{"id":"https://openalex.org/W4411880378","doi":"https://doi.org/10.1152/physiol.2025.40.s1.1802","title":"Parabrachial Tac1 Neurons Are Conditionally Activated During Dynamic Breathing Patterns","display_name":"Parabrachial Tac1 Neurons Are Conditionally Activated During Dynamic Breathing Patterns","publication_year":2025,"publication_date":"2025-05-01","ids":{"openalex":"https://openalex.org/W4411880378","doi":"https://doi.org/10.1152/physiol.2025.40.s1.1802"},"language":"en","primary_location":{"id":"doi:10.1152/physiol.2025.40.s1.1802","doi":"https://doi.org/10.1152/physiol.2025.40.s1.1802","is_oa":false,"landing_page_url":"https://doi.org/10.1152/physiol.2025.40.s1.1802","pdf_url":null,"source":{"id":"https://openalex.org/S88977973","display_name":"Physiology","issn_l":"0886-1714","issn":["0886-1714","1522-161X","1548-9213","1548-9221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042278933","display_name":"Joe Arthurs","orcid":"https://orcid.org/0000-0002-8992-7982","observed_orcids":["https://orcid.org/0000-0002-8992-7982","https://orcid.org/0000-0002-5339-7908"]},"institutions":[{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joe Arthurs","raw_affiliation_strings":["Seattle Children's Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seattle Children's Research Institute","institution_ids":["https://openalex.org/I4405262941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058679610","display_name":"Nicholas Edward Bush","orcid":"https://orcid.org/0000-0003-0186-6394","observed_orcids":["https://orcid.org/0000-0003-0186-6394"]},"institutions":[{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas Bush","raw_affiliation_strings":["Seattle Children's Research Institute, SEATTLE, WA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seattle Children's Research Institute, SEATTLE, WA, United States","institution_ids":["https://openalex.org/I4405262941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108933958","display_name":"Elora Reilly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elora Reilly","raw_affiliation_strings":["Seattle Children's Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seattle Children's Research Institute","institution_ids":["https://openalex.org/I4405262941"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069915171","display_name":"Nathan Andrew Baertsch","orcid":"https://orcid.org/0000-0003-1589-5575","observed_orcids":["https://orcid.org/0000-0003-1589-5575"]},"institutions":[{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan Baertsch","raw_affiliation_strings":["Seattle Children's Research Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seattle Children's Research Institute","institution_ids":["https://openalex.org/I4405262941"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5042278933"],"corresponding_institution_ids":["https://openalex.org/I4405262941"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12418","display_name":"Respiratory and Cough-Related Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lateral-parabrachial-nucleus","display_name":"lateral parabrachial nucleus","score":0.9169999957084656},{"id":"https://openalex.org/keywords/respiratory-control","display_name":"respiratory control","score":0.7070000171661377},{"id":"https://openalex.org/keywords/optogenetic-stimulation","display_name":"optogenetic stimulation","score":0.531000018119812},{"id":"https://openalex.org/keywords/multi-unit-recording","display_name":"multi-unit recording","score":0.5730000138282776},{"id":"https://openalex.org/keywords/neuropixels-probes","display_name":"Neuropixels","score":0.47999998927116394},{"id":"https://openalex.org/keywords/respiratory-rate","display_name":"respiratory rate","score":0.5210000276565552},{"id":"https://openalex.org/keywords/sniffing","display_name":"sniffing","score":0.6309999823570251},{"id":"https://openalex.org/keywords/aroma-compounds","display_name":"aroma compounds","score":0.5649999976158142},{"id":"https://openalex.org/keywords/isoflurane-anesthesia","display_name":"isoflurane anesthesia","score":0.828000009059906}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.48783281445503235},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4046018719673157}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1152/physiol.2025.40.s1.1802","doi":"https://doi.org/10.1152/physiol.2025.40.s1.1802","is_oa":false,"landing_page_url":"https://doi.org/10.1152/physiol.2025.40.s1.1802","pdf_url":null,"source":{"id":"https://openalex.org/S88977973","display_name":"Physiology","issn_l":"0886-1714","issn":["0886-1714","1522-161X","1548-9213","1548-9221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4398175102","https://openalex.org/W4321452648","https://openalex.org/W4384560560","https://openalex.org/W3177314413","https://openalex.org/W7160950439","https://openalex.org/W1120815349","https://openalex.org/W4281385388","https://openalex.org/W4319461547","https://openalex.org/W4200151371","https://openalex.org/W3019903002"],"abstract_inverted_index":{"Homeostatic":[0],"breathing":[1,18,39,61,143,156,205,275,306,357,398],"is":[2,19,29,341,389,419,426],"continuously":[3],"regulated":[4],"by":[5,23,315,363],"reflexive":[6],"neural":[7],"circuits":[8,33],"that":[9,34,44,63,88,121,172,177,221,337,379,388,400],"provide":[10],"physiological":[11],"feedback.":[12],"However,":[13],"in":[14,95,142,155,175,183,224,305,333,422,440],"the":[15,32,69,86,108,184,195,207,238,246,262,265,285,404,413,441],"awake":[16,334,405],"state,":[17],"also":[20,158],"conditionally":[21,394],"altered":[22],"behaviors":[24],"and":[25,79,240,254,320,393,418],"emotions.":[26],"Relatively":[27],"little":[28],"known":[30],"about":[31],"mediate":[35],"this":[36,89,338,380],"dynamic":[37],"\u201cnon-homeostatic''":[38],"control.":[40,101],"We":[41,377],"previously":[42],"found":[43],"optogenetic":[45,162],"activation":[46,296],"of":[47,55,72,110,125,164,170,186,198,209,280,284,297,355,370],"a":[48,231,241,255,302,385],"Tac1,":[49],"but":[50,97,180,228,348],"not":[51,98,138,181,229,438],"Calca,":[52],"expressing":[53],"subpopulation":[54,340,382],"lateral":[56],"parabrachial":[57],"(PBN)":[58],"neurons":[59,106,167,176,201,225],"drives":[60,122],"frequencies":[62],"far":[64],"exceed":[65],"those":[66],"relevant":[67],"for":[68,133,293],"homeostatic":[70,346],"control":[71,152],"breathing.":[73],"Here,":[74],"we":[75],"combine":[76],"cell-type-specific":[77],"silencing":[78],"multi-unit":[80,331],"recording":[81,279],"approaches":[82],"to":[83,148,203,237,245,322,350,403],"further":[84],"test":[85],"hypothesis":[87],"circuit":[90],"plays":[91],"an":[92,119,219],"important":[93],"role":[94],"state-dependent,":[96],"automatic,":[99],"respiratory":[100,281],"To":[102,193],"render":[103],"Tac1":[104,112,187,199,210],"PBN":[105,109,185,200,208,239,263,299,309,339,381],"non-functional,":[107],"adult":[111],"Cre":[113,179,188,211,227],"mice":[114,149,215,251,276,335],"was":[115,216,234,259,270,291,410,437],"injected":[116,150,217],"bilaterally":[117],"with":[118,151,218,288],"AAV":[120,171,220],"Cre-dependent":[123],"expression":[124],"tetanus":[126],"light":[127,290,326],"chain.":[128],"After":[129,248],"allowing":[130],"4":[131],"weeks":[132],"viral":[134],"expression,":[135],"plethysmography":[136],"did":[137],"reveal":[139],"any":[140],"differences":[141],"frequency":[144],"or":[145,430],"pattern":[146],"compared":[147],"AAV.":[153],"Changes":[154],"were":[157,252,311],"absent":[159],"during":[160,277,329,344,353,396],"acute":[161],"inhibition":[163],"Tac1+;":[165],"Calca-":[166],"following":[168],"injection":[169],"expresses":[173,222],"iC++":[174],"contain":[178],"FlpO":[182,191,214],";":[189,212],"Calca":[190,213],"mice.":[192],"assess":[194],"spiking":[196,352],"activity":[197,269,369],"relative":[202],"ongoing":[204],"patterns,":[206],"ChRmine":[223,294],"containing":[226],"FlpO,":[230],"cranial":[232,266,286],"window":[233,287],"created":[235],"dorsal":[236],"head":[242],"bar":[243],"secured":[244],"skull.":[247],"2":[249],"weeks,":[250],"head-fixed":[253],"high-density":[256],"neuropixels":[257],"probe":[258],"inserted":[260],"into":[261],"via":[264],"window.":[267],"Multi-unit":[268],"recorded":[271],"from":[272],"awake,":[273],"freely":[274],"simultaneous":[278],"pattern.":[282],"Illumination":[283],"red":[289],"sufficient":[292],"mediated":[295],"Tac1+;Calca-":[298],"neurons,":[300,372],"producing":[301],"robust":[303],"increase":[304],"frequency.":[307],"Recorded":[308],"units":[310],"then":[312],"optically":[313],"tagged":[314],"assessing":[316],"their":[317,374],"response":[318],"latency":[319],"fidelity":[321],"repeated":[323],"10":[324],"ms":[325],"pulses.":[327],"\u201cOptotagging\u201d":[328],"Neuropixels":[330],"recordings":[332],"suggested":[336],"mostly":[342],"quiescent":[343],"resting":[345],"breathing,":[347],"switches":[349],"tonic":[351],"periods":[354],"non-homeostatic":[356,397],"including":[358],"rapid":[359],"sniffing":[360],"bouts":[361],"induced":[362],"odorants.":[364],"Isoflurane":[365],"anesthesia":[366],"abolished":[367],"light-evoked":[368],"optotagged":[371],"underlying":[373],"state-dependent":[375],"function.":[376],"conclude":[378],"functions":[383],"as":[384],"switch-like":[386],"mechanism":[387],"inactive":[390],"at":[391,412],"rest":[392],"activated":[395],"patters":[399],"are":[401],"unique":[402],"state.":[406],"R01HL166317":[407],"This":[408],"abstract":[409],"presented":[411],"American":[414],"Physiology":[415,434],"Summit":[416],"2025":[417],"only":[420],"available":[421],"HTML":[423],"format.":[424],"There":[425],"no":[427],"downloadable":[428],"file":[429],"PDF":[431],"version.":[432],"The":[433],"editorial":[435],"board":[436],"involved":[439],"peer":[442],"review":[443],"process.":[444]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2025-10-10T00:00:00"}
