{"id":"https://openalex.org/W4411997703","doi":"https://doi.org/10.1016/s0016-5085(25)01306-x","title":"640: AURKA REGULATES LGR5 DURING H. PYLORI INFECTION BY MODULATING ITS DEUBIQUITINATION","display_name":"640: AURKA REGULATES LGR5 DURING H. PYLORI INFECTION BY MODULATING ITS DEUBIQUITINATION","publication_year":2025,"publication_date":"2025-05-01","ids":{"openalex":"https://openalex.org/W4411997703","doi":"https://doi.org/10.1016/s0016-5085(25)01306-x"},"language":"en","primary_location":{"id":"doi:10.1016/s0016-5085(25)01306-x","doi":"https://doi.org/10.1016/s0016-5085(25)01306-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0016-5085(25)01306-x","pdf_url":null,"source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037628408","display_name":"Ahmed R. Gomaa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ahmed R. Gomaa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003269523","display_name":"Selma Maacha","orcid":"https://orcid.org/0000-0002-4187-8480","observed_orcids":["https://orcid.org/0000-0002-4187-8480"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Selma Maacha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090233695","display_name":"Mohammed Soutto","orcid":"https://orcid.org/0000-0002-5597-4588","observed_orcids":["https://orcid.org/0000-0002-5597-4588"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohammed Soutto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081740383","display_name":"Nadeem Sidiq Bhat","orcid":"https://orcid.org/0000-0001-9776-0193","observed_orcids":["https://orcid.org/0000-0001-9776-0193"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nadeem S. Bhat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043640546","display_name":"Oliver Gene McDonald","orcid":"https://orcid.org/0000-0002-6602-7535","observed_orcids":["https://orcid.org/0000-0002-6602-7535"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Oliver G. McDonald","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5001099941","display_name":"Wael M. El-Rifai","orcid":"https://orcid.org/0000-0003-2101-6098","observed_orcids":["https://orcid.org/0000-0003-2101-6098"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wael El-Rifai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4180,"currency":"USD","value_usd":4180},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.22638035,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"169","issue":"1","first_page":"S","last_page":"157"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.9491999745368958,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.021199999377131462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aurora-a-kinase","display_name":"AURKA","score":0.8970000147819519},{"id":"https://openalex.org/keywords/lgr5","display_name":"Lgr5","score":0.9340000152587891},{"id":"https://openalex.org/keywords/helicobacter-pylori-infection","display_name":"Helicobacter pylori infection","score":0.9629999995231628},{"id":"https://openalex.org/keywords/deubiquitination","display_name":"deubiquitination","score":0.9779999852180481},{"id":"https://openalex.org/keywords/ubiquitin-ligase","display_name":"ubiquitin ligase","score":0.5929999947547913},{"id":"https://openalex.org/keywords/gastric-epithelial-cells","display_name":"gastric epithelial cells","score":0.48100000619888306},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.5609999895095825},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.3070000112056732}],"concepts":[{"id":"https://openalex.org/C10116572","wikidata":"https://www.wikidata.org/wiki/Q18033097","display_name":"LGR5","level":4,"score":0.8268469572067261},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.376914918422699},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3601859211921692},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18740251660346985},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.07495439052581787},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.032842546701431274}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0016-5085(25)01306-x","doi":"https://doi.org/10.1016/s0016-5085(25)01306-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0016-5085(25)01306-x","pdf_url":null,"source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4282960642","https://openalex.org/W4383383292","https://openalex.org/W7160093106","https://openalex.org/W3161905883","https://openalex.org/W2015980415","https://openalex.org/W3035616820","https://openalex.org/W4396632543","https://openalex.org/W2268756100","https://openalex.org/W2607385318","https://openalex.org/W4411998909"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}