{"id":"https://openalex.org/W4412002296","doi":"https://doi.org/10.1016/j.bja.2025.05.030","title":"Association of peripheral nerve blocks with increased postoperative pain and opioid use in orthopaedic surgery: a single-centre retrospective cohort study","display_name":"Association of peripheral nerve blocks with increased postoperative pain and opioid use in orthopaedic surgery: a single-centre retrospective cohort study","publication_year":2025,"publication_date":"2025-07-03","ids":{"openalex":"https://openalex.org/W4412002296","doi":"https://doi.org/10.1016/j.bja.2025.05.030","pmid":"https://pubmed.ncbi.nlm.nih.gov/40610285","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12291095"},"language":"en","primary_location":{"id":"doi:10.1016/j.bja.2025.05.030","doi":"https://doi.org/10.1016/j.bja.2025.05.030","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bja.2025.05.030","pdf_url":"https://www.bjanaesthesia.org/article/S0007-0912(25)00344-7/pdf","source":{"id":"https://openalex.org/S33418846","display_name":"British Journal of Anaesthesia","issn_l":"0007-0912","issn":["0007-0912","1471-6771"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Anaesthesia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.bjanaesthesia.org/article/S0007-0912(25)00344-7/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111225269","display_name":"Ashley R. Chung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashley R. Chung","raw_affiliation_strings":["Stanford University School of Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Palo Alto, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University School of Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Palo Alto, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044998120","display_name":"Rory Vu Mather","orcid":"https://orcid.org/0000-0002-5667-9732","observed_orcids":["https://orcid.org/0000-0002-5667-9732"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rory Vu Mather","raw_affiliation_strings":["Stanford University School of Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Palo Alto, CA, USA; Harvard/MIT MD-PhD Program, Boston, MA, USA; Harvard/MIT Program in Health, Sciences, and Technology, Cambridge, MA, USA; Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA. Electronic address: rorymather@hms.harvard.edu"],"raw_orcid":"https://orcid.org/0000-0002-5667-9732","affiliations":[{"raw_affiliation_string":"Stanford University School of Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Palo Alto, CA, USA; Harvard/MIT MD-PhD Program, Boston, MA, USA; Harvard/MIT Program in Health, Sciences, and Technology, Cambridge, MA, USA; Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA. Electronic address: rorymather@hms.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210137306","https://openalex.org/I63966007","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rodrigo Gutierrez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["CL","US"],"is_corresponding":false,"raw_author_name":"Rodrigo Gutierrez","raw_affiliation_strings":["Stanford University School of Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Palo Alto, CA, USA; Department of Anesthesia and Perioperative Medicine, University of Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University School of Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Palo Alto, CA, USA; Department of Anesthesia and Perioperative Medicine, University of Chile, Santiago, Chile","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I69737025","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100448097","display_name":"Ran Liu","orcid":"https://orcid.org/0000-0002-0866-9281","observed_orcids":["https://orcid.org/0000-0002-0866-9281"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ran Liu","raw_affiliation_strings":["Stanford University School of Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Palo Alto, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University School of Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Palo Alto, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chee Fai A. Leung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chee Fai A. Leung","raw_affiliation_strings":["Stanford University School of Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Palo Alto, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University School of Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Palo Alto, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mae Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mae Zhang","raw_affiliation_strings":["Stanford University School of Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Palo Alto, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford University School of Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Palo Alto, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053027647","display_name":"Laura A. Santa Cruz Mercado","orcid":"https://orcid.org/0009-0004-7886-480X","observed_orcids":["https://orcid.org/0009-0004-7886-480X"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura A. Santa Cruz Mercado","raw_affiliation_strings":["Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA","institution_ids":["https://openalex.org/I1316535847"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071653590","display_name":"Timothy T. Houle","orcid":"https://orcid.org/0000-0001-9584-5580","observed_orcids":["https://orcid.org/0000-0001-9584-5580"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy T. Houle","raw_affiliation_strings":["Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033813700","display_name":"Edward A. Bittner","orcid":"https://orcid.org/0000-0002-0159-2373","observed_orcids":["https://orcid.org/0000-0002-0159-2373"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward A. Bittner","raw_affiliation_strings":["Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005240128","display_name":"Patrick L. Purdon","orcid":"https://orcid.org/0000-0003-0080-3340","observed_orcids":["https://orcid.org/0000-0003-0080-3340"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick L. Purdon","raw_affiliation_strings":["Stanford University School of Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Palo Alto, CA, USA"],"raw_orcid":"https://orcid.org/0000-0003-0080-3340","affiliations":[{"raw_affiliation_string":"Stanford University School of Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Palo Alto, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5044998120"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210137306","https://openalex.org/I63966007","https://openalex.org/I97018004"],"apc_list":{"value":4450,"currency":"USD","value_usd":4450},"apc_paid":{"value":4450,"currency":"USD","value_usd":4450},"fwci":18.4283,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.9964866,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"135","issue":"5","first_page":"1286","last_page":"1296"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peripheral-nerve-block","display_name":"peripheral nerve block","score":0.9980000257492065},{"id":"https://openalex.org/keywords/postoperative-pain","display_name":"postoperative pain","score":0.9409999847412109},{"id":"https://openalex.org/keywords/opioid-consumption","display_name":"opioid consumption","score":0.8730000257492065},{"id":"https://openalex.org/keywords/orthopedic-surgery","display_name":"orthopedic surgery","score":0.9240000247955322},{"id":"https://openalex.org/keywords/opioid-use-disorder","display_name":"opioid use disorder","score":0.7870000004768372},{"id":"https://openalex.org/keywords/rebound-pain","display_name":"rebound pain","score":0.7990000247955322},{"id":"https://openalex.org/keywords/post-anesthesia-care-unit","display_name":"post-anesthesia care unit","score":0.7590000033378601},{"id":"https://openalex.org/keywords/chronic-pain","display_name":"chronic pain","score":0.6660000085830688},{"id":"https://openalex.org/keywords/general-anesthesia","display_name":"general anesthesia","score":0.5989999771118164},{"id":"https://openalex.org/keywords/morphine-milligram-equivalents","display_name":"morphine milligram equivalents","score":0.7730000019073486}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.916192889213562},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.7635679244995117},{"id":"https://openalex.org/C2777395641","wikidata":"https://www.wikidata.org/wiki/Q14517578","display_name":"Pacu","level":2,"score":0.7196471095085144},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6596863269805908},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.6302120685577393},{"id":"https://openalex.org/C2777389121","wikidata":"https://www.wikidata.org/wiki/Q81225","display_name":"Morphine","level":2,"score":0.572873055934906},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.4267466068267822},{"id":"https://openalex.org/C2781118164","wikidata":"https://www.wikidata.org/wiki/Q1088113","display_name":"Chronic pain","level":2,"score":0.41616323590278625},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.30957484245300293},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2009899914264679},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.14705350995063782},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009407","descriptor_name":"Nerve Block","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D009407","descriptor_name":"Nerve Block","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010149","descriptor_name":"Postoperative Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010149","descriptor_name":"Postoperative Pain","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019637","descriptor_name":"Orthopedic Procedures","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.bja.2025.05.030","doi":"https://doi.org/10.1016/j.bja.2025.05.030","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bja.2025.05.030","pdf_url":"https://www.bjanaesthesia.org/article/S0007-0912(25)00344-7/pdf","source":{"id":"https://openalex.org/S33418846","display_name":"British Journal of Anaesthesia","issn_l":"0007-0912","issn":["0007-0912","1471-6771"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Anaesthesia","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11405095","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12291095","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:40610285","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40610285","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of anaesthesia","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12291095","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12291095/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Anaesth","raw_type":"Text"},{"id":"pmh:oai:repositorio.uchile.cl:2250/210967","doi":null,"is_oa":true,"landing_page_url":"https://repositorio.uchile.cl/handle/2250/210967","pdf_url":"https://repositorio.uchile.cl/bitstream/2250/210967/-1/PIIS0007091225003447.pdf","source":{"id":"https://openalex.org/S4306481413","display_name":"Universidad de Chile","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"British Journal of Anaesthesia","raw_type":"Art\u00edculo de revista"}],"best_oa_location":{"id":"doi:10.1016/j.bja.2025.05.030","doi":"https://doi.org/10.1016/j.bja.2025.05.030","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.bja.2025.05.030","pdf_url":"https://www.bjanaesthesia.org/article/S0007-0912(25)00344-7/pdf","source":{"id":"https://openalex.org/S33418846","display_name":"British Journal of Anaesthesia","issn_l":"0007-0912","issn":["0007-0912","1471-6771"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Anaesthesia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1328243299","display_name":"Developing novel technologies to monitor nociception and opioid administration during surgery and general anesthesia in order to minimize post-operative opioid requirements","funder_award_id":"R42DA053075","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G134326649","display_name":"Model-based optimization of pain management in surgical patients","funder_award_id":"F32GM148114","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1815946096","display_name":null,"funder_award_id":"T32-EB001680","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G3522989319","display_name":"Medical Scientist Training Program","funder_award_id":"T32GM007753","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5800753445","display_name":"A pilot study to characterize brain dynamic biomarkers of fentanyl for opioid overdose monitoring","funder_award_id":"R21DA048323","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G9000863871","display_name":"Neuroimaging Training Program","funder_award_id":"2t32eb001680-21","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000901346","display_name":"Medical Scientist Training Program","funder_award_id":"T32GM144273","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4412002296.pdf","grobid_xml":"https://content.openalex.org/works/W4412002296.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W174512470","https://openalex.org/W1969147270","https://openalex.org/W1974525808","https://openalex.org/W1988060232","https://openalex.org/W2053835246","https://openalex.org/W2089904271","https://openalex.org/W2119570071","https://openalex.org/W2145790640","https://openalex.org/W2168914677","https://openalex.org/W2333043986","https://openalex.org/W2419533811","https://openalex.org/W2460066114","https://openalex.org/W2518771067","https://openalex.org/W2530746066","https://openalex.org/W2765742218","https://openalex.org/W2780815759","https://openalex.org/W2803156967","https://openalex.org/W2905299859","https://openalex.org/W2937677536","https://openalex.org/W2938546210","https://openalex.org/W2954937370","https://openalex.org/W2972277969","https://openalex.org/W2981997083","https://openalex.org/W2986340159","https://openalex.org/W3048426041","https://openalex.org/W3119249525","https://openalex.org/W3158896016","https://openalex.org/W3200787148","https://openalex.org/W4206842191","https://openalex.org/W4210312067","https://openalex.org/W4255611642","https://openalex.org/W4380577390","https://openalex.org/W4388730556","https://openalex.org/W4390638317","https://openalex.org/W4399972031","https://openalex.org/W4401114982"],"related_works":["https://openalex.org/W4415698552","https://openalex.org/W7131347270","https://openalex.org/W3177276301","https://openalex.org/W7153302691","https://openalex.org/W4416566229","https://openalex.org/W4414491657","https://openalex.org/W2972277969","https://openalex.org/W7131786769","https://openalex.org/W7167837052","https://openalex.org/W4283582152"],"abstract_inverted_index":{"BACKGROUND:":[0],"Peripheral":[1,171],"nerve":[2,37,90,132,172,210],"blocks":[3,38,91,173,211],"have":[4],"become":[5],"popular":[6],"in":[7,22,107,112,148,164,179,214],"orthopaedic":[8,61],"surgeries":[9],"to":[10,33,68,82,239],"improve":[11],"acute":[12],"postoperative":[13,24,40,217,249],"pain.":[14],"However,":[15,151],"studies":[16],"are":[17],"mixed":[18],"on":[19,79],"their":[20],"effectiveness":[21],"decreasing":[23],"opioid":[25,41,46,104,121,146,165,180,220,227,235,250],"consumption.":[26],"A":[27],"more":[28],"comprehensive":[29],"analysis":[30],"is":[31],"necessary":[32],"understand":[34],"if":[35],"peripheral":[36,89,131,209],"reduce":[39],"exposure":[42],"and":[43,92,102,120,142,160,195,219],"risk":[44,233,242],"for":[45,58,234,243],"dependence.":[47,236],"METHODS:":[48],"This":[49],"retrospective":[50],"cohort":[51],"study":[52],"evaluated":[53],"electronic":[54],"health":[55],"record":[56],"data":[57,81],"adults":[59],"undergoing":[60],"surgery":[62],"with":[63,118,137,155,176,196,225],"general":[64],"anaesthesia":[65],"from":[66],"2016":[67],"2020":[69],"at":[70,182,190],"the":[71,84,113,149,168,232,241],"Massachusetts":[72],"General":[73],"Hospital.":[74],"Linear":[75],"models":[76],"were":[77,98,123,174,212,223],"fitted":[78],"propensity-weighted":[80],"characterise":[83],"association":[85],"between":[86],"single":[87,207],"injection":[88,208],"clinical":[93],"outcomes.":[94],"Our":[95],"primary":[96],"outcomes":[97,116],"maximum":[99,139,157],"pain":[100,119,140,158,199,218,245],"score":[101],"cumulative":[103],"dose,":[105],"quantified":[106],"morphine":[108],"milligram":[109],"equivalents,":[110],"administered":[111],"PACU.":[114,150],"Post-discharge":[115],"associated":[117,136,154,175,224],"consumption":[122,166,228],"also":[124],"evaluated.":[125],"RESULTS:":[126],"Among":[127],"22":[128],"956":[129],"patients,":[130],"block":[133],"administration":[134,147],"was":[135,153],"lower":[138,143],"scores":[141,159],"probability":[144],"of":[145],"it":[152],"higher":[156],"a":[161],"22.7%":[162],"increase":[163,178,189,231],"during":[167],"hospital":[169],"stay.":[170],"an":[177],"prescriptions":[181],"30":[183],"days":[184],"after":[185,203],"discharge,":[186],"but":[187],"no":[188],"90":[191],"or":[192],"180":[193],"days,":[194],"decreased":[197],"chronic":[198],"diagnoses":[200],"1":[201],"yr":[202],"operation.":[204],"CONCLUSIONS:":[205],"Although":[206],"effective":[213],"reducing":[215],"immediate":[216],"consumption,":[221],"they":[222],"greater":[226],"that":[229],"could":[230,246],"Standardised":[237],"protocols":[238],"mitigate":[240],"rebound":[244],"help":[247],"minimise":[248],"exposure.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-10T00:00:00"}