":"Receptor activator of nuclear factor-kappa B ligand-derived microglia healing peptide 1-AcN inhibits osteoarthritis progression in mice","publication_year":2025,"publication_date":"2025-07-09","ids":{"openalex":"https://openalex.org/W4412178262","doi":"https://doi.org/10.1186/s13075-025-03609-5","pmid":"https://pubmed.ncbi.nlm.nih.gov/40635000","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12239387"},"language":"en","primary_location":{"id":"doi:10.1186/s13075-025-03609-5","doi":"https://doi.org/10.1186/s13075-025-03609-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13075-025-03609-5","pdf_url":null,"source":{"id":"https://openalex.org/S149170128","display_name":"Arthritis Research & Therapy","issn_l":"1478-6354","issn":["1478-6354","1478-6362"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Research & Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s13075-025-03609-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013606990","display_name":"Yuji Fukuda","orcid":"https://orcid.org/0000-0002-3889-0999","observed_orcids":["https://orcid.org/0000-0002-3889-0999"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuji Fukuda","raw_affiliation_strings":["Department of Orthopaedic Surgery, The University of Osaka Graduate School of Medicine Faculty of Medicine, 2-2 Yamada-oka, Suita, 565-0871, Osaka, Japan"],"raw_orcid":"https://orcid.org/0000-0002-3889-0999","affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, The University of Osaka Graduate School of Medicine Faculty of Medicine, 2-2 Yamada-oka, Suita, 565-0871, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043476878","display_name":"Munehisa Shimamura","orcid":"https://orcid.org/0000-0003-0374-0787","observed_orcids":["https://orcid.org/0000-0003-0374-0787"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Munehisa Shimamura","raw_affiliation_strings":["Department of Gene & Stem Cell Regenerative Therapy, The University of Osaka Graduate School of Medicine Faculty of Medicine, 2-2 Yamada-oka, Suita, 565-0871, Osaka, Japan"],"raw_orcid":"https://orcid.org/0000-0003-0374-0787","affiliations":[{"raw_affiliation_string":"Department of Gene & Stem Cell Regenerative Therapy, The University of Osaka Graduate School of Medicine Faculty of Medicine, 2-2 Yamada-oka, Suita, 565-0871, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014950876","display_name":"Yuki Etani","orcid":"https://orcid.org/0000-0001-5741-5969","observed_orcids":["https://orcid.org/0000-0001-5741-5969"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuki Etani","raw_affiliation_strings":["Department of Orthopaedic Surgery, The University of Osaka Graduate School of Medicine Faculty of Medicine, 2-2 Yamada-oka, Suita, 565-0871, Osaka, Japan","Department of Sports Medical Biomechanics, The University of Osaka Graduate School of Medicine Faculty of Medicine, 2-2 Yamada-oka, Suita, 565-0871, Osaka, Japan"],"raw_orcid":"https://orcid.org/0000-0001-5741-5969","affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, The University of Osaka Graduate School of Medicine Faculty of Medicine, 2-2 Yamada-oka, Suita, 565-0871, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Sports Medical Biomechanics, The University of Osaka Graduate School of Medicine Faculty of Medicine, 2-2 Yamada-oka, Suita, 565-0871, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016688691","display_name":"Takaaki Noguchi","orcid":"https://orcid.org/0000-0001-9938-6780","observed_orcids":["https://orcid.org/0000-0001-9938-6780"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takaaki Noguchi","raw_affiliation_strings":["Department of Orthopaedic Surgery, The University of Osaka Graduate School of Medicine Faculty of Medicine, 2-2 Yamada-oka, Suita, 565-0871, Osaka, Japan"],"raw_orcid":"https://orcid.org/0000-0001-9938-6780","affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, The University of Osaka Graduate School of Medicine Faculty of Medicine, 2-2 Yamada-oka, Suita, 565-0871, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090752217","display_name":"Takuya Kurihara","orcid":"https://orcid.org/0009-0005-3892-123X","observed_orcids":["https://orcid.org/0009-0005-3892-123X"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuya Kurihara","raw_affiliation_strings":["Department of Orthopaedic Surgery, The University of Osaka Graduate School of Medicine Faculty of Medicine, 2-2 Yamada-oka, Suita, 565-0871, Osaka, Japan"],"raw_orcid":"https://orcid.org/0009-0005-3892-123X","affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, The University of Osaka Graduate School of Medicine Faculty of Medicine, 2-2 Yamada-oka, Suita, 565-0871, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060031431","display_name":"Atsushi Goshima","orcid":"https://orcid.org/0000-0002-0729-668X","observed_orcids":["https://orcid.org/0000-0002-0729-668X"]},"institutions":[{"id":"https://openalex.org/I4210112889","display_name":"Osaka Rosai Hospital","ror":"https://ror.org/02bj40x52","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210112889"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Goshima","raw_affiliation_strings":["Department of Orthopaedic Surgery, Osaka Rosai Hospital, 1179-3 Nagasone-cho, Kita-ku, Sakai, 591-8025, Japan"],"raw_orcid":"https://orcid.org/0000-0002-0729-668X","affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Osaka Rosai Hospital, 1179-3 Nagasone-cho, Kita-ku, Sakai, 591-8025, Japan","institution_ids":["https://openalex.org/I4210112889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021326361","display_name":"Taihei Miura","orcid":"https://orcid.org/0000-0002-1270-9864","observed_orcids":["https://orcid.org/0000-0002-1270-9864"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Taihei Miura","raw_affiliation_strings":["Clinical and research institute for foot and ankle surgery, Jujo Hospital, 341-1, Mangoku, Kisarazu, 292-0003, Chiba, Japan"],"raw_orcid":"https://orcid.org/0000-0002-1270-9864","affiliations":[{"raw_affiliation_string":"Clinical and research institute for foot and ankle surgery, Jujo Hospital, 341-1, Mangoku, Kisarazu, 292-0003, Chiba, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043551691","display_name":"Makoto Hirao","orcid":"https://orcid.org/0000-0002-1408-7851","observed_orcids":["https://orcid.org/0000-0002-1408-7851"]},"institutions":[{"id":"https://openalex.org/I4210121381","display_name":"Osaka Minami Medical Center","ror":"https://ror.org/02k3rdd90","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210121381","https://openalex.org/I4210137409"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Hirao","raw_affiliation_strings":["Department of Orthopaedic Surgery, NHO Osaka Minami Medical Center, 2-1, kawachinagano, Kawachinagano, 586-8521, Osaka, Japan"],"raw_orcid":"https://orcid.org/0000-0002-1408-7851","affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, NHO Osaka Minami Medical Center, 2-1, kawachinagano, Kawachinagano, 586-8521, Osaka, Japan","institution_ids":["https://openalex.org/I4210121381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000342710","display_name":"Nagahiro Ochiai","orcid":"https://orcid.org/0000-0001-7834-539X","observed_orcids":["https://orcid.org/0000-0001-7834-539X"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nagahiro Ochiai","raw_affiliation_strings":["Department of Musculoskeletal Regenerative Medicine, The University of Osaka Graduate School of Medicine Faculty of Medicine, 2-2 Yamada-oka, Suita, 565-0871, Osaka, Japan"],"raw_orcid":"https://orcid.org/0000-0001-7834-539X","affiliations":[{"raw_affiliation_string":"Department of Musculoskeletal Regenerative Medicine, The University of Osaka Graduate School of Medicine Faculty of Medicine, 2-2 Yamada-oka, Suita, 565-0871, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063256243","display_name":"Nan Ju","orcid":"https://orcid.org/0000-0003-3421-7104","observed_orcids":["https://orcid.org/0000-0003-3421-7104"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nan Ju","raw_affiliation_strings":["Department of Gene & Stem Cell Regenerative Therapy, The University of Osaka Graduate School of Medicine Faculty of Medicine, 2-2 Yamada-oka, Suita, 565-0871, Osaka, Japan"],"raw_orcid":"https://orcid.org/0000-0003-3421-7104","affiliations":[{"raw_affiliation_string":"Department of Gene & Stem Cell Regenerative Therapy, The University of Osaka Graduate School of Medicine Faculty of Medicine, 2-2 Yamada-oka, Suita, 565-0871, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069192456","display_name":"Atsushi Sugimoto","orcid":"https://orcid.org/0009-0004-4784-5526","observed_orcids":["https://orcid.org/0009-0004-4784-5526"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Sugimoto","raw_affiliation_strings":["Department of Orthopaedic Surgery, The University of Osaka Graduate School of Medicine Faculty of Medicine, 2-2 Yamada-oka, Suita, 565-0871, Osaka, Japan"],"raw_orcid":"https://orcid.org/0009-0004-4784-5526","affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, The University of Osaka Graduate School of Medicine Faculty of Medicine, 2-2 Yamada-oka, Suita, 565-0871, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067328622","display_name":"Takashi Kanamoto","orcid":"https://orcid.org/0000-0001-6689-7277","observed_orcids":["https://orcid.org/0000-0001-6689-7277"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Kanamoto","raw_affiliation_strings":["Department of Medicine for Sports and Performing Arts, The University of Osaka Graduate School of Medicine Faculty of Medicine, 2-2 Yamadaoka, Suita, 565-0871, Osaka, Japan"],"raw_orcid":"https://orcid.org/0000-0001-6689-7277","affiliations":[{"raw_affiliation_string":"Department of Medicine for Sports and Performing Arts, The University of Osaka Graduate School of Medicine Faculty of Medicine, 2-2 Yamadaoka, Suita, 565-0871, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028081368","display_name":"Ken Nakata","orcid":"https://orcid.org/0000-0002-8964-4229","observed_orcids":["https://orcid.org/0000-0002-8964-4229","https://orcid.org/0000-0002-4086-4984"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken Nakata","raw_affiliation_strings":["Department of Medicine for Sports and Performing Arts, The University of Osaka Graduate School of Medicine Faculty of Medicine, 2-2 Yamadaoka, Suita, 565-0871, Osaka, Japan"],"raw_orcid":"https://orcid.org/0000-0002-8964-4229","affiliations":[{"raw_affiliation_string":"Department of Medicine for Sports and Performing Arts, The University of Osaka Graduate School of Medicine Faculty of Medicine, 2-2 Yamadaoka, Suita, 565-0871, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058646134","display_name":"Seiji Okada","orcid":"https://orcid.org/0000-0002-5107-8209","observed_orcids":["https://orcid.org/0000-0002-5107-8209"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Seiji Okada","raw_affiliation_strings":["Department of Orthopaedic Surgery, The University of Osaka Graduate School of Medicine Faculty of Medicine, 2-2 Yamada-oka, Suita, 565-0871, Osaka, Japan"],"raw_orcid":"https://orcid.org/0000-0002-5107-8209","affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, The University of Osaka Graduate School of Medicine Faculty of Medicine, 2-2 Yamada-oka, Suita, 565-0871, Osaka, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033870789","display_name":"Kosuke Ebina","orcid":"https://orcid.org/0000-0002-2426-1024","observed_orcids":["https://orcid.org/0000-0002-2426-1024"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kosuke Ebina","raw_affiliation_strings":["Department of Orthopaedic Surgery, The University of Osaka Graduate School of Medicine Faculty of Medicine, 2-2 Yamada-oka, Suita, 565-0871, Osaka, Japan. k-ebina@ort.med.osaka-u.ac.jp","Department of Sports Medical Biomechanics, The University of Osaka Graduate School of Medicine Faculty of Medicine, 2-2 Yamada-oka, Suita, 565-0871, Osaka, Japan. k-ebina@ort.med.osaka-u.ac.jp"],"raw_orcid":"https://orcid.org/0000-0002-2426-1024","affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, The University of Osaka Graduate School of Medicine Faculty of Medicine, 2-2 Yamada-oka, Suita, 565-0871, Osaka, Japan. k-ebina@ort.med.osaka-u.ac.jp","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Sports Medical Biomechanics, The University of Osaka Graduate School of Medicine Faculty of Medicine, 2-2 Yamada-oka, Suita, 565-0871, Osaka, Japan. k-ebina@ort.med.osaka-u.ac.jp","institution_ids":["https://openalex.org/I98285908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5033870789"],"corresponding_institution_ids":["https://openalex.org/I98285908"],"apc_list":{"value":3690,"currency":"USD","value_usd":3690},"apc_paid":{"value":3690,"currency":"USD","value_usd":3690},"fwci":4.1863,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.93793642,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"27","issue":"1","first_page":"142","last_page":"142"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.9010000228881836},{"id":"https://openalex.org/keywords/rankl","display_name":"RANKL","score":0.6380000114440918},{"id":"https://openalex.org/keywords/osteoclastogenesis","display_name":"osteoclastogenesis","score":0.8040000200271606},{"id":"https://openalex.org/keywords/subchondral-sclerosis","display_name":"subchondral sclerosis","score":0.8579999804496765},{"id":"https://openalex.org/keywords/cartilage-degeneration","display_name":"cartilage degeneration","score":0.8379999995231628},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.6710000038146973},{"id":"https://openalex.org/keywords/m1-macrophage-polarization","display_name":"M1 macrophage polarization","score":0.9269999861717224},{"id":"https://openalex.org/keywords/inflammasome","display_name":"inflammasome","score":0.7950000166893005},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.7590000033378601},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.8579999804496765},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8970000147819519},{"id":"https://openalex.org/keywords/synovitis","display_name":"synovitis","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.7559335827827454},{"id":"https://openalex.org/C198451711","wikidata":"https://www.wikidata.org/wiki/Q327657","display_name":"Rheumatology","level":2,"score":0.7281408309936523},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6746174097061157},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6093393564224243},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.5672086477279663},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.5362391471862793},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4950332045555115},{"id":"https://openalex.org/C2778724333","wikidata":"https://www.wikidata.org/wiki/Q14401","display_name":"Kappa","level":2,"score":0.44360631704330444},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4232342839241028},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3408624231815338},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.27512842416763306},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053245","descriptor_name":"RANK Ligand","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053245","descriptor_name":"RANK Ligand","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s13075-025-03609-5","doi":"https://doi.org/10.1186/s13075-025-03609-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13075-025-03609-5","pdf_url":null,"source":{"id":"https://openalex.org/S149170128","display_name":"Arthritis Research & Therapy","issn_l":"1478-6354","issn":["1478-6354","1478-6362"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Research & Therapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12239387","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12239387","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12239387/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Res Ther","raw_type":"Text"},{"id":"pmid:40635000","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40635000","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis research & therapy","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:e5ce8d46744c41718cce8cb25faa0dd6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e5ce8d46744c41718cce8cb25faa0dd6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Arthritis Research & Therapy, Vol 27, Iss 1, Pp 1-15 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13075-025-03609-5","doi":"https://doi.org/10.1186/s13075-025-03609-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13075-025-03609-5","pdf_url":null,"source":{"id":"https://openalex.org/S149170128","display_name":"Arthritis Research & Therapy","issn_l":"1478-6354","issn":["1478-6354","1478-6362"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Research & Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320312288","display_name":"Asahi Kasei Pharma Corporation","ror":"https://ror.org/018wp0236"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412178262.pdf","grobid_xml":"https://content.openalex.org/works/W4412178262.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W2002251686","https://openalex.org/W2013352191","https://openalex.org/W2015329065","https://openalex.org/W2021308032","https://openalex.org/W2061261019","https://openalex.org/W2091206338","https://openalex.org/W2112653375","https://openalex.org/W2129719054","https://openalex.org/W2146548807","https://openalex.org/W2167795966","https://openalex.org/W2507683743","https://openalex.org/W2558394172","https://openalex.org/W2560957403","https://openalex.org/W2754179004","https://openalex.org/W2783585403","https://openalex.org/W2788239455","https://openalex.org/W2807060002","https://openalex.org/W2888818635","https://openalex.org/W2899768885","https://openalex.org/W2903174596","https://openalex.org/W2981355305","https://openalex.org/W3012744005","https://openalex.org/W3017732567","https://openalex.org/W3039688063","https://openalex.org/W3096429227","https://openalex.org/W3109289412","https://openalex.org/W3114050181","https://openalex.org/W3138613518","https://openalex.org/W3139450778","https://openalex.org/W3145648779","https://openalex.org/W3170574462","https://openalex.org/W3174691691","https://openalex.org/W4200202552","https://openalex.org/W4211067786","https://openalex.org/W4212959738","https://openalex.org/W4223508253","https://openalex.org/W4232024554","https://openalex.org/W4280545707","https://openalex.org/W4282032740","https://openalex.org/W4286203431","https://openalex.org/W4293516532","https://openalex.org/W4309467164","https://openalex.org/W4376610916","https://openalex.org/W4381847987","https://openalex.org/W4385652377","https://openalex.org/W4388078897","https://openalex.org/W4388857152","https://openalex.org/W4391605164","https://openalex.org/W4400086184","https://openalex.org/W4408076876"],"related_works":["https://openalex.org/W6939849639","https://openalex.org/W7131680017","https://openalex.org/W4400957363","https://openalex.org/W7162121556","https://openalex.org/W2626688160","https://openalex.org/W1785490663","https://openalex.org/W4389742538","https://openalex.org/W4412522663","https://openalex.org/W4399627761","https://openalex.org/W4416841182"],"abstract_inverted_index":{"BACKGROUND:":[0],"Osteoarthritis":[1],"(OA)":[2],"is":[3],"a":[4,90,120,178,324],"degenerative":[5],"disease":[6],"characterized":[7],"by":[8,20,270,312],"subchondral":[9,254],"bone":[10,47,213,224,255,317],"sclerosis,":[11],"chronic":[12],"inflammation,":[13,252],"and":[14,25,43,49,74,86,106,124,162,189,207,228,259,275,296,305,320],"cartilage":[15,50,75,260],"degradation.":[16],"Abnormal":[17],"mechanical":[18],"stress":[19],"meniscal":[21],"deviation":[22],"activates":[23],"osteoclasts":[24],"induces":[26],"the":[27,67,114,138,195],"release":[28],"of":[29,97,117,137,197,223,230,246],"transforming":[30],"growth":[31],"factor-beta":[32],"(TGF-\u03b2),":[33],"which":[34],"promotes":[35],"mesenchymal":[36],"stem":[37],"cell":[38],"(MSC)-mediated":[39],"type":[40],"H":[41],"angiogenesis":[42,229],"osteogenesis,":[44],"contributing":[45],"to":[46,112,147],"sclerosis":[48],"damage.":[51],"Subsequently,":[52],"macrophages":[53],"recognize":[54],"cartilage-derived":[55],"damage-associated":[56],"molecular":[57],"patterns":[58],"(DAMPs)":[59],"via":[60,135,299],"Toll-like":[61],"receptor":[62,95],"4":[63],"(TLR4),":[64],"polarizing":[65],"into":[66],"pro-inflammatory":[68],"M1":[69,272],"phenotype,":[70],"thereby":[71],"exacerbating":[72],"synovitis":[73],"loss.":[76],"We":[77],"developed":[78],"Microglia":[79],"Healing":[80],"Peptide":[81],"1":[82],"with":[83],"N-terminal":[84],"acetylation":[85],"C-terminal":[87],"amidation":[88],"(MHP1-AcN),":[89],"modified":[91],"peptide":[92],"derived":[93,280],"from":[94,177,281],"activator":[96],"nuclear":[98],"factor-kappa":[99],"B":[100],"ligand":[101],"(RANKL),":[102],"exhibiting":[103],"both":[104],"anti-osteoclastic":[105],"anti-inflammatory":[107],"properties.":[108],"This":[109],"study":[110],"aimed":[111],"evaluate":[113],"therapeutic":[115,327],"potential":[116],"MHP1-AcN":[118,163,167,198,240,264,283,292,308],"in":[119,133,248,303],"murine":[121],"OA":[122,130,247,310],"model":[123],"elucidate":[125],"its":[126,217],"underlying":[127],"mechanisms.":[128],"METHODS:":[129],"was":[131,170],"induced":[132],"mice":[134],"destabilization":[136],"medial":[139],"meniscus":[140],"(DMM)":[141],"surgery.":[142,181],"Mice":[143],"were":[144,184,199,237],"randomly":[145],"assigned":[146],"three":[148],"groups":[149],"(n":[150],"=":[151],"8/group):":[152],"Sham":[153],"(sham":[154],"surgery":[155],"+":[156,160,165],"saline),":[157,161],"Vehicle":[158],"(DMM":[159,164],"MHP1-AcN).":[166],"(600":[168],"\u00b5g)":[169],"administered":[171],"intraperitoneally":[172],"five":[173],"times":[174],"per":[175],"week":[176],"day":[179],"after":[180],"Knee":[182],"joints":[183],"harvested":[185],"at":[186],"2,":[187],"4,":[188],"8":[190],"weeks":[191],"post-surgery.":[192],"In":[193,262],"vitro,":[194,263],"effects":[196,218],"assessed":[200],"on":[201,219],"osteoclast":[202],"differentiation,":[203],"inflammatory":[204,268],"cytokine":[205],"expression,":[206],"M1/M2":[208],"macrophage":[209,273,321],"polarization":[210,274],"using":[211],"mouse":[212],"marrow-derived":[214,225],"macrophages.":[215],"Additionally,":[216],"TGF-\u03b2-induced":[220,294],"osteogenic":[221,295],"differentiation":[222],"MSCs":[226],"(BMMSCs)":[227],"human":[231],"umbilical":[232],"vein":[233],"endothelial":[234],"cells":[235],"(HUVECs)":[236],"evaluated.":[238],"RESULTS:":[239],"markedly":[241],"suppressed":[242],"key":[243],"pathological":[244],"features":[245],"vivo,":[249],"including":[250,315],"synovial":[251],"osteoclast-driven":[253],"remodeling,":[256,318],"aberrant":[257,316],"angiogenesis,":[258,319],"degeneration.":[261],"effectively":[265],"inhibited":[266],"TLR4-mediated":[267],"cascades":[269],"reducing":[271],"inflammasome":[276],"activation.":[277],"Despite":[278],"being":[279],"RANKL,":[282],"supressed":[284],"RANKL-induced":[285],"osteoclastogenesis":[286],"through":[287],"NF-\u03baB":[288],"pathway":[289],"suppression.":[290],"Furthermore,":[291],"attenuated":[293],"angiogenic":[297],"activities":[298],"Smad2":[300],"signaling":[301],"inhibition":[302],"BMMSCs":[304],"HUVECs.":[306],"CONCLUSION:":[307],"attenuates":[309],"progression":[311],"modulating":[313],"multi-pathways":[314],"polarization,":[322],"representing":[323],"promising":[325],"disease-modifying":[326],"candidate":[328],"for":[329],"OA.":[330]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2025-10-10T00:00:00"}