{"id":"https://openalex.org/W4412106972","doi":"https://doi.org/10.2337/figshare.29310200","title":"Changes in \u03b2-Cell Function and Insulin Sensitivity During Treatment With Dapagliflozin Alone or in Combination With Exenatide in Type 2 Diabetes","display_name":"Changes in \u03b2-Cell Function and Insulin Sensitivity During Treatment With Dapagliflozin Alone or in Combination With Exenatide in Type 2 Diabetes","publication_year":2025,"publication_date":"2025-07-08","ids":{"openalex":"https://openalex.org/W4412106972","doi":"https://doi.org/10.2337/figshare.29310200"},"language":"en","primary_location":{"id":"doi:10.2337/figshare.29310200","doi":"https://doi.org/10.2337/figshare.29310200","is_oa":true,"landing_page_url":"https://doi.org/10.2337/figshare.29310200","pdf_url":null,"source":null,"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Diabetes Association","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.2337/figshare.29310200","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083775716","display_name":"Curtis L. Triplitt","orcid":"https://orcid.org/0000-0002-7775-7816","observed_orcids":["https://orcid.org/0000-0002-7775-7816"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Curtis Triplitt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079024626","display_name":"Eug\u00eanio Cers\u00f3simo","orcid":"https://orcid.org/0000-0002-2573-0208","observed_orcids":["https://orcid.org/0000-0002-2573-0208"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eugenio Cersosimo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080529340","display_name":"Mariam Alatrach","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mariam Alatrach","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004047023","display_name":"John Adams","orcid":"https://orcid.org/0000-0003-4567-5725","observed_orcids":["https://orcid.org/0000-0003-4567-5725"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Adams","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065253973","display_name":"ANDREA A. HANSIS-DIARTE","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrea Hansis-Diarte","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063163214","display_name":"Gozde Baskoy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gozde Baskoy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064556745","display_name":"Amalia Gastaldelli","orcid":"https://orcid.org/0000-0003-2594-1651","observed_orcids":["https://orcid.org/0000-0003-2594-1651"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amalia Gastaldelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073948447","display_name":"Alberto Chavez-Velazquez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alberto Chavez-Velazquez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5091912602","display_name":"Ralph A. DeFronzo","orcid":"https://orcid.org/0000-0003-3839-1724","observed_orcids":["https://orcid.org/0000-0003-3839-1724"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ralph A DeFronzo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dapagliflozin","display_name":"dapagliflozin","score":0.8069999814033508},{"id":"https://openalex.org/keywords/exenatide","display_name":"exenatide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sglt2-inhibitors","display_name":"SGLT2 inhibitors","score":0.8989999890327454},{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.9959999918937683},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8500000238418579},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.8230000138282776},{"id":"https://openalex.org/keywords/beta-cell-function","display_name":"beta-cell function","score":0.8619999885559082},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.8370000123977661},{"id":"https://openalex.org/keywords/matsuda-index","display_name":"Matsuda index","score":0.8510000109672546},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.7710000276565552},{"id":"https://openalex.org/keywords/oral-glucose-tolerance-test","display_name":"oral glucose tolerance test","score":0.8230000138282776},{"id":"https://openalex.org/keywords/drug-safety-and-tolerability","display_name":"drug safety and tolerability","score":0.4269999861717224},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.3630000054836273},{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":0.7099999785423279}],"concepts":[{"id":"https://openalex.org/C2780533449","wikidata":"https://www.wikidata.org/wiki/Q417762","display_name":"Exenatide","level":4,"score":0.9644677639007568},{"id":"https://openalex.org/C2777422806","wikidata":"https://www.wikidata.org/wiki/Q409898","display_name":"Dapagliflozin","level":4,"score":0.924419641494751},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.7434874773025513},{"id":"https://openalex.org/C3017594256","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin sensitivity","level":4,"score":0.6871230006217957},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5535076260566711},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5390955209732056},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5349648594856262},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.49342241883277893},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.46047794818878174},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.43883687257766724},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.24893105030059814},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2337/figshare.29310200","doi":"https://doi.org/10.2337/figshare.29310200","is_oa":true,"landing_page_url":"https://doi.org/10.2337/figshare.29310200","pdf_url":null,"source":null,"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Diabetes Association","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.2337/figshare.29310200","doi":"https://doi.org/10.2337/figshare.29310200","is_oa":true,"landing_page_url":"https://doi.org/10.2337/figshare.29310200","pdf_url":null,"source":null,"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Diabetes Association","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2145625393","https://openalex.org/W2887342240","https://openalex.org/W4211259843","https://openalex.org/W2794275614","https://openalex.org/W4210258699","https://openalex.org/W3035400399","https://openalex.org/W1993206248","https://openalex.org/W2463440353","https://openalex.org/W1992299744","https://openalex.org/W4299644834"],"abstract_inverted_index":{"Objective:":[0],"To":[1],"examine":[2],"the":[3],"effects":[4],"of":[5,69],"SGLT2i":[6],"alone":[7],"or":[8],"with":[9,23,228,242],"GLP-1":[10,24],"RA":[11],"on":[12],"\u03b2-cell":[13,30,83,221],"function":[14,31,84,222,236],"in":[15,29,96,118,124,132,143,151,154,166,171,176,181,187,201,210,220],"type":[16],"2":[17],"diabetes":[18],"[T2D].":[19],"Hypothesis:":[20],"SGLT-2i,":[21],"combined":[22],"RA,":[25],"provides":[26],"superior":[27],"improvement":[28],"than":[32,107,162],"either":[33,243],"agent":[34,244],"alone.":[35,245],"Research":[36],"Design":[37],"and":[38,63,67,82,101,112,120,126,145,149,153,184,196,203,214,223,237],"Methods:":[39],"90":[40],"patients":[41],"received":[42],"180-min":[43],"OGTT:":[44],"(i)":[45],"after":[46,65],"1":[47],"drug":[48],"dose":[49],"(ACUTE":[50],"study):":[51],"placebo":[52],"[PCB,":[53],"n=15];":[54],"dapagliflozin":[55,229],"[DAPA,":[56],"n=25];":[57,60],"exenatide":[58,215,231],"[EXE,":[59],"[DAPA/EXE,":[61],"n=25],":[62],"(ii)":[64],"1-":[66,111,148],"4-months":[68,150,197],"therapy.":[70],"Matsuda":[71],"index":[72,165],"corrected":[73],"(cMI)":[74],"for":[75],"urinary":[76],"glucose":[77],"loss,":[78],"insulin":[79,224,238],"secretion":[80],"[IS]":[81],"[BCF]":[85],"indices":[86],"were":[87,104],"calculated":[88],"during":[89],"OGTT.":[90],"Results:":[91],"In":[92,128],"ACUTE":[93,129,167],"study,":[94,130],"cMI":[95,114],"DAPA":[97,125,133,177,202],"(2.29\u00b10.33),":[98],"EXE":[99,119,144,152,182,204],"(2.03\u00b10.12)":[100],"DAPA+EXE":[102,188],"(2.36\u00b10.14)":[103],"higher":[105,139,158,174,180,186],"(p<0.05)":[106,175],"PCB":[108,137],"(1.63\u00b10.36).":[109],"After":[110,147],"4-months,":[113],"remained":[115,157],"similarly":[116],"elevated":[117],"increased":[121],"further":[122,200,209],"(p<0.001)":[123],"DAPA+EXE.":[127,211],"IS":[131,156],"was":[134,169],"similar":[135],"to":[136],"but":[138,205],"(p<0.001":[140],"vs.":[141,160,192],"both)":[142,161],"DAPA/EXE.":[146],"DAPA+EXE,":[155],"(p<0.01":[159],"DAPA.":[163],"BCF":[164,198],"study":[168],"0.40\u00b10.04":[170],"PCB,":[172],"62%":[173],"(0.65\u00b10.10),":[178],"3-fold":[179],"(1.17\u00b10.22)":[183],"4-fold":[185],"(1.69\u00b10.12)":[189],"(all":[190],"p<0.001":[191],"PCB).":[193],"At":[194],"1-month":[195],"rose":[199],"did":[206],"not":[207],"increase":[208],"Conclusion:":[212],"Dapagliflozin":[213],"monotherapy":[216],"cause":[217],"sustained":[218],"improvements":[219],"sensitivity.":[225],"Combination":[226],"therapy":[227],"plus":[230],"markedly":[232],"augmented":[233],"both":[234],"b-cell":[235],"sensitivity":[239],"above":[240],"that":[241]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2025-10-10T00:00:00"}