{"id":"https://openalex.org/W4411908097","doi":"https://doi.org/10.1158/1078-0432.c.7903399","title":"Data from Quantitative Protein Expression of Antibody\u2013Drug Conjugate Targets in EGFR Mutated and Wild-type Non\u2013Small Cell Lung Cancer","display_name":"Data from Quantitative Protein Expression of Antibody\u2013Drug Conjugate Targets in EGFR Mutated and Wild-type Non\u2013Small Cell Lung Cancer","publication_year":2025,"publication_date":"2025-07-01","ids":{"openalex":"https://openalex.org/W4411908097","doi":"https://doi.org/10.1158/1078-0432.c.7903399"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.7903399","doi":"https://doi.org/10.1158/1078-0432.c.7903399","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.7903399","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.c.7903399","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008473824","display_name":"Ioannis Panagiotis Trontzas","orcid":"https://orcid.org/0000-0003-3706-9995","observed_orcids":["https://orcid.org/0000-0003-3706-9995"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ioannis P. Trontzas","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3706-9995","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104186042","display_name":"Mengni He","orcid":"https://orcid.org/0000-0003-4228-4462","observed_orcids":["https://orcid.org/0000-0003-4228-4462","https://orcid.org/0000-0003-4456-680X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mengni He","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4228-4462","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049906346","display_name":"Anna Wurtz","orcid":"https://orcid.org/0000-0002-9720-8427","observed_orcids":["https://orcid.org/0000-0002-9720-8427"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Wurtz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9720-8427","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Charles J. Robbins","orcid":"https://orcid.org/0000-0002-3130-7107","observed_orcids":["https://orcid.org/0000-0002-3130-7107"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles J. Robbins","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3130-7107","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Nathaniel Robinson","orcid":"https://orcid.org/0000-0003-1238-0381","observed_orcids":["https://orcid.org/0000-0003-1238-0381"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nathaniel Robinson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1238-0381","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086534064","display_name":"Katherine Bates","orcid":"https://orcid.org/0000-0001-8956-6331","observed_orcids":["https://orcid.org/0000-0001-8956-6331"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katherine Bates","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8956-6331","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101791604","display_name":"Matthew Liu","orcid":"https://orcid.org/0000-0002-2229-5124","observed_orcids":["https://orcid.org/0000-0002-2229-5124"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2229-5124","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011946828","display_name":"Thazin Nwe Aung","orcid":"https://orcid.org/0000-0003-4150-0426","observed_orcids":["https://orcid.org/0000-0003-4150-0426"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thazin N. Aung","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4150-0426","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004278549","display_name":"Liam Scott","orcid":"https://orcid.org/0000-0002-6114-6324","observed_orcids":["https://orcid.org/0000-0002-6114-6324"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liam Scott","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6114-6324","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046787323","display_name":"Nay Nwe Nyein Chan","orcid":"https://orcid.org/0009-0006-1633-6125","observed_orcids":["https://orcid.org/0009-0006-1633-6125"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nay Chan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-1633-6125","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009801511","display_name":"Sneha Burela","orcid":"https://orcid.org/0000-0003-0287-0336","observed_orcids":["https://orcid.org/0000-0003-0287-0336"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sneha Burela","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0287-0336","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Jacob Schillo","orcid":"https://orcid.org/0000-0002-4897-3165","observed_orcids":["https://orcid.org/0000-0002-4897-3165"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jacob Schillo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4897-3165","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071022580","display_name":"Daniel C. Liebler","orcid":"https://orcid.org/0000-0002-7873-3031","observed_orcids":["https://orcid.org/0000-0002-7873-3031"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel C. Liebler","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7873-3031","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043898530","display_name":"Salisha Hill","orcid":"https://orcid.org/0000-0002-4145-969X","observed_orcids":["https://orcid.org/0000-0002-4145-969X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Salisha Hill","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4145-969X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037110629","display_name":"Ryan D. Morrison","orcid":"https://orcid.org/0000-0003-4995-8001","observed_orcids":["https://orcid.org/0000-0003-4995-8001"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ryan D. Morrison","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4995-8001","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029208140","display_name":"Ioannis Athanasios Vathiotis","orcid":"https://orcid.org/0000-0002-1772-5986","observed_orcids":["https://orcid.org/0000-0002-1772-5986"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ioannis Vathiotis","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1772-5986","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049509860","display_name":"Konstantinos N. Syrigos","orcid":"https://orcid.org/0000-0002-3474-1363","observed_orcids":["https://orcid.org/0000-0002-3474-1363"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Konstantinos N. Syrigos","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3474-1363","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028192791","display_name":"Sarah B. Goldberg","orcid":"https://orcid.org/0000-0002-0920-1381","observed_orcids":["https://orcid.org/0000-0002-0920-1381"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarah B. Goldberg","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0920-1381","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067248479","display_name":"Katerina A. Politi","orcid":"https://orcid.org/0000-0001-6064-4527","observed_orcids":["https://orcid.org/0000-0001-6064-4527","https://orcid.org/0000-0002-6399-2735"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katerina Politi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6064-4527","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5027326018","display_name":"David L. Rimm","orcid":"https://orcid.org/0000-0001-5820-4397","observed_orcids":["https://orcid.org/0000-0001-5820-4397"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David L. Rimm","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5820-4397","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antibody-drug-conjugates","display_name":"antibody-drug conjugates","score":0.996999979019165},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9879999756813049},{"id":"https://openalex.org/keywords/egfr-mutation","display_name":"EGFR mutation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/egfr-expression","display_name":"EGFR expression","score":0.722000002861023},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.9639999866485596},{"id":"https://openalex.org/keywords/trop2","display_name":"TROP2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/her3","display_name":"HER3","score":1.0},{"id":"https://openalex.org/keywords/quantitative-immunofluorescence","display_name":"quantitative immunofluorescence","score":0.9039999842643738},{"id":"https://openalex.org/keywords/patient-selection","display_name":"patient selection","score":0.671999990940094},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.669569730758667},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.586423397064209},{"id":"https://openalex.org/C2777325958","wikidata":"https://www.wikidata.org/wiki/Q1069596","display_name":"Antibody-drug conjugate","level":4,"score":0.586349368095398},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5680739879608154},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5339010953903198},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5047785043716431},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4842495620250702},{"id":"https://openalex.org/C6856738","wikidata":"https://www.wikidata.org/wiki/Q331672","display_name":"Protein expression","level":3,"score":0.4422558546066284},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.439394474029541},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3637157678604126},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.3103221654891968},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2969299554824829},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24550822377204895},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2171633243560791},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.14702308177947998},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11668536067008972},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11365506052970886},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.c.7903399","doi":"https://doi.org/10.1158/1078-0432.c.7903399","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.7903399","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.7903399","doi":"https://doi.org/10.1158/1078-0432.c.7903399","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.7903399","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4408191659","https://openalex.org/W4410805073","https://openalex.org/W4403410176","https://openalex.org/W4410805137","https://openalex.org/W4409475777","https://openalex.org/W2146346695","https://openalex.org/W1996910715","https://openalex.org/W4393073450","https://openalex.org/W4397007410","https://openalex.org/W2312227384"],"abstract_inverted_index":{"AbstractPurpose:":[0],"Antibody\u2013drug":[1],"conjugates":[2],"(ADC)":[3],"are":[4,192],"a":[5,21,95,125,134,158,249],"promising":[6],"approach":[7],"for":[8,116,224],"the":[9,40,113,199,234,243],"management":[10],"of":[11,24,42,101,109,121,128],"patients":[12,25,223],"with":[13,130,137,151,162,169,183],"non\u2013small":[14],"cell":[15,88],"lung":[16],"cancer":[17],"(NSCLC).":[18],"However,":[19],"only":[20],"small":[22],"subset":[23],"derive":[26],"benefit":[27,200],"from":[28,201,208],"these":[29,202,209],"therapies.":[30],"Experimental":[31],"Design:":[32],"We":[33],"used":[34],"quantitative":[35,218,245],"immunofluorescence":[36,246],"assays":[37],"to":[38,60,252],"measure":[39],"levels":[41],"four":[43,92],"ADC":[44,190,225,254],"target":[45,122],"proteins":[46],"(HER2,":[47],"TROP2,":[48],"HER3,":[49],"and":[50,73,97,133,143,175,216],"EGFR)":[51],"in":[52,103,195],"three":[53,105],"NSCLC":[54],"tissue":[55],"microarray":[56],"cohorts":[57],"stratified":[58],"according":[59],"EGFR":[61,68,74,131,138,152,163,170,178,184],"mutation":[62,139,164,185,214],"[EGFR":[63],"mutated":[64],"(n":[65,70,76],"=":[66,71,77,141,187],"83),":[67],"wild-type":[69],"128),":[72],"unknown":[75],"232)].":[78],"Assay":[79],"limits":[80,115],"were":[81,111],"established":[82],"by":[83,260],"mass":[84],"spectrometry":[85],"on":[86,233],"standard":[87],"lines.":[89],"Results:":[90],"All":[91],"targets":[93,191],"demonstrated":[94,157],"broad":[96],"comparable":[98],"dynamic":[99],"range":[100],"expression":[102,123,132,147,153,171,179],"all":[104,117],"cohorts.":[106],"High":[107],"proportions":[108],"cases":[110],"above":[112],"assay":[114],"targets.":[118],"A":[119],"comparison":[120],"showed":[124],"significant":[126,159,167],"association":[127,136,168],"HER2":[129],"nonsignificant":[135],"(P":[140,172,186],"0.0005":[142],"0.14,":[144],"respectively).":[145,177],"TROP2":[146],"was":[148,180],"not":[149],"associated":[150,182],"or":[154],"mutation.":[155],"HER3":[156],"negative":[160],"correlation":[161,228],"but":[165],"no":[166],"<":[173],"0.0001":[174],"0.9869,":[176],"significantly":[181],"0.047).":[188],"Conclusions:":[189],"highly":[193],"expressed":[194],"NSCLC,":[196],"implying":[197],"that":[198],"agents":[203],"may":[204,211,220,229,247],"be":[205,248],"broad.":[206],"Benefit":[207],"therapies":[210],"go":[212],"beyond":[213],"status,":[215],"fully":[217],"approaches":[219],"help":[221],"select":[222,253],"targeting.":[226],"Intertarget":[227],"provide":[230],"an":[231],"insight":[232],"underlying":[235],"signaling":[236],"pathways":[237],"and/or":[238],"treatment-related":[239],"resistant":[240],"mechanisms.":[241],"In":[242],"future,":[244],"valuable":[250],"tool":[251],"treatment":[255],"sequence.":[256],"See":[257],"related":[258],"commentary":[259],"Hirsch,":[261],"p.":[262],"2550":[263]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2025-10-10T00:00:00"}