{"id":"https://openalex.org/W4412062007","doi":"https://doi.org/10.1016/j.prmcm.2025.100657","title":"Buyang Huanwu Decoction attenuates silicosis progression via NF-\u03baB/IL-17 signaling axis modulation: a network pharmacology and experimental validation study","display_name":"Buyang Huanwu Decoction attenuates silicosis progression via NF-\u03baB/IL-17 signaling axis modulation: a network pharmacology and experimental validation study","publication_year":2025,"publication_date":"2025-07-06","ids":{"openalex":"https://openalex.org/W4412062007","doi":"https://doi.org/10.1016/j.prmcm.2025.100657"},"language":"en","primary_location":{"id":"doi:10.1016/j.prmcm.2025.100657","doi":"https://doi.org/10.1016/j.prmcm.2025.100657","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.prmcm.2025.100657","pdf_url":null,"source":{"id":"https://openalex.org/S4210232177","display_name":"Pharmacological Research - Modern Chinese Medicine","issn_l":"2667-1425","issn":["2667-1425"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research - Modern Chinese Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.prmcm.2025.100657","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074481593","display_name":"Hejuntao Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184681353","display_name":"Anhui University of Science and Technology","ror":"https://ror.org/00q9atg80","country_code":"CN","type":"education","lineage":["https://openalex.org/I184681353"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hejuntao Chen","raw_affiliation_strings":["Huainan First People's Hospital and First Affiliated Hospital of Anhui University of Science & Technology, Huainan, Anhui 232001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huainan First People's Hospital and First Affiliated Hospital of Anhui University of Science & Technology, Huainan, Anhui 232001","institution_ids":["https://openalex.org/I184681353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111370177","display_name":"Ruiyang Wang","orcid":"https://orcid.org/0000-0001-9603-5352","observed_orcids":["https://orcid.org/0000-0001-9603-5352"]},"institutions":[{"id":"https://openalex.org/I184681353","display_name":"Anhui University of Science and Technology","ror":"https://ror.org/00q9atg80","country_code":"CN","type":"education","lineage":["https://openalex.org/I184681353"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ruiyang Wang","raw_affiliation_strings":["Huainan First People's Hospital and First Affiliated Hospital of Anhui University of Science & Technology, Huainan, Anhui 232001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huainan First People's Hospital and First Affiliated Hospital of Anhui University of Science & Technology, Huainan, Anhui 232001","institution_ids":["https://openalex.org/I184681353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102262400","display_name":"Xu Chen","orcid":"https://orcid.org/0000-0003-3576-5049","observed_orcids":["https://orcid.org/0000-0003-3576-5049"]},"institutions":[{"id":"https://openalex.org/I184681353","display_name":"Anhui University of Science and Technology","ror":"https://ror.org/00q9atg80","country_code":"CN","type":"education","lineage":["https://openalex.org/I184681353"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xu Chen","raw_affiliation_strings":["Huainan First People's Hospital and First Affiliated Hospital of Anhui University of Science & Technology, Huainan, Anhui 232001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huainan First People's Hospital and First Affiliated Hospital of Anhui University of Science & Technology, Huainan, Anhui 232001","institution_ids":["https://openalex.org/I184681353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100665065","display_name":"Wenli Liu","orcid":"https://orcid.org/0000-0003-1036-4564","observed_orcids":["https://orcid.org/0000-0003-1036-4564"]},"institutions":[{"id":"https://openalex.org/I184681353","display_name":"Anhui University of Science and Technology","ror":"https://ror.org/00q9atg80","country_code":"CN","type":"education","lineage":["https://openalex.org/I184681353"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenli Liu","raw_affiliation_strings":["Huainan First People's Hospital and First Affiliated Hospital of Anhui University of Science & Technology, Huainan, Anhui 232001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huainan First People's Hospital and First Affiliated Hospital of Anhui University of Science & Technology, Huainan, Anhui 232001","institution_ids":["https://openalex.org/I184681353"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Huihui Fang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184681353","display_name":"Anhui University of Science and Technology","ror":"https://ror.org/00q9atg80","country_code":"CN","type":"education","lineage":["https://openalex.org/I184681353"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huihui Fang","raw_affiliation_strings":["Huainan First People's Hospital and First Affiliated Hospital of Anhui University of Science & Technology, Huainan, Anhui 232001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huainan First People's Hospital and First Affiliated Hospital of Anhui University of Science & Technology, Huainan, Anhui 232001","institution_ids":["https://openalex.org/I184681353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104228035","display_name":"Ya\u2010Ya Xie","orcid":"https://orcid.org/0000-0001-9241-1496","observed_orcids":["https://orcid.org/0000-0001-9241-1496"]},"institutions":[{"id":"https://openalex.org/I184681353","display_name":"Anhui University of Science and Technology","ror":"https://ror.org/00q9atg80","country_code":"CN","type":"education","lineage":["https://openalex.org/I184681353"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaya Xie","raw_affiliation_strings":["Huainan First People's Hospital and First Affiliated Hospital of Anhui University of Science & Technology, Huainan, Anhui 232001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huainan First People's Hospital and First Affiliated Hospital of Anhui University of Science & Technology, Huainan, Anhui 232001","institution_ids":["https://openalex.org/I184681353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051822690","display_name":"Fan Yin","orcid":"https://orcid.org/0000-0001-8621-4998","observed_orcids":["https://orcid.org/0000-0001-8621-4998"]},"institutions":[{"id":"https://openalex.org/I184681353","display_name":"Anhui University of Science and Technology","ror":"https://ror.org/00q9atg80","country_code":"CN","type":"education","lineage":["https://openalex.org/I184681353"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fan Yin","raw_affiliation_strings":["Huainan First People's Hospital and First Affiliated Hospital of Anhui University of Science & Technology, Huainan, Anhui 232001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huainan First People's Hospital and First Affiliated Hospital of Anhui University of Science & Technology, Huainan, Anhui 232001","institution_ids":["https://openalex.org/I184681353"]}]},{"author_position":"last","author":{"id":null,"display_name":"Xiaojuan Wang","orcid":"https://orcid.org/0009-0003-6025-6710","observed_orcids":["https://orcid.org/0009-0003-6025-6710"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaojuan Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-6025-6710","affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111370177"],"corresponding_institution_ids":["https://openalex.org/I184681353"],"apc_list":{"value":1550,"currency":"USD","value_usd":1550},"apc_paid":{"value":1550,"currency":"USD","value_usd":1550},"fwci":0.5303,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.57867413,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"16","issue":null,"first_page":"100657","last_page":"100657"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.8378999829292297,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.8378999829292297,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.13670000433921814,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13444","display_name":"Traditional Chinese Medicine Clinical Research","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/buyang-huanwu-decoction","display_name":"Buyang Huanwu Decoction","score":0.9879999756813049},{"id":"https://openalex.org/keywords/silicosis","display_name":"silicosis","score":1.0},{"id":"https://openalex.org/keywords/pulmonary-fibrosis","display_name":"pulmonary fibrosis","score":0.9539999961853027},{"id":"https://openalex.org/keywords/chinese-herbal-medicine","display_name":"Chinese herbal medicine","score":0.824999988079071},{"id":"https://openalex.org/keywords/prophylaxis","display_name":"prophylaxis","score":0.753000020980835},{"id":"https://openalex.org/keywords/silica-exposure","display_name":"silica exposure","score":0.8220000267028809},{"id":"https://openalex.org/keywords/hepatorenal-toxicity","display_name":"hepatorenal toxicity","score":0.847000002861023},{"id":"https://openalex.org/keywords/network-pharmacology","display_name":"network pharmacology","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5847649574279785},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.5256831645965576},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4466467499732971},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.18415603041648865},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15400871634483337}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.prmcm.2025.100657","doi":"https://doi.org/10.1016/j.prmcm.2025.100657","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.prmcm.2025.100657","pdf_url":null,"source":{"id":"https://openalex.org/S4210232177","display_name":"Pharmacological Research - Modern Chinese Medicine","issn_l":"2667-1425","issn":["2667-1425"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research - Modern Chinese Medicine","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:24b6151d1ccd46d38ede0c07d79851d3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/24b6151d1ccd46d38ede0c07d79851d3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmacological Research - Modern Chinese Medicine, Vol 16, Iss , Pp 100657- (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.prmcm.2025.100657","doi":"https://doi.org/10.1016/j.prmcm.2025.100657","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.prmcm.2025.100657","pdf_url":null,"source":{"id":"https://openalex.org/S4210232177","display_name":"Pharmacological Research - Modern Chinese Medicine","issn_l":"2667-1425","issn":["2667-1425"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research - Modern Chinese Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8486888766","display_name":null,"funder_award_id":"YZ2023H1B006","funder_id":"https://openalex.org/F4320323708","funder_display_name":"Anhui University of Science and Technology"}],"funders":[{"id":"https://openalex.org/F4320323708","display_name":"Anhui University of Science and Technology","ror":"https://ror.org/00q9atg80"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W2064937642","https://openalex.org/W2067786443","https://openalex.org/W2124679671","https://openalex.org/W2600669583","https://openalex.org/W2770262779","https://openalex.org/W2790731355","https://openalex.org/W2908020673","https://openalex.org/W2970639879","https://openalex.org/W2996552716","https://openalex.org/W3009979587","https://openalex.org/W3173233941","https://openalex.org/W3208682914","https://openalex.org/W4210932593","https://openalex.org/W4308877107","https://openalex.org/W4311275500","https://openalex.org/W4322505937","https://openalex.org/W4353042437","https://openalex.org/W4375866270","https://openalex.org/W4378087407","https://openalex.org/W4382796459","https://openalex.org/W4386098952","https://openalex.org/W4388487026","https://openalex.org/W4388805902","https://openalex.org/W4389572314","https://openalex.org/W4400300014","https://openalex.org/W4403841667","https://openalex.org/W6855597497"],"related_works":["https://openalex.org/W7161150413","https://openalex.org/W4403117396","https://openalex.org/W4382319141","https://openalex.org/W4376132910","https://openalex.org/W4401011863","https://openalex.org/W4410528325","https://openalex.org/W4405028828","https://openalex.org/W7220735312","https://openalex.org/W7127073747","https://openalex.org/W4312220695"],"abstract_inverted_index":{"Background":[0],"Silicosis":[1],"is":[2],"a":[3,20,238,250],"prevalent,":[4],"irreversible":[5],"occupational":[6],"pulmonary":[7,34,163],"fibrotic":[8],"disease":[9,60],"caused":[10],"by":[11,70,109],"crystalline":[12],"silica":[13,89,159],"dust":[14],"inhalation.":[15],"Buyang":[16,201],"Huanwu":[17,202],"Decoction":[18,203],"(BYHWD),":[19],"classical":[21],"Chinese":[22],"herbal":[23],"formula":[24],"with":[25,171],"anti-inflammatory":[26],"and":[27,59,98,112,122],"circulation-enhancing":[28],"properties,":[29],"shows":[30],"potential":[31,199],"in":[32,78,103,186,191,204,206,225,244],"inhibiting":[33],"fibrosis.":[35],"This":[36,166,247],"study":[37,210,248],"investigated":[38],"its":[39,223],"preventive":[40,84,153],"mechanism":[41,217],"against":[42],"silicosis":[43,80,136,207,256],"based":[44],"on":[45,135],"TCM\u2019s":[46],"\"preventive":[47],"treatment\"":[48],"principle.":[49],"Methods":[50],"Network":[51,125],"pharmacology":[52,126],"identified":[53],"BYHWD-silicosis":[54],"overlapping":[55],"targets":[56,102],"using":[57],"TCMSP":[58],"databases.":[61],"Protein-protein":[62],"interaction":[63],"(PPI)":[64],"networks":[65],"were":[66,107],"constructed":[67],"(STRING/Cytoscape),":[68],"followed":[69],"GO/KEGG":[71],"pathway":[72,106],"enrichment":[73],"(Metscape).":[74],"Mechanistic":[75],"validation":[76],"employed":[77],"vivo":[79,148],"models:":[81],"Mice":[82],"received":[83],"BYHWD":[85,134,156,179,243],"administration":[86,154],"prior":[87,157],"to":[88,158],"exposure.":[90],"Lung":[91],"fibrosis":[92,164],"was":[93,116,169],"assessed":[94],"via":[95],"H&E":[96],"staining":[97],"immunohistochemistry":[99],"(IHC).":[100],"Key":[101],"the":[104,130,143,174,197,215,227],"NF-\u03baB/IL-17":[105,144,175,228],"quantified":[108],"Western":[110],"blotting":[111],"qPCR.":[113],"Liver/kidney":[114],"toxicity":[115,235],"evaluated":[117],"through":[118,140],"serum":[119],"biochemical":[120],"analysis":[121,127],"histopathology.":[123],"Results":[124],"revealed":[128],"that":[129,152],"therapeutic":[131,198,252],"effects":[132],"of":[133,142,155,173,200,232],"are":[137],"potentially":[138],"mediated":[139],"regulation":[141],"signaling":[145,176],"pathway.":[146,229],"In":[147],"mechanistic":[149],"studies":[150],"confirmed":[151],"exposure":[160],"significantly":[161],"attenuated":[162],"progression.":[165,208,257],"protective":[167],"effect":[168],"associated":[170],"suppression":[172],"axis.":[177],"Additionally,":[178],"treatment":[180],"did":[181],"not":[182],"induce":[183],"significant":[184,233],"impairment":[185],"liver":[187],"or":[188],"kidney":[189],"function":[190],"mice.":[192],"Discussion":[193],"These":[194],"findings":[195],"support":[196],"intervening":[205],"The":[209,230],"provides":[211],"novel":[212,251],"insights":[213],"into":[214],"molecular":[216],"underlying":[218],"BYHWD's":[219],"efficacy,":[220],"specifically":[221],"highlighting":[222],"role":[224],"modulating":[226],"lack":[231],"hepatorenal":[234],"further":[236],"suggests":[237],"favorable":[239],"safety":[240],"profile":[241],"for":[242,254],"this":[245],"context.":[246],"proposes":[249],"strategy":[253],"targeting":[255]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}