{"id":"https://openalex.org/W4412071809","doi":"https://doi.org/10.3390/biology14070818","title":"Heavy Metal-Associated (HMA) Domain-Containing Proteins: Insight into Their Features and Roles in Bread Wheat (Triticum aestivum L.)","display_name":"Heavy Metal-Associated (HMA) Domain-Containing Proteins: Insight into Their Features and Roles in Bread Wheat (Triticum aestivum L.)","publication_year":2025,"publication_date":"2025-07-05","ids":{"openalex":"https://openalex.org/W4412071809","doi":"https://doi.org/10.3390/biology14070818","pmid":"https://pubmed.ncbi.nlm.nih.gov/40723376"},"language":"en","primary_location":{"id":"doi:10.3390/biology14070818","doi":"https://doi.org/10.3390/biology14070818","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biology14070818","pdf_url":null,"source":{"id":"https://openalex.org/S153489431","display_name":"Biology","issn_l":"2079-7737","issn":["2079-7737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/biology14070818","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089642448","display_name":"Mehak Taneja","orcid":"https://orcid.org/0000-0002-5125-4540","observed_orcids":["https://orcid.org/0000-0002-5125-4540"]},"institutions":[{"id":"https://openalex.org/I165682329","display_name":"Guru Nanak Dev University","ror":"https://ror.org/05ghzpa93","country_code":"IN","type":"education","lineage":["https://openalex.org/I165682329"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mehak Taneja","raw_affiliation_strings":["Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar 143005, India"],"raw_orcid":"https://orcid.org/0000-0002-5125-4540","affiliations":[{"raw_affiliation_string":"Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar 143005, India","institution_ids":["https://openalex.org/I165682329"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101867348","display_name":"Santosh Kumar Upadhyay","orcid":"https://orcid.org/0000-0001-6991-0502","observed_orcids":["https://orcid.org/0000-0001-6991-0502"]},"institutions":[{"id":"https://openalex.org/I51452335","display_name":"Panjab University","ror":"https://ror.org/04p2sbk06","country_code":"IN","type":"education","lineage":["https://openalex.org/I51452335"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Santosh Kumar Upadhyay","raw_affiliation_strings":["Department of Botany, Panjab University, Chandigarh 160014, India"],"raw_orcid":"https://orcid.org/0000-0001-6991-0502","affiliations":[{"raw_affiliation_string":"Department of Botany, Panjab University, Chandigarh 160014, India","institution_ids":["https://openalex.org/I51452335"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101867348"],"corresponding_institution_ids":["https://openalex.org/I51452335"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":1.0226,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.76030391,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"14","issue":"7","first_page":"818","last_page":"818"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.6875,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.6875,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11418","display_name":"Plant Micronutrient Interactions and Effects","score":0.2433999925851822,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11247","display_name":"Plant nutrient uptake and metabolism","score":0.013700000010430813,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wheat","display_name":"wheat","score":0.9210000038146973},{"id":"https://openalex.org/keywords/metal-ion-transport","display_name":"metal ion transport","score":0.875},{"id":"https://openalex.org/keywords/gene-family-evolution","display_name":"gene family evolution","score":0.7379999756813049},{"id":"https://openalex.org/keywords/gene-duplication","display_name":"gene duplication","score":0.7549999952316284},{"id":"https://openalex.org/keywords/tandem-duplication","display_name":"tandem duplication","score":0.5929999947547913},{"id":"https://openalex.org/keywords/segmental-duplication","display_name":"segmental duplication","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cis-regulatory-elements","display_name":"cis-regulatory elements","score":0.8199999928474426},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.8090000152587891},{"id":"https://openalex.org/keywords/abiotic-stress-response","display_name":"abiotic stress response","score":0.7760000228881836},{"id":"https://openalex.org/keywords/histogenesis","display_name":"histogenesis","score":0.7540000081062317},{"id":"https://openalex.org/keywords/phylogenetic-clades","display_name":"phylogenetic clades","score":0.6679999828338623},{"id":"https://openalex.org/keywords/synteny","display_name":"synteny","score":0.8040000200271606}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9272226095199585},{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.7989110946655273},{"id":"https://openalex.org/C53702515","wikidata":"https://www.wikidata.org/wiki/Q971246","display_name":"Synteny","level":4,"score":0.7881898880004883},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7113402485847473},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.546764612197876},{"id":"https://openalex.org/C2779491563","wikidata":"https://www.wikidata.org/wiki/Q157892","display_name":"Arabidopsis","level":4,"score":0.5423264503479004},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.5217538475990295},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.48793360590934753},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.4752485752105713},{"id":"https://openalex.org/C2775988993","wikidata":"https://www.wikidata.org/wiki/Q158695","display_name":"Arabidopsis thaliana","level":4,"score":0.4701633155345917},{"id":"https://openalex.org/C57808653","wikidata":"https://www.wikidata.org/wiki/Q7446270","display_name":"Segmental duplication","level":5,"score":0.4663526117801666},{"id":"https://openalex.org/C5911399","wikidata":"https://www.wikidata.org/wiki/Q2278983","display_name":"Gene family","level":4,"score":0.4599570035934448},{"id":"https://openalex.org/C156446351","wikidata":"https://www.wikidata.org/wiki/Q7682435","display_name":"Tandem exon duplication","level":4,"score":0.4375714063644409},{"id":"https://openalex.org/C89519541","wikidata":"https://www.wikidata.org/wiki/Q4667893","display_name":"Abiotic stress","level":3,"score":0.4337434768676758},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3343941569328308},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.17350417375564575}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/biology14070818","doi":"https://doi.org/10.3390/biology14070818","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biology14070818","pdf_url":null,"source":{"id":"https://openalex.org/S153489431","display_name":"Biology","issn_l":"2079-7737","issn":["2079-7737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"journal-article"},{"id":"pmid:40723376","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40723376","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12292569","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12292569","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biology (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:5096518a203d4b028a19d74db2b8f8cf","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5096518a203d4b028a19d74db2b8f8cf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biology, Vol 14, Iss 7, p 818 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biology14070818","doi":"https://doi.org/10.3390/biology14070818","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biology14070818","pdf_url":null,"source":{"id":"https://openalex.org/S153489431","display_name":"Biology","issn_l":"2079-7737","issn":["2079-7737"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.8409000039100647}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.5400000214576721}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1562315224","https://openalex.org/W1970392858","https://openalex.org/W2004622806","https://openalex.org/W2011657487","https://openalex.org/W2035908878","https://openalex.org/W2061027543","https://openalex.org/W2101289352","https://openalex.org/W2106882534","https://openalex.org/W2107158607","https://openalex.org/W2110596109","https://openalex.org/W2119205648","https://openalex.org/W2136229065","https://openalex.org/W2137468028","https://openalex.org/W2145091349","https://openalex.org/W2146857662","https://openalex.org/W2158173168","https://openalex.org/W2161656526","https://openalex.org/W2242580666","https://openalex.org/W2311203695","https://openalex.org/W2403008074","https://openalex.org/W2418044989","https://openalex.org/W2470286516","https://openalex.org/W2805519510","https://openalex.org/W2810101462","https://openalex.org/W2921638504","https://openalex.org/W2977796271","https://openalex.org/W2991012415","https://openalex.org/W3023309870","https://openalex.org/W3036319615","https://openalex.org/W3098606581","https://openalex.org/W3128134680","https://openalex.org/W3156458251","https://openalex.org/W3196826633","https://openalex.org/W4225627383","https://openalex.org/W4281708416","https://openalex.org/W4323047544","https://openalex.org/W4361273960","https://openalex.org/W4376114567","https://openalex.org/W4387404219","https://openalex.org/W4389683915","https://openalex.org/W4390538807","https://openalex.org/W4391848711","https://openalex.org/W4392767718","https://openalex.org/W4399246522","https://openalex.org/W4402638897","https://openalex.org/W4404252773","https://openalex.org/W4404531735","https://openalex.org/W4405353862"],"related_works":["https://openalex.org/W1970221653","https://openalex.org/W2765671423","https://openalex.org/W3003460912","https://openalex.org/W3017020035","https://openalex.org/W2903868423","https://openalex.org/W2947176566","https://openalex.org/W4386319054","https://openalex.org/W4224095691","https://openalex.org/W2160128250","https://openalex.org/W4285289417"],"abstract_inverted_index":{"The":[0,54],"heavy":[1],"metal-associated":[2],"(HMA)":[3],"domain-harboring":[4],"proteins":[5,56],"constitute":[6],"critical":[7],"players":[8],"involved":[9],"in":[10,17,36,59,62,124,156,160,194],"the":[11,37,69,72,81,93,125,133,152,161,165,170,178,190],"transport":[12],"of":[13,30,42,71,102,127,136,154,167,172],"various":[14,173],"metal":[15],"ions":[16],"plants,":[18],"and":[19,24,49,120,144,169,183,188],"are":[20],"associated":[21],"with":[22,66,92,139],"development":[23,166],"stress":[25,175],"responses.":[26],"Herein,":[27],"a":[28,45,50,100,114],"total":[29],"243":[31],"TaHMA":[32,55,82,128,137],"genes":[33,138],"were":[34,57],"identified":[35],"bread":[38],"wheat":[39],"genome,":[40],"each":[41],"which":[43,64],"had":[44],"characteristic":[46],"molecular":[47],"profile":[48],"distinct":[51],"chromosomal":[52],"localization.":[53],"distributed":[58],"five":[60],"clades":[61],"phylogeny,":[63],"differed":[65],"respect":[67],"to":[68,185,196],"distribution":[70],"key":[73],"HMA":[74],"domain.":[75],"Sub-cellular":[76],"localization":[77],"was":[78],"variable":[79],"for":[80],"proteins.":[83],"Gene":[84,110],"structure":[85],"analysis":[86,98,112,131,147],"yielded":[87],"similar":[88],"results":[89],"when":[90],"compared":[91],"orthologous":[94],"counterparts.":[95],"Cis-regulatory":[96],"element":[97],"produced":[99],"range":[101],"promoter":[103],"elements,":[104],"suggesting":[105],"their":[106,198],"diverse":[107],"biological":[108],"roles.":[109],"duplication":[111,122],"revealed":[113],"crucial":[115,149],"role":[116,153],"played":[117],"by":[118],"tandem":[119],"segmental":[121],"events":[123],"expansion":[126],"genes.":[129],"Synteny":[130],"highlighted":[132],"evolutionary":[134],"relatedness":[135],"those":[140],"derived":[141],"from":[142],"Arabidopsis":[143],"rice.":[145],"Expression":[146],"provided":[148],"information":[150],"about":[151],"TaHMAs":[155,193],"mediating":[157],"vital":[158],"responses":[159],"plant":[162],"body,":[163],"including":[164],"tissues":[168],"regulation":[171],"abiotic":[174],"conditions.":[176],"Overall,":[177],"study":[179],"provides":[180],"significant":[181],"cues":[182],"evidence":[184],"functionally":[186],"annotate":[187],"characterize":[189],"differentially":[191],"expressed":[192],"order":[195],"validate":[197],"role.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-09-21T07:43:02.447757","created_date":"2025-07-07T00:00:00"}
