{"id":"https://openalex.org/W4411907293","doi":"https://doi.org/10.1158/2643-3230.29444503","title":"Supplementary Figure S12 from Single-cell Transcriptional Atlas of Human Hematopoiesis Reveals Genetic and Hierarchy-Based Determinants of Aberrant AML Differentiation","display_name":"Supplementary Figure S12 from Single-cell Transcriptional Atlas of Human Hematopoiesis Reveals Genetic and Hierarchy-Based Determinants of Aberrant AML Differentiation","publication_year":2025,"publication_date":"2025-07-01","ids":{"openalex":"https://openalex.org/W4411907293","doi":"https://doi.org/10.1158/2643-3230.29444503"},"language":"en","primary_location":{"id":"doi:10.1158/2643-3230.29444503","doi":"https://doi.org/10.1158/2643-3230.29444503","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2643-3230.29444503","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_S12_from_Single-cell_Transcriptional_Atlas_of_Human_Hematopoiesis_Reveals_Genetic_and_Hierarchy-Based_Determinants_of_Aberrant_AML_Differentiation/29444503/1/files/55877200.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_S12_from_Single-cell_Transcriptional_Atlas_of_Human_Hematopoiesis_Reveals_Genetic_and_Hierarchy-Based_Determinants_of_Aberrant_AML_Differentiation/29444503/1/files/55877200.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074167760","display_name":"Andy G.X. Zeng","orcid":"https://orcid.org/0000-0002-3223-6400","observed_orcids":["https://orcid.org/0000-0002-3223-6400"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andy G.X. Zeng","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3223-6400","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060457186","display_name":"Ilaria Iacobucci","orcid":"https://orcid.org/0000-0003-2008-1365","observed_orcids":["https://orcid.org/0000-0003-2008-1365"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ilaria Iacobucci","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2008-1365","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046266051","display_name":"Sayyam Shah","orcid":"https://orcid.org/0009-0005-1064-3223","observed_orcids":["https://orcid.org/0009-0005-1064-3223"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sayyam Shah","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-1064-3223","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Amanda Mitchell","orcid":"https://orcid.org/0009-0005-7444-5306","observed_orcids":["https://orcid.org/0009-0005-7444-5306"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amanda Mitchell","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-7444-5306","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114113246","display_name":"Gordon Wong","orcid":"https://orcid.org/0009-0007-2408-1393","observed_orcids":["https://orcid.org/0009-0007-2408-1393"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gordon Wong","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-2408-1393","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032981919","display_name":"Suraj Bansal","orcid":"https://orcid.org/0000-0003-4023-6635","observed_orcids":["https://orcid.org/0000-0003-4023-6635"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suraj Bansal","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4023-6635","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038511575","display_name":"David Chen","orcid":"https://orcid.org/0000-0003-3178-519X","observed_orcids":["https://orcid.org/0000-0003-3178-519X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Chen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3178-519X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015935509","display_name":"Qingsong Gao","orcid":"https://orcid.org/0000-0002-9930-8499","observed_orcids":["https://orcid.org/0000-0002-9930-8499"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qingsong Gao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9930-8499","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038196805","display_name":"Hyerin Kim","orcid":"https://orcid.org/0009-0002-6860-1227","observed_orcids":["https://orcid.org/0009-0002-6860-1227"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hyerin Kim","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-6860-1227","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060095506","display_name":"James A. Kennedy","orcid":"https://orcid.org/0009-0007-2844-2256","observed_orcids":["https://orcid.org/0009-0007-2844-2256"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James A. Kennedy","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-2844-2256","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083780768","display_name":"Andrea Arruda","orcid":"https://orcid.org/0000-0003-2516-8005","observed_orcids":["https://orcid.org/0000-0003-2516-8005"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrea Arruda","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2516-8005","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026397928","display_name":"Mark David Minden","orcid":"https://orcid.org/0000-0002-9089-8816","observed_orcids":["https://orcid.org/0000-0002-9089-8816"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark D. Minden","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9089-8816","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043414993","display_name":"Torsten Haferlach","orcid":"https://orcid.org/0000-0003-0196-2837","observed_orcids":["https://orcid.org/0000-0003-0196-2837"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Torsten Haferlach","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0196-2837","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048744038","display_name":"Charles Grenfell Mullighan","orcid":"https://orcid.org/0000-0002-1871-1850","observed_orcids":["https://orcid.org/0000-0002-1871-1850","https://orcid.org/0000-0002-1678-5864"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles G. Mullighan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1871-1850","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5090356933","display_name":"John Edgar Dick","orcid":"https://orcid.org/0000-0002-9527-8317","observed_orcids":["https://orcid.org/0000-0002-9527-8317"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John E. Dick","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9527-8317","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hematopoiesis","display_name":"hematopoiesis","score":0.7799999713897705},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.7620000243186951},{"id":"https://openalex.org/keywords/2022-who-classification","display_name":"WHO 2022 classification","score":0.9359999895095825},{"id":"https://openalex.org/keywords/gene-expression-clusters","display_name":"gene expression clusters","score":0.8119999766349792},{"id":"https://openalex.org/keywords/cebpa-mutation","display_name":"CEBPA mutation","score":0.8180000185966492},{"id":"https://openalex.org/keywords/flt3-itd-mutation","display_name":"FLT3-ITD","score":0.7490000128746033},{"id":"https://openalex.org/keywords/dnmt3a-mutation","display_name":"DNMT3A mutation","score":0.722000002861023},{"id":"https://openalex.org/keywords/npm1-mutation","display_name":"NPM1 mutation","score":0.6480000019073486},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.6039999723434448},{"id":"https://openalex.org/keywords/idh2-mutation","display_name":"IDH2 mutation","score":0.4869999885559082},{"id":"https://openalex.org/keywords/idh1-mutation","display_name":"IDH1 mutation","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C2776673561","wikidata":"https://www.wikidata.org/wiki/Q655357","display_name":"Atlas (anatomy)","level":2,"score":0.74416184425354},{"id":"https://openalex.org/C31170391","wikidata":"https://www.wikidata.org/wiki/Q188619","display_name":"Hierarchy","level":2,"score":0.6565389037132263},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5293120741844177},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5064162015914917},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.49414852261543274},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.4444124102592468},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.411434143781662},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.23972022533416748},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.18146145343780518},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.09921786189079285},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/2643-3230.29444503","doi":"https://doi.org/10.1158/2643-3230.29444503","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2643-3230.29444503","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_S12_from_Single-cell_Transcriptional_Atlas_of_Human_Hematopoiesis_Reveals_Genetic_and_Hierarchy-Based_Determinants_of_Aberrant_AML_Differentiation/29444503/1/files/55877200.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/29444503","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figure_S12_from_Single-cell_Transcriptional_Atlas_of_Human_Hematopoiesis_Reveals_Genetic_and_Hierarchy-Based_Determinants_of_Aberrant_AML_Differentiation/29444503","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/2643-3230.29444503","doi":"https://doi.org/10.1158/2643-3230.29444503","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2643-3230.29444503","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_S12_from_Single-cell_Transcriptional_Atlas_of_Human_Hematopoiesis_Reveals_Genetic_and_Hierarchy-Based_Determinants_of_Aberrant_AML_Differentiation/29444503/1/files/55877200.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411907293.pdf","grobid_xml":"https://content.openalex.org/works/W4411907293.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4411907262","https://openalex.org/W4410595770","https://openalex.org/W4409872473","https://openalex.org/W4417002130","https://openalex.org/W4310127270","https://openalex.org/W2555106461","https://openalex.org/W4385667680","https://openalex.org/W2981991247","https://openalex.org/W4310102412","https://openalex.org/W2471532396"],"abstract_inverted_index":{"Supplementary":[0],"Figure":[1],"S12.":[2],"Clinical":[3],"and":[4,56,67,108,133,169,216,219],"genomic":[5,21],"correlates":[6],"of":[7,16,32,59,97,128],"AML":[8,17,24],"differentiation":[9,18],"state":[10],"abundance":[11,15,66],"Associations":[12,92,230],"between":[13],"inferred":[14],"states":[19],"with":[20,74,86,284],"alterations":[22],"across":[23,105,118,144,185,238],"patient":[25],"samples":[26],"profiled":[27],"by":[28,79,122,148,189,242],"RNA-seq.":[29],"The":[30],"strength":[31],"each":[33,60,96],"association,":[34],"quantified":[35],"as":[36,48],"the":[37,54],"test":[38,82],"statistic":[39],"from":[40,157,176,204,227],"a":[41,49],"generalized":[42],"linear":[43],"model":[44],"adjusting":[45],"for":[46,95,231,256],"cohort":[47],"covariate,":[50],"is":[51],"depicted":[52,94,255],"through":[53],"size":[55],"color":[57],"intensity":[58],"dot,":[61],"wherein":[62],"green":[63],"denotes":[64,69],"higher":[65],"purple":[68],"lower":[70],"abundance.":[71],"Only":[72],"associations":[73,85],"unadjusted":[75],"P":[76],"<":[77,88],"0.05":[78,89],"likelihood":[80],"ratio":[81],"are":[83,90,93,254],"shown,":[84],"FDR":[87],"starred.":[91],"A)":[98],"FAB":[99],"morphology":[100],"(n":[101,115,140,162,181,209,223,261,271,281],"=":[102,116,141,163,182,210,224,262,272,282],"411":[103],"patients":[104,143,165,184,212,226,237],"TCGA,":[106,129,167,214],"BeatAML1,":[107,168,215],"Leucegene)":[109,170,217],"(59\u201361),":[110],"B)":[111],"WHO":[112],"2022":[113,138,161],"classification":[114,139,156,203],"1166":[117],"5":[119,145,186,239],"cohorts":[120,146,187,240],"re-analyzed":[121,147,188,241],"Severens":[123,149,177,190,243],"et":[124,150,159,178,191,206,244],"al":[125,151,160,179,192,207,245],"2024,":[126],"consisting":[127],"BeatAML2,":[130,248],"Leucegene,":[131,249],"TARGET,":[132,250],"LUMC)":[134,251],"(31,58\u201362),":[135,153,194],"C)":[136],"ICC":[137],"1192":[142],"2024)":[152,193],"D)":[154],"Hierarchy":[155,199],"Zeng":[158],"864":[164],"spanning":[166,213,235],"(30,59\u201361),":[171],"E)":[172],"Gene":[173],"expression":[174],"clusters":[175],"2024":[180,246],"1224":[183,236],"F)":[195],"Integrated":[196],"RNA":[197],"+":[198,200],"Methylation":[201],"based":[202],"Ma":[205],"2025":[208],"812":[211],"(59\u201361,65),":[218],"G)":[220],"Disease":[221],"history":[222],"487":[225],"BeatAML2).":[228],"H-J)":[229],"specific":[232],"mutation":[233,259,269,279],"patterns":[234],"(TCGA,":[247],"(31,58\u201362).":[252],"Comparisons":[253],"H)":[257],"CEBPA":[258,265],"type":[260,270],"99)":[263],"versus":[264,274,287],"wildtype,":[266,276],"I)":[267],"FLT3":[268,275],"340)":[273],"J)":[277],"NPM1":[278,288],"combination":[280],"249":[283],"normal":[285],"karyotype)":[286],"wildtype.":[289]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2025-10-10T00:00:00"}