{"id":"https://openalex.org/W4411907136","doi":"https://doi.org/10.1158/1078-0432.c.7903454","title":"Data from Multimetric MRI Captures Early Response and Acquired Resistance of Pancreatic Cancer to KRAS Inhibitor Therapy","display_name":"Data from Multimetric MRI Captures Early Response and Acquired Resistance of Pancreatic Cancer to KRAS Inhibitor Therapy","publication_year":2025,"publication_date":"2025-07-01","ids":{"openalex":"https://openalex.org/W4411907136","doi":"https://doi.org/10.1158/1078-0432.c.7903454"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.7903454","doi":"https://doi.org/10.1158/1078-0432.c.7903454","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.7903454","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.c.7903454","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005556148","display_name":"Mamta Gupta","orcid":"https://orcid.org/0000-0003-0928-1104","observed_orcids":["https://orcid.org/0000-0003-0928-1104"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mamta Gupta","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0928-1104","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102855835","display_name":"Hoon Choi","orcid":"https://orcid.org/0000-0003-0064-5290","observed_orcids":["https://orcid.org/0000-0003-0064-5290"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hoon Choi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0064-5290","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058464154","display_name":"Samantha B. Kemp","orcid":"https://orcid.org/0000-0002-1505-4015","observed_orcids":["https://orcid.org/0000-0002-1505-4015"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samantha B. Kemp","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1505-4015","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042763431","display_name":"Emma Elizabeth Furth","orcid":"https://orcid.org/0000-0002-9309-985X","observed_orcids":["https://orcid.org/0000-0002-9309-985X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emma E. Furth","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9309-985X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019161876","display_name":"Stephen Pickup","orcid":"https://orcid.org/0000-0002-7016-8648","observed_orcids":["https://orcid.org/0000-0002-7016-8648"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen Pickup","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7016-8648","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086174004","display_name":"Cynthia J. Clendenin","orcid":"https://orcid.org/0000-0003-4535-2088","observed_orcids":["https://orcid.org/0000-0003-4535-2088"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cynthia Clendenin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4535-2088","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059797626","display_name":"Margo Orlen","orcid":"https://orcid.org/0000-0002-9834-6282","observed_orcids":["https://orcid.org/0000-0002-9834-6282"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Margo Orlen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9834-6282","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Mark Rosen","orcid":"https://orcid.org/0000-0002-1581-0220","observed_orcids":["https://orcid.org/0000-0002-1581-0220"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Rosen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1581-0220","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100453122","display_name":"Fang Liu","orcid":"https://orcid.org/0000-0003-2922-4414","observed_orcids":["https://orcid.org/0000-0003-2922-4414"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fang Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2922-4414","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050804390","display_name":"Quy Cao","orcid":"https://orcid.org/0000-0002-6204-1305","observed_orcids":["https://orcid.org/0000-0002-6204-1305"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Quy Cao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6204-1305","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057187872","display_name":"Ben Z. Stanger","orcid":"https://orcid.org/0000-0003-0410-4037","observed_orcids":["https://orcid.org/0000-0003-0410-4037"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ben Z. Stanger","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0410-4037","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5069305433","display_name":"Rong Zhou","orcid":"https://orcid.org/0000-0003-4018-381X","observed_orcids":["https://orcid.org/0000-0003-4018-381X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rong Zhou","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4018-381X","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.039000000804662704,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/kras-inhibitors","display_name":"KRAS inhibitors","score":0.9490000009536743},{"id":"https://openalex.org/keywords/mrtx1133","display_name":"MRTX1133","score":0.9860000014305115},{"id":"https://openalex.org/keywords/kras-g12d","display_name":"KRAS G12D","score":0.8769999742507935},{"id":"https://openalex.org/keywords/kras-g12c","display_name":"KRAS G12C","score":0.9750000238418579},{"id":"https://openalex.org/keywords/acquired-drug-resistance","display_name":"acquired drug resistance","score":0.8709999918937683},{"id":"https://openalex.org/keywords/early-treatment-response","display_name":"early treatment response","score":0.8769999742507935},{"id":"https://openalex.org/keywords/diffusion-weighted-imaging","display_name":"diffusion-weighted imaging","score":0.8629999756813049},{"id":"https://openalex.org/keywords/apparent-diffusion-coefficient","display_name":"apparent diffusion coefficient","score":0.9649999737739563},{"id":"https://openalex.org/keywords/dynamic-contrast-enhanced-mri","display_name":"dynamic contrast-enhanced MRI","score":0.9089999794960022},{"id":"https://openalex.org/keywords/microvessel-density","display_name":"microvessel density","score":0.8939999938011169},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8489999771118164},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.746999979019165},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.7440000176429749},{"id":"https://openalex.org/keywords/kpc-mouse-model","display_name":"KPC mouse model","score":0.7710000276565552},{"id":"https://openalex.org/keywords/survival-prediction","display_name":"survival prediction","score":0.3529999852180481}],"concepts":[{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.7095813155174255},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.6771592497825623},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49567878246307373},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44371554255485535},{"id":"https://openalex.org/C57473165","wikidata":"https://www.wikidata.org/wiki/Q7315604","display_name":"Resistance (ecology)","level":2,"score":0.4161224663257599},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.40085768699645996},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3762853145599365},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3687135577201843},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16009998321533203},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.11140584945678711},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.05521517992019653}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.c.7903454","doi":"https://doi.org/10.1158/1078-0432.c.7903454","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.7903454","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.7903454","doi":"https://doi.org/10.1158/1078-0432.c.7903454","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.7903454","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4409681524","https://openalex.org/W4390917835","https://openalex.org/W4412844366","https://openalex.org/W4404750478","https://openalex.org/W4409039147","https://openalex.org/W2620510330","https://openalex.org/W4235277909","https://openalex.org/W4412844538","https://openalex.org/W2889633323","https://openalex.org/W7167761932"],"abstract_inverted_index":{"AbstractPurpose:":[0],"In":[1],"pancreatic":[2],"ductal":[3],"adenocarcinoma":[4],"(PDAC),":[5],"Kirsten":[6],"rat":[7],"sarcoma":[8],"viral":[9],"oncogene":[10],"homolog":[11],"(KRAS)":[12],"mutations":[13],"drive":[14],"both":[15],"cancer":[16,234],"cell":[17,67,162],"growth":[18],"and":[19,73,84,146,157,164,235,241],"formation":[20],"of":[21,34,58,154,192,223,233,249],"a":[22,30,104,112,219],"dense":[23],"stroma.":[24],"Small-molecule":[25],"KRAS":[26],"inhibitors":[27],"(KRASi)":[28],"represent":[29],"promising":[31],"new":[32],"class":[33],"therapy":[35],"for":[36,115,245],"PDAC;":[37],"hence,":[38],"clinical":[39,56],"tools":[40],"that":[41,62],"can":[42,65],"assess":[43],"early":[44,142,230],"response,":[45],"detect":[46,66],"resistance,":[47],"and/or":[48],"predict":[49],"prolonged":[50,170],"survival":[51,172],"are":[52,78],"desirable":[53],"to":[54,80,148,197,212,238],"understand":[55],"biology":[57],"KRASi.":[59],"We":[60],"hypothesized":[61],"diffusion-weighted":[63,136],"MRI":[64,72,137,181,203,228,253],"death,":[68],"whereas":[69],"dynamic":[70,179],"contrast-enhanced":[71,180],"magnetization":[74],"transfer":[75],"ratio":[76],"imaging":[77,119,215],"sensitive":[79],"tumor":[81,90,131],"microenvironment":[82],"changes,":[83],"these":[85,250],"metrics":[86,204],"shed":[87],"insights":[88,232],"into":[89],"size":[91],"change":[92],"induced":[93],"by":[94,201],"KRASi":[95,113,155,239,258],"treatment.":[96],"Experimental":[97],"Design:":[98],"Multiple":[99],"preclinical":[100],"PDAC":[101],"models,":[102],"including":[103],"genetically":[105],"engineered":[106],"mouse":[107],"model":[108],"(KPC),":[109],"received":[110],"MRTX1133,":[111,213],"specific":[114],"KRASG12D":[116,195],"mutation.":[117],"Quantitative":[118],"markers":[120],"were":[121,199],"corroborated":[122,205],"with":[123,161,187,206],"IHC":[124],"analyses.":[125],"Results:":[126],"A":[127],"significant":[128],"increase":[129],"in":[130,168,173,255],"apparent":[132],"diffusion":[133],"coefficient":[134],"(a":[135,178],"metric)":[138,182],"was":[139,158],"detected":[140],"as":[141,143],"48":[144],"hours":[145],"persisted":[147],"day":[149],"7":[150],"after":[151],"the":[152,202,214,243,247],"initiation":[153],"treatment":[156,240],"strongly":[159],"correlated":[160],"death":[163],"reduced":[165],"cellularity,":[166],"resulting":[167],"greatly":[169],"median":[171],"treated":[174],"mice.":[175],"Capillary":[176],"perfusion/permeability":[177],"exhibited":[183,218],"an":[184],"inverse":[185],"relationship":[186],"microvascular":[188],"density.":[189],"Distinct":[190],"responses":[191,237],"KRASG12C":[193],"versus":[194],"tumors":[196,209],"MRTX1133":[198],"captured":[200],"IHC.":[207],"When":[208],"developed":[210],"resistance":[211],"marker":[216],"values":[217],"reversal":[220],"from":[221],"those":[222],"responding":[224],"tumors.":[225],"Conclusions:":[226],"Multiparametric":[227],"provides":[229],"biological":[231],"stromal":[236],"sets":[242],"stage":[244],"testing":[246],"utility":[248],"clinically":[251],"ready":[252],"methods":[254],"patients":[256],"receiving":[257],"therapy.":[259]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}