{"id":"https://openalex.org/W4412108572","doi":"https://doi.org/10.1158/2326-6066.cir-24-0532","title":"EML4\u2013ALK Rearrangement Creates a Distinctive Myeloid Cell\u2013Dominant Immunosuppressive Microenvironment in Lung Cancer","display_name":"EML4\u2013ALK Rearrangement Creates a Distinctive Myeloid Cell\u2013Dominant Immunosuppressive Microenvironment in Lung Cancer","publication_year":2025,"publication_date":"2025-07-08","ids":{"openalex":"https://openalex.org/W4412108572","doi":"https://doi.org/10.1158/2326-6066.cir-24-0532","pmid":"https://pubmed.ncbi.nlm.nih.gov/40627846"},"language":"en","primary_location":{"id":"doi:10.1158/2326-6066.cir-24-0532","doi":"https://doi.org/10.1158/2326-6066.cir-24-0532","is_oa":false,"landing_page_url":"https://doi.org/10.1158/2326-6066.cir-24-0532","pdf_url":null,"source":{"id":"https://openalex.org/S2765010658","display_name":"Cancer Immunology Research","issn_l":"2326-6066","issn":["2326-6066","2326-6074"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017344276","display_name":"Kosuke Arai","orcid":"https://orcid.org/0000-0003-1106-8329","observed_orcids":["https://orcid.org/0000-0003-1106-8329"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]},{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kosuke Arai","raw_affiliation_strings":["1Department of Immune Medicine, National Cancer Center Research Institute, Tokyo, Japan","2Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan","National Cancer Center Research Institute, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0003-1106-8329","affiliations":[{"raw_affiliation_string":"1Department of Immune Medicine, National Cancer Center Research Institute, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287541"]},{"raw_affiliation_string":"2Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"National Cancer Center Research Institute, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031716197","display_name":"Yukari Nishito","orcid":"https://orcid.org/0000-0002-9331-4820","observed_orcids":["https://orcid.org/0000-0002-9331-4820"]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukari Nishito","raw_affiliation_strings":["3Kamakura Research Laboratories, Chugai Pharmaceutical Co., Ltd., Kanagawa, Japan","Chugai Pharmaceutical Co., Ltd., Yokohama, Kanagawa, Japan"],"raw_orcid":"https://orcid.org/0000-0002-9331-4820","affiliations":[{"raw_affiliation_string":"3Kamakura Research Laboratories, Chugai Pharmaceutical Co., Ltd., Kanagawa, Japan","institution_ids":["https://openalex.org/I4405254473"]},{"raw_affiliation_string":"Chugai Pharmaceutical Co., Ltd., Yokohama, Kanagawa, Japan","institution_ids":["https://openalex.org/I4405254473"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090770070","display_name":"Hideaki Mizuno","orcid":"https://orcid.org/0000-0002-7246-2576","observed_orcids":["https://orcid.org/0000-0002-7246-2576"]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideaki Mizuno","raw_affiliation_strings":["3Kamakura Research Laboratories, Chugai Pharmaceutical Co., Ltd., Kanagawa, Japan","Chugai Pharmaceutical Co., Ltd., Yokohama, Kanagawa, Japan"],"raw_orcid":"https://orcid.org/0000-0002-7246-2576","affiliations":[{"raw_affiliation_string":"3Kamakura Research Laboratories, Chugai Pharmaceutical Co., Ltd., Kanagawa, Japan","institution_ids":["https://openalex.org/I4405254473"]},{"raw_affiliation_string":"Chugai Pharmaceutical Co., Ltd., Yokohama, Kanagawa, Japan","institution_ids":["https://openalex.org/I4405254473"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007635404","display_name":"Noriko Motoi","orcid":"https://orcid.org/0000-0001-7098-3311","observed_orcids":["https://orcid.org/0000-0001-7098-3311"]},"institutions":[{"id":"https://openalex.org/I4210123465","display_name":"Saitama Cancer Center","ror":"https://ror.org/03a4d7t12","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210123465"]},{"id":"https://openalex.org/I4405285273","display_name":"National Cancer Center Hospital","ror":"https://ror.org/053hhpd64","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405285273"]},{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noriko Motoi","raw_affiliation_strings":["4Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan","5Department of Pathology, Center for Cancer Genomic Medicine, Saitama Cancer Center, Saitama, Japan","National Cancer Center Research Institute, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0001-7098-3311","affiliations":[{"raw_affiliation_string":"4Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan","institution_ids":["https://openalex.org/I4405285273"]},{"raw_affiliation_string":"5Department of Pathology, Center for Cancer Genomic Medicine, Saitama Cancer Center, Saitama, Japan","institution_ids":["https://openalex.org/I4210123465"]},{"raw_affiliation_string":"National Cancer Center Research Institute, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053946306","display_name":"Nobuyoshi Hiraoka","orcid":"https://orcid.org/0000-0003-4215-4385","observed_orcids":["https://orcid.org/0000-0003-4215-4385"]},"institutions":[{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuyoshi Hiraoka","raw_affiliation_strings":["6Department of Analytical Pathology, National Cancer Center Research Institute, Tokyo, Japan","National Cancer Center Research Institute, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0003-4215-4385","affiliations":[{"raw_affiliation_string":"6Department of Analytical Pathology, National Cancer Center Research Institute, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287541"]},{"raw_affiliation_string":"National Cancer Center Research Institute, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001168434","display_name":"Masanori Fuse","orcid":"https://orcid.org/0009-0009-3448-3614","observed_orcids":["https://orcid.org/0009-0009-3448-3614"]},"institutions":[{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masanori Fuse","raw_affiliation_strings":["6Department of Analytical Pathology, National Cancer Center Research Institute, Tokyo, Japan","National Cancer Center Research Institute, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0009-0009-3448-3614","affiliations":[{"raw_affiliation_string":"6Department of Analytical Pathology, National Cancer Center Research Institute, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287541"]},{"raw_affiliation_string":"National Cancer Center Research Institute, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019988905","display_name":"Yasuhito Arai","orcid":"https://orcid.org/0000-0001-6306-9409","observed_orcids":["https://orcid.org/0000-0001-6306-9409"]},"institutions":[{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhito Arai","raw_affiliation_strings":["7Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan","National Cancer Center Research Institute, Tokyo, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0001-6306-9409","affiliations":[{"raw_affiliation_string":"7Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287541"]},{"raw_affiliation_string":"National Cancer Center Research Institute, Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054256781","display_name":"Tatsuhiro Shibata","orcid":"https://orcid.org/0000-0002-0477-210X","observed_orcids":["https://orcid.org/0000-0002-0477-210X"]},"institutions":[{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuhiro Shibata","raw_affiliation_strings":["7Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan","National Cancer Center Research Institute, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-0477-210X","affiliations":[{"raw_affiliation_string":"7Division of Cancer Genomics, National Cancer Center Research Institute, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287541"]},{"raw_affiliation_string":"National Cancer Center Research Institute, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086600861","display_name":"Yukiko Sonobe","orcid":"https://orcid.org/0009-0005-0591-4623","observed_orcids":["https://orcid.org/0009-0005-0591-4623"]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukiko Sonobe","raw_affiliation_strings":["3Kamakura Research Laboratories, Chugai Pharmaceutical Co., Ltd., Kanagawa, Japan","Chugai Pharmaceutical Co., Ltd., Yokohama City, Japan"],"raw_orcid":"https://orcid.org/0009-0005-0591-4623","affiliations":[{"raw_affiliation_string":"3Kamakura Research Laboratories, Chugai Pharmaceutical Co., Ltd., Kanagawa, Japan","institution_ids":["https://openalex.org/I4405254473"]},{"raw_affiliation_string":"Chugai Pharmaceutical Co., Ltd., Yokohama City, Japan","institution_ids":["https://openalex.org/I4405254473"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085240991","display_name":"Yoko Kayukawa","orcid":"https://orcid.org/0009-0003-8848-2840","observed_orcids":["https://orcid.org/0009-0003-8848-2840"]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoko Kayukawa","raw_affiliation_strings":["3Kamakura Research Laboratories, Chugai Pharmaceutical Co., Ltd., Kanagawa, Japan","Chugai Pharmaceutical Co. Ltd., Yokohama, Kanagawa, Japan"],"raw_orcid":"https://orcid.org/0009-0003-8848-2840","affiliations":[{"raw_affiliation_string":"3Kamakura Research Laboratories, Chugai Pharmaceutical Co., Ltd., Kanagawa, Japan","institution_ids":["https://openalex.org/I4405254473"]},{"raw_affiliation_string":"Chugai Pharmaceutical Co. Ltd., Yokohama, Kanagawa, Japan","institution_ids":["https://openalex.org/I4405254473"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063029271","display_name":"Toru Maruyama","orcid":"https://orcid.org/0000-0002-1729-7766","observed_orcids":["https://orcid.org/0000-0002-1729-7766"]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]},{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]}],"countries":["CH","JP"],"is_corresponding":false,"raw_author_name":"Toru Maruyama","raw_affiliation_strings":["3Kamakura Research Laboratories, Chugai Pharmaceutical Co., Ltd., Kanagawa, Japan","Roche (Switzerland), Basel, Basel-stadt, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-1729-7766","affiliations":[{"raw_affiliation_string":"3Kamakura Research Laboratories, Chugai Pharmaceutical Co., Ltd., Kanagawa, Japan","institution_ids":["https://openalex.org/I4405254473"]},{"raw_affiliation_string":"Roche (Switzerland), Basel, Basel-stadt, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073431810","display_name":"Hironori Fukuda","orcid":"https://orcid.org/0009-0008-3009-0146","observed_orcids":["https://orcid.org/0009-0008-3009-0146"]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]},{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hironori Fukuda","raw_affiliation_strings":["1Department of Immune Medicine, National Cancer Center Research Institute, Tokyo, Japan","Tokyo Women's Medical University, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0009-0008-3009-0146","affiliations":[{"raw_affiliation_string":"1Department of Immune Medicine, National Cancer Center Research Institute, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287541"]},{"raw_affiliation_string":"Tokyo Women's Medical University, Tokyo, Japan","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064387735","display_name":"Yukihiro Mizoguchi","orcid":"https://orcid.org/0009-0004-9296-2625","observed_orcids":["https://orcid.org/0009-0004-9296-2625","https://orcid.org/0000-0001-8733-2486"]},"institutions":[{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]},{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukihiro Mizoguchi","raw_affiliation_strings":["1Department of Immune Medicine, National Cancer Center Research Institute, Tokyo, Japan","Japanese Foundation For Cancer Research, Koto-ku, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0009-0004-9296-2625","affiliations":[{"raw_affiliation_string":"1Department of Immune Medicine, National Cancer Center Research Institute, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287541"]},{"raw_affiliation_string":"Japanese Foundation For Cancer Research, Koto-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106408398","display_name":"Yukiko Aikawa","orcid":"https://orcid.org/0009-0008-3526-386X","observed_orcids":["https://orcid.org/0009-0008-3526-386X"]},"institutions":[{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukiko Aikawa","raw_affiliation_strings":["1Department of Immune Medicine, National Cancer Center Research Institute, Tokyo, Japan","National Cancer Center Research Institute, Tokyo, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0009-0008-3526-386X","affiliations":[{"raw_affiliation_string":"1Department of Immune Medicine, National Cancer Center Research Institute, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287541"]},{"raw_affiliation_string":"National Cancer Center Research Institute, Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101992523","display_name":"Yukihiro Yoshida","orcid":"https://orcid.org/0000-0002-6494-2318","observed_orcids":["https://orcid.org/0000-0002-6494-2318"]},"institutions":[{"id":"https://openalex.org/I4210145079","display_name":"National Cancer Center Hospital East","ror":"https://ror.org/03rm3gk43","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210145079"]},{"id":"https://openalex.org/I4405285273","display_name":"National Cancer Center Hospital","ror":"https://ror.org/053hhpd64","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405285273"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukihiro Yoshida","raw_affiliation_strings":["8Department of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan","National Cancer Center Hospital East, Chuo-ku, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-6494-2318","affiliations":[{"raw_affiliation_string":"8Department of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan","institution_ids":["https://openalex.org/I4405285273"]},{"raw_affiliation_string":"National Cancer Center Hospital East, Chuo-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I4210145079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042740858","display_name":"Shun-ichi J. WATANABE","orcid":"https://orcid.org/0009-0005-1927-9675","observed_orcids":["https://orcid.org/0009-0005-1927-9675"]},"institutions":[{"id":"https://openalex.org/I4210145079","display_name":"National Cancer Center Hospital East","ror":"https://ror.org/03rm3gk43","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210145079"]},{"id":"https://openalex.org/I4405285273","display_name":"National Cancer Center Hospital","ror":"https://ror.org/053hhpd64","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405285273"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shun-ichi Watanabe","raw_affiliation_strings":["8Department of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan","National Cancer Center Hospital East, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0009-0005-1927-9675","affiliations":[{"raw_affiliation_string":"8Department of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan","institution_ids":["https://openalex.org/I4405285273"]},{"raw_affiliation_string":"National Cancer Center Hospital East, Tokyo, Japan","institution_ids":["https://openalex.org/I4210145079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023467757","display_name":"Hiromi Sakamoto","orcid":"https://orcid.org/0009-0003-1037-8146","observed_orcids":["https://orcid.org/0009-0003-1037-8146"]},"institutions":[{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromi Sakamoto","raw_affiliation_strings":["9Department of Clinical Genomics, National Cancer Center Research Institute, Tokyo, Japan","National Cancer Center Research Institute, Tokyo, Chuo-ku, Japan"],"raw_orcid":"https://orcid.org/0009-0003-1037-8146","affiliations":[{"raw_affiliation_string":"9Department of Clinical Genomics, National Cancer Center Research Institute, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287541"]},{"raw_affiliation_string":"National Cancer Center Research Institute, Tokyo, Chuo-ku, Japan","institution_ids":["https://openalex.org/I4405287541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014196694","display_name":"Makiko Yamashita","orcid":"https://orcid.org/0009-0006-9281-8759","observed_orcids":["https://orcid.org/0009-0006-9281-8759"]},"institutions":[{"id":"https://openalex.org/I4210137039","display_name":"The Cancer Institute Hospital","ror":"https://ror.org/03md8p445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137039"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makiko Yamashita","raw_affiliation_strings":["10Department of Advanced Medical Development, The Japanese Foundation for Cancer Research, Tokyo, Japan","The Cancer Institute Hospital of JFCR, Koto-ku, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0009-0006-9281-8759","affiliations":[{"raw_affiliation_string":"10Department of Advanced Medical Development, The Japanese Foundation for Cancer Research, Tokyo, Japan","institution_ids":["https://openalex.org/I42570316"]},{"raw_affiliation_string":"The Cancer Institute Hospital of JFCR, Koto-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015229603","display_name":"Shigehisa Kitano","orcid":"https://orcid.org/0000-0002-4041-8298","observed_orcids":["https://orcid.org/0000-0002-4041-8298"]},"institutions":[{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigehisa Kitano","raw_affiliation_strings":["10Department of Advanced Medical Development, The Japanese Foundation for Cancer Research, Tokyo, Japan","Japanese Foundation For Cancer Research, Koto-ku, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-4041-8298","affiliations":[{"raw_affiliation_string":"10Department of Advanced Medical Development, The Japanese Foundation for Cancer Research, Tokyo, Japan","institution_ids":["https://openalex.org/I42570316"]},{"raw_affiliation_string":"Japanese Foundation For Cancer Research, Koto-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037644594","display_name":"Yuki Nagata","orcid":"https://orcid.org/0000-0002-7859-9661","observed_orcids":["https://orcid.org/0000-0002-7859-9661"]},"institutions":[{"id":"https://openalex.org/I125602781","display_name":"Tokyo Medical and Dental University","ror":"https://ror.org/051k3eh31","country_code":"JP","type":"education","lineage":["https://openalex.org/I125602781","https://openalex.org/I4400009020"]},{"id":"https://openalex.org/I4405286724","display_name":"Research Institute, National Center for Geriatrics and Gerontology","ror":"https://ror.org/02xbv4565","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210160102","https://openalex.org/I4405286724"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuki Nagata","raw_affiliation_strings":["11Medical Genome Center, Research Institute, National Center for Geriatrics and Gerontology, Aichi, Japan","12Bioresource Research Center, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo, Japan","Tokyo Medical and Dental University, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-7859-9661","affiliations":[{"raw_affiliation_string":"11Medical Genome Center, Research Institute, National Center for Geriatrics and Gerontology, Aichi, Japan","institution_ids":["https://openalex.org/I4405286724"]},{"raw_affiliation_string":"12Bioresource Research Center, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]},{"raw_affiliation_string":"Tokyo Medical and Dental University, Tokyo, Japan","institution_ids":["https://openalex.org/I125602781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055375264","display_name":"Risa Mitsumori","orcid":"https://orcid.org/0009-0000-3383-1327","observed_orcids":["https://orcid.org/0009-0000-3383-1327"]},"institutions":[{"id":"https://openalex.org/I4210160102","display_name":"National Center for Geriatrics and Gerontology","ror":"https://ror.org/05h0rw812","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210160102"]},{"id":"https://openalex.org/I4405286724","display_name":"Research Institute, National Center for Geriatrics and Gerontology","ror":"https://ror.org/02xbv4565","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210160102","https://openalex.org/I4405286724"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Risa Mitsumori","raw_affiliation_strings":["11Medical Genome Center, Research Institute, National Center for Geriatrics and Gerontology, Aichi, Japan","National Center for Geriatrics and Gerontology, Obu, Aichi, Japan"],"raw_orcid":"https://orcid.org/0009-0000-3383-1327","affiliations":[{"raw_affiliation_string":"11Medical Genome Center, Research Institute, National Center for Geriatrics and Gerontology, Aichi, Japan","institution_ids":["https://openalex.org/I4405286724"]},{"raw_affiliation_string":"National Center for Geriatrics and Gerontology, Obu, Aichi, Japan","institution_ids":["https://openalex.org/I4210160102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053237195","display_name":"Kouichi Ozaki","orcid":"https://orcid.org/0000-0003-0028-1570","observed_orcids":["https://orcid.org/0000-0003-0028-1570"]},"institutions":[{"id":"https://openalex.org/I4210160102","display_name":"National Center for Geriatrics and Gerontology","ror":"https://ror.org/05h0rw812","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210160102"]},{"id":"https://openalex.org/I4405286724","display_name":"Research Institute, National Center for Geriatrics and Gerontology","ror":"https://ror.org/02xbv4565","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210160102","https://openalex.org/I4405286724"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kouichi Ozaki","raw_affiliation_strings":["11Medical Genome Center, Research Institute, National Center for Geriatrics and Gerontology, Aichi, Japan","National Center for Geriatrics and Gerontology, Obu, Japan"],"raw_orcid":"https://orcid.org/0000-0003-0028-1570","affiliations":[{"raw_affiliation_string":"11Medical Genome Center, Research Institute, National Center for Geriatrics and Gerontology, Aichi, Japan","institution_ids":["https://openalex.org/I4405286724"]},{"raw_affiliation_string":"National Center for Geriatrics and Gerontology, Obu, Japan","institution_ids":["https://openalex.org/I4210160102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082018968","display_name":"Shumpei Niida","orcid":"https://orcid.org/0000-0002-6192-8035","observed_orcids":["https://orcid.org/0000-0002-6192-8035"]},"institutions":[{"id":"https://openalex.org/I4210160102","display_name":"National Center for Geriatrics and Gerontology","ror":"https://ror.org/05h0rw812","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210160102"]},{"id":"https://openalex.org/I4405286724","display_name":"Research Institute, National Center for Geriatrics and Gerontology","ror":"https://ror.org/02xbv4565","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210160102","https://openalex.org/I4405286724"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shumpei Niida","raw_affiliation_strings":["11Medical Genome Center, Research Institute, National Center for Geriatrics and Gerontology, Aichi, Japan","National Center for Geriatrics and Gerontology, Obu, Aichi, Japan"],"raw_orcid":"https://orcid.org/0000-0002-6192-8035","affiliations":[{"raw_affiliation_string":"11Medical Genome Center, Research Institute, National Center for Geriatrics and Gerontology, Aichi, Japan","institution_ids":["https://openalex.org/I4405286724"]},{"raw_affiliation_string":"National Center for Geriatrics and Gerontology, Obu, Aichi, Japan","institution_ids":["https://openalex.org/I4210160102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074419698","display_name":"Yae Kanai","orcid":"https://orcid.org/0000-0002-7904-9506","observed_orcids":["https://orcid.org/0000-0002-7904-9506"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yae Kanai","raw_affiliation_strings":["13Department of Pathology, Keio University School of Medicine, Tokyo, Japan","Keio University, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-7904-9506","affiliations":[{"raw_affiliation_string":"13Department of Pathology, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]},{"raw_affiliation_string":"Keio University, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046623627","display_name":"Akiyoshi Hirayama","orcid":"https://orcid.org/0000-0002-0440-6820","observed_orcids":["https://orcid.org/0000-0002-0440-6820"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I4405286215","display_name":"Institute for Advanced Biosciences, Keio University","ror":"https://ror.org/01ft26j90","country_code":"JP","type":"facility","lineage":["https://openalex.org/I203951103","https://openalex.org/I4405286215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akiyoshi Hirayama","raw_affiliation_strings":["14Institute for Advanced Biosciences, Keio University, Yamagata, Japan","Keio University, Tsuruoka, Yamagata, Japan"],"raw_orcid":"https://orcid.org/0000-0002-0440-6820","affiliations":[{"raw_affiliation_string":"14Institute for Advanced Biosciences, Keio University, Yamagata, Japan","institution_ids":["https://openalex.org/I203951103","https://openalex.org/I4405286215"]},{"raw_affiliation_string":"Keio University, Tsuruoka, Yamagata, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038138665","display_name":"Tomoyoshi Soga","orcid":"https://orcid.org/0000-0001-9502-2509","observed_orcids":["https://orcid.org/0000-0001-9502-2509"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]},{"id":"https://openalex.org/I4405286215","display_name":"Institute for Advanced Biosciences, Keio University","ror":"https://ror.org/01ft26j90","country_code":"JP","type":"facility","lineage":["https://openalex.org/I203951103","https://openalex.org/I4405286215"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoyoshi Soga","raw_affiliation_strings":["14Institute for Advanced Biosciences, Keio University, Yamagata, Japan","Keio University, Tsuruoka, Yamagata, Japan"],"raw_orcid":"https://orcid.org/0000-0001-9502-2509","affiliations":[{"raw_affiliation_string":"14Institute for Advanced Biosciences, Keio University, Yamagata, Japan","institution_ids":["https://openalex.org/I203951103","https://openalex.org/I4405286215"]},{"raw_affiliation_string":"Keio University, Tsuruoka, Yamagata, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101789636","display_name":"Teruhiko Yoshida","orcid":"https://orcid.org/0000-0003-1607-3899","observed_orcids":["https://orcid.org/0000-0003-1607-3899"]},"institutions":[{"id":"https://openalex.org/I4210145079","display_name":"National Cancer Center Hospital East","ror":"https://ror.org/03rm3gk43","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210145079"]},{"id":"https://openalex.org/I4405285273","display_name":"National Cancer Center Hospital","ror":"https://ror.org/053hhpd64","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405285273"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Teruhiko Yoshida","raw_affiliation_strings":["15Department of Genetic Medicine and Services, National Cancer Center Hospital, Tokyo, Japan","National Cancer Center Hospital East, Chuo-ku, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0003-1607-3899","affiliations":[{"raw_affiliation_string":"15Department of Genetic Medicine and Services, National Cancer Center Hospital, Tokyo, Japan","institution_ids":["https://openalex.org/I4405285273"]},{"raw_affiliation_string":"National Cancer Center Hospital East, Chuo-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I4210145079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089470172","display_name":"Kazuki Yasuda","orcid":"https://orcid.org/0000-0002-6966-496X","observed_orcids":["https://orcid.org/0000-0002-6966-496X"]},"institutions":[{"id":"https://openalex.org/I4210094012","display_name":"National Center for Global Health and Medicine","ror":"https://ror.org/00r9w3j27","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210094012"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuki Yasuda","raw_affiliation_strings":["16National Center for Global Health and Medicine, Tokyo, Japan","National Center for Global Health and Medicine, Japan"],"raw_orcid":"https://orcid.org/0000-0002-6966-496X","affiliations":[{"raw_affiliation_string":"16National Center for Global Health and Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I4210094012"]},{"raw_affiliation_string":"National Center for Global Health and Medicine, Japan","institution_ids":["https://openalex.org/I4210094012"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038375140","display_name":"Atsushi Ochiai","orcid":"https://orcid.org/0000-0001-6857-4009","observed_orcids":["https://orcid.org/0000-0001-6857-4009"]},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]},{"id":"https://openalex.org/I4210087348","display_name":"National Cancer Centre Japan","ror":"https://ror.org/0025ww868","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210087348"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Ochiai","raw_affiliation_strings":["17Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Chiba, Japan","Tokyo University of Science, Noda, Chiba, Japan"],"raw_orcid":"https://orcid.org/0000-0001-6857-4009","affiliations":[{"raw_affiliation_string":"17Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Chiba, Japan","institution_ids":["https://openalex.org/I4210087348"]},{"raw_affiliation_string":"Tokyo University of Science, Noda, Chiba, Japan","institution_ids":["https://openalex.org/I161296585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009149364","display_name":"Hiroyuki Tsunoda","orcid":"https://orcid.org/0009-0005-5016-4366","observed_orcids":["https://orcid.org/0009-0005-5016-4366"]},"institutions":[{"id":"https://openalex.org/I4405254473","display_name":"Chugai Pharmaceutical Co., Ltd. (Japan)","ror":"https://ror.org/01v743b94","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405254473"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Tsunoda","raw_affiliation_strings":["3Kamakura Research Laboratories, Chugai Pharmaceutical Co., Ltd., Kanagawa, Japan","Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan"],"raw_orcid":"https://orcid.org/0009-0005-5016-4366","affiliations":[{"raw_affiliation_string":"3Kamakura Research Laboratories, Chugai Pharmaceutical Co., Ltd., Kanagawa, Japan","institution_ids":["https://openalex.org/I4405254473"]},{"raw_affiliation_string":"Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan","institution_ids":["https://openalex.org/I4405254473"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070444406","display_name":"Kazunori Aoki","orcid":"https://orcid.org/0000-0002-1292-3764","observed_orcids":["https://orcid.org/0000-0002-1292-3764"]},"institutions":[{"id":"https://openalex.org/I4405287541","display_name":"National Cancer Center Research Institute","ror":"https://ror.org/05fd4mq57","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210087348","https://openalex.org/I4405287541"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kazunori Aoki","raw_affiliation_strings":["1Department of Immune Medicine, National Cancer Center Research Institute, Tokyo, Japan","National Cancer Center Research Institute, Tokyo, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0002-1292-3764","affiliations":[{"raw_affiliation_string":"1Department of Immune Medicine, National Cancer Center Research Institute, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287541"]},{"raw_affiliation_string":"National Cancer Center Research Institute, Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4405287541"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":17,"corresponding_author_ids":["https://openalex.org/A5070444406"],"corresponding_institution_ids":["https://openalex.org/I4405287541"],"apc_list":null,"apc_paid":null,"fwci":3.0035,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.91522029,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"13","issue":"9","first_page":"1435","last_page":"1452"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.8241999745368958,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.8241999745368958,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.13899999856948853,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.016200000420212746,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eml4-alk-fusion","display_name":"EML4-ALK fusion","score":0.8740000128746033},{"id":"https://openalex.org/keywords/alk-positive-lung-adenocarcinoma","display_name":"ALK-positive lung adenocarcinoma","score":0.9340000152587891},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.796999990940094},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.9570000171661377},{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/macrophage-polarization","display_name":"macrophage polarization","score":0.6949999928474426},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.7490000128746033},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.5830000042915344},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9179999828338623},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitor-resistance","display_name":"tyrosine kinase inhibitor resistance","score":0.8870000243186951},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.8209999799728394},{"id":"https://openalex.org/keywords/tumor-infiltrating-t-cells","display_name":"tumor-infiltrating T cells","score":0.7279999852180481}],"concepts":[{"id":"https://openalex.org/C117643217","wikidata":"https://www.wikidata.org/wiki/Q17824987","display_name":"Anaplastic lymphoma kinase","level":4,"score":0.7037159204483032},{"id":"https://openalex.org/C2779422266","wikidata":"https://www.wikidata.org/wiki/Q5186964","display_name":"Crizotinib","level":4,"score":0.6762216091156006},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6585570573806763},{"id":"https://openalex.org/C2779220645","wikidata":"https://www.wikidata.org/wiki/Q21099132","display_name":"Alectinib","level":5,"score":0.6108411550521851},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6004188060760498},{"id":"https://openalex.org/C17502307","wikidata":"https://www.wikidata.org/wiki/Q411999","display_name":"CXCL9","level":5,"score":0.5116294026374817},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.49610862135887146},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.48681017756462097},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4722801148891449},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.469511479139328},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.4329797923564911},{"id":"https://openalex.org/C5858377","wikidata":"https://www.wikidata.org/wiki/Q986112","display_name":"CXCL10","level":4,"score":0.3729957640171051},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36920469999313354},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3521471917629242},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3149165213108063},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.27639806270599365},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09397432208061218},{"id":"https://openalex.org/C2776232967","wikidata":"https://www.wikidata.org/wiki/Q6743514","display_name":"Malignant pleural effusion","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072737","descriptor_name":"Myeloid-Derived Suppressor Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000077548","descriptor_name":"Anaplastic Lymphoma Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015321","descriptor_name":"Gene Rearrangement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015514","descriptor_name":"Oncogene Proteins, Fusion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D022423","descriptor_name":"Myeloid Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D022423","descriptor_name":"Myeloid Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1158/2326-6066.cir-24-0532","doi":"https://doi.org/10.1158/2326-6066.cir-24-0532","is_oa":false,"landing_page_url":"https://doi.org/10.1158/2326-6066.cir-24-0532","pdf_url":null,"source":{"id":"https://openalex.org/S2765010658","display_name":"Cancer Immunology Research","issn_l":"2326-6066","issn":["2326-6066","2326-6074"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology Research","raw_type":"journal-article"},{"id":"pmid:40627846","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40627846","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer immunology research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G263314311","display_name":"Study on pathological indicator to predict response of cancer immune therapy","funder_award_id":"18K07036","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4044411238","display_name":null,"funder_award_id":"21ck0106532h0002","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G6091209874","display_name":null,"funder_award_id":"21ck010640h0002","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G6714567748","display_name":"Development study on pathological predictive biomarkers for cancer treatment","funder_award_id":"21K06900","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G689033303","display_name":null,"funder_award_id":"JP19ak0101043h0105A","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G8222950730","display_name":null,"funder_award_id":"2020-J-2","funder_id":"https://openalex.org/F4320315717","funder_display_name":"National Cancer Center Japan"},{"id":"https://openalex.org/G8436154792","display_name":null,"funder_award_id":"JP19ak0101044h0104","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G958530372","display_name":null,"funder_award_id":"21K07951","funder_id":"https://openalex.org/F4320320212","funder_display_name":"Japan Society for the Promotion of Science London"}],"funders":[{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320315717","display_name":"National Cancer Center Japan","ror":"https://ror.org/0025ww868"},{"id":"https://openalex.org/F4320320212","display_name":"Japan Society for the Promotion of Science London","ror":"https://ror.org/02m7axw05"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W1667820694","https://openalex.org/W2016293419","https://openalex.org/W2035618305","https://openalex.org/W2050249255","https://openalex.org/W2062873927","https://openalex.org/W2079357192","https://openalex.org/W2104830962","https://openalex.org/W2107277218","https://openalex.org/W2107551122","https://openalex.org/W2140380746","https://openalex.org/W2149436029","https://openalex.org/W2151948277","https://openalex.org/W2156353875","https://openalex.org/W2160390319","https://openalex.org/W2166084034","https://openalex.org/W2168635759","https://openalex.org/W2179438025","https://openalex.org/W2205646851","https://openalex.org/W2229658487","https://openalex.org/W2316348835","https://openalex.org/W2537220355","https://openalex.org/W2581592505","https://openalex.org/W2610224116","https://openalex.org/W2624310346","https://openalex.org/W2791886669","https://openalex.org/W2797685139","https://openalex.org/W2811001941","https://openalex.org/W2894476389","https://openalex.org/W2914311347","https://openalex.org/W2938929416","https://openalex.org/W2946166987","https://openalex.org/W2947216697","https://openalex.org/W2980670340","https://openalex.org/W2981114563","https://openalex.org/W2982017357","https://openalex.org/W2984472267","https://openalex.org/W2989969508","https://openalex.org/W3003320500","https://openalex.org/W3005583371","https://openalex.org/W3010279415","https://openalex.org/W3038112096","https://openalex.org/W3087030541","https://openalex.org/W3088048752","https://openalex.org/W3094464503","https://openalex.org/W3095726304","https://openalex.org/W3127051356","https://openalex.org/W3139883958","https://openalex.org/W3164692211","https://openalex.org/W3188101582","https://openalex.org/W3213992117","https://openalex.org/W4211059596","https://openalex.org/W4229365571","https://openalex.org/W4280560293","https://openalex.org/W4286587051","https://openalex.org/W4294953495","https://openalex.org/W4311257363","https://openalex.org/W4311691578","https://openalex.org/W4321076614","https://openalex.org/W4328010609","https://openalex.org/W4378234677","https://openalex.org/W4383814952","https://openalex.org/W4389410347","https://openalex.org/W4390637702","https://openalex.org/W4392243479","https://openalex.org/W4392384776","https://openalex.org/W4393139489"],"related_works":["https://openalex.org/W4413051413","https://openalex.org/W4406057151","https://openalex.org/W3167891114","https://openalex.org/W3137552976","https://openalex.org/W4303709754","https://openalex.org/W4322207990","https://openalex.org/W4379280785","https://openalex.org/W4393088133","https://openalex.org/W4220853020","https://openalex.org/W3094464503"],"abstract_inverted_index":{"Tyrosine":[0],"kinase":[1,9,28],"inhibitors":[2,37],"are":[3,24],"initially":[4],"efficacious":[5],"against":[6],"anaplastic":[7],"lymphoma":[8],"(ALK)":[10],"fusion":[11,227],"gene-positive":[12],"lung":[13,46,51,82,104,110,144,149,163,175,187,241],"adenocarcinoma,":[14],"but":[15],"acquired":[16],"resistance":[17,63],"inevitably":[18],"occurs.":[19],"Therefore,":[20],"alternative":[21],"treatment":[22],"strategies":[23],"needed":[25],"for":[26,234,239],"tyrosine":[27],"inhibitor-resistant":[29],"cases.":[30],"Although":[31,200],"the":[32,41,61,72,76,138,181,211,223],"use":[33],"of":[34,43,75,91,125,154,168,208,226],"immune":[35],"checkpoint":[36],"(ICI)":[38],"has":[39,112],"improved":[40],"prognosis":[42],"patients":[44,48],"with":[45,49],"cancer,":[47],"ALK+":[50,81,109,143,148,162,186,240],"adenocarcinoma":[52,83,105,111,150,164,188],"exhibit":[53],"little":[54],"or":[55],"no":[56],"response":[57],"to":[58,102,195],"immunotherapy":[59,238],"and":[60,95,135,137,158,210,248],"underlying":[62],"mechanisms":[64],"remain":[65],"unknown.":[66],"In":[67,146,160],"this":[68],"study,":[69],"we":[70],"explored":[71],"immunologic":[73],"status":[74],"tumor":[77],"microenvironment":[78],"(TME)":[79],"in":[80,142,183,218],"tissues.":[84],"Tumor-infiltrating":[85],"leukocyte":[86],"analysis":[87,121],"revealed":[88],"reduced":[89],"numbers":[90],"effector":[92],"T":[93,130,197],"cells":[94,99],"increased":[96],"myeloid-derived":[97],"suppressor":[98],"(MDSC)":[100],"relative":[101],"ALK-":[103,174],"cases,":[106],"indicating":[107],"that":[108,127],"a":[113,123,184,196,206,232,235],"myeloid":[114],"cell-dominant":[115,198],"immunosuppressive":[116,194,229],"TME.":[117],"Single-cell":[118],"RNA":[119],"sequencing":[120],"identified":[122],"subset":[124],"macrophages":[126,139],"expressed":[128,151],"most":[129],"cell-attractant":[131],"chemokines":[132,156],"(CXCL9,":[133],"CXCL10,":[134],"CXCL11),":[136],"were":[140],"inactivated":[141],"adenocarcinoma.":[145,176,242],"contrast,":[147],"high":[152],"levels":[153,167],"MDSC-attractant":[155],"(CXCL1":[157],"CXCL8).":[159],"addition,":[161],"showed":[165],"higher":[166],"IL6,":[169],"an":[170,193],"MDSC-inducing":[171],"cytokine,":[172],"than":[173],"An":[177],"IL6R":[178,212],"inhibitor":[179,213],"transformed":[180],"TME":[182],"murine":[185],"model,":[189],"shifting":[190],"it":[191],"from":[192],"status.":[199],"ICI":[201,209],"monotherapy":[202],"lacked":[203],"antitumor":[204,216],"effects,":[205],"combination":[207,237],"had":[214],"significant":[215],"effects":[217],"mice.":[219],"Our":[220],"findings":[221],"illustrate":[222],"molecular":[224],"basis":[225],"gene-mediated":[228],"TMEs,":[230],"providing":[231],"rationale":[233],"novel":[236],"See":[243],"related":[244],"Spotlight":[245],"by":[246],"Vitale":[247],"Bria,":[249],"p.1326.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2025-10-10T00:00:00"}
