{"id":"https://openalex.org/W4411934026","doi":"https://doi.org/10.55779/nsb17212395","title":"Haematological and biochemical alterations induced by sodium metavanadate toxicity in male Wistar rats","display_name":"Haematological and biochemical alterations induced by sodium metavanadate toxicity in male Wistar rats","publication_year":2025,"publication_date":"2025-06-17","ids":{"openalex":"https://openalex.org/W4411934026","doi":"https://doi.org/10.55779/nsb17212395"},"language":"en","primary_location":{"id":"doi:10.55779/nsb17212395","doi":"https://doi.org/10.55779/nsb17212395","is_oa":true,"landing_page_url":"https://doi.org/10.55779/nsb17212395","pdf_url":"https://www.notulaebiologicae.ro/index.php/nsb/article/download/12395/9782","source":{"id":"https://openalex.org/S4210231388","display_name":"Notulae Scientia Biologicae","issn_l":"2067-3205","issn":["2067-3205","2067-3264"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310314595","host_organization_name":"University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca","host_organization_lineage":["https://openalex.org/P4310314595"],"host_organization_lineage_names":["University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Notulae Scientia Biologicae","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.notulaebiologicae.ro/index.php/nsb/article/download/12395/9782","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071975854","display_name":"Ogechukwu Grace Onuoha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100116408","display_name":"University of Port Harcourt","ror":"https://ror.org/005bw2d06","country_code":"NG","type":"education","lineage":["https://openalex.org/I100116408"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Ogechukwu G. ONUOHA","raw_affiliation_strings":["University of Port Harcourt, School of Science Laboratory Technology, Department of Biomedical Technology, Port Harcourt, East/West Road, PMB 5323 Choba, Rivers State"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Port Harcourt, School of Science Laboratory Technology, Department of Biomedical Technology, Port Harcourt, East/West Road, PMB 5323 Choba, Rivers State","institution_ids":["https://openalex.org/I100116408"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053650225","display_name":"Bruno Chukwuemeka Chinko","orcid":"https://orcid.org/0000-0002-0457-2853","observed_orcids":["https://orcid.org/0000-0002-0457-2853"]},"institutions":[{"id":"https://openalex.org/I100116408","display_name":"University of Port Harcourt","ror":"https://ror.org/005bw2d06","country_code":"NG","type":"education","lineage":["https://openalex.org/I100116408"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Bruno C. CHINKO","raw_affiliation_strings":["University of Port Harcourt, Faculty of Basic Medical Sciences, Department of Human Physiology, College of Health Sciences, Port Harcourt, East/West Road, PMB 5323 Choba, Rivers State"],"raw_orcid":"https://orcid.org/0000-0002-0457-2853","affiliations":[{"raw_affiliation_string":"University of Port Harcourt, Faculty of Basic Medical Sciences, Department of Human Physiology, College of Health Sciences, Port Harcourt, East/West Road, PMB 5323 Choba, Rivers State","institution_ids":["https://openalex.org/I100116408"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I100116408"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09663956,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"2","first_page":"12395","last_page":"12395"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.9042999744415283,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.9042999744415283,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0421999990940094,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.020099999383091927,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sodium-metavanadate","display_name":"sodium metavanadate","score":1.0},{"id":"https://openalex.org/keywords/vanadium-toxicity","display_name":"vanadium toxicity","score":0.8220000267028809},{"id":"https://openalex.org/keywords/acute-toxicity","display_name":"acute toxicity","score":0.7960000038146973},{"id":"https://openalex.org/keywords/median-lethal-dose","display_name":"median lethal dose","score":0.9660000205039978},{"id":"https://openalex.org/keywords/hematological-parameters","display_name":"hematological parameters","score":0.8629999756813049},{"id":"https://openalex.org/keywords/biochemical-parameters","display_name":"biochemical parameters","score":0.5180000066757202},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8759999871253967},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.7870000004768372},{"id":"https://openalex.org/keywords/liver-histopathology","display_name":"liver histopathology","score":0.8529999852180481},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.9160000085830688},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.7200000286102295},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8920000195503235},{"id":"https://openalex.org/keywords/aspartate-aminotransferase","display_name":"aspartate aminotransferase","score":0.871999979019165},{"id":"https://openalex.org/keywords/alanine-aminotransferase","display_name":"alanine aminotransferase","score":0.9350000023841858},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.8330000042915344},{"id":"https://openalex.org/keywords/serum-albumin","display_name":"serum albumin","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.7087510824203491},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.48827624320983887},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.45406079292297363},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40928512811660767},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33677610754966736},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31839096546173096},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.55779/nsb17212395","doi":"https://doi.org/10.55779/nsb17212395","is_oa":true,"landing_page_url":"https://doi.org/10.55779/nsb17212395","pdf_url":"https://www.notulaebiologicae.ro/index.php/nsb/article/download/12395/9782","source":{"id":"https://openalex.org/S4210231388","display_name":"Notulae Scientia Biologicae","issn_l":"2067-3205","issn":["2067-3205","2067-3264"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310314595","host_organization_name":"University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca","host_organization_lineage":["https://openalex.org/P4310314595"],"host_organization_lineage_names":["University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Notulae Scientia Biologicae","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:d48c4436147444a983d13df97ea1a777","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d48c4436147444a983d13df97ea1a777","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Notulae Scientia Biologicae, Vol 17, Iss 2 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.55779/nsb17212395","doi":"https://doi.org/10.55779/nsb17212395","is_oa":true,"landing_page_url":"https://doi.org/10.55779/nsb17212395","pdf_url":"https://www.notulaebiologicae.ro/index.php/nsb/article/download/12395/9782","source":{"id":"https://openalex.org/S4210231388","display_name":"Notulae Scientia Biologicae","issn_l":"2067-3205","issn":["2067-3205","2067-3264"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj"],"host_organization":"https://openalex.org/P4310314595","host_organization_name":"University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca","host_organization_lineage":["https://openalex.org/P4310314595"],"host_organization_lineage_names":["University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Notulae Scientia Biologicae","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411934026.pdf","grobid_xml":"https://content.openalex.org/works/W4411934026.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2899084033","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W4391375266","https://openalex.org/W2078814861","https://openalex.org/W2527526854","https://openalex.org/W1976181487"],"abstract_inverted_index":{"Sodium":[0],"metavanadate":[1,76],"(SMV)":[2,77],"is":[3,286],"an":[4],"inorganic":[5],"compound":[6],"that":[7,175,268],"can":[8],"enter":[9],"the":[10,28,105,205,210,222,237,242],"human":[11],"body":[12],"through":[13,289],"multiple":[14],"pathways,":[15],"including":[16],"inhalation,":[17],"ingestion,":[18],"dermal":[19],"absorption,":[20],"or":[21],"intentional":[22],"consumption.":[23],"The":[24,69,83,159,169],"present":[25],"study":[26,173,266],"evaluated":[27],"toxicity":[29,64],"profile":[30],"of":[31,74,124,161,225,247,260],"SVM":[32],"and":[33,38,52,65,107,115,121,140,152,201,233,258,274,279,297],"its":[34],"impact":[35],"on":[36],"haematological":[37,139],"biochemical":[39,141],"parameters":[40],"using":[41,80],"Wistar":[42,56,87],"rat":[43],"models.":[44],"Ten":[45],"(10)":[46],"healthy":[47],"male":[48,55,86],"mice":[49],"(20-30":[50],"g)":[51,59],"twenty":[53,84],"(20)":[54,85],"rats":[57,88],"(180-200":[58],"were":[60,89,117,136,150],"used":[61],"for":[62,130,138],"acute":[63],"experimental":[66,206,238],"studies,":[67],"respectively.":[68],"median":[70],"lethal":[71],"dose":[72],"(LD\u2085\u2080)":[73],"sodium":[75],"was":[78,163,219],"determined":[79,164],"Lorke\u2019s":[81],"method.":[82],"randomly":[90],"assigned":[91],"into":[92],"four":[93],"(4)":[94],"groups":[95,207],"(n":[96],"=":[97],"5":[98],"per":[99],"group).":[100],"Group":[101],"I":[102],"served":[103],"as":[104],"control":[106,211,243],"received":[108],"tap":[109],"water,":[110],"while":[111],"Groups":[112],"II,":[113],"III,":[114],"IV":[116],"administered":[118],"7.5,":[119],"15,":[120],"30":[122],"mg/kg":[123],"SMV,":[125],"respectively":[126],"via":[127],"oral":[128],"gavage":[129],"twenty-eight":[131],"(28)":[132],"days.":[133],"Blood":[134],"samples":[135,149],"collected":[137],"analysis":[142,246],"following":[143],"standard":[144],"protocols.":[145],"Also,":[146],"Liver":[147],"tissue":[148,249],"harvested":[151],"analysed":[153],"histologically":[154],"to":[155,165,209,241,295],"assess":[156],"structural":[157,298],"alterations.":[158],"LD\u2085\u2080":[160],"SMV":[162,176,269],"be":[166],"80":[167],"mg/kg.":[168],"findings":[170],"from":[171,264],"this":[172,265],"indicate":[174],"exposure":[177,270],"resulted":[178],"in":[179,183,204,221,300],"a":[180,216],"significant":[181,217],"decrease":[182],"superoxide":[184],"dismutase,":[185],"catalase,":[186],"glutathione,":[187],"plasma":[188],"albumin,":[189],"packed":[190],"cell":[191,254,282],"volume,":[192],"haemoglobin":[193],"concentration,":[194],"red":[195,278],"blood":[196,199,281],"cells,":[197,200],"white":[198,280],"lymphocyte":[202],"counts":[203],"compared":[208],"(p":[212],"<":[213],"0.05).":[214],"Conversely,":[215],"increase":[218],"observed":[220],"mean":[223],"levels":[224],"malondialdehyde,":[226],"aspartate":[227],"aminotransferase,":[228,230],"alanine":[229],"alkaline":[231],"phosphatase,":[232],"total":[234],"protein":[235],"among":[236],"animals":[239],"relative":[240],"(p<0.05).":[244],"Histopathological":[245],"liver":[248,301],"further":[250],"revealed":[251],"pronounced":[252],"Kupffer":[253],"hypertrophy,":[255],"sinusoidal":[256],"congestion,":[257],"disruption":[259],"hepatic":[261],"architecture.":[262],"Evidence":[263],"suggests":[267],"may":[271],"induce":[272],"anaemia":[273],"immunosuppression":[275],"by":[276],"disrupting":[277],"indices.":[283],"This":[284],"effect":[285],"likely":[287],"mediated":[288],"increased":[290],"oxidative":[291],"stress,":[292],"which":[293],"contributes":[294],"hepatotoxicity":[296],"alterations":[299],"cytoarchitecture.":[302]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2025-10-10T00:00:00"}