{"id":"https://openalex.org/W4412070788","doi":"https://doi.org/10.1158/2767-9764.crc-25-0051","title":"Impact of Glucocorticoids on Immune Checkpoint Inhibitor Efficacy and Circulating Biomarkers in Non\u2013Small Cell Lung Cancer Patients","display_name":"Impact of Glucocorticoids on Immune Checkpoint Inhibitor Efficacy and Circulating Biomarkers in Non\u2013Small Cell Lung Cancer Patients","publication_year":2025,"publication_date":"2025-07-01","ids":{"openalex":"https://openalex.org/W4412070788","doi":"https://doi.org/10.1158/2767-9764.crc-25-0051","pmid":"https://pubmed.ncbi.nlm.nih.gov/40622275"},"language":"en","primary_location":{"id":"doi:10.1158/2767-9764.crc-25-0051","doi":"https://doi.org/10.1158/2767-9764.crc-25-0051","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.crc-25-0051","pdf_url":"https://aacrjournals.org/cancerrescommun/article-pdf/5/7/1082/3628195/crc-25-0051.pdf","source":{"id":"https://openalex.org/S4210217028","display_name":"Cancer Research Communications","issn_l":"2767-9764","issn":["2767-9764"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacrjournals.org/cancerrescommun/article-pdf/5/7/1082/3628195/crc-25-0051.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113034509","display_name":"Lauren Polyakov","orcid":"https://orcid.org/0009-0009-9682-9772","observed_orcids":["https://orcid.org/0009-0009-9682-9772"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren Polyakov","raw_affiliation_strings":["1Department of Surgery, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California"],"raw_orcid":"https://orcid.org/0009-0009-9682-9772","affiliations":[{"raw_affiliation_string":"1Department of Surgery, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101535254","display_name":"Angelina E. Lim","orcid":"https://orcid.org/0000-0001-5508-0392","observed_orcids":["https://orcid.org/0000-0001-5508-0392"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angelina Lim","raw_affiliation_strings":["1Department of Surgery, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California"],"raw_orcid":"https://orcid.org/0000-0001-5508-0392","affiliations":[{"raw_affiliation_string":"1Department of Surgery, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104046138","display_name":"Alexandra Meyer","orcid":"https://orcid.org/0009-0008-3220-5445","observed_orcids":["https://orcid.org/0009-0008-3220-5445"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra Meyer","raw_affiliation_strings":["1Department of Surgery, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California"],"raw_orcid":"https://orcid.org/0009-0008-3220-5445","affiliations":[{"raw_affiliation_string":"1Department of Surgery, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073526710","display_name":"Aubree Mades","orcid":"https://orcid.org/0000-0003-4707-9505","observed_orcids":["https://orcid.org/0000-0003-4707-9505"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aubree Mades","raw_affiliation_strings":["2Department of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California"],"raw_orcid":"https://orcid.org/0000-0003-4707-9505","affiliations":[{"raw_affiliation_string":"2Department of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016305195","display_name":"Joshua Ni","orcid":"https://orcid.org/0009-0009-8572-9418","observed_orcids":["https://orcid.org/0009-0009-8572-9418"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua Ni","raw_affiliation_strings":["1Department of Surgery, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California"],"raw_orcid":"https://orcid.org/0009-0009-8572-9418","affiliations":[{"raw_affiliation_string":"1Department of Surgery, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ryan Cooper","orcid":"https://orcid.org/0000-0002-5473-2392","observed_orcids":["https://orcid.org/0000-0002-5473-2392"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan Cooper","raw_affiliation_strings":["2Department of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California"],"raw_orcid":"https://orcid.org/0000-0002-5473-2392","affiliations":[{"raw_affiliation_string":"2Department of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061624529","display_name":"Shirley Ye","orcid":"https://orcid.org/0009-0002-0126-6962","observed_orcids":["https://orcid.org/0009-0002-0126-6962"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shirley Ye","raw_affiliation_strings":["2Department of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California"],"raw_orcid":"https://orcid.org/0009-0002-0126-6962","affiliations":[{"raw_affiliation_string":"2Department of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023083411","display_name":"Ryutaro Kajihara","orcid":"https://orcid.org/0000-0003-0908-2543","observed_orcids":["https://orcid.org/0000-0003-0908-2543"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Ryutaro Kajihara","raw_affiliation_strings":["3Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, New York","4Department of Hematology and Immunology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan"],"raw_orcid":"https://orcid.org/0000-0003-0908-2543","affiliations":[{"raw_affiliation_string":"3Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, New York","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"4Department of Hematology and Immunology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086349111","display_name":"Takaaki Oba","orcid":"https://orcid.org/0000-0001-8283-4989","observed_orcids":["https://orcid.org/0000-0001-8283-4989"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I137975476","display_name":"Shinshu University","ror":"https://ror.org/0244rem06","country_code":"JP","type":"education","lineage":["https://openalex.org/I137975476"]},{"id":"https://openalex.org/I4210129652","display_name":"Shinshu University Hospital","ror":"https://ror.org/03a2hf118","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210129652"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Takaaki Oba","raw_affiliation_strings":["3Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, New York","5Division of Breast and Endocrine Surgery, Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan"],"raw_orcid":"https://orcid.org/0000-0001-8283-4989","affiliations":[{"raw_affiliation_string":"3Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, New York","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"5Division of Breast and Endocrine Surgery, Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan","institution_ids":["https://openalex.org/I137975476","https://openalex.org/I4210129652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027188434","display_name":"Leslie Contreras","orcid":"https://orcid.org/0009-0009-4631-2855","observed_orcids":["https://orcid.org/0009-0009-4631-2855"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leslie Contreras","raw_affiliation_strings":["1Department of Surgery, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California"],"raw_orcid":"https://orcid.org/0009-0009-4631-2855","affiliations":[{"raw_affiliation_string":"1Department of Surgery, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075834471","display_name":"Eihab Abdelfatah","orcid":"https://orcid.org/0000-0002-5503-8685","observed_orcids":["https://orcid.org/0000-0002-5503-8685"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eihab Abdelfatah","raw_affiliation_strings":["6Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, New York"],"raw_orcid":"https://orcid.org/0000-0002-5503-8685","affiliations":[{"raw_affiliation_string":"6Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, New York","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075692104","display_name":"Joy Sarkar","orcid":"https://orcid.org/0000-0002-7920-1926","observed_orcids":["https://orcid.org/0000-0002-7920-1926"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joy Sarkar","raw_affiliation_strings":["6Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, New York"],"raw_orcid":"https://orcid.org/0000-0002-7920-1926","affiliations":[{"raw_affiliation_string":"6Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, New York","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007565860","display_name":"Junko Matsuzaki","orcid":"https://orcid.org/0000-0002-2555-1234","observed_orcids":["https://orcid.org/0000-0002-2555-1234"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junko Matsuzaki","raw_affiliation_strings":["3Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, New York"],"raw_orcid":"https://orcid.org/0000-0002-2555-1234","affiliations":[{"raw_affiliation_string":"3Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, New York","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100351412","display_name":"Ming Li","orcid":"https://orcid.org/0009-0007-4563-6917","observed_orcids":["https://orcid.org/0009-0007-4563-6917"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming Li","raw_affiliation_strings":["7Department of Population and Public Health Sciences, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California"],"raw_orcid":"https://orcid.org/0009-0007-4563-6917","affiliations":[{"raw_affiliation_string":"7Department of Population and Public Health Sciences, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021643149","display_name":"Rajeev Sharma","orcid":"https://orcid.org/0000-0003-1342-7153","observed_orcids":["https://orcid.org/0000-0003-1342-7153"]},"institutions":[{"id":"https://openalex.org/I1324520350","display_name":"Hackensack University Medical Center","ror":"https://ror.org/008zj0x80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1324520350"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajeev Sharma","raw_affiliation_strings":["8Department of Medicine, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, The State University of New York, Buffalo, New York","9Division of Endocrinology, Hackensack Meridian Hackensack University Medical Center, Hackensack, New Jersey"],"raw_orcid":"https://orcid.org/0000-0003-1342-7153","affiliations":[{"raw_affiliation_string":"8Department of Medicine, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, The State University of New York, Buffalo, New York","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"9Division of Endocrinology, Hackensack Meridian Hackensack University Medical Center, Hackensack, New Jersey","institution_ids":["https://openalex.org/I1324520350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059770078","display_name":"Brahm H. Segal","orcid":"https://orcid.org/0000-0001-5043-7380","observed_orcids":["https://orcid.org/0000-0001-5043-7380"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brahm H. Segal","raw_affiliation_strings":["10Department of Medical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, New York","8Department of Medicine, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, The State University of New York, Buffalo, New York"],"raw_orcid":"https://orcid.org/0000-0001-5043-7380","affiliations":[{"raw_affiliation_string":"10Department of Medical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, New York","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"8Department of Medicine, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, The State University of New York, Buffalo, New York","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040242676","display_name":"Robert C. Hsu","orcid":"https://orcid.org/0000-0003-3957-6106","observed_orcids":["https://orcid.org/0000-0003-3957-6106"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert C. Hsu","raw_affiliation_strings":["2Department of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California"],"raw_orcid":"https://orcid.org/0000-0003-3957-6106","affiliations":[{"raw_affiliation_string":"2Department of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065057709","display_name":"Hongbin Chen","orcid":"https://orcid.org/0000-0002-5086-4769","observed_orcids":["https://orcid.org/0000-0002-5086-4769"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongbin Chen","raw_affiliation_strings":["10Department of Medical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, New York","8Department of Medicine, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, The State University of New York, Buffalo, New York"],"raw_orcid":"https://orcid.org/0000-0002-5086-4769","affiliations":[{"raw_affiliation_string":"10Department of Medical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, New York","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"8Department of Medicine, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, The State University of New York, Buffalo, New York","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071469591","display_name":"Jorge J. Nieva","orcid":"https://orcid.org/0000-0003-1605-4719","observed_orcids":["https://orcid.org/0000-0003-1605-4719"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jorge Nieva","raw_affiliation_strings":["2Department of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California"],"raw_orcid":"https://orcid.org/0000-0003-1605-4719","affiliations":[{"raw_affiliation_string":"2Department of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009056123","display_name":"Fumito Ito","orcid":"https://orcid.org/0000-0002-6866-671X","observed_orcids":["https://orcid.org/0000-0002-6866-671X"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I4210117038","display_name":"USC Norris Comprehensive Cancer Center","ror":"https://ror.org/01nmyfr60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431","https://openalex.org/I4210117038"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Fumito Ito","raw_affiliation_strings":["11Department of Molecular Microbiology and Immunology, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California","1Department of Surgery, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California","3Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, New York","6Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, New York"],"raw_orcid":"https://orcid.org/0000-0002-6866-671X","affiliations":[{"raw_affiliation_string":"11Department of Molecular Microbiology and Immunology, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]},{"raw_affiliation_string":"1Department of Surgery, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I4210117038"]},{"raw_affiliation_string":"3Center for Immunotherapy, Roswell Park Comprehensive Cancer Center, Buffalo, New York","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"6Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, New York","institution_ids":["https://openalex.org/I1292894508"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5009056123"],"corresponding_institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1292894508","https://openalex.org/I4210117038"],"apc_list":{"value":2550,"currency":"USD","value_usd":2550},"apc_paid":{"value":2550,"currency":"USD","value_usd":2550},"fwci":4.723,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.95944392,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"5","issue":"7","first_page":"1082","last_page":"1094"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.9399999976158142},{"id":"https://openalex.org/keywords/corticosteroid-use","display_name":"corticosteroid use","score":0.8970000147819519},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.8730000257492065},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9950000047683716},{"id":"https://openalex.org/keywords/anti-pd-1-therapy","display_name":"anti-PD-1 therapy","score":0.953000009059906},{"id":"https://openalex.org/keywords/neutrophil-to-lymphocyte-ratio","display_name":"neutrophil-to-lymphocyte ratio","score":0.9769999980926514},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7860000133514404},{"id":"https://openalex.org/keywords/effector-t-cell-differentiation","display_name":"effector T cell differentiation","score":0.7710000276565552},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.5339999794960022},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.5770000219345093},{"id":"https://openalex.org/keywords/mc38-tumor-model","display_name":"MC38 tumor","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7840344905853271},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6464586853981018},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5820134282112122},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5505908727645874},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.5497204065322876},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5433663725852966},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5200707316398621},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4996771812438965},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.41452062129974365},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3468523621559143}],"mesh":[{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1158/2767-9764.crc-25-0051","doi":"https://doi.org/10.1158/2767-9764.crc-25-0051","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.crc-25-0051","pdf_url":"https://aacrjournals.org/cancerrescommun/article-pdf/5/7/1082/3628195/crc-25-0051.pdf","source":{"id":"https://openalex.org/S4210217028","display_name":"Cancer Research Communications","issn_l":"2767-9764","issn":["2767-9764"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research Communications","raw_type":"journal-article"},{"id":"pmid:40622275","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40622275","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research communications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12232904","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12232904","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Res Commun","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/2767-9764.crc-25-0051","doi":"https://doi.org/10.1158/2767-9764.crc-25-0051","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.crc-25-0051","pdf_url":"https://aacrjournals.org/cancerrescommun/article-pdf/5/7/1082/3628195/crc-25-0051.pdf","source":{"id":"https://openalex.org/S4210217028","display_name":"Cancer Research Communications","issn_l":"2767-9764","issn":["2767-9764"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8600000143051147}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G215985982","display_name":null,"funder_award_id":"#P30 CA016056","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2499552460","display_name":null,"funder_award_id":"K08CA197966","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G434192171","display_name":null,"funder_award_id":"R25 CA225513","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4802861952","display_name":null,"funder_award_id":"R01 CA255240","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4803952451","display_name":null,"funder_award_id":"LC180245","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G4864313915","display_name":null,"funder_award_id":"R01 CA272827","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5566852224","display_name":null,"funder_award_id":"P30CA016056","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G7548596865","display_name":null,"funder_award_id":"R01CA267690","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8885149308","display_name":"Novel immunological biomarkers ovarian cancer prognosis","funder_award_id":"R01CA188900","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000910363","display_name":"University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)","funder_award_id":"P30CA014089","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412070788.pdf","grobid_xml":"https://content.openalex.org/works/W4412070788.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1502181242","https://openalex.org/W1658971720","https://openalex.org/W1982906652","https://openalex.org/W2075691289","https://openalex.org/W2137953708","https://openalex.org/W2242638094","https://openalex.org/W2527905628","https://openalex.org/W2529904548","https://openalex.org/W2560258181","https://openalex.org/W2581283430","https://openalex.org/W2584487585","https://openalex.org/W2765763462","https://openalex.org/W2799511849","https://openalex.org/W2809351334","https://openalex.org/W2888599070","https://openalex.org/W2892640821","https://openalex.org/W2912418732","https://openalex.org/W2912571746","https://openalex.org/W2918511688","https://openalex.org/W2925446385","https://openalex.org/W2946386783","https://openalex.org/W2952666958","https://openalex.org/W2981221722","https://openalex.org/W2988124258","https://openalex.org/W2998010334","https://openalex.org/W3003592141","https://openalex.org/W3015116944","https://openalex.org/W3022919793","https://openalex.org/W3083740637","https://openalex.org/W3085213187","https://openalex.org/W3091399767","https://openalex.org/W3096137571","https://openalex.org/W3118904262","https://openalex.org/W3119587099","https://openalex.org/W3131289431","https://openalex.org/W3133736305","https://openalex.org/W3135828336","https://openalex.org/W3146357267","https://openalex.org/W3182710358","https://openalex.org/W4205465153","https://openalex.org/W4225972077","https://openalex.org/W4316927914","https://openalex.org/W4318269751","https://openalex.org/W4321613528","https://openalex.org/W4376630600","https://openalex.org/W4377046678","https://openalex.org/W4385532362","https://openalex.org/W6744981209"],"related_works":["https://openalex.org/W2360693916","https://openalex.org/W2464739384","https://openalex.org/W2415484199","https://openalex.org/W4320086256","https://openalex.org/W2419505618","https://openalex.org/W2580334472","https://openalex.org/W3121096891","https://openalex.org/W4409543283","https://openalex.org/W4254834665","https://openalex.org/W2060361110"],"abstract_inverted_index":{"Corticosteroids":[0],"are":[1],"frequently":[2],"prescribed":[3,261],"to":[4],"patients":[5,46,58,151,167,236,252,286],"with":[6,47,50,78,87,223,237,287],"non-small":[7],"cell":[8],"lung":[9],"cancer":[10],"(NSCLC)":[11],"for":[12,104,262],"palliation":[13,263],"of":[14,21,44,66,123,145,158,184,191,202,207,229,258,264,303],"cancer-related":[15,265],"symptoms;":[16],"however,":[17,141],"the":[18,64,98,142,155,189,205,245,296],"potential":[19],"impact":[20,214,257],"baseline":[22,70,130,156,218,276],"steroid":[23,95,178,203,219,277],"use":[24,96,179,220,278],"on":[25,69,168,215,253,267],"immune":[26],"checkpoint":[27],"inhibitor":[28],"(ICI)":[29],"therapy":[30,52,186,269,291],"and":[31,83,107,121,187,226,292,301],"its":[32],"underlying":[33],"mechanisms":[34],"remain":[35],"unclear.":[36,271],"In":[37,92],"this":[38],"study,":[39],"we":[40,174],"evaluated":[41],"clinical":[42],"outcomes":[43,225],"277":[45],"NSCLC":[48,288],"treated":[49],"ICI":[51,268,290],"at":[53,63,204],"two":[54],"academic":[55],"institutions.":[56],"Twenty-one":[57],"(8%)":[59],"were":[60],"taking":[61],"steroids":[62,71],"start":[65,206],"ICIs.":[67],"Patients":[68],"had":[72],"a":[73,137,171,212,280],"lower":[74,165],"overall":[75,84],"response":[76],"rate":[77],"markedly":[79],"shorter":[80],"progression-free":[81],"survival":[82,85],"compared":[86],"those":[88],"not":[89,210],"receiving":[90,152],"steroids.":[91,153,169,254,308],"multivariate":[93],"analysis,":[94],"was":[97,136,148,163,221],"only":[99],"significant":[100],"independent":[101,111,282],"risk":[102],"factor":[103,284],"disease":[105],"progression":[106],"mortality":[108],"in":[109,150,166,195,235,251,285],"both":[110],"cohorts,":[112],"Roswell":[113],"Park":[114],"Comprehensive":[115],"Cancer":[116],"Center":[117],"(n":[118,126],"=":[119,127],"88)":[120],"University":[122],"Southern":[124],"California":[125],"189).":[128],"A":[129],"peripheral":[131],"blood":[132],"neutrophil-to-lymphocyte":[133,146],"ratio":[134,147],"<5":[135],"strong":[138],"prognostic":[139,143,283],"indicator;":[140],"value":[144],"absent":[149],"Additionally,":[154],"frequency":[157,228],"circulating":[159,230,248],"CX3CR1+CD8+":[160,192],"T":[161,193,233],"cells":[162,194,234],"substantially":[164],"Using":[170],"bedside-to-bench":[172],"approach,":[173],"found":[175],"that":[176,275],"concurrent":[177],"significantly":[180],"decreased":[181,227,297],"antitumor":[182],"efficacy":[183],"anti-PD-1":[185],"attenuated":[188],"increase":[190],"mice":[196],"bearing":[197],"MC38":[198],"tumors":[199],"whereas":[200],"discontinuation":[201],"treatment":[208],"did":[209],"make":[211],"negative":[213,281],"survival.":[216],"Collectively,":[217],"associated":[222],"worse":[224],"differentiated":[231],"effector":[232,299],"NSCLC.":[238],"Caution":[239],"should":[240],"be":[241],"taken":[242],"when":[243],"interpreting":[244],"results":[246],"from":[247],"immune-related":[249],"biomarkers":[250],"SIGNIFICANCE:":[255],"The":[256],"corticosteroids,":[259],"widely":[260],"symptoms,":[266],"remains":[270],"This":[272],"study":[273],"shows":[274],"is":[279],"undergoing":[289],"provides":[293],"insights":[294],"into":[295],"T-cell":[298],"differentiation":[300],"utility":[302],"predictive":[304],"blood-based":[305],"markers":[306],"by":[307]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":3}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}
