{"id":"https://openalex.org/W4411891723","doi":"https://doi.org/10.3390/ijms26136338","title":"The Whole Blood Transcriptomic Analysis in Sickle Cell Disease Reveals RUNX3 as a Potential Marker for Vaso-Occlusive Crises","display_name":"The Whole Blood Transcriptomic Analysis in Sickle Cell Disease Reveals RUNX3 as a Potential Marker for Vaso-Occlusive Crises","publication_year":2025,"publication_date":"2025-06-30","ids":{"openalex":"https://openalex.org/W4411891723","doi":"https://doi.org/10.3390/ijms26136338","pmid":"https://pubmed.ncbi.nlm.nih.gov/40650112","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12250390"},"language":"en","primary_location":{"id":"doi:10.3390/ijms26136338","doi":"https://doi.org/10.3390/ijms26136338","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms26136338","pdf_url":"https://www.mdpi.com/1422-0067/26/13/6338/pdf?version=1751298243","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4411891723"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/26/13/6338/pdf?version=1751298243","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025299157","display_name":"Safa Taha","orcid":"https://orcid.org/0000-0002-8276-4535","observed_orcids":["https://orcid.org/0000-0002-8276-4535"]},"institutions":[{"id":"https://openalex.org/I53218197","display_name":"Arabian Gulf University","ror":"https://ror.org/04gd4wn47","country_code":"BH","type":"education","lineage":["https://openalex.org/I53218197"]}],"countries":["BH"],"is_corresponding":false,"raw_author_name":"Safa Taha","raw_affiliation_strings":["Department of Molecular Medicine, Princess Al Jawhara Center for Molecular Medicine, Genetics and Inherited Diseases, College of Medicine and Health Sciences, Arabian Gulf University, Manama P.O. Box 26671, Bahrain"],"raw_orcid":"https://orcid.org/0000-0002-8276-4535","affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Princess Al Jawhara Center for Molecular Medicine, Genetics and Inherited Diseases, College of Medicine and Health Sciences, Arabian Gulf University, Manama P.O. Box 26671, Bahrain","institution_ids":["https://openalex.org/I53218197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048868990","display_name":"Hawra Abdulwahab","orcid":"https://orcid.org/0000-0002-6819-5487","observed_orcids":["https://orcid.org/0000-0002-6819-5487"]},"institutions":[{"id":"https://openalex.org/I53218197","display_name":"Arabian Gulf University","ror":"https://ror.org/04gd4wn47","country_code":"BH","type":"education","lineage":["https://openalex.org/I53218197"]}],"countries":["BH"],"is_corresponding":true,"raw_author_name":"Hawra Abdulwahab","raw_affiliation_strings":["Department of Molecular Medicine, Princess Al Jawhara Center for Molecular Medicine, Genetics and Inherited Diseases, College of Medicine and Health Sciences, Arabian Gulf University, Manama P.O. Box 26671, Bahrain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Princess Al Jawhara Center for Molecular Medicine, Genetics and Inherited Diseases, College of Medicine and Health Sciences, Arabian Gulf University, Manama P.O. Box 26671, Bahrain","institution_ids":["https://openalex.org/I53218197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077126829","display_name":"Muna Aljishi","orcid":"https://orcid.org/0000-0003-1178-8625","observed_orcids":["https://orcid.org/0000-0003-1178-8625"]},"institutions":[{"id":"https://openalex.org/I53218197","display_name":"Arabian Gulf University","ror":"https://ror.org/04gd4wn47","country_code":"BH","type":"education","lineage":["https://openalex.org/I53218197"]}],"countries":["BH"],"is_corresponding":false,"raw_author_name":"Muna Aljishi","raw_affiliation_strings":["Department of Molecular Medicine, Princess Al Jawhara Center for Molecular Medicine, Genetics and Inherited Diseases, College of Medicine and Health Sciences, Arabian Gulf University, Manama P.O. Box 26671, Bahrain"],"raw_orcid":"https://orcid.org/0000-0003-1178-8625","affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Princess Al Jawhara Center for Molecular Medicine, Genetics and Inherited Diseases, College of Medicine and Health Sciences, Arabian Gulf University, Manama P.O. Box 26671, Bahrain","institution_ids":["https://openalex.org/I53218197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046214546","display_name":"Ameera Sultan","orcid":"https://orcid.org/0000-0002-6660-3627","observed_orcids":["https://orcid.org/0000-0002-6660-3627"]},"institutions":[{"id":"https://openalex.org/I53218197","display_name":"Arabian Gulf University","ror":"https://ror.org/04gd4wn47","country_code":"BH","type":"education","lineage":["https://openalex.org/I53218197"]}],"countries":["BH"],"is_corresponding":false,"raw_author_name":"Ameera Sultan","raw_affiliation_strings":["Department of Molecular Medicine, Princess Al Jawhara Center for Molecular Medicine, Genetics and Inherited Diseases, College of Medicine and Health Sciences, Arabian Gulf University, Manama P.O. Box 26671, Bahrain"],"raw_orcid":"https://orcid.org/0000-0002-6660-3627","affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Princess Al Jawhara Center for Molecular Medicine, Genetics and Inherited Diseases, College of Medicine and Health Sciences, Arabian Gulf University, Manama P.O. Box 26671, Bahrain","institution_ids":["https://openalex.org/I53218197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018715958","display_name":"Moiz Bakhiet","orcid":"https://orcid.org/0000-0002-5148-8849","observed_orcids":["https://orcid.org/0000-0002-5148-8849"]},"institutions":[{"id":"https://openalex.org/I53218197","display_name":"Arabian Gulf University","ror":"https://ror.org/04gd4wn47","country_code":"BH","type":"education","lineage":["https://openalex.org/I53218197"]}],"countries":["BH"],"is_corresponding":false,"raw_author_name":"Moiz Bakhiet","raw_affiliation_strings":["Department of Molecular Medicine, Princess Al Jawhara Center for Molecular Medicine, Genetics and Inherited Diseases, College of Medicine and Health Sciences, Arabian Gulf University, Manama P.O. Box 26671, Bahrain"],"raw_orcid":"https://orcid.org/0000-0002-5148-8849","affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Princess Al Jawhara Center for Molecular Medicine, Genetics and Inherited Diseases, College of Medicine and Health Sciences, Arabian Gulf University, Manama P.O. Box 26671, Bahrain","institution_ids":["https://openalex.org/I53218197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091488339","display_name":"Salvatore Spicuglia","orcid":"https://orcid.org/0000-0002-8101-7108","observed_orcids":["https://orcid.org/0000-0002-8101-7108"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I21491767","display_name":"Aix-Marseille Universit\u00e9","ror":"https://ror.org/035xkbk20","country_code":"FR","type":"education","lineage":["https://openalex.org/I21491767"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Salvatore Spicuglia","raw_affiliation_strings":["Equipe Lab\u00e9lis\u00e9e Ligue Contre le Cancer, Aix-Marseille University, INSERM, TAGC, UMR1090, 13288 Marseille, France"],"raw_orcid":"https://orcid.org/0000-0002-8101-7108","affiliations":[{"raw_affiliation_string":"Equipe Lab\u00e9lis\u00e9e Ligue Contre le Cancer, Aix-Marseille University, INSERM, TAGC, UMR1090, 13288 Marseille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I21491767"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035030607","display_name":"Mohamed Belhocine","orcid":"https://orcid.org/0000-0001-9523-0658","observed_orcids":["https://orcid.org/0000-0001-9523-0658"]},"institutions":[{"id":"https://openalex.org/I53218197","display_name":"Arabian Gulf University","ror":"https://ror.org/04gd4wn47","country_code":"BH","type":"education","lineage":["https://openalex.org/I53218197"]}],"countries":["BH"],"is_corresponding":false,"raw_author_name":"Mohamed Belhocine","raw_affiliation_strings":["Department of Molecular Medicine, Princess Al Jawhara Center for Molecular Medicine, Genetics and Inherited Diseases, College of Medicine and Health Sciences, Arabian Gulf University, Manama P.O. Box 26671, Bahrain"],"raw_orcid":"https://orcid.org/0000-0001-9523-0658","affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Princess Al Jawhara Center for Molecular Medicine, Genetics and Inherited Diseases, College of Medicine and Health Sciences, Arabian Gulf University, Manama P.O. Box 26671, Bahrain","institution_ids":["https://openalex.org/I53218197"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5048868990"],"corresponding_institution_ids":["https://openalex.org/I53218197"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":1.5907,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.76989529,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"26","issue":"13","first_page":"6338","last_page":"6338"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":1.0},{"id":"https://openalex.org/keywords/vaso-occlusive-crisis","display_name":"vaso-occlusive crisis","score":0.9589999914169312},{"id":"https://openalex.org/keywords/runx3","display_name":"RUNX3","score":0.9929999709129333},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.7739999890327454},{"id":"https://openalex.org/keywords/whole-blood-transcriptome","display_name":"whole blood transcriptome","score":0.8579999804496765},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8529999852180481},{"id":"https://openalex.org/keywords/immune-dysregulation","display_name":"immune dysregulation","score":0.6000000238418579},{"id":"https://openalex.org/keywords/hemoglobinopathies","display_name":"hemoglobinopathies","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.621148943901062},{"id":"https://openalex.org/C2779018089","wikidata":"https://www.wikidata.org/wiki/Q17014303","display_name":"Fold change","level":4,"score":0.5764234662055969},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5669147968292236},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5462389588356018},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5457595586776733},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4906071722507477},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.4808672070503235},{"id":"https://openalex.org/C2780441568","wikidata":"https://www.wikidata.org/wiki/Q7916864","display_name":"Vaso-occlusive crisis","level":4,"score":0.47425761818885803},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.46928510069847107},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.4673483967781067},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46500787138938904},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4590105414390564},{"id":"https://openalex.org/C2778620579","wikidata":"https://www.wikidata.org/wiki/Q185034","display_name":"Sickle cell anemia","level":3,"score":0.44834113121032715},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4429444968700409},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.42327409982681274},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3500507175922394},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3156587481498718},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3015232980251312},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28145596385002136}],"mesh":[{"descriptor_ui":"D000098644","descriptor_name":"Vaso-Occlusive Crises","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050677","descriptor_name":"Core Binding Factor Alpha 3 Subunit","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D050677","descriptor_name":"Core Binding Factor Alpha 3 Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/ijms26136338","doi":"https://doi.org/10.3390/ijms26136338","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms26136338","pdf_url":"https://www.mdpi.com/1422-0067/26/13/6338/pdf?version=1751298243","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-5397806/v1","doi":"https://doi.org/10.21203/rs.3.rs-5397806/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-5397806/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:40650112","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40650112","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12250390","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12250390/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-05500881v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-05500881v1/file/ijms-26-06338.pdf","pdf_url":"https://hal.science/hal-05500881v1/file/ijms-26-06338.pdf","source":{"id":"https://openalex.org/S4406922393","display_name":"HAL AMU","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, 2025, 26 (13), pp.6338. &#x27E8;10.3390/ijms26136338&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3390/ijms26136338","doi":"https://doi.org/10.3390/ijms26136338","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms26136338","pdf_url":"https://www.mdpi.com/1422-0067/26/13/6338/pdf?version=1751298243","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G4972421834","display_name":null,"funder_award_id":"grant number E003-PI-04/18.","funder_id":"https://openalex.org/F4320311396","funder_display_name":"Arabian Gulf University"}],"funders":[{"id":"https://openalex.org/F4320311396","display_name":"Arabian Gulf University","ror":"https://ror.org/04gd4wn47"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411891723.pdf","grobid_xml":"https://content.openalex.org/works/W4411891723.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1525090063","https://openalex.org/W1833592659","https://openalex.org/W1965582389","https://openalex.org/W1967457336","https://openalex.org/W1976597038","https://openalex.org/W2011596946","https://openalex.org/W2019381418","https://openalex.org/W2053495832","https://openalex.org/W2093002151","https://openalex.org/W2098349919","https://openalex.org/W2109581539","https://openalex.org/W2136908022","https://openalex.org/W2140441447","https://openalex.org/W2150576367","https://openalex.org/W2169690871","https://openalex.org/W2192733338","https://openalex.org/W2466331987","https://openalex.org/W2474747771","https://openalex.org/W2737653206","https://openalex.org/W2737809424","https://openalex.org/W2756132092","https://openalex.org/W2781620608","https://openalex.org/W2787997569","https://openalex.org/W2788596350","https://openalex.org/W2800405047","https://openalex.org/W2855054980","https://openalex.org/W2883866025","https://openalex.org/W2889928731","https://openalex.org/W2902220943","https://openalex.org/W2916450952","https://openalex.org/W2942737016","https://openalex.org/W2964263062","https://openalex.org/W2965562857","https://openalex.org/W2991010274","https://openalex.org/W2999855906","https://openalex.org/W3112376646","https://openalex.org/W4213060373","https://openalex.org/W4372332501","https://openalex.org/W6640706774"],"related_works":["https://openalex.org/W3214668009","https://openalex.org/W4389248599","https://openalex.org/W7134191955","https://openalex.org/W2107734982","https://openalex.org/W2888569138","https://openalex.org/W2011006554","https://openalex.org/W1969331736","https://openalex.org/W4389221481","https://openalex.org/W4387410774","https://openalex.org/W3097518634"],"abstract_inverted_index":{"Sickle":[0],"cell":[1,136],"disease":[2,31],"(SCD)":[3],"is":[4],"the":[5,14,49,129,142],"most":[6],"common":[7],"hemoglobinopathy,":[8],"caused":[9],"by":[10],"a":[11,158,184],"mutation":[12],"in":[13,112,134,150,154],"\u03b2-globin":[15],"gene":[16,52],"of":[17,55,119,162],"hemoglobin.":[18],"It":[19],"predisposes":[20],"patients":[21],"to":[22,39,47,74,93,168,200],"painful":[23],"Vaso-occlusive":[24],"crises":[25],"(VOC)":[26],"and":[27,42,68,83,89,114,125,138,156,195,205],"multi-organ":[28],"dysfunctions.":[29],"The":[30],"exhibits":[32],"significant":[33,110],"phenotypic":[34],"variability,":[35],"making":[36],"it":[37],"challenging":[38],"predict":[40],"severity":[41],"outcomes.":[43],"This":[44],"study":[45],"aimed":[46],"characterize":[48],"whole":[50],"blood":[51],"expression":[53],"profile":[54],"Bahraini":[56],"SCD":[57],"patients,":[58],"identifying":[59],"differentially":[60,98],"expressed":[61,99],"genes":[62,86,97,121],"during":[63,87,100,165,171],"steady-state":[64,88,172],"(n":[65,70,77],"=":[66,71,78],"10)":[67,72],"VOC":[69,101,166],"compared":[73,92,167],"healthy":[75],"controls":[76],"8).":[79],"Analysis":[80],"revealed":[81],"2073":[82],"3363":[84],"dysregulated":[85],"VOC,":[90],"respectively,":[91],"controls,":[94],"with":[95],"1078":[96],"versus":[102],"steady-state.":[103],"Gene":[104],"Ontology":[105],"(GO)":[106],"enrichment":[107],"analysis":[108],"highlighted":[109],"deregulation":[111],"immune":[113,123,135],"hematopoietic":[115,126],"pathways,":[116],"including":[117],"down-regulation":[118],"critical":[120],"for":[122,187],"modulation":[124],"balance.":[127],"Notably,":[128],"transcription":[130],"factor":[131],"RUNX3,":[132],"involved":[133],"differentiation":[137],"inflammation,":[139],"was":[140,147],"among":[141],"668":[143],"down-regulated":[144,149],"genes.":[145],"RUNX3":[146,180],"four-fold":[148],"microarray":[151],"analysis,":[152],"three-fold":[153],"PCR,":[155],"showed":[157],"mean":[159],"protein":[160],"concentration":[161],"11.13":[163],"pg/mL":[164,170],"457.93":[169],"(p":[173],"<":[174],"0.01).":[175],"These":[176],"findings":[177],"suggest":[178],"that":[179],"may":[181],"serve":[182],"as":[183],"potential":[185],"biomarker":[186],"VOC.":[188],"Future":[189],"large-scale":[190],"validation,":[191],"additional":[192],"proteomic":[193],"studies,":[194],"functional":[196],"investigations":[197],"are":[198],"recommended":[199],"confirm":[201],"its":[202],"clinical":[203],"utility":[204],"significance.":[206]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2025-10-10T00:00:00"}
