{"id":"https://openalex.org/W4412095000","doi":"https://doi.org/10.15294/biosaintifika.v17i2.26258","title":"Modulatory Effects of Noni (Morinda citrifolia L.) Fruit Polysaccharide Syrup on IgG Production and T Cell Activity","display_name":"Modulatory Effects of Noni (Morinda citrifolia L.) Fruit Polysaccharide Syrup on IgG Production and T Cell Activity","publication_year":2025,"publication_date":"2025-07-07","ids":{"openalex":"https://openalex.org/W4412095000","doi":"https://doi.org/10.15294/biosaintifika.v17i2.26258"},"language":"en","primary_location":{"id":"doi:10.15294/biosaintifika.v17i2.26258","doi":"https://doi.org/10.15294/biosaintifika.v17i2.26258","is_oa":true,"landing_page_url":"https://doi.org/10.15294/biosaintifika.v17i2.26258","pdf_url":null,"source":{"id":"https://openalex.org/S2764832501","display_name":"Biosaintifika Journal of Biology & Biology Education","issn_l":"2085-191X","issn":["2085-191X","2338-7610"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310315184","host_organization_name":"State University of Semarang","host_organization_lineage":["https://openalex.org/P4310315184"],"host_organization_lineage_names":["State University of Semarang"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biosaintifika: Journal of Biology &amp; Biology Education","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.15294/biosaintifika.v17i2.26258","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111071523","display_name":"La Ode Muhammad Anwar","orcid":"https://orcid.org/0009-0004-3090-4374","observed_orcids":["https://orcid.org/0009-0004-3090-4374"]},"institutions":[{"id":"https://openalex.org/I4405276155","display_name":"Universitas Medika Suherman","ror":"https://ror.org/04xtsbg21","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405276155"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"La Ode Muhammad Anwar","raw_affiliation_strings":["Faculty of Health Science, Universitas Medika Suherman, Bekasi, 17530, Indonesia"],"raw_orcid":"https://orcid.org/0009-0004-3090-4374","affiliations":[{"raw_affiliation_string":"Faculty of Health Science, Universitas Medika Suherman, Bekasi, 17530, Indonesia","institution_ids":["https://openalex.org/I4405276155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078693808","display_name":"Ediati Sasmito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165230279","display_name":"Universitas Gadjah Mada","ror":"https://ror.org/03ke6d638","country_code":"ID","type":"education","lineage":["https://openalex.org/I165230279"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Ediati Sasmito","raw_affiliation_strings":["Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia","institution_ids":["https://openalex.org/I165230279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061039599","display_name":"La Ode Akbar Rasydy","orcid":"https://orcid.org/0000-0003-4774-654X","observed_orcids":["https://orcid.org/0000-0003-4774-654X"]},"institutions":[{"id":"https://openalex.org/I4405275746","display_name":"Universitas Muhammadiyah Banten","ror":"https://ror.org/0478xzv45","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405275746"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"La Ode Akbar Rasydy","raw_affiliation_strings":["Faculty of Pharmacy, Universitas Muhammadiyah A.R. Fachruddin, Banten, 15720, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Universitas Muhammadiyah A.R. Fachruddin, Banten, 15720, Indonesia","institution_ids":["https://openalex.org/I4405275746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050820845","display_name":"Tri Wahyuni Ismoyowati","orcid":"https://orcid.org/0000-0002-6746-9335","observed_orcids":["https://orcid.org/0000-0002-6746-9335"]},"institutions":[{"id":"https://openalex.org/I4405276155","display_name":"Universitas Medika Suherman","ror":"https://ror.org/04xtsbg21","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405276155"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Tri Wahyuni Ismoyowati","raw_affiliation_strings":["Faculty of Health Science, Universitas Medika Suherman, Bekasi, 17530, Indonesia"],"raw_orcid":"https://orcid.org/0000-0002-6746-9335","affiliations":[{"raw_affiliation_string":"Faculty of Health Science, Universitas Medika Suherman, Bekasi, 17530, Indonesia","institution_ids":["https://openalex.org/I4405276155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092781125","display_name":"Salma Hilmy Rusydi Hashim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405276155","display_name":"Universitas Medika Suherman","ror":"https://ror.org/04xtsbg21","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405276155"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Salma Hilmy Rusydi Hashim","raw_affiliation_strings":["Faculty of Health Science, Universitas Medika Suherman, Bekasi, 17530, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health Science, Universitas Medika Suherman, Bekasi, 17530, Indonesia","institution_ids":["https://openalex.org/I4405276155"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rohani Siregar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405276155","display_name":"Universitas Medika Suherman","ror":"https://ror.org/04xtsbg21","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405276155"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Rohani Siregar","raw_affiliation_strings":["Faculty of Health Science, Universitas Medika Suherman, Bekasi, 17530, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health Science, Universitas Medika Suherman, Bekasi, 17530, Indonesia","institution_ids":["https://openalex.org/I4405276155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039568673","display_name":"Emmelia Kristina Hutagaol","orcid":"https://orcid.org/0000-0001-5741-8780","observed_orcids":["https://orcid.org/0000-0001-5741-8780"]},"institutions":[{"id":"https://openalex.org/I4405276155","display_name":"Universitas Medika Suherman","ror":"https://ror.org/04xtsbg21","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405276155"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Emmelia Kristina Hutagaol","raw_affiliation_strings":["Faculty of Health Science, Universitas Medika Suherman, Bekasi, 17530, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health Science, Universitas Medika Suherman, Bekasi, 17530, Indonesia","institution_ids":["https://openalex.org/I4405276155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070132053","display_name":"Cicilia Nony Ayuningsih Bratajaya","orcid":"https://orcid.org/0000-0002-7344-2374","observed_orcids":["https://orcid.org/0000-0002-7344-2374"]},"institutions":[{"id":"https://openalex.org/I4405276155","display_name":"Universitas Medika Suherman","ror":"https://ror.org/04xtsbg21","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405276155"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Cicilia Nony Ayuningsih Bratajaya","raw_affiliation_strings":["Faculty of Health Science, Universitas Medika Suherman, Bekasi, 17530, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health Science, Universitas Medika Suherman, Bekasi, 17530, Indonesia","institution_ids":["https://openalex.org/I4405276155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118850689","display_name":"Aprilina Sartika","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405276155","display_name":"Universitas Medika Suherman","ror":"https://ror.org/04xtsbg21","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405276155"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Aprilina Sartika","raw_affiliation_strings":["Faculty of Health Science, Universitas Medika Suherman, Bekasi, 17530, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health Science, Universitas Medika Suherman, Bekasi, 17530, Indonesia","institution_ids":["https://openalex.org/I4405276155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118850686","display_name":"Dandi Sanjaya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405276155","display_name":"Universitas Medika Suherman","ror":"https://ror.org/04xtsbg21","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405276155"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Dandi Sanjaya","raw_affiliation_strings":["Faculty of Health Science, Universitas Medika Suherman, Bekasi, 17530, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health Science, Universitas Medika Suherman, Bekasi, 17530, Indonesia","institution_ids":["https://openalex.org/I4405276155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060481856","display_name":"Hajar Nur Fathur Rohmah","orcid":"https://orcid.org/0000-0002-6725-4668","observed_orcids":["https://orcid.org/0000-0002-6725-4668"]},"institutions":[{"id":"https://openalex.org/I4405276155","display_name":"Universitas Medika Suherman","ror":"https://ror.org/04xtsbg21","country_code":"ID","type":"education","lineage":["https://openalex.org/I4405276155"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Hajar Nur Fathur Rohmah","raw_affiliation_strings":["Faculty of Health Science, Universitas Medika Suherman, Bekasi, 17530, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health Science, Universitas Medika Suherman, Bekasi, 17530, Indonesia","institution_ids":["https://openalex.org/I4405276155"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032198865","display_name":"Joao Manuel Correia Ximenes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387154880","display_name":"Universidade de D\u00edli","ror":"https://ror.org/02p435225","country_code":"TL","type":"education","lineage":["https://openalex.org/I4387154880"]}],"countries":["TL"],"is_corresponding":false,"raw_author_name":"Joao Manuel Correia Ximenes","raw_affiliation_strings":["Faculty of Health Sciences, Universidade de D\u00edli, Dili, Timor Leste"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health Sciences, Universidade de D\u00edli, Dili, Timor Leste","institution_ids":["https://openalex.org/I4387154880"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1500000,"currency":"IDR","value_usd":98},"apc_paid":{"value":1500000,"currency":"IDR","value_usd":98},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"2","first_page":"349","last_page":"357"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13792","display_name":"Morinda citrifolia extract uses","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13792","display_name":"Morinda citrifolia extract uses","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12192","display_name":"Polysaccharides Composition and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/noni-fruit","display_name":"noni fruit","score":0.8479999899864197},{"id":"https://openalex.org/keywords/morinda-citrifolia","display_name":"Morinda citrifolia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fruit-polysaccharides","display_name":"fruit polysaccharides","score":0.8479999899864197},{"id":"https://openalex.org/keywords/igg","display_name":"IgG","score":0.8320000171661377},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.7990000247955322},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.968999981880188},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":1.0},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/hepatitis-b-vaccination","display_name":"hepatitis B vaccination","score":0.8550000190734863},{"id":"https://openalex.org/keywords/liver-and-kidney-histopathology","display_name":"liver and kidney histopathology","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C2781264782","wikidata":"https://www.wikidata.org/wiki/Q901656","display_name":"Immunostimulant","level":3,"score":0.7274032235145569},{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.6621025204658508},{"id":"https://openalex.org/C2779308761","wikidata":"https://www.wikidata.org/wiki/Q850491","display_name":"Morinda","level":2,"score":0.6148629188537598},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5768834948539734},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5665605068206787},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5582806468009949},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.46945804357528687},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43025511503219604},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.42990541458129883},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4009115397930145},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.38352158665657043},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3696596920490265},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19532054662704468}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.15294/biosaintifika.v17i2.26258","doi":"https://doi.org/10.15294/biosaintifika.v17i2.26258","is_oa":true,"landing_page_url":"https://doi.org/10.15294/biosaintifika.v17i2.26258","pdf_url":null,"source":{"id":"https://openalex.org/S2764832501","display_name":"Biosaintifika Journal of Biology & Biology Education","issn_l":"2085-191X","issn":["2085-191X","2338-7610"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310315184","host_organization_name":"State University of Semarang","host_organization_lineage":["https://openalex.org/P4310315184"],"host_organization_lineage_names":["State University of Semarang"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biosaintifika: Journal of Biology &amp; Biology Education","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:36846e3b6af74ba6a0689f1adb9bf825","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/36846e3b6af74ba6a0689f1adb9bf825","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biosaintifika: Journal of Biology & Biology Education, Vol 17, Iss 2 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.15294/biosaintifika.v17i2.26258","doi":"https://doi.org/10.15294/biosaintifika.v17i2.26258","is_oa":true,"landing_page_url":"https://doi.org/10.15294/biosaintifika.v17i2.26258","pdf_url":null,"source":{"id":"https://openalex.org/S2764832501","display_name":"Biosaintifika Journal of Biology & Biology Education","issn_l":"2085-191X","issn":["2085-191X","2338-7610"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310315184","host_organization_name":"State University of Semarang","host_organization_lineage":["https://openalex.org/P4310315184"],"host_organization_lineage_names":["State University of Semarang"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biosaintifika: Journal of Biology &amp; Biology Education","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3009374485","https://openalex.org/W2973048949","https://openalex.org/W4283706277","https://openalex.org/W2139357378","https://openalex.org/W2341274091","https://openalex.org/W7099441248","https://openalex.org/W3136498719","https://openalex.org/W2292841930","https://openalex.org/W1531791692","https://openalex.org/W4286009479"],"abstract_inverted_index":{"Noni":[0],"fruit":[1,21],"containing":[2],"polysaccharides,":[3],"has":[4],"the":[5,27,33,36,62,68,125,176,185],"potential":[6],"to":[7,25,43,60,120,175],"be":[8,195],"developed":[9],"into":[10],"pharmaceutical":[11],"products":[12],"such":[13],"as":[14],"SPF":[15,65,91,141,181,190],"syrup.":[16],"The":[17,54,77,137],"content":[18],"of":[19,29,35,56,64,70,96,170,187],"noni":[20],"polysaccharides":[22,193],"is":[23,49],"known":[24],"increase":[26],"proliferation":[28],"T":[30,75,129,158],"lymphocyte":[31,159],"cells,":[32],"regulation":[34],"immune":[37],"system":[38],"molecularly,":[39],"especially":[40],"with":[41],"regard":[42],"antibodies":[44],"(IgG),":[45],"CD4+,":[46],"and":[47,74,99,128,132,151,178],"CD8+,":[48],"still":[50],"not":[51,183],"widely":[52],"studied.":[53],"aim":[55],"this":[57],"study":[58,78],"was":[59,79],"assess":[61],"impact":[63],"syrup":[66,92],"on":[67,81,117,147],"modulation":[69],"immunoglobulin":[71],"G":[72],"(IgG)":[73],"lymphocytes.":[76],"conducted":[80],"female":[82],"Wistar":[83],"rats":[84],"aged":[85],"8-9":[86],"months,":[87],"which":[88],"were":[89,106,115,153],"given":[90],"orally":[93],"at":[94],"doses":[95],"25,":[97],"50,":[98],"100":[100],"mg/kgBB":[101],"for":[102],"31":[103,119],"days.":[104],"Mice":[105],"vaccinated":[107],"against":[108],"hepatitis":[109,171],"B":[110,172],"every":[111],"week.":[112],"Blood":[113],"samples":[114],"taken":[116],"day":[118],"measure":[121],"IgG":[122,148],"levels":[123,149],"by":[124,134],"ELISA":[126],"method":[127],"cells":[130,160],"(CD4+":[131],"CD8+)":[133,162],"flow":[135],"cytometry.":[136],"results":[138],"showed":[139,166],"that":[140,167,191],"administration":[142],"had":[143],"a":[144],"significant":[145,155],"effect":[146],"(p<0.05),":[150],"there":[152],"no":[154],"changes":[156],"in":[157,199],"(CD4+,":[161],"(p>0.05).":[163],"Histopathological":[164],"examination":[165],"long-term":[168],"induction":[169],"caused":[173],"damage":[174],"liver":[177],"kidney,":[179],"but":[180],"did":[182],"affect":[184],"condition":[186],"these":[188],"organs.":[189],"contains":[192],"can":[194],"an":[196],"innovative":[197],"component":[198],"immunostimulant":[200],"formulations.":[201]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2025-10-10T00:00:00"}