{"id":"https://openalex.org/W4411929607","doi":"https://doi.org/10.17650/2313-805x-2025-12-2-58-67","title":"Ferroptosis determinants \u2013 potential predictors and therapeutic targets for acute myeloid leukemia","display_name":"Ferroptosis determinants \u2013 potential predictors and therapeutic targets for acute myeloid leukemia","publication_year":2025,"publication_date":"2025-06-29","ids":{"openalex":"https://openalex.org/W4411929607","doi":"https://doi.org/10.17650/2313-805x-2025-12-2-58-67"},"language":"en","primary_location":{"id":"doi:10.17650/2313-805x-2025-12-2-58-67","doi":"https://doi.org/10.17650/2313-805x-2025-12-2-58-67","is_oa":true,"landing_page_url":"https://doi.org/10.17650/2313-805x-2025-12-2-58-67","pdf_url":"https://umo.abvpress.ru/jour/article/download/785/392","source":{"id":"https://openalex.org/S4210205379","display_name":"Advances in molecular oncology","issn_l":"2313-805X","issn":["2313-805X","2413-3787"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310312679","host_organization_name":"ABV-press","host_organization_lineage":["https://openalex.org/P4310312679"],"host_organization_lineage_names":["ABV-press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Molecular Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://umo.abvpress.ru/jour/article/download/785/392","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101516765","display_name":"\u0412. \u0415. \u0428\u0435\u0432\u0447\u0435\u043d\u043a\u043e","orcid":"https://orcid.org/0000-0002-0401-9900","observed_orcids":["https://orcid.org/0000-0002-0401-9900"]},"institutions":[{"id":"https://openalex.org/I4210090957","display_name":"Russian Cancer Research Center NN Blokhin","ror":"https://ror.org/00ab9fg88","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210090957"]},{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"V. E. Shevchenko","raw_affiliation_strings":["N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia"],"raw_orcid":"https://orcid.org/0000-0002-0401-9900","affiliations":[{"raw_affiliation_string":"N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia","institution_ids":["https://openalex.org/I4210090957","https://openalex.org/I4210117042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009622308","display_name":"Tatyana Kushnir","orcid":"https://orcid.org/0000-0001-9626-6847","observed_orcids":["https://orcid.org/0000-0001-9626-6847","https://orcid.org/0000-0002-1901-6665"]},"institutions":[{"id":"https://openalex.org/I4210090957","display_name":"Russian Cancer Research Center NN Blokhin","ror":"https://ror.org/00ab9fg88","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210090957"]},{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"T. I. Kushnir","raw_affiliation_strings":["N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia"],"raw_orcid":"https://orcid.org/0000-0001-9626-6847","affiliations":[{"raw_affiliation_string":"N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia","institution_ids":["https://openalex.org/I4210090957","https://openalex.org/I4210117042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071795515","display_name":"Margarita V. Gudkova","orcid":"https://orcid.org/0000-0003-2694-5232","observed_orcids":["https://orcid.org/0000-0003-2694-5232"]},"institutions":[{"id":"https://openalex.org/I4210090957","display_name":"Russian Cancer Research Center NN Blokhin","ror":"https://ror.org/00ab9fg88","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210090957"]},{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"M. V. Gudkova","raw_affiliation_strings":["N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia"],"raw_orcid":"https://orcid.org/0000-0003-2694-5232","affiliations":[{"raw_affiliation_string":"N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia","institution_ids":["https://openalex.org/I4210090957","https://openalex.org/I4210117042"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091689051","display_name":"Natalia E. Arnotskaya","orcid":"https://orcid.org/0000-0002-0154-8604","observed_orcids":["https://orcid.org/0000-0002-0154-8604"]},"institutions":[{"id":"https://openalex.org/I4210090957","display_name":"Russian Cancer Research Center NN Blokhin","ror":"https://ror.org/00ab9fg88","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210090957"]},{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"N. E. Arnotskaya","raw_affiliation_strings":["N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia"],"raw_orcid":"https://orcid.org/0000-0002-0154-8604","affiliations":[{"raw_affiliation_string":"N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia","institution_ids":["https://openalex.org/I4210090957","https://openalex.org/I4210117042"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6075,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.68019546,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"12","issue":"2","first_page":"58","last_page":"67"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":1.0},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":1.0},{"id":"https://openalex.org/keywords/gpx4","display_name":"GPX4","score":0.9359999895095825},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9779999852180481},{"id":"https://openalex.org/keywords/iron-metabolism","display_name":"iron metabolism","score":0.7950000166893005},{"id":"https://openalex.org/keywords/polyunsaturated-fatty-acids","display_name":"polyunsaturated fatty acids","score":0.703000009059906},{"id":"https://openalex.org/keywords/chemosensitivity","display_name":"chemosensitivity","score":0.6899999976158142},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.5920000076293945},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8799999952316284},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.9279999732971191},{"id":"https://openalex.org/keywords/age-related-cancer","display_name":"age-related cancer","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.8303216695785522},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5227734446525574},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4864901900291443},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35407376289367676},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.30402350425720215}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.17650/2313-805x-2025-12-2-58-67","doi":"https://doi.org/10.17650/2313-805x-2025-12-2-58-67","is_oa":true,"landing_page_url":"https://doi.org/10.17650/2313-805x-2025-12-2-58-67","pdf_url":"https://umo.abvpress.ru/jour/article/download/785/392","source":{"id":"https://openalex.org/S4210205379","display_name":"Advances in molecular oncology","issn_l":"2313-805X","issn":["2313-805X","2413-3787"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310312679","host_organization_name":"ABV-press","host_organization_lineage":["https://openalex.org/P4310312679"],"host_organization_lineage_names":["ABV-press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Molecular Oncology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:8be651fe8c3443e7aa92848b4d138f06","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8be651fe8c3443e7aa92848b4d138f06","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u0423\u0441\u043f\u0435\u0445\u0438 \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u043e\u0439 \u043e\u043d\u043a\u043e\u043b\u043e\u0433\u0438\u0438, Vol 12, Iss 2, Pp 58-67 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.17650/2313-805x-2025-12-2-58-67","doi":"https://doi.org/10.17650/2313-805x-2025-12-2-58-67","is_oa":true,"landing_page_url":"https://doi.org/10.17650/2313-805x-2025-12-2-58-67","pdf_url":"https://umo.abvpress.ru/jour/article/download/785/392","source":{"id":"https://openalex.org/S4210205379","display_name":"Advances in molecular oncology","issn_l":"2313-805X","issn":["2313-805X","2413-3787"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310312679","host_organization_name":"ABV-press","host_organization_lineage":["https://openalex.org/P4310312679"],"host_organization_lineage_names":["ABV-press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Molecular Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411929607.pdf","grobid_xml":"https://content.openalex.org/works/W4411929607.grobid-xml"},"referenced_works_count":92,"referenced_works":["https://openalex.org/W2055196208","https://openalex.org/W2100671540","https://openalex.org/W2163294546","https://openalex.org/W2509517672","https://openalex.org/W2592804355","https://openalex.org/W2605757478","https://openalex.org/W2733753099","https://openalex.org/W2745520112","https://openalex.org/W2804789540","https://openalex.org/W2883979293","https://openalex.org/W2897111276","https://openalex.org/W2913973491","https://openalex.org/W2917452836","https://openalex.org/W2924471609","https://openalex.org/W2939322913","https://openalex.org/W2942855506","https://openalex.org/W2946704044","https://openalex.org/W2952322991","https://openalex.org/W2959498392","https://openalex.org/W2979937337","https://openalex.org/W2981370517","https://openalex.org/W2986439472","https://openalex.org/W3003960907","https://openalex.org/W3006048658","https://openalex.org/W3012295934","https://openalex.org/W3015589734","https://openalex.org/W3029628311","https://openalex.org/W3034923646","https://openalex.org/W3036665361","https://openalex.org/W3039649812","https://openalex.org/W3077764649","https://openalex.org/W3088229934","https://openalex.org/W3090693089","https://openalex.org/W3099291212","https://openalex.org/W3101330565","https://openalex.org/W3108493784","https://openalex.org/W3112599058","https://openalex.org/W3122102409","https://openalex.org/W3145198654","https://openalex.org/W3162094205","https://openalex.org/W3169941200","https://openalex.org/W3185478702","https://openalex.org/W3187077968","https://openalex.org/W3213404735","https://openalex.org/W4206460957","https://openalex.org/W4207050381","https://openalex.org/W4210495883","https://openalex.org/W4210576858","https://openalex.org/W4210867925","https://openalex.org/W4211027571","https://openalex.org/W4220660501","https://openalex.org/W4220927620","https://openalex.org/W4221112683","https://openalex.org/W4223447553","https://openalex.org/W4223969900","https://openalex.org/W4224231165","https://openalex.org/W4224444138","https://openalex.org/W4225498438","https://openalex.org/W4226367800","https://openalex.org/W4280540981","https://openalex.org/W4281679894","https://openalex.org/W4284889683","https://openalex.org/W4291464747","https://openalex.org/W4303449234","https://openalex.org/W4307313878","https://openalex.org/W4312060024","https://openalex.org/W4317696744","https://openalex.org/W4319461334","https://openalex.org/W4321768735","https://openalex.org/W4322743974","https://openalex.org/W4324344296","https://openalex.org/W4328054384","https://openalex.org/W4361293128","https://openalex.org/W4376131839","https://openalex.org/W4382369455","https://openalex.org/W4382810856","https://openalex.org/W4382937517","https://openalex.org/W4385999009","https://openalex.org/W4386387123","https://openalex.org/W4386466818","https://openalex.org/W4387058694","https://openalex.org/W4388033937","https://openalex.org/W4388140927","https://openalex.org/W4388818923","https://openalex.org/W4389133970","https://openalex.org/W4389338790","https://openalex.org/W4390226028","https://openalex.org/W4391986855","https://openalex.org/W4396613690","https://openalex.org/W4399297771","https://openalex.org/W4400010748","https://openalex.org/W4400425943"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W2990397977","https://openalex.org/W2364732766"],"abstract_inverted_index":{"Ferroptosis":[0],"(FP)":[1],"is":[2,16,29,95,143],"a":[3,19,53,76,134],"type":[4],"of":[5,24,34,38,43,59,68,82,98,103,121,129,150,158,164,168,181,192,197,204,213,216,223],"non-apoptotic":[6],"programmed":[7],"cell":[8,44],"death":[9],"associated":[10],"with":[11,199],"iron-dependent":[12],"lipid":[13,35],"peroxidation.":[14],"FP":[15,51,74,99,116,154,169,193,198,217],"characterized":[17],"by":[18],"decrease":[20],"in":[21,56,100,137,146,170,210,218],"the":[22,32,57,65,80,96,101,119,130,148,156,165,177,187,195,200,211,214,219],"activity":[23],"glutathione":[25],"peroxidase":[26],"4,":[27],"which":[28],"necessary":[30],"for":[31],"suppression":[33],"peroxidation,":[36],"accumulation":[37],"redox-active":[39],"iron":[40],"and":[41,71,90,127,155,179,194,202,221],"oxidation":[42],"membrane":[45],"phospholipids":[46],"containing":[47],"polyunsaturated":[48],"fatty":[49],"acids.":[50],"plays":[52],"central":[54],"role":[55,136,215],"mechanisms":[58,191],"human":[60],"aging,":[61],"regulating":[62],"degeneration":[63],"\u2013":[64],"main":[66,188],"cause":[67],"tissue":[69],"damage":[70],"organ":[72],"failure.":[73],"makes":[75],"significant":[77],"contribution":[78],"to":[79,124],"development":[81,203],"age-related":[83,104],"pathologies,":[84],"including":[85,107],"neurodegenerative":[86],"conditions,":[87],"cardiovascular":[88],"diseases,":[89,106],"cancer.":[91],"Of":[92],"particular":[93],"interest":[94,145],"participation":[97],"pathogenesis":[102],"oncological":[105],"acute":[108],"myeloid":[109],"leukemia":[110],"(AML).":[111],"Previous":[112],"studies":[113],"show":[114],"that":[115],"largely":[117],"regulates":[118],"sensitivity":[120],"AML":[122,138,171,224],"cells":[123],"chemotherapeutic":[125],"drugs,":[126],"some":[128],"FP-related":[131],"genes":[132],"play":[133],"vital":[135],"oncogenesis.":[139],"In":[140,206],"addition,":[141,207],"there":[142],"considerable":[144],"investigating":[147],"effect":[149],"immune":[151],"infiltration":[152],"on":[153],"prognosis":[157,220],"AML.":[159,205],"Thus,":[160],"an":[161],"in-depth":[162],"study":[163,212],"unique":[166],"mechanism":[167],"may":[172],"provide":[173],"new":[174],"insights":[175],"into":[176],"diagnosis":[178],"treatment":[180],"this":[182],"disease.":[183],"This":[184],"review":[185],"analyzes":[186],"regulatory":[189],"molecular":[190],"relationship":[196],"occurrence":[201],"recent":[208],"advances":[209],"therapy":[222],"are":[225],"summarized.":[226]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2025-10-10T00:00:00"}