{"id":"https://openalex.org/W4411960874","doi":"https://doi.org/10.3390/biomedicines13071623","title":"Role of BMPR2 Mutation in Lung Organoid Differentiation","display_name":"Role of BMPR2 Mutation in Lung Organoid Differentiation","publication_year":2025,"publication_date":"2025-07-02","ids":{"openalex":"https://openalex.org/W4411960874","doi":"https://doi.org/10.3390/biomedicines13071623","pmid":"https://pubmed.ncbi.nlm.nih.gov/40722696","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12292610"},"language":"en","primary_location":{"id":"doi:10.3390/biomedicines13071623","doi":"https://doi.org/10.3390/biomedicines13071623","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines13071623","pdf_url":"https://www.mdpi.com/2227-9059/13/7/1623/pdf?version=1751455988","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2227-9059/13/7/1623/pdf?version=1751455988","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103238474","display_name":"Simin Jiang","orcid":"https://orcid.org/0000-0002-9015-4411","observed_orcids":["https://orcid.org/0000-0002-9015-4411","https://orcid.org/0000-0001-9289-5187"]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Simin Jiang","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China"],"raw_orcid":"https://orcid.org/0000-0002-9015-4411","affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101949656","display_name":"Dian Chen","orcid":"https://orcid.org/0000-0002-2911-9019","observed_orcids":["https://orcid.org/0000-0002-2911-9019"]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dian Chen","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Liangliang Tian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liangliang Tian","raw_affiliation_strings":["Beijing Advanced Center of Cellular Homeostasis and Aging-Related Diseases, Clinical Stem Cell Research Center, State Key Laboratory of Vascular Homeostasis and Remodeling, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Third Hospital, Peking University, Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Advanced Center of Cellular Homeostasis and Aging-Related Diseases, Clinical Stem Cell Research Center, State Key Laboratory of Vascular Homeostasis and Remodeling, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Third Hospital, Peking University, Beijing 100191, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082643982","display_name":"Zihang Pan","orcid":"https://orcid.org/0000-0003-4195-7207","observed_orcids":["https://orcid.org/0000-0003-4195-7207"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zihang Pan","raw_affiliation_strings":["Beijing Advanced Center of Cellular Homeostasis and Aging-Related Diseases, Clinical Stem Cell Research Center, State Key Laboratory of Vascular Homeostasis and Remodeling, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Third Hospital, Peking University, Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Advanced Center of Cellular Homeostasis and Aging-Related Diseases, Clinical Stem Cell Research Center, State Key Laboratory of Vascular Homeostasis and Remodeling, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Third Hospital, Peking University, Beijing 100191, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042218157","display_name":"Huanyu Long","orcid":"https://orcid.org/0000-0001-7424-3492","observed_orcids":["https://orcid.org/0000-0001-7424-3492"]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huanyu Long","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084971205","display_name":"Lanhe Chu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lanhe Chu","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Weijing Kong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weijing Kong","raw_affiliation_strings":["Beijing Advanced Center of Cellular Homeostasis and Aging-Related Diseases, Clinical Stem Cell Research Center, State Key Laboratory of Vascular Homeostasis and Remodeling, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Third Hospital, Peking University, Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Advanced Center of Cellular Homeostasis and Aging-Related Diseases, Clinical Stem Cell Research Center, State Key Laboratory of Vascular Homeostasis and Remodeling, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Third Hospital, Peking University, Beijing 100191, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qiyang Yao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiyang Yao","raw_affiliation_strings":["Beijing Advanced Center of Cellular Homeostasis and Aging-Related Diseases, Clinical Stem Cell Research Center, State Key Laboratory of Vascular Homeostasis and Remodeling, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Third Hospital, Peking University, Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Advanced Center of Cellular Homeostasis and Aging-Related Diseases, Clinical Stem Cell Research Center, State Key Laboratory of Vascular Homeostasis and Remodeling, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Third Hospital, Peking University, Beijing 100191, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079207956","display_name":"Xiaojing Ma","orcid":"https://orcid.org/0000-0003-3043-1840","observed_orcids":["https://orcid.org/0000-0003-3043-1840"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaojing Ma","raw_affiliation_strings":["Beijing Advanced Center of Cellular Homeostasis and Aging-Related Diseases, Clinical Stem Cell Research Center, State Key Laboratory of Vascular Homeostasis and Remodeling, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Third Hospital, Peking University, Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Advanced Center of Cellular Homeostasis and Aging-Related Diseases, Clinical Stem Cell Research Center, State Key Laboratory of Vascular Homeostasis and Remodeling, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Third Hospital, Peking University, Beijing 100191, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101805108","display_name":"Yun Zhao","orcid":"https://orcid.org/0000-0002-7550-2158","observed_orcids":["https://orcid.org/0000-0002-7550-2158"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun Zhao","raw_affiliation_strings":["Beijing Advanced Center of Cellular Homeostasis and Aging-Related Diseases, Clinical Stem Cell Research Center, State Key Laboratory of Vascular Homeostasis and Remodeling, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Third Hospital, Peking University, Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Advanced Center of Cellular Homeostasis and Aging-Related Diseases, Clinical Stem Cell Research Center, State Key Laboratory of Vascular Homeostasis and Remodeling, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Third Hospital, Peking University, Beijing 100191, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210141942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100436929","display_name":"Kai Wang","orcid":"https://orcid.org/0000-0001-6240-0147","observed_orcids":["https://orcid.org/0000-0001-6240-0147"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Kai Wang","raw_affiliation_strings":["Beijing Advanced Center of Cellular Homeostasis and Aging-Related Diseases, Clinical Stem Cell Research Center, State Key Laboratory of Vascular Homeostasis and Remodeling, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Third Hospital, Peking University, Beijing 100191, China"],"raw_orcid":"https://orcid.org/0000-0001-6240-0147","affiliations":[{"raw_affiliation_string":"Beijing Advanced Center of Cellular Homeostasis and Aging-Related Diseases, Clinical Stem Cell Research Center, State Key Laboratory of Vascular Homeostasis and Remodeling, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Third Hospital, Peking University, Beijing 100191, China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210141942"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045270019","display_name":"Yahong Chen","orcid":"https://orcid.org/0000-0003-3258-8032","observed_orcids":["https://orcid.org/0000-0003-3258-8032","https://orcid.org/0000-0003-4566-8197"]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yahong Chen","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China","institution_ids":["https://openalex.org/I4210141942"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5045270019","https://openalex.org/A5100436929"],"corresponding_institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210141942"],"apc_list":{"value":2600,"currency":"CHF","value_usd":3137},"apc_paid":{"value":2600,"currency":"CHF","value_usd":3137},"fwci":0.8892,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.69489274,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"13","issue":"7","first_page":"1623","last_page":"1623"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.4871000051498413,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.4871000051498413,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.2517000138759613,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.04349999874830246,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bmpr2-mutations","display_name":"BMPR2 mutations","score":0.9819999933242798},{"id":"https://openalex.org/keywords/bmp-signaling","display_name":"BMP signaling","score":0.746999979019165},{"id":"https://openalex.org/keywords/lung-organoids","display_name":"lung organoids","score":0.8220000267028809},{"id":"https://openalex.org/keywords/lung-development","display_name":"lung development","score":0.6370000243186951},{"id":"https://openalex.org/keywords/lung-progenitor-cells","display_name":"lung progenitor cells","score":0.7879999876022339},{"id":"https://openalex.org/keywords/airway-epithelium","display_name":"airway epithelium","score":0.8140000104904175},{"id":"https://openalex.org/keywords/alveolar-epithelium","display_name":"alveolar epithelium","score":0.9409999847412109},{"id":"https://openalex.org/keywords/goblet-cells","display_name":"goblet cells","score":0.6309999823570251},{"id":"https://openalex.org/keywords/ciliated-cells","display_name":"ciliated cells","score":0.972000002861023},{"id":"https://openalex.org/keywords/club-cells","display_name":"Clara cells","score":0.8019999861717224},{"id":"https://openalex.org/keywords/basal-cells","display_name":"basal cells","score":0.6520000100135803},{"id":"https://openalex.org/keywords/ipsc-derived-organoids","display_name":"iPSC-derived organoids","score":0.6650000214576721},{"id":"https://openalex.org/keywords/crispr-cas9-gene-correction","display_name":"CRISPR/Cas9 gene correction","score":0.7820000052452087},{"id":"https://openalex.org/keywords/bmpr1a","display_name":"BMPR1A","score":0.4830000102519989},{"id":"https://openalex.org/keywords/bmpr1b","display_name":"BMPR1B","score":0.9879999756813049}],"concepts":[{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.7328827977180481},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7317500710487366},{"id":"https://openalex.org/C73834784","wikidata":"https://www.wikidata.org/wiki/Q17849752","display_name":"BMPR2","level":4,"score":0.7308927774429321},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6322218179702759},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.6313434839248657},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5370148420333862},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.5314124226570129},{"id":"https://openalex.org/C87568996","wikidata":"https://www.wikidata.org/wiki/Q1428754","display_name":"Respiratory epithelium","level":3,"score":0.5190728306770325},{"id":"https://openalex.org/C2777164004","wikidata":"https://www.wikidata.org/wiki/Q331858","display_name":"Endoderm","level":4,"score":0.4465809762477875},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.4066431522369385},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3939395546913147},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.25722140073776245},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20383766293525696},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10350686311721802}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/biomedicines13071623","doi":"https://doi.org/10.3390/biomedicines13071623","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines13071623","pdf_url":"https://www.mdpi.com/2227-9059/13/7/1623/pdf?version=1751455988","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12292610","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12292610","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Text"},{"id":"pmid:40722696","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40722696","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d2ec42fa6bfd4f08bb4cf6ee63a4778e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d2ec42fa6bfd4f08bb4cf6ee63a4778e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedicines, Vol 13, Iss 7, p 1623 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biomedicines13071623","doi":"https://doi.org/10.3390/biomedicines13071623","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines13071623","pdf_url":"https://www.mdpi.com/2227-9059/13/7/1623/pdf?version=1751455988","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1496946619","display_name":null,"funder_award_id":"82090014","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2410287011","display_name":null,"funder_award_id":"2025-VHR-O-SY-01","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5114380507","display_name":null,"funder_award_id":"J230030","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7526603168","display_name":null,"funder_award_id":"2022YFC3401100","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G8734139443","display_name":null,"funder_award_id":"2022YFC3401100","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411960874.pdf","grobid_xml":"https://content.openalex.org/works/W4411960874.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W1959932605","https://openalex.org/W1976397516","https://openalex.org/W1982263927","https://openalex.org/W1998540184","https://openalex.org/W2003211588","https://openalex.org/W2007260996","https://openalex.org/W2020549986","https://openalex.org/W2029998066","https://openalex.org/W2040111212","https://openalex.org/W2065839331","https://openalex.org/W2070864748","https://openalex.org/W2098144345","https://openalex.org/W2117962623","https://openalex.org/W2121672537","https://openalex.org/W2125135590","https://openalex.org/W2126380346","https://openalex.org/W2131993231","https://openalex.org/W2132020845","https://openalex.org/W2147892082","https://openalex.org/W2168680682","https://openalex.org/W2172111284","https://openalex.org/W2178641192","https://openalex.org/W2340923921","https://openalex.org/W2341828371","https://openalex.org/W2466883271","https://openalex.org/W2533632435","https://openalex.org/W2564191431","https://openalex.org/W2598899113","https://openalex.org/W2800406470","https://openalex.org/W2900846558","https://openalex.org/W2905257285","https://openalex.org/W3034905506","https://openalex.org/W3047507938","https://openalex.org/W3087577251","https://openalex.org/W3088109010","https://openalex.org/W3117317823","https://openalex.org/W3157387169","https://openalex.org/W4200426895","https://openalex.org/W4293178741","https://openalex.org/W4293217384","https://openalex.org/W4313555267","https://openalex.org/W4376118197","https://openalex.org/W4386574175","https://openalex.org/W4391110251","https://openalex.org/W4398240517"],"related_works":["https://openalex.org/W2800406470","https://openalex.org/W4399492130","https://openalex.org/W1966607776","https://openalex.org/W1976213734","https://openalex.org/W4293577024","https://openalex.org/W2015254140","https://openalex.org/W2088573269","https://openalex.org/W4402134918","https://openalex.org/W1963272169","https://openalex.org/W2057700884"],"abstract_inverted_index":{"Background:":[0],"The":[1,94],"bone":[2],"morphogenetic":[3],"protein":[4],"(BMP)":[5],"signaling":[6],"pathway":[7],"is":[8],"essential":[9],"for":[10],"lung":[11,48,82,128,177],"development.":[12],"BMP4,":[13],"a":[14,62,65,117,124],"key":[15],"regulator,":[16],"binds":[17],"to":[18,27,39,88],"type":[19,23],"I":[20],"(BMPR1)":[21],"and":[22,36,69,85,91,97,107,151,160,180],"II":[24],"(BMPR2)":[25],"receptors":[26],"initiate":[28],"downstream":[29],"signaling.":[30],"While":[31],"the":[32,42,189],"inactivation":[33],"of":[34,44,192],"Bmpr1a":[35],"Bmpr1b":[37],"leads":[38],"tracheoesophageal":[40],"fistulae,":[41],"role":[43],"BMPR2":[45,66,172,193],"mutations":[46],"in":[47,115,127,158],"epithelial":[49,98,137,183],"development":[50],"remains":[51],"unclear.":[52],"Methods:":[53],"We":[54],"generated":[55],"induced":[56],"pluripotent":[57],"stem":[58],"cells":[59,84,147],"(iPSCs)":[60],"from":[61,145],"patient":[63],"carrying":[64],"mutation":[67],"(c.631C>T),":[68],"gene-corrected":[70],"isogenic":[71],"controls":[72],"were":[73,79,101],"created":[74],"using":[75,103],"CRISPR/Cas9.":[76],"These":[77],"iPSCs":[78,111],"differentiated":[80],"into":[81,188],"progenitor":[83,129,178],"subsequently":[86],"cultured":[87],"generate":[89],"alveolar":[90,136],"airway":[92,142,168,182],"organoids.":[93],"differentiation":[95,131,138],"efficiency":[96],"lineage":[99],"specification":[100,179],"assessed":[102],"immunofluorescence,":[104],"flow":[105],"cytometry,":[106],"qRT-PCR.":[108],"Results:":[109],"BMPR2-mutant":[110,146],"showed":[112],"no":[113],"impairment":[114],"forming":[116],"definitive":[118],"or":[119],"anterior":[120],"foregut":[121],"endoderm.":[122],"However,":[123],"significant":[125],"reduction":[126],"cell":[130,153,162,169],"was":[132],"observed.":[133],"Further,":[134],"while":[135],"remained":[139],"largely":[140],"unaffected,":[141],"organoids":[143],"derived":[144],"exhibited":[148],"impaired":[149],"goblet":[150],"ciliated":[152],"development,":[154],"with":[155],"an":[156],"increase":[157],"basal":[159],"club":[161],"markers,":[163],"indicating":[164],"skewing":[165],"toward":[166],"undifferentiated":[167],"populations.":[170],"Conclusions:":[171],"dysfunction":[173],"selectively":[174],"impairs":[175],"late-stage":[176],"disrupts":[181],"maturation,":[184],"providing":[185],"new":[186],"insights":[187],"developmental":[190],"impacts":[191],"mutations.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2025-10-10T00:00:00"}
