{"id":"https://openalex.org/W4411961311","doi":"https://doi.org/10.3390/ph18070984","title":"Discovery of Cyclopentane-Based Phospholipids as Miltefosine Analogs with Superior Potency and Enhanced Selectivity Against Naegleria fowleri","display_name":"Discovery of Cyclopentane-Based Phospholipids as Miltefosine Analogs with Superior Potency and Enhanced Selectivity Against Naegleria fowleri","publication_year":2025,"publication_date":"2025-06-30","ids":{"openalex":"https://openalex.org/W4411961311","doi":"https://doi.org/10.3390/ph18070984","pmid":"https://pubmed.ncbi.nlm.nih.gov/40732274","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12298883"},"language":"en","primary_location":{"id":"doi:10.3390/ph18070984","doi":"https://doi.org/10.3390/ph18070984","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ph18070984","pdf_url":"https://www.mdpi.com/1424-8247/18/7/984/pdf?version=1751439120","source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1424-8247/18/7/984/pdf?version=1751439120","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008682765","display_name":"Ahmed H.E. Hassan","orcid":"https://orcid.org/0000-0002-1048-6281","observed_orcids":["https://orcid.org/0000-0002-1048-6281"]},"institutions":[{"id":"https://openalex.org/I159247623","display_name":"Mansoura University","ror":"https://ror.org/01k8vtd75","country_code":"EG","type":"education","lineage":["https://openalex.org/I159247623"]},{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["EG","KR"],"is_corresponding":false,"raw_author_name":"Ahmed H. E. Hassan","raw_affiliation_strings":["Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt","Department of Pharmacy, College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Seoul 02447, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-1048-6281","affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt","institution_ids":["https://openalex.org/I159247623"]},{"raw_affiliation_string":"Department of Pharmacy, College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Seoul 02447, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015074423","display_name":"H\u01b0\u01a1ng Giang L\u00ea","orcid":"https://orcid.org/0000-0001-6294-9017","observed_orcids":["https://orcid.org/0000-0001-6294-9017"]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"H\u01b0\u01a1ng Giang L\u00ea","raw_affiliation_strings":["Department of Parasitology and Tropical Medicine, Department of Convergence Medical Science, Gyeongsang National University College of Medicine, Jinju 52727, Republic of Korea","Institute of Health Science, Gyeongsang National University College of Medicine, Jinju 52727, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Parasitology and Tropical Medicine, Department of Convergence Medical Science, Gyeongsang National University College of Medicine, Jinju 52727, Republic of Korea","institution_ids":["https://openalex.org/I189442560"]},{"raw_affiliation_string":"Institute of Health Science, Gyeongsang National University College of Medicine, Jinju 52727, Republic of Korea","institution_ids":["https://openalex.org/I189442560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058115577","display_name":"Tu\u1ea5n C\u01b0\u1eddng V\u00f5","orcid":"https://orcid.org/0000-0002-6604-4888","observed_orcids":["https://orcid.org/0000-0002-6604-4888"]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Tu\u1ea5n C\u01b0\u1eddng V\u00f5","raw_affiliation_strings":["Department of Parasitology and Tropical Medicine, Department of Convergence Medical Science, Gyeongsang National University College of Medicine, Jinju 52727, Republic of Korea","Institute of Health Science, Gyeongsang National University College of Medicine, Jinju 52727, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Parasitology and Tropical Medicine, Department of Convergence Medical Science, Gyeongsang National University College of Medicine, Jinju 52727, Republic of Korea","institution_ids":["https://openalex.org/I189442560"]},{"raw_affiliation_string":"Institute of Health Science, Gyeongsang National University College of Medicine, Jinju 52727, Republic of Korea","institution_ids":["https://openalex.org/I189442560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100317765","display_name":"Minji Kim","orcid":"https://orcid.org/0000-0003-2322-9900","observed_orcids":["https://orcid.org/0000-0003-2322-9900"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Minji Kim","raw_affiliation_strings":["Department of Fundamental Pharmaceutical Science, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Fundamental Pharmaceutical Science, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033959758","display_name":"Joo Hwan No","orcid":"https://orcid.org/0000-0002-3896-9808","observed_orcids":["https://orcid.org/0000-0002-3896-9808"]},"institutions":[{"id":"https://openalex.org/I136761661","display_name":"Institut Pasteur Korea","ror":"https://ror.org/04t0zhb48","country_code":"KR","type":"nonprofit","lineage":["https://openalex.org/I136761661"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Joo Hwan No","raw_affiliation_strings":["Chemical and Structural Biology of Pathogens, Institut Pasteur Korea, Seongnam-si 13488, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical and Structural Biology of Pathogens, Institut Pasteur Korea, Seongnam-si 13488, Republic of Korea","institution_ids":["https://openalex.org/I136761661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047031146","display_name":"Mohamed H. Aboutaleb","orcid":"https://orcid.org/0000-0002-3954-5783","observed_orcids":["https://orcid.org/0000-0002-3954-5783"]},"institutions":[{"id":"https://openalex.org/I4405268078","display_name":"Horus University \u2013 Egypt","ror":"https://ror.org/05qh69251","country_code":"EG","type":"education","lineage":["https://openalex.org/I4405268078"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mohamed H. Aboutaleb","raw_affiliation_strings":["Pharmaceutical Chemistry Department, Faculty of Pharmacy, Horus University, New Damietta 34518, Egypt"],"raw_orcid":"https://orcid.org/0000-0002-3954-5783","affiliations":[{"raw_affiliation_string":"Pharmaceutical Chemistry Department, Faculty of Pharmacy, Horus University, New Damietta 34518, Egypt","institution_ids":["https://openalex.org/I4405268078"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045273202","display_name":"Jaehoon Sim","orcid":"https://orcid.org/0000-0001-7981-9892","observed_orcids":["https://orcid.org/0000-0001-7981-9892"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jaehoon Sim","raw_affiliation_strings":["Department of Pharmacy, College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Seoul 02447, Republic of Korea","Department of Regulatory Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea","Institute of Regulatory Innovation through Science, Kyung Hee University, Seoul 02447, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Seoul 02447, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]},{"raw_affiliation_string":"Department of Regulatory Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]},{"raw_affiliation_string":"Institute of Regulatory Innovation through Science, Kyung Hee University, Seoul 02447, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010479025","display_name":"Byoung\u2010Kuk Na","orcid":"https://orcid.org/0000-0002-6734-1673","observed_orcids":["https://orcid.org/0000-0002-6734-1673"]},"institutions":[{"id":"https://openalex.org/I189442560","display_name":"Gyeongsang National University","ror":"https://ror.org/00saywf64","country_code":"KR","type":"education","lineage":["https://openalex.org/I189442560"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Byoung-Kuk Na","raw_affiliation_strings":["Department of Parasitology and Tropical Medicine, Department of Convergence Medical Science, Gyeongsang National University College of Medicine, Jinju 52727, Republic of Korea","Institute of Health Science, Gyeongsang National University College of Medicine, Jinju 52727, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-6734-1673","affiliations":[{"raw_affiliation_string":"Department of Parasitology and Tropical Medicine, Department of Convergence Medical Science, Gyeongsang National University College of Medicine, Jinju 52727, Republic of Korea","institution_ids":["https://openalex.org/I189442560"]},{"raw_affiliation_string":"Institute of Health Science, Gyeongsang National University College of Medicine, Jinju 52727, Republic of Korea","institution_ids":["https://openalex.org/I189442560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034944739","display_name":"Yong Sup Lee","orcid":"https://orcid.org/0000-0001-6523-6979","observed_orcids":["https://orcid.org/0000-0001-6523-6979"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Yong Sup Lee","raw_affiliation_strings":["Department of Fundamental Pharmaceutical Science, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea","Department of Pharmacy, College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Seoul 02447, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-6523-6979","affiliations":[{"raw_affiliation_string":"Department of Fundamental Pharmaceutical Science, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]},{"raw_affiliation_string":"Department of Pharmacy, College of Pharmacy, Kyung Hee University, 26 Kyungheedae-ro, Seoul 02447, Republic of Korea","institution_ids":["https://openalex.org/I35928602"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5010479025","https://openalex.org/A5034944739"],"corresponding_institution_ids":["https://openalex.org/I189442560","https://openalex.org/I35928602"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"7","first_page":"984","last_page":"984"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11916","display_name":"Legionella and Acanthamoeba research","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11916","display_name":"Legionella and Acanthamoeba research","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11748","display_name":"Organophosphorus compounds synthesis","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/naegleria-fowleri","display_name":"Naegleria fowleri","score":0.9890000224113464},{"id":"https://openalex.org/keywords/primary-amebic-meningoencephalitis","display_name":"primary amoebic meningoencephalitis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/conformationally-restricted-analogues","display_name":"conformationally restricted analogues","score":0.878000020980835},{"id":"https://openalex.org/keywords/alkyl-chain-length","display_name":"alkyl chain length","score":0.7620000243186951},{"id":"https://openalex.org/keywords/stereochemical-configuration","display_name":"stereochemical configuration","score":0.6949999928474426},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7009999752044678},{"id":"https://openalex.org/keywords/selectivity-index","display_name":"selectivity index","score":0.8550000190734863},{"id":"https://openalex.org/keywords/apoptosis-like-cell-death","display_name":"apoptosis-like cell death","score":0.8009999990463257},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.7870000004768372},{"id":"https://openalex.org/keywords/mitochondrial-membrane-potential","display_name":"mitochondrial membrane potential","score":0.9580000042915344},{"id":"https://openalex.org/keywords/antiamoebic-agents","display_name":"antiamoebic agents","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C2781155112","wikidata":"https://www.wikidata.org/wiki/Q131273","display_name":"Naegleria fowleri","level":3,"score":0.9707262516021729},{"id":"https://openalex.org/C2781417161","wikidata":"https://www.wikidata.org/wiki/Q411787","display_name":"Miltefosine","level":4,"score":0.9593884348869324},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.486606240272522},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4655027985572815},{"id":"https://openalex.org/C2776172558","wikidata":"https://www.wikidata.org/wiki/Q46729","display_name":"Amoeba (genus)","level":2,"score":0.4634442627429962},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.44563180208206177},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4372740685939789},{"id":"https://openalex.org/C2781421772","wikidata":"https://www.wikidata.org/wiki/Q581102","display_name":"Antiparasitic","level":2,"score":0.42187952995300293},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42182207107543945},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3586706519126892},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34796804189682007},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25796112418174744},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.1908637285232544},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1876009702682495},{"id":"https://openalex.org/C2778621254","wikidata":"https://www.wikidata.org/wiki/Q2346415","display_name":"Meningoencephalitis","level":2,"score":0.17416897416114807},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.13488057255744934},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1269109547138214},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.09472757577896118},{"id":"https://openalex.org/C2778689377","wikidata":"https://www.wikidata.org/wiki/Q2046113","display_name":"Visceral leishmaniasis","level":3,"score":0.0},{"id":"https://openalex.org/C2776555147","wikidata":"https://www.wikidata.org/wiki/Q331283","display_name":"Leishmaniasis","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/ph18070984","doi":"https://doi.org/10.3390/ph18070984","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ph18070984","pdf_url":"https://www.mdpi.com/1424-8247/18/7/984/pdf?version=1751439120","source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"},{"id":"pmid:40732274","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40732274","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12298883","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12298883/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:ec9dd75386ef4e30a1d608afa384481f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ec9dd75386ef4e30a1d608afa384481f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceuticals, Vol 18, Iss 7, p 984 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ph18070984","doi":"https://doi.org/10.3390/ph18070984","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ph18070984","pdf_url":"https://www.mdpi.com/1424-8247/18/7/984/pdf?version=1751439120","source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6874614277","display_name":null,"funder_award_id":"RS-2024-00333842","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411961311.pdf","grobid_xml":"https://content.openalex.org/works/W4411961311.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W304168149","https://openalex.org/W574529454","https://openalex.org/W2007959663","https://openalex.org/W2019316774","https://openalex.org/W2020037351","https://openalex.org/W2062651234","https://openalex.org/W2062941476","https://openalex.org/W2070220192","https://openalex.org/W2071358460","https://openalex.org/W2081138669","https://openalex.org/W2126420606","https://openalex.org/W2146071910","https://openalex.org/W2146615843","https://openalex.org/W2152793164","https://openalex.org/W2164333948","https://openalex.org/W2234351497","https://openalex.org/W2336732132","https://openalex.org/W2513169749","https://openalex.org/W2518675083","https://openalex.org/W2522425610","https://openalex.org/W2793919752","https://openalex.org/W2886678897","https://openalex.org/W2951512731","https://openalex.org/W2971293153","https://openalex.org/W2972850585","https://openalex.org/W2979651267","https://openalex.org/W2980845752","https://openalex.org/W2999725576","https://openalex.org/W3005575131","https://openalex.org/W3020867682","https://openalex.org/W3046330329","https://openalex.org/W3112920053","https://openalex.org/W3115020790","https://openalex.org/W3127311830","https://openalex.org/W3135141004","https://openalex.org/W3196147846","https://openalex.org/W4210563432","https://openalex.org/W4255064049","https://openalex.org/W4282937816","https://openalex.org/W4292099802","https://openalex.org/W4293769572","https://openalex.org/W4320731570","https://openalex.org/W4321483180","https://openalex.org/W4323667763","https://openalex.org/W4382501575","https://openalex.org/W4384695312","https://openalex.org/W4385163500","https://openalex.org/W4386851897","https://openalex.org/W4387035949","https://openalex.org/W4388635132","https://openalex.org/W4388639017","https://openalex.org/W4390743773","https://openalex.org/W4390971458","https://openalex.org/W4391361302","https://openalex.org/W4396686246","https://openalex.org/W4397007483","https://openalex.org/W4400780160","https://openalex.org/W4402619136","https://openalex.org/W4403510752","https://openalex.org/W4407059001","https://openalex.org/W4410118317"],"related_works":["https://openalex.org/W4408185409","https://openalex.org/W2978442899","https://openalex.org/W4362473221","https://openalex.org/W2075358512","https://openalex.org/W4403435566","https://openalex.org/W4389628339","https://openalex.org/W7164016122","https://openalex.org/W4378715614","https://openalex.org/W7157261935","https://openalex.org/W7160278262"],"abstract_inverted_index":{"Background/Objectives:":[0],"Naegleria":[1],"fowleri":[2,121,143,153,185],"is":[3,23],"a":[4],"free-living":[5],"amoeba":[6],"that":[7],"invades":[8],"brain":[9],"tissues":[10],"causing":[11],"fatal":[12],"primary":[13],"amoebic":[14],"meningoencephalitis":[15],"(PAM).":[16],"An":[17],"effective":[18,51,179],"and":[19,41,52,65,74,85,92,97,103,106,114,132,137,172,178],"tolerable":[20],"therapeutic":[21],"agent":[22],"still":[24],"lacking.":[25],"Methods:":[26],"A":[27],"series":[28],"of":[29,33,43,141,151,161],"conformationally":[30],"restricted":[31],"analogs":[32],"miltefosine":[34,102,182],"with":[35,72,158],"varied":[36],"restriction":[37,71],"positions,":[38],"stereochemical":[39],"configuration":[40],"lengths":[42],"alkyl":[44,78],"chain":[45],"was":[46],"investigated":[47],"to":[48,101],"discover":[49],"more":[50,83,175],"less":[53,86],"toxic":[54],"agents":[55,180],"than":[56,123,181],"miltefosine.":[57],"Results:":[58],"Among":[59],"tested":[60],"compounds,":[61],"derivatives":[62],"2a,":[63,90,130],"3b":[64,91,115,131,173],"3d":[66,93,133],"featuring":[67],"1,2-":[68],"or":[69,76],"2,3-positional":[70],"trans-configuration":[73],"tridecyl":[75],"behenyl":[77],"chains":[79],"were":[80],"discovered":[81],"as":[82,174],"potent":[84],"cytotoxic":[87],"agents.":[88],"Compounds":[89,129],"elicited":[94],"3.49-,":[95],"3.58-":[96],"6.03-fold":[98],"relative":[99],"potencies":[100],"7.53,":[104],"3.90":[105],"3.49":[107],"selectivity":[108],"indices,":[109],"respectively.":[110],"Furthermore,":[111],"compounds":[112,170],"2a":[113,171],"showed":[116],"IC90":[117],"values":[118],"for":[119,186],"N.":[120,142,152,184],"lower":[122],"CC50":[124],"against":[125,183],"glial":[126],"C6":[127],"cells.":[128],"induced":[134,149],"morphological":[135],"changes":[136],"programmed":[138],"cell":[139],"death":[140,150],"via":[144],"the":[145,159],"apoptosis-like":[146],"pathway.":[147],"The":[148,166],"involved":[154],"DNA":[155],"fragmentation":[156],"along":[157],"loss":[160],"mitochondrial":[162],"membrane":[163],"potential.":[164],"Conclusions:":[165],"current":[167],"research":[168],"presents":[169],"potent,":[176],"selective":[177],"further":[187],"development.":[188]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-07-03T00:00:00"}
