{"id":"https://openalex.org/W4411939705","doi":"https://doi.org/10.2147/ijn.s534137","title":"A Review on QbD-Driven Optimization of Lipid Nanoparticles for Oral Drug Delivery: From Framework to Formulation","display_name":"A Review on QbD-Driven Optimization of Lipid Nanoparticles for Oral Drug Delivery: From Framework to Formulation","publication_year":2025,"publication_date":"2025-07-01","ids":{"openalex":"https://openalex.org/W4411939705","doi":"https://doi.org/10.2147/ijn.s534137","pmid":"https://pubmed.ncbi.nlm.nih.gov/40626137","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12232942"},"language":"en","primary_location":{"id":"doi:10.2147/ijn.s534137","doi":"https://doi.org/10.2147/ijn.s534137","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s534137","pdf_url":"https://www.dovepress.com/article/download/104452","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/article/download/104452","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000413133","display_name":"Aulia Fikri Hidayat","orcid":"https://orcid.org/0000-0001-5111-8613","observed_orcids":["https://orcid.org/0000-0001-5111-8613"]},"institutions":[{"id":"https://openalex.org/I4210150439","display_name":"Bandung Islamic University","ror":"https://ror.org/04tp6pr14","country_code":"ID","type":"education","lineage":["https://openalex.org/I4210150439"]},{"id":"https://openalex.org/I91819753","display_name":"Padjadjaran University","ror":"https://ror.org/00xqf8t64","country_code":"ID","type":"education","lineage":["https://openalex.org/I91819753"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Aulia Hidayat","raw_affiliation_strings":["Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Islam Bandung, Bandung, Indonesia","Doctoral Program of Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia"],"raw_orcid":"https://orcid.org/0000-0001-5111-8613","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Islam Bandung, Bandung, Indonesia","institution_ids":["https://openalex.org/I4210150439"]},{"raw_affiliation_string":"Doctoral Program of Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia","institution_ids":["https://openalex.org/I91819753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016854122","display_name":"Yoga Windhu Wardhana","orcid":"https://orcid.org/0000-0002-4337-899X","observed_orcids":["https://orcid.org/0000-0002-4337-899X"]},"institutions":[{"id":"https://openalex.org/I91819753","display_name":"Padjadjaran University","ror":"https://ror.org/00xqf8t64","country_code":"ID","type":"education","lineage":["https://openalex.org/I91819753"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Yoga Wardhana","raw_affiliation_strings":["Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia"],"raw_orcid":"https://orcid.org/0000-0002-4337-899X","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia","institution_ids":["https://openalex.org/I91819753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012193300","display_name":"Suwendar Suwendar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150439","display_name":"Bandung Islamic University","ror":"https://ror.org/04tp6pr14","country_code":"ID","type":"education","lineage":["https://openalex.org/I4210150439"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Suwendar Suwendar","raw_affiliation_strings":["Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Islam Bandung, Bandung, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Islam Bandung, Bandung, Indonesia","institution_ids":["https://openalex.org/I4210150439"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029318036","display_name":"Ahmed Fouad Abdelwahab Mohammed","orcid":"https://orcid.org/0000-0003-3368-0340","observed_orcids":["https://orcid.org/0000-0003-3368-0340"]},"institutions":[{"id":"https://openalex.org/I89466785","display_name":"Minia University","ror":"https://ror.org/02hcv4z63","country_code":"EG","type":"education","lineage":["https://openalex.org/I89466785"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ahmed Mohammed","raw_affiliation_strings":["Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt","institution_ids":["https://openalex.org/I89466785"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054037926","display_name":"Safwat A. Mahmoud","orcid":"https://orcid.org/0000-0003-3323-2644","observed_orcids":["https://orcid.org/0000-0003-3323-2644","https://orcid.org/0000-0002-1923-4734"]},"institutions":[{"id":"https://openalex.org/I118590987","display_name":"Northern Border University","ror":"https://ror.org/03j9tzj20","country_code":"SA","type":"education","lineage":["https://openalex.org/I118590987"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Safwat Mahmoud","raw_affiliation_strings":["Center for Scientific Research and Entrepreneurship, Northern Border University, Arar, 73213, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Scientific Research and Entrepreneurship, Northern Border University, Arar, 73213, Saudi Arabia","institution_ids":["https://openalex.org/I118590987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000277947","display_name":"Khaled M. Elamin","orcid":"https://orcid.org/0000-0001-9555-1814","observed_orcids":["https://orcid.org/0000-0001-9555-1814"]},"institutions":[{"id":"https://openalex.org/I96036126","display_name":"Kumamoto University","ror":"https://ror.org/02cgss904","country_code":"JP","type":"education","lineage":["https://openalex.org/I96036126"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Khaled Elamin","raw_affiliation_strings":["Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan"],"raw_orcid":"https://orcid.org/0000-0001-9555-1814","affiliations":[{"raw_affiliation_string":"Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan","institution_ids":["https://openalex.org/I96036126"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072621688","display_name":"Nasrul Wathoni","orcid":"https://orcid.org/0000-0002-5985-6909","observed_orcids":["https://orcid.org/0000-0002-5985-6909"]},"institutions":[{"id":"https://openalex.org/I91819753","display_name":"Padjadjaran University","ror":"https://ror.org/00xqf8t64","country_code":"ID","type":"education","lineage":["https://openalex.org/I91819753"]}],"countries":["ID"],"is_corresponding":true,"raw_author_name":"Nasrul Wathoni","raw_affiliation_strings":["Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia"],"raw_orcid":"https://orcid.org/0000-0002-5985-6909","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia","institution_ids":["https://openalex.org/I91819753"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5072621688"],"corresponding_institution_ids":["https://openalex.org/I91819753"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":3.7192,"has_fulltext":true,"cited_by_count":56,"citation_normalized_percentile":{"value":0.95444915,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"Volume 20","issue":null,"first_page":"8611","last_page":"8651"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.7598000168800354,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.7598000168800354,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.149399995803833,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.04749999940395355,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipid-nanoparticles","display_name":"lipid nanoparticles","score":0.8230000138282776},{"id":"https://openalex.org/keywords/oral-drug-delivery","display_name":"oral drug delivery","score":0.8289999961853027},{"id":"https://openalex.org/keywords/quality-by-design","display_name":"quality by design","score":0.8479999899864197},{"id":"https://openalex.org/keywords/solid-lipid-nanoparticles","display_name":"solid lipid nanoparticles","score":0.9909999966621399},{"id":"https://openalex.org/keywords/nanostructured-lipid-carriers","display_name":"nanostructured lipid carriers","score":1.0},{"id":"https://openalex.org/keywords/quality-target-product-profile","display_name":"quality target product profile","score":0.8930000066757202},{"id":"https://openalex.org/keywords/critical-quality-attributes","display_name":"critical quality attributes","score":0.9710000157356262},{"id":"https://openalex.org/keywords/critical-process-parameters","display_name":"critical process parameters","score":0.921999990940094},{"id":"https://openalex.org/keywords/experimental-design","display_name":"experimental design","score":0.8230000138282776},{"id":"https://openalex.org/keywords/formulation-optimization","display_name":"formulation optimization","score":0.7210000157356262},{"id":"https://openalex.org/keywords/particle-size","display_name":"particle size","score":0.7110000252723694},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.9660000205039978},{"id":"https://openalex.org/keywords/drug-release","display_name":"drug release","score":0.5640000104904175},{"id":"https://openalex.org/keywords/bioavailability-enhancement","display_name":"bioavailability enhancement","score":0.6880000233650208},{"id":"https://openalex.org/keywords/scalable-fabrication","display_name":"scalable fabrication","score":0.4169999957084656}],"concepts":[{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.7079452872276306},{"id":"https://openalex.org/C199529486","wikidata":"https://www.wikidata.org/wiki/Q7557912","display_name":"Solid lipid nanoparticle","level":3,"score":0.5466558933258057},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.5401799082756042},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5231560468673706},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5214994549751282},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.48430338501930237},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.41792163252830505},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.30985090136528015},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19066885113716125}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D065546","descriptor_name":"Drug Liberation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.2147/ijn.s534137","doi":"https://doi.org/10.2147/ijn.s534137","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s534137","pdf_url":"https://www.dovepress.com/article/download/104452","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},{"id":"pmid:40626137","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40626137","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of nanomedicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12232942","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12232942/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Nanomedicine","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:daf1b1e55b3942edb264915baa759b5a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/daf1b1e55b3942edb264915baa759b5a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Nanomedicine, Vol Volume 20, Iss Issue 1, Pp 8611-8651 (2025)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/104452","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/a-review-on-qbd-driven-optimization-of-lipid-nanoparticles-for-oral-dr-peer-reviewed-fulltext-article-IJN","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Review"}],"best_oa_location":{"id":"doi:10.2147/ijn.s534137","doi":"https://doi.org/10.2147/ijn.s534137","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ijn.s534137","pdf_url":"https://www.dovepress.com/article/download/104452","source":{"id":"https://openalex.org/S101287785","display_name":"International Journal of Nanomedicine","issn_l":"1176-9114","issn":["1176-9114","1178-2013"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Nanomedicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3249130758","display_name":null,"funder_award_id":"NBU\u2010CRP\u20102025\u20102292","funder_id":"https://openalex.org/F4320328654","funder_display_name":"Northern Border University"}],"funders":[{"id":"https://openalex.org/F4320328515","display_name":"Lembaga Pengelola Dana Pendidikan","ror":"https://ror.org/05p2xef58"},{"id":"https://openalex.org/F4320328654","display_name":"Northern Border University","ror":null},{"id":"https://openalex.org/F4320329092","display_name":"Universitas Padjadjaran","ror":"https://ror.org/00xqf8t64"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411939705.pdf","grobid_xml":"https://content.openalex.org/works/W4411939705.grobid-xml"},"referenced_works_count":178,"referenced_works":["https://openalex.org/W43308025","https://openalex.org/W105785269","https://openalex.org/W1543357255","https://openalex.org/W1605008923","https://openalex.org/W1958714784","https://openalex.org/W1971120211","https://openalex.org/W1981758784","https://openalex.org/W1983439306","https://openalex.org/W1987688990","https://openalex.org/W1994881743","https://openalex.org/W1998154903","https://openalex.org/W1999481657","https://openalex.org/W2003110090","https://openalex.org/W2018867583","https://openalex.org/W2028920414","https://openalex.org/W2045044392","https://openalex.org/W2049147399","https://openalex.org/W2050399519","https://openalex.org/W2059166844","https://openalex.org/W2064274693","https://openalex.org/W2064597901","https://openalex.org/W2068820688","https://openalex.org/W2101898878","https://openalex.org/W2112707382","https://openalex.org/W2188860227","https://openalex.org/W2211540712","https://openalex.org/W2215404676","https://openalex.org/W2250686278","https://openalex.org/W2343039489","https://openalex.org/W2346316495","https://openalex.org/W2346454802","https://openalex.org/W2473025341","https://openalex.org/W2477103182","https://openalex.org/W2492154838","https://openalex.org/W2504684453","https://openalex.org/W2505448267","https://openalex.org/W2572223192","https://openalex.org/W2585655283","https://openalex.org/W2586783706","https://openalex.org/W2592513719","https://openalex.org/W2623676679","https://openalex.org/W2742978833","https://openalex.org/W2750807571","https://openalex.org/W2765561039","https://openalex.org/W2766812273","https://openalex.org/W2770959664","https://openalex.org/W2782690276","https://openalex.org/W2789243161","https://openalex.org/W2791283433","https://openalex.org/W2792681312","https://openalex.org/W2794370011","https://openalex.org/W2802983224","https://openalex.org/W2803382820","https://openalex.org/W2804846127","https://openalex.org/W2805112001","https://openalex.org/W2807694747","https://openalex.org/W2889000313","https://openalex.org/W2895662630","https://openalex.org/W2900705947","https://openalex.org/W2901020484","https://openalex.org/W2901092246","https://openalex.org/W2903987878","https://openalex.org/W2908880800","https://openalex.org/W2910254754","https://openalex.org/W2910641286","https://openalex.org/W2912228197","https://openalex.org/W2912724923","https://openalex.org/W2916175089","https://openalex.org/W2922068855","https://openalex.org/W2922248411","https://openalex.org/W2968029582","https://openalex.org/W2985392711","https://openalex.org/W2996481756","https://openalex.org/W3003292038","https://openalex.org/W3005107782","https://openalex.org/W3005539395","https://openalex.org/W3007207274","https://openalex.org/W3008004285","https://openalex.org/W3013526487","https://openalex.org/W3017787430","https://openalex.org/W3018801359","https://openalex.org/W3027422973","https://openalex.org/W3029364720","https://openalex.org/W3029623884","https://openalex.org/W3033732135","https://openalex.org/W3034124595","https://openalex.org/W3043142327","https://openalex.org/W3046953475","https://openalex.org/W3047510030","https://openalex.org/W3048106068","https://openalex.org/W3080888660","https://openalex.org/W3081442601","https://openalex.org/W3081614287","https://openalex.org/W3096650650","https://openalex.org/W3096803825","https://openalex.org/W3097498660","https://openalex.org/W3097774983","https://openalex.org/W3097913870","https://openalex.org/W3102545218","https://openalex.org/W3109118760","https://openalex.org/W3117045246","https://openalex.org/W3127911256","https://openalex.org/W3130405326","https://openalex.org/W3130917553","https://openalex.org/W3131769770","https://openalex.org/W3132915820","https://openalex.org/W3133998132","https://openalex.org/W3134219660","https://openalex.org/W3135666948","https://openalex.org/W3152393734","https://openalex.org/W3157245446","https://openalex.org/W3159470405","https://openalex.org/W3161044173","https://openalex.org/W3163918784","https://openalex.org/W3164510921","https://openalex.org/W3169596260","https://openalex.org/W3170578903","https://openalex.org/W3174778648","https://openalex.org/W3183743918","https://openalex.org/W3185032225","https://openalex.org/W3185757947","https://openalex.org/W3186062289","https://openalex.org/W3192936247","https://openalex.org/W3195965191","https://openalex.org/W3197080952","https://openalex.org/W4200326140","https://openalex.org/W4205748714","https://openalex.org/W4224314779","https://openalex.org/W4225285654","https://openalex.org/W4226182751","https://openalex.org/W4280503300","https://openalex.org/W4281393038","https://openalex.org/W4282590257","https://openalex.org/W4282827343","https://openalex.org/W4285011275","https://openalex.org/W4285332415","https://openalex.org/W4285891149","https://openalex.org/W4292454698","https://openalex.org/W4293769852","https://openalex.org/W4297224367","https://openalex.org/W4308032359","https://openalex.org/W4308069723","https://openalex.org/W4309462640","https://openalex.org/W4309581304","https://openalex.org/W4312195182","https://openalex.org/W4312212010","https://openalex.org/W4313681057","https://openalex.org/W4319073852","https://openalex.org/W4324352310","https://openalex.org/W4376132221","https://openalex.org/W4378380780","https://openalex.org/W4381839608","https://openalex.org/W4381952894","https://openalex.org/W4383912288","https://openalex.org/W4385143685","https://openalex.org/W4385318568","https://openalex.org/W4386210528","https://openalex.org/W4386544909","https://openalex.org/W4387116141","https://openalex.org/W4388033581","https://openalex.org/W4388442324","https://openalex.org/W4388572698","https://openalex.org/W4388672414","https://openalex.org/W4391512766","https://openalex.org/W4391512951","https://openalex.org/W4394870040","https://openalex.org/W4395460494","https://openalex.org/W4399390073","https://openalex.org/W4399571906","https://openalex.org/W4399883152","https://openalex.org/W4400190930","https://openalex.org/W4400408250","https://openalex.org/W4401560899","https://openalex.org/W4401899166","https://openalex.org/W4402274411","https://openalex.org/W4403002259","https://openalex.org/W4403986441","https://openalex.org/W4406268718"],"related_works":["https://openalex.org/W3186062289","https://openalex.org/W3017787430","https://openalex.org/W4311963650","https://openalex.org/W3097913870","https://openalex.org/W7203559051","https://openalex.org/W4387540616","https://openalex.org/W7168381296","https://openalex.org/W7128814184","https://openalex.org/W4401479805","https://openalex.org/W7117742854"],"abstract_inverted_index":{"Oral":[0],"administration":[1],"is":[2,20],"the":[3,100,104,109,120,160,178,201],"most":[4],"preferred":[5],"route":[6],"for":[7,72,200,213],"drug":[8,32,57,173,210],"delivery":[9,211],"due":[10],"to":[11,51,75],"its":[12],"convenience,":[13],"non-invasiveness,":[14],"and":[15,27,42,60,84,107,138,143,149,157,172,183,204],"patient":[16],"compliance.":[17],"However,":[18],"it":[19],"challenged":[21],"by":[22,55,64,98],"gastrointestinal":[23],"barriers,":[24],"enzymatic":[25],"degradation,":[26],"first-pass":[28],"metabolism,":[29],"which":[30],"reduce":[31],"bioavailability.":[33],"Lipid":[34],"nanoparticles":[35,40],"(LNPs),":[36],"including":[37],"solid":[38],"lipid":[39,44],"(SLNs)":[41],"nanostructured":[43],"carriers":[45],"(NLCs),":[46],"offer":[47],"a":[48,69,197],"promising":[49],"strategy":[50],"overcome":[52],"these":[53],"limitations":[54],"enhancing":[56],"stability,":[58],"permeability,":[59],"absorption.":[61],"The":[62,152],"Quality":[63],"Design":[65],"(QbD)":[66],"framework":[67],"provides":[68],"systematic":[70],"approach":[71],"LNP":[73],"development":[74,92,105],"ensure":[76],"consistent":[77],"product":[78,123],"quality.":[79],"By":[80],"promoting":[81],"process":[82,135,150],"understanding":[83],"control,":[85],"QbD":[86,116,195],"not":[87],"only":[88],"supports":[89],"scientific":[90],"formulation":[91,148],"but":[93],"also":[94],"enhances":[95],"industrial":[96],"scalability":[97],"reducing":[99],"experimental":[101],"workload,":[102],"shortening":[103],"time,":[106],"lowering":[108],"production":[110,206],"costs.":[111],"This":[112],"review":[113],"highlights":[114],"key":[115],"elements":[117],"such":[118,162],"as":[119,163],"quality":[121,127],"target":[122],"profile":[124],"(QTPP),":[125],"critical":[126,130,134],"attributes":[128,132],"(CQAs),":[129],"material":[131],"(CMAs),":[133],"parameters":[136],"(CPPs),":[137],"design":[139,203],"of":[140,154,187,207],"experiments":[141],"(DoE)":[142],"their":[144],"roles":[145],"in":[146,179,181,192],"guiding":[147],"optimization.":[151],"effects":[153],"various":[155],"CMAs":[156],"CPPs":[158],"on":[159],"CQAs":[161],"particle":[164],"size,":[165],"polydispersity":[166],"index,":[167],"encapsulation":[168],"efficiency,":[169],"zeta":[170],"potential,":[171],"release":[174],"are":[175],"discussed.":[176],"Furthermore,":[177],"vitro,":[180],"vivo,":[182],"ex":[184],"vivo":[185],"performances":[186],"optimized":[188],"LNPs":[189],"were":[190],"explored":[191],"detail.":[193],"Overall,":[194],"offers":[196],"robust":[198],"platform":[199],"rational":[202],"scalable":[205],"high-quality":[208],"lipid-based":[209],"systems":[212],"oral":[214],"administration.":[215]},"counts_by_year":[{"year":2026,"cited_by_count":48},{"year":2025,"cited_by_count":8}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2025-10-10T00:00:00"}