{"id":"https://openalex.org/W4411955700","doi":"https://doi.org/10.1016/j.medidd.2025.100214","title":"Flavonoids and anxiety: decoding their role in brain function and pathophysiology","display_name":"Flavonoids and anxiety: decoding their role in brain function and pathophysiology","publication_year":2025,"publication_date":"2025-07-02","ids":{"openalex":"https://openalex.org/W4411955700","doi":"https://doi.org/10.1016/j.medidd.2025.100214"},"language":"en","primary_location":{"id":"doi:10.1016/j.medidd.2025.100214","doi":"https://doi.org/10.1016/j.medidd.2025.100214","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.medidd.2025.100214","pdf_url":null,"source":{"id":"https://openalex.org/S4210216844","display_name":"Medicine in Drug Discovery","issn_l":"2590-0986","issn":["2590-0986"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine in Drug Discovery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.medidd.2025.100214","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102607431","display_name":"Riya Singla","orcid":"https://orcid.org/0009-0000-4925-7964","observed_orcids":["https://orcid.org/0009-0000-4925-7964"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Riya Singla","raw_affiliation_strings":["Ch. Devi Lal College of Pharmacy, Jagadhri, Yamunanagar, Haryana 135003, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ch. Devi Lal College of Pharmacy, Jagadhri, Yamunanagar, Haryana 135003, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024976019","display_name":"Sonia Kamboj","orcid":"https://orcid.org/0000-0002-2969-4910","observed_orcids":["https://orcid.org/0000-0002-2969-4910"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sonia Kamboj","raw_affiliation_strings":["Ch. Devi Lal College of Pharmacy, Jagadhri, Yamunanagar, Haryana 135003, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ch. Devi Lal College of Pharmacy, Jagadhri, Yamunanagar, Haryana 135003, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090382231","display_name":"Brijesh Kumar Duvey","orcid":"https://orcid.org/0009-0006-1343-2453","observed_orcids":["https://orcid.org/0009-0006-1343-2453"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brijesh Kumar Duvey","raw_affiliation_strings":["Ch. Devi Lal College of Pharmacy, Jagadhri, Yamunanagar, Haryana 135003, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ch. Devi Lal College of Pharmacy, Jagadhri, Yamunanagar, Haryana 135003, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anurag Bhargava","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anurag Bhargava","raw_affiliation_strings":["Ch. Devi Lal College of Pharmacy, Jagadhri, Yamunanagar, Haryana 135003, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ch. Devi Lal College of Pharmacy, Jagadhri, Yamunanagar, Haryana 135003, India","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001658856","display_name":"Jasmine Chaudhary","orcid":"https://orcid.org/0000-0001-6974-4890","observed_orcids":["https://orcid.org/0000-0001-6974-4890"]},"institutions":[{"id":"https://openalex.org/I155284866","display_name":"Maharishi Markandeshwar University, Mullana","ror":"https://ror.org/013qfkw58","country_code":"IN","type":"education","lineage":["https://openalex.org/I155284866"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jasmine Chaudhary","raw_affiliation_strings":["MM College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MM College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, India","institution_ids":["https://openalex.org/I155284866"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5024976019"],"corresponding_institution_ids":[],"apc_list":{"value":2460,"currency":"USD","value_usd":2460},"apc_paid":{"value":2460,"currency":"USD","value_usd":2460},"fwci":4.9419,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.94234522,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"27","issue":null,"first_page":"100214","last_page":"100214"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.016899999231100082,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9980000257492065},{"id":"https://openalex.org/keywords/anxiety-disorders","display_name":"anxiety disorders","score":0.9769999980926514},{"id":"https://openalex.org/keywords/anxiolytic-effects","display_name":"anxiolytic effects","score":0.9670000076293945},{"id":"https://openalex.org/keywords/apigenin","display_name":"apigenin","score":0.8140000104904175},{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":1.0},{"id":"https://openalex.org/keywords/luteolin","display_name":"luteolin","score":1.0},{"id":"https://openalex.org/keywords/serotonergic-system","display_name":"serotonergic system","score":0.8579999804496765},{"id":"https://openalex.org/keywords/dopaminergic-system","display_name":"dopaminergic system","score":0.9919999837875366},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.7639999985694885},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9810000061988831},{"id":"https://openalex.org/keywords/natural-medicine","display_name":"natural medicine","score":0.41999998688697815},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.6389999985694885},{"id":"https://openalex.org/keywords/neurotransmitter-modulation","display_name":"neurotransmitter modulation","score":0.45899999141693115}],"concepts":[{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.7170022130012512},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.606703519821167},{"id":"https://openalex.org/C57273362","wikidata":"https://www.wikidata.org/wiki/Q576722","display_name":"Decoding methods","level":2,"score":0.5336074829101562},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5180357098579407},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4484364092350006},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4470255374908447},{"id":"https://openalex.org/C3018390542","wikidata":"https://www.wikidata.org/wiki/Q1073","display_name":"Brain function","level":2,"score":0.44158411026000977},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.376228928565979},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.18475067615509033},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.18362736701965332},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.14072811603546143},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1373661458492279},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.12341633439064026},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08712321519851685}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.medidd.2025.100214","doi":"https://doi.org/10.1016/j.medidd.2025.100214","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.medidd.2025.100214","pdf_url":null,"source":{"id":"https://openalex.org/S4210216844","display_name":"Medicine in Drug Discovery","issn_l":"2590-0986","issn":["2590-0986"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine in Drug Discovery","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:daf4f96894c74586b9b61c69e87b0e2d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/daf4f96894c74586b9b61c69e87b0e2d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Medicine in Drug Discovery, Vol 27, Iss , Pp 100214- (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.medidd.2025.100214","doi":"https://doi.org/10.1016/j.medidd.2025.100214","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.medidd.2025.100214","pdf_url":null,"source":{"id":"https://openalex.org/S4210216844","display_name":"Medicine in Drug Discovery","issn_l":"2590-0986","issn":["2590-0986"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine in Drug Discovery","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W1635400258","https://openalex.org/W1977136230","https://openalex.org/W1988984446","https://openalex.org/W1990145288","https://openalex.org/W1990598466","https://openalex.org/W1994136305","https://openalex.org/W1995717578","https://openalex.org/W1997993237","https://openalex.org/W2008245053","https://openalex.org/W2011144770","https://openalex.org/W2017116746","https://openalex.org/W2018955399","https://openalex.org/W2033103225","https://openalex.org/W2035602526","https://openalex.org/W2040054348","https://openalex.org/W2059198552","https://openalex.org/W2065976917","https://openalex.org/W2080962368","https://openalex.org/W2081101292","https://openalex.org/W2084438494","https://openalex.org/W2103606317","https://openalex.org/W2117315687","https://openalex.org/W2126054880","https://openalex.org/W2153531592","https://openalex.org/W2155608175","https://openalex.org/W2161687092","https://openalex.org/W2177350069","https://openalex.org/W2182576560","https://openalex.org/W2183652061","https://openalex.org/W2320856080","https://openalex.org/W2418938844","https://openalex.org/W2536028387","https://openalex.org/W2587822630","https://openalex.org/W2620808833","https://openalex.org/W2738299024","https://openalex.org/W2810953247","https://openalex.org/W2909395738","https://openalex.org/W2923991245","https://openalex.org/W2938063442","https://openalex.org/W2996844137","https://openalex.org/W3038852650","https://openalex.org/W3044860056","https://openalex.org/W3045763050","https://openalex.org/W3081547488","https://openalex.org/W3108519652","https://openalex.org/W3211568683","https://openalex.org/W4200417281","https://openalex.org/W4223602629","https://openalex.org/W4239407950","https://openalex.org/W4281965082","https://openalex.org/W4291708664","https://openalex.org/W4296168194","https://openalex.org/W4296625572","https://openalex.org/W4307262230","https://openalex.org/W4307703022","https://openalex.org/W4308767262","https://openalex.org/W4309160586","https://openalex.org/W4311852521","https://openalex.org/W4312210558","https://openalex.org/W4319295179","https://openalex.org/W4323032819","https://openalex.org/W4380997818","https://openalex.org/W4387386673","https://openalex.org/W4387656010","https://openalex.org/W4388562777","https://openalex.org/W4394763914","https://openalex.org/W4394774540","https://openalex.org/W4400641223","https://openalex.org/W4403476000","https://openalex.org/W4403569206","https://openalex.org/W4404287208","https://openalex.org/W4404859941","https://openalex.org/W6864585199"],"related_works":["https://openalex.org/W3025158165","https://openalex.org/W3108519652","https://openalex.org/W4319295179","https://openalex.org/W4415673458","https://openalex.org/W4380997818","https://openalex.org/W4399274336","https://openalex.org/W7161636379","https://openalex.org/W4223602629","https://openalex.org/W4413935675","https://openalex.org/W7108249703"],"abstract_inverted_index":{"Anxiety":[0],"disorder":[1],"ranks":[2],"among":[3],"the":[4,13,17,59,67,72,95,117,127,134,140,194,208,224,227],"most":[5],"common":[6],"mental":[7],"health":[8],"issues":[9],"globally,":[10],"thereby":[11],"emphasizing":[12],"pressing":[14],"necessity":[15],"for":[16,58,145],"development":[18],"of":[19,29,61,75,98,130,137,152,173,181,191,210,230],"safer":[20],"and":[21,47,88,132,142,154,164,240],"more":[22],"effective":[23],"treatment":[24],"alternatives.":[25],"A":[26],"noteworthy":[27],"class":[28],"compounds":[30,52],"in":[31,42,177,207,256],"this":[32,122],"context":[33],"is":[34,220],"flavonoids,":[35,160],"which":[36],"are":[37,248],"naturally":[38],"polyphenolic":[39],"substances":[40],"found":[41],"abundance":[43],"within":[44],"fruits,":[45],"vegetables,":[46],"various":[48],"medicinal":[49],"plants.":[50],"These":[51],"have":[53],"garnered":[54],"attention":[55],"as":[56,200],"candidates":[57],"modulation":[60],"behaviours":[62],"associated":[63],"with":[64,80,86,139],"anxiety.":[65,147],"Examining":[66],"neurological":[68],"mechanisms":[69,225],"that":[70,158,196,217],"underlie":[71],"anxiolytic":[73],"effects":[74,183,229],"flavonoids":[76,138,197],"reveals":[77],"significant":[78],"interaction":[79],"essential":[81,249],"neurotransmitter":[82],"systems.":[83],"Specifically,":[84],"engagement":[85],"serotonergic":[87],"dopaminergic":[89],"pathways":[90],"has":[91],"been":[92],"observed,":[93],"indicating":[94],"multifaceted":[96],"nature":[97],"flavonoids\u2019":[99],"influence":[100],"on":[101,126],"anxiety":[102,131,211,257],"responses.":[103],"The":[104],"biological":[105],"activities,":[106],"including":[107,161],"antioxidant,":[108],"anti-inflammatory":[109],"properties,":[110],"contribute":[111],"to":[112,116,170,185,204,222,250],"an":[113],"additional":[114,218],"layer":[115],"potential":[118,255],"therapeutic":[119,254],"effect.":[120],"Therefore,":[121],"review":[123],"mainly":[124],"focuses":[125],"pathological":[128],"facets":[129],"explores":[133],"possible":[135],"mechanism":[136],"preclinical":[141],"clinical":[143,155,242],"aspects":[144],"curing":[146],"Moreover,":[148],"a":[149,167,178],"growing":[150],"body":[151,190],"experimental":[153],"evidence":[156],"indicates":[157],"certain":[159],"apigenin,":[162],"quercetin,":[163],"luteolin,":[165],"possess":[166],"considerable":[168],"capacity":[169],"mitigate":[171],"symptoms":[172],"anxiety,":[174],"frequently":[175],"resulting":[176],"reduced":[179],"incidence":[180],"adverse":[182],"relative":[184],"traditional":[186],"pharmacological":[187,228],"therapies.":[188],"This":[189],"work":[192],"reinforces":[193],"proposition":[195],"may":[198],"serve":[199],"viable":[201],"natural":[202],"alternatives":[203],"supplementary":[205],"treatments":[206],"management":[209,258],"disorders.":[212],"Nevertheless,":[213],"it":[214],"remains":[215],"imperative":[216],"research":[219],"conducted":[221],"clarify":[223],"underlying":[226],"these":[231],"flavonoids.":[232],"Furthermore,":[233],"investigations":[234],"aimed":[235],"at":[236],"optimizing":[237],"their":[238,253],"bioavailability":[239],"validating":[241],"efficacy":[243],"through":[244],"extensive":[245],"human":[246],"trials":[247],"fully":[251],"ascertain":[252]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
