{"id":"https://openalex.org/W4411936964","doi":"https://doi.org/10.1021/acs.analchem.5c01536","title":"Continuous FACS Sorting of Double Emulsion Picoreactors with a 3D-Printed Vertical Mixer","display_name":"Continuous FACS Sorting of Double Emulsion Picoreactors with a 3D-Printed Vertical Mixer","publication_year":2025,"publication_date":"2025-07-02","ids":{"openalex":"https://openalex.org/W4411936964","doi":"https://doi.org/10.1021/acs.analchem.5c01536","pmid":"https://pubmed.ncbi.nlm.nih.gov/40161623","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11952560"},"language":"en","primary_location":{"id":"doi:10.1021/acs.analchem.5c01536","doi":"https://doi.org/10.1021/acs.analchem.5c01536","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.analchem.5c01536","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.5c01536?ref=article_openPDF","source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.5c01536?ref=article_openPDF","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113956013","display_name":"Zijian Yang","orcid":"https://orcid.org/0000-0001-9152-515X","observed_orcids":["https://orcid.org/0000-0001-9152-515X"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zijian Yang","raw_affiliation_strings":["Department of Radiology","Stanford University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology","institution_ids":[]},{"raw_affiliation_string":"Stanford University","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080200934","display_name":"Samuel Thompson","orcid":"https://orcid.org/0000-0001-6468-9538","observed_orcids":["https://orcid.org/0000-0001-6468-9538"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Samuel Thompson","raw_affiliation_strings":["Department of Bioengineering","Department of Genetics","Stanford University"],"raw_orcid":"https://orcid.org/0000-0001-6468-9538","affiliations":[{"raw_affiliation_string":"Department of Bioengineering","institution_ids":[]},{"raw_affiliation_string":"Department of Genetics","institution_ids":[]},{"raw_affiliation_string":"Stanford University","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100734742","display_name":"Yanrong Zhang","orcid":"https://orcid.org/0000-0002-5641-3539","observed_orcids":["https://orcid.org/0000-0002-5641-3539"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanrong Zhang","raw_affiliation_strings":["Stanford Shared FACS Facility","Stanford University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Shared FACS Facility","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Stanford University","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068207701","display_name":"Iene Rutten","orcid":"https://orcid.org/0000-0002-1144-3056","observed_orcids":["https://orcid.org/0000-0002-1144-3056"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Iene Rutten","raw_affiliation_strings":["Department of Biosystems - Biosensors group","KU Leuven"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosystems - Biosensors group","institution_ids":[]},{"raw_affiliation_string":"KU Leuven","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039628057","display_name":"Julie Van Duyse","orcid":"https://orcid.org/0000-0001-7170-0061","observed_orcids":["https://orcid.org/0000-0001-7170-0061"]},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]},{"id":"https://openalex.org/I4210139803","display_name":"VIB-UGent Center for Inflammation Research","ror":"https://ror.org/04q4ydz28","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950","https://openalex.org/I32597200","https://openalex.org/I4210139803"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Julie Van Duyse","raw_affiliation_strings":["Ghent University","VIB Center for Inflammation Research, Department of Biomedical Molecular Biology","VIB Flow Core","VIB Technologies"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ghent University","institution_ids":["https://openalex.org/I32597200"]},{"raw_affiliation_string":"VIB Center for Inflammation Research, Department of Biomedical Molecular Biology","institution_ids":["https://openalex.org/I4210139803"]},{"raw_affiliation_string":"VIB Flow Core","institution_ids":[]},{"raw_affiliation_string":"VIB Technologies","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017402538","display_name":"Gert Van Isterdael","orcid":"https://orcid.org/0000-0001-6626-1316","observed_orcids":["https://orcid.org/0000-0001-6626-1316"]},"institutions":[{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]},{"id":"https://openalex.org/I4210139803","display_name":"VIB-UGent Center for Inflammation Research","ror":"https://ror.org/04q4ydz28","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950","https://openalex.org/I32597200","https://openalex.org/I4210139803"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Gert Van Isterdael","raw_affiliation_strings":["Ghent University","VIB Center for Inflammation Research, Department of Biomedical Molecular Biology","VIB Flow Core","VIB Technologies"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ghent University","institution_ids":["https://openalex.org/I32597200"]},{"raw_affiliation_string":"VIB Center for Inflammation Research, Department of Biomedical Molecular Biology","institution_ids":["https://openalex.org/I4210139803"]},{"raw_affiliation_string":"VIB Flow Core","institution_ids":[]},{"raw_affiliation_string":"VIB Technologies","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027078262","display_name":"Lisa A. Nichols","orcid":"https://orcid.org/0000-0003-3635-0435","observed_orcids":["https://orcid.org/0000-0003-3635-0435"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa Nichols","raw_affiliation_strings":["Center for Molecular and Genetic Medicine","Stanford Shared FACS Facility","Stanford University"],"raw_orcid":"https://orcid.org/0000-0003-3635-0435","affiliations":[{"raw_affiliation_string":"Center for Molecular and Genetic Medicine","institution_ids":[]},{"raw_affiliation_string":"Stanford Shared FACS Facility","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Stanford University","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064200316","display_name":"Jeroen Lammertyn","orcid":"https://orcid.org/0000-0001-8143-6794","observed_orcids":["https://orcid.org/0000-0001-8143-6794"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jeroen Lammertyn","raw_affiliation_strings":["Department of Biosystems - Biosensors group","KU Leuven"],"raw_orcid":"https://orcid.org/0000-0001-8143-6794","affiliations":[{"raw_affiliation_string":"Department of Biosystems - Biosensors group","institution_ids":[]},{"raw_affiliation_string":"KU Leuven","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020581130","display_name":"Hyongsok Tom Soh","orcid":"https://orcid.org/0000-0001-9443-857X","observed_orcids":["https://orcid.org/0000-0001-9443-857X","https://orcid.org/0000-0001-9432-4011"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hyongsok T Soh","raw_affiliation_strings":["Department of Electrical Engineering","Stanford University"],"raw_orcid":"https://orcid.org/0000-0001-9443-857X","affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering","institution_ids":[]},{"raw_affiliation_string":"Stanford University","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085863617","display_name":"Polly Morrell Fordyce","orcid":"https://orcid.org/0000-0002-9505-0638","observed_orcids":["https://orcid.org/0000-0002-9505-0638"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Polly Fordyce","raw_affiliation_strings":["Chan Zuckerberg Biohub","Department of Bioengineering","Department of Genetics","Sarafan ChEM-H Institute","Stanford University"],"raw_orcid":"https://orcid.org/0000-0002-9505-0638","affiliations":[{"raw_affiliation_string":"Chan Zuckerberg Biohub","institution_ids":[]},{"raw_affiliation_string":"Department of Bioengineering","institution_ids":[]},{"raw_affiliation_string":"Department of Genetics","institution_ids":[]},{"raw_affiliation_string":"Sarafan ChEM-H Institute","institution_ids":[]},{"raw_affiliation_string":"Stanford University","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5080200934","https://openalex.org/A5085863617","https://openalex.org/A5113956013"],"corresponding_institution_ids":["https://openalex.org/I97018004"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":0.7248,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.63439354,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"97","issue":"27","first_page":"14406","last_page":"14414"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluorescence-activated-droplet-sorting","display_name":"fluorescence-activated droplet sorting","score":0.8270000219345093},{"id":"https://openalex.org/keywords/surfactant-optimization","display_name":"surfactant optimization","score":0.902999997138977},{"id":"https://openalex.org/keywords/directed-evolution","display_name":"directed evolution","score":0.6940000057220459},{"id":"https://openalex.org/keywords/high-throughput-screening","display_name":"high-throughput screening","score":0.8199999928474426},{"id":"https://openalex.org/keywords/droplet-stability","display_name":"droplet stability","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.953819751739502},{"id":"https://openalex.org/C3019308078","wikidata":"https://www.wikidata.org/wiki/Q229367","display_name":"3d printed","level":2,"score":0.6017612814903259},{"id":"https://openalex.org/C2778123984","wikidata":"https://www.wikidata.org/wiki/Q187634","display_name":"Emulsion","level":2,"score":0.5792118906974792},{"id":"https://openalex.org/C111696304","wikidata":"https://www.wikidata.org/wiki/Q2303697","display_name":"Sorting","level":2,"score":0.47899577021598816},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3426029086112976},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.3223978579044342},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11770874261856079},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.08963698148727417},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":9,"locations":[{"id":"doi:10.1021/acs.analchem.5c01536","doi":"https://doi.org/10.1021/acs.analchem.5c01536","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.analchem.5c01536","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.5c01536?ref=article_openPDF","source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"doi:10.1101/2025.03.13.643134","doi":"https://doi.org/10.1101/2025.03.13.643134","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.03.13.643134","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:12268830","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12268830","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anal Chem","raw_type":"Text"},{"id":"pmid:40161623","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40161623","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmid:40602756","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40602756","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:archive.ugent.be:01K8AZCKT0SPQ7GW2PFPNCNZG3","doi":null,"is_oa":true,"landing_page_url":"https://biblio.ugent.be/publication/01K8AZCKT0SPQ7GW2PFPNCNZG3","pdf_url":"https://biblio.ugent.be/publication/01K8AZCKT0SPQ7GW2PFPNCNZG3/file/01K8AZDYKS6XMD3JSNRXXS9ZAT.pdf","source":{"id":"https://openalex.org/S4306400478","display_name":"Ghent University Academic Bibliography (Ghent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32597200","host_organization_name":"Ghent University","host_organization_lineage":["https://openalex.org/I32597200"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1520-6882","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:20.500.12942/769044","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/20.500.12942/769044","pdf_url":"https://lirias.kuleuven.be/retrieve/a5a7f0bf-4434-4030-9565-073c5b85241a","source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Analytical Chemistry, vol. 97 (27), (14406-14414)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:europepmc.org:10763496","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11952560","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:11952560","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11952560","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1021/acs.analchem.5c01536","doi":"https://doi.org/10.1021/acs.analchem.5c01536","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.analchem.5c01536","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.5c01536?ref=article_openPDF","source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G63506251","display_name":"BD Canto II RUO Cytometer","funder_award_id":"S10RR027431","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G7553290246","display_name":"Four Laser, 18 Color Cell Sorter in the SSFF","funder_award_id":"S10RR025518","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G9000864029","display_name":"Using microfluidics to realize patient-specific anti-cancer immunotherapies","funder_award_id":"DP1CA290563","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306253","display_name":"Arnold and Mabel Beckman Foundation","ror":"https://ror.org/05avmtm72"},{"id":"https://openalex.org/F4320308507","display_name":"Stanford University","ror":"https://ror.org/00f54p054"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411936964.pdf","grobid_xml":"https://content.openalex.org/works/W4411936964.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W981600441","https://openalex.org/W1493227903","https://openalex.org/W1774638877","https://openalex.org/W1971486985","https://openalex.org/W1975581000","https://openalex.org/W2009797503","https://openalex.org/W2011426960","https://openalex.org/W2014916384","https://openalex.org/W2029886517","https://openalex.org/W2048420629","https://openalex.org/W2050255833","https://openalex.org/W2056025943","https://openalex.org/W2062384499","https://openalex.org/W2087669232","https://openalex.org/W2118131251","https://openalex.org/W2149093225","https://openalex.org/W2313698209","https://openalex.org/W2324129405","https://openalex.org/W2400733142","https://openalex.org/W2427197815","https://openalex.org/W2555293666","https://openalex.org/W2567800980","https://openalex.org/W2608167804","https://openalex.org/W2762368071","https://openalex.org/W2767044445","https://openalex.org/W2795963939","https://openalex.org/W2979110830","https://openalex.org/W2996030271","https://openalex.org/W3001972792","https://openalex.org/W3024434553","https://openalex.org/W3083950783","https://openalex.org/W3108171657","https://openalex.org/W3151309882","https://openalex.org/W3154713775","https://openalex.org/W3157077482","https://openalex.org/W3216151460","https://openalex.org/W4206654464","https://openalex.org/W4280634382","https://openalex.org/W4281261562","https://openalex.org/W4296899757","https://openalex.org/W4306728695","https://openalex.org/W4311189565","https://openalex.org/W4313476900","https://openalex.org/W4317438718","https://openalex.org/W4322422963","https://openalex.org/W4390509294","https://openalex.org/W4392905626","https://openalex.org/W4394681636","https://openalex.org/W4401226417","https://openalex.org/W4405025572"],"related_works":["https://openalex.org/W4405025572","https://openalex.org/W2029886517","https://openalex.org/W4296899757","https://openalex.org/W4402215294","https://openalex.org/W4394918495","https://openalex.org/W3198930819","https://openalex.org/W2014916384","https://openalex.org/W6939344914","https://openalex.org/W2485453997","https://openalex.org/W6964353112"],"abstract_inverted_index":{"High-throughput":[0],"screening":[1],"and":[2,23,54,99,119,181,196],"directed":[3,206],"evolution":[4,207],"using":[5,66],"microfluidic":[6,48,68],"picoreactors":[7,25],"have":[8,58],"produced":[9],"high-activity":[10],"enzymes.":[11],"In":[12],"this":[13],"approach,":[14],"a":[15,20,122,131,156,168],"substrate":[16],"is":[17],"coencapsulated":[18],"with":[19,83,155,186],"candidate":[21],"enzyme,":[22],"individual":[24],"are":[26,104],"sorted":[27,82],"based":[28],"on":[29,46,125],"an":[30],"activity":[31],"reporter.":[32],"While":[33],"many":[34],"approaches":[35,57],"use":[36,195],"water-in-oil":[37],"droplets":[38,74],"(single":[39],"emulsions)":[40],"for":[41,198],"fluorescence-activated":[42],"droplet":[43,69],"sorting":[44,153],"(FADS)":[45],"custom-fabricated":[47],"devices":[49],"that":[50,79,121],"require":[51],"integrated":[52],"optics":[53],"electronics,":[55],"recent":[56],"lowered":[59],"the":[60,90,126,203],"engineering":[61,92],"barriers":[62,105],"to":[63,71,106,115,134],"adoption":[64],"by":[65],"simple":[67],"generators":[70],"produce":[72],"water-in-oil-in-water":[73],"(double":[75],"emulsion":[76],"picoreactors,":[77],"DEs)":[78],"can":[80],"be":[81],"commercial":[84],"FACS":[85,109],"(fluorescence-activated":[86],"cell":[87],"sorting).":[88],"Despite":[89],"simplified":[91],"requirements,":[93],"high":[94],"variability":[95],"in":[96,149,167,208,210],"loading":[97,103,142,189],"rates":[98],"low":[100],"yields":[101],"during":[102],"efficient":[107],"DE":[108,117],"sorting.":[110],"Here,":[111],"we":[112,144,175],"optimized":[113,141,188],"surfactants":[114],"enhance":[116],"stability":[118],"demonstrated":[120],"3D-printed":[123],"corkscrew":[124],"sample":[127,165],"line":[128],"acts":[129],"as":[130],"vertical":[132],"mixer":[133],"enable":[135],"more":[136],"continuous":[137],"loading.":[138],"With":[139],"these":[140],"conditions,":[143],"analyzed":[145],"1.17":[146],"million":[147],"DEs":[148,200],"four":[150],"10":[151],"min":[152],"rounds":[154],"mean":[157],"frequency":[158],"of":[159,171,194,205],"480":[160],"Hz":[161,163],"(390":[162],"including":[164],"exchanges);":[166],"mock":[169],"sort":[170],"10%":[172],"fluorescent":[173],"DEs,":[174],"achieved":[176],"89":[177],"\u00b1":[178,183],"1%":[179],"accuracy":[180],"78.0":[182],"0.9%":[184],"recovery":[185],"our":[187],"protocol.":[190],"Overall,":[191],"improved":[192],"ease":[193],"throughput":[197],"FACS-sortable":[199],"should":[201],"expand":[202],"accessibility":[204],"controlled":[209],"vitro":[211],"environments.":[212]},"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2025-10-10T00:00:00"}
