{"id":"https://openalex.org/W4411875673","doi":"https://doi.org/10.1152/physiol.2025.40.s1.0516","title":"Regulation of acid-base balance in Dahl Salt-sensitive rats on normal- and high-salt diets","display_name":"Regulation of acid-base balance in Dahl Salt-sensitive rats on normal- and high-salt diets","publication_year":2025,"publication_date":"2025-05-01","ids":{"openalex":"https://openalex.org/W4411875673","doi":"https://doi.org/10.1152/physiol.2025.40.s1.0516"},"language":"en","primary_location":{"id":"doi:10.1152/physiol.2025.40.s1.0516","doi":"https://doi.org/10.1152/physiol.2025.40.s1.0516","is_oa":false,"landing_page_url":"https://doi.org/10.1152/physiol.2025.40.s1.0516","pdf_url":null,"source":{"id":"https://openalex.org/S88977973","display_name":"Physiology","issn_l":"0886-1714","issn":["0886-1714","1522-161X","1548-9213","1548-9221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079987363","display_name":"Biyang Xu","orcid":"https://orcid.org/0000-0002-9395-5097","observed_orcids":["https://orcid.org/0000-0002-9395-5097"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Biyang Xu","raw_affiliation_strings":["University of South Florida, Tampa, FL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Florida, Tampa, FL, United States","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118749480","display_name":"Washington Drosin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Washington Drosin","raw_affiliation_strings":["University of South Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Florida","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091734587","display_name":"Steven Didik","orcid":"https://orcid.org/0000-0001-7078-7193","observed_orcids":["https://orcid.org/0000-0001-7078-7193"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Didik","raw_affiliation_strings":["University of South Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Florida","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103102416","display_name":"Vladislav Levchenko","orcid":"https://orcid.org/0000-0003-0771-8034","observed_orcids":["https://orcid.org/0000-0003-0771-8034"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vladislav Levchenko","raw_affiliation_strings":["University of South Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Florida","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005174825","display_name":"Alexander Staruschenko","orcid":"https://orcid.org/0000-0002-5190-8356","observed_orcids":["https://orcid.org/0000-0002-5190-8356"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Staruschenko","raw_affiliation_strings":["University of South Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South Florida","institution_ids":["https://openalex.org/I2613432"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5079987363"],"corresponding_institution_ids":["https://openalex.org/I2613432"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1593818,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10606","display_name":"Kidney Stones and Urolithiasis Treatments","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acid-base-balance","display_name":"acid-base balance","score":0.9089999794960022},{"id":"https://openalex.org/keywords/dahl-salt-sensitive-rats","display_name":"Dahl salt-sensitive rats","score":0.8790000081062317},{"id":"https://openalex.org/keywords/salt-sensitivity","display_name":"salt sensitivity","score":0.7350000143051147},{"id":"https://openalex.org/keywords/high-salt-diet","display_name":"high-salt diet","score":0.9440000057220459},{"id":"https://openalex.org/keywords/acid-load","display_name":"acid load","score":0.8019999861717224},{"id":"https://openalex.org/keywords/ammonium-chloride","display_name":"ammonium chloride","score":0.8529999852180481},{"id":"https://openalex.org/keywords/blood-ph","display_name":"blood pH","score":0.9070000052452087},{"id":"https://openalex.org/keywords/blood-bicarbonate","display_name":"blood bicarbonate","score":0.8379999995231628},{"id":"https://openalex.org/keywords/urine-ph","display_name":"urine pH","score":0.6700000166893005},{"id":"https://openalex.org/keywords/urinary-ammonium","display_name":"urinary ammonium","score":0.9369999766349792},{"id":"https://openalex.org/keywords/renal-acid-excretion","display_name":"renal acid excretion","score":0.6800000071525574},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7319999933242798},{"id":"https://openalex.org/keywords/sodium-chloride-intake","display_name":"sodium chloride intake","score":0.5950000286102295},{"id":"https://openalex.org/keywords/hypertension-risk","display_name":"hypertension risk","score":0.45399999618530273},{"id":"https://openalex.org/keywords/urine-output","display_name":"urine output","score":0.32199999690055847},{"id":"https://openalex.org/keywords/urine-osmolality","display_name":"urine osmolality","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C134746045","wikidata":"https://www.wikidata.org/wiki/Q3275718","display_name":"Acid\u2013base homeostasis","level":2,"score":0.7140700817108154},{"id":"https://openalex.org/C2776371256","wikidata":"https://www.wikidata.org/wiki/Q12370","display_name":"Salt (chemistry)","level":2,"score":0.6668068170547485},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5343121290206909},{"id":"https://openalex.org/C42058472","wikidata":"https://www.wikidata.org/wiki/Q810214","display_name":"Base (topology)","level":2,"score":0.501713752746582},{"id":"https://openalex.org/C168031717","wikidata":"https://www.wikidata.org/wiki/Q1530280","display_name":"Balance (ability)","level":2,"score":0.49368128180503845},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4367419183254242},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4227755069732666},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40710940957069397},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4056480824947357},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.33096662163734436},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18601706624031067},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.06697064638137817},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1152/physiol.2025.40.s1.0516","doi":"https://doi.org/10.1152/physiol.2025.40.s1.0516","is_oa":false,"landing_page_url":"https://doi.org/10.1152/physiol.2025.40.s1.0516","pdf_url":null,"source":{"id":"https://openalex.org/S88977973","display_name":"Physiology","issn_l":"0886-1714","issn":["0886-1714","1522-161X","1548-9213","1548-9221"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2040290132","https://openalex.org/W2386367800","https://openalex.org/W2353574976","https://openalex.org/W2361068457","https://openalex.org/W1824021510","https://openalex.org/W4384702906","https://openalex.org/W2302275837","https://openalex.org/W2146016398","https://openalex.org/W2157129342","https://openalex.org/W2318820787"],"abstract_inverted_index":{"Acid-base":[0],"homeostasis":[1],"is":[2,16,594,601],"essential":[3],"for":[4,74,93,110],"normal":[5,40],"physiological":[6],"function.":[7],"Previous":[8],"studies":[9,543],"suggested":[10],"that":[11,133],"salt":[12,41,47],"sensitivity":[13],"in":[14,71,107,264,386,394,445,549,552,555,597,615],"humans":[15],"associated":[17],"with":[18,68,89,104,192,358],"abnormal":[19],"acid-base":[20,536,553],"regulation.":[21],"Here,":[22],"we":[23],"aim":[24],"to":[25,31,37,151,282,428,501,522,539],"use":[26],"Dahl":[27],"salt-sensitive":[28],"(SS)":[29],"rats":[30,60,85,136,163,199,206,256,278,302,307,324,375,389,395,405,431,475,485,507,533],"evaluate":[32],"the":[33,53,78,129,157,193,204,208,213,218,289,310,319,400,440,526,547,556,562,588,616],"response":[34],"of":[35,128,160,196,223,296,370,566,575],"kidneys":[36],"acid-loading":[38,149,209,286,359,401,437],"under":[39],"(0.4%":[42],"NaCl,":[43,49],"NS)":[44,339,355,426],"and":[45,58,83,96,116,126,178,239,276,292,300,364,373,379,461,494,511,530,560,573,593],"high":[46],"(4%":[48],"HS)":[50],"conditions.":[51],"For":[52,77],"NS":[54,152,165,205,226,255,275,299,306,372,397,430,448,502,523,540],"group,":[55,80],"10-week-old":[56],"male":[57,82,134,162,197,225,254,283,322,371,387,483,529],"female":[59,84,274,298,429,447,505,531],"were":[61,86,120,271],"given":[62,98],"0.28":[63,99],"M":[64,100],"NH":[65,101,343,367,383,414,442,497,518],"4":[66,102,344,368,384,415,443,498,519],"Cl":[67,103],"1%":[69,105],"sucrose":[70,106],"drinking":[72,108],"water":[73,109],"8":[75,111,127],"days.":[76,112],"HS":[79,91,135,179,198,240,277,301,323,337,353,374,388,404,424,462,484,506,532],"8-week-old":[81],"first":[87],"fed":[88,164,396],"a":[90],"diet":[92,398],"3":[94,146,221,269,294,313,378],"weeks":[95],"then":[97],"Tail":[113],"vein":[114],"blood":[115,140,144,158,194,219,265,290,311,489,510],"24":[117],"hr":[118],"urine":[119,328,362,408,492,512],"collected":[121],"at":[122,587],"days":[123,377],"0,":[124],"3,":[125,305],"acid-loading.":[130,280,563],"Results":[131],"showed":[132,534],"had":[137,406,486,508],"significantly":[138,155,201,216,287,326,360,391,411,438,487,515],"lower":[139,202,341,392,412,488,495,516],"pH":[141,159,195,266,291,329,363,409,513],"but":[142,340,410,514],"similar":[143,407,509],"HCO":[145,220,268,293,312],"-":[147,222,270,295,314],"before":[148,279,356,432,481,559],"compared":[150,427,500,521,538],"rats.":[153,524,541],"Acid-loading":[154],"decreased":[156,217],"both":[161,224,297,446,528,558],"(7.39":[166],"\u00b1":[167,171,181,185,228,232,242,246,331,335,347,351,418,422,450,454,464,468],"0.02":[168],"vs":[169,175,183,189,230,236,244,250,333,338,349,354,420,425,452,458,466,472],"7.27":[170],"0.09;":[172],"day":[173,176,187,190,234,237,248,251,260,304,316,456,459,470,473,477],"0":[174,188,235,249,457,471],"3)":[177,238,252,460,474],"(7.37":[180],"0.01":[182],"7.15":[184],"0.06;":[186],"3),":[191],"remained":[200,390],"than":[203,393],"throughout":[207,399],"period.":[210,402],"Interesintly,":[211],"although":[212],"acid":[214,433],"loading":[215],"(27.3":[227],"2.3":[229],"17.9":[231],"3.7;":[233],"(27.4":[241],"0.5":[243],"13.9":[245],"2.2;":[247],"rats,":[253,284,503],"completely":[257,308],"recovered":[258,309],"on":[259,303,315,376,476,545],"8.":[261,317,380],"No":[262],"differences":[263],"or":[267,605],"observed":[272],"between":[273],"Similar":[281],"while":[285,504],"lowered":[288,361],"On":[318],"other":[320],"hand,":[321],"exhibited":[325],"higher":[327,491],"(5.7":[330],"0.1":[332],"5.6":[334],"0.1;":[336],"urinary":[342,366,382,413,441,496,517],"+":[345,369,385,416,444,499,520],"(8.7":[346],"3.5":[348],"33.0":[350],"11.4;":[352],"acid-loading,":[357,482,527],"elevated":[365],"Additionally,":[381],"Female":[403],"(10.7":[417,463],"4.8":[419,465],"34.6":[421],"7.2;":[423],"loading.":[434],"Further":[435],"more,":[436],"increased":[439],"(34.6":[449],"8.5":[451],"80.0":[453],"26.6;":[455],"41.2":[467],"4.5;":[469],"3.":[478],"In":[479],"summary,":[480],"pH,":[490,493],"During":[525],"impaired":[535],"regulation":[537,554],"Ongoing":[542],"focus":[544],"evaluating":[546],"changes":[548],"key":[550],"transporters":[551],"kidney":[557],"after":[561],"National":[564],"Institute":[565],"Health":[567],"Grants":[568],"R01":[569],"DK135644":[570],"(to":[571,581],"AS)":[572],"Department":[574],"Veterans":[576],"Affairs":[577],"grant":[578],"I01":[579],"BX004024":[580],"AS).":[582],"This":[583],"abstract":[584],"was":[585,612],"presented":[586],"American":[589],"Physiology":[590,609],"Summit":[591],"2025":[592],"only":[595],"available":[596],"HTML":[598],"format.":[599],"There":[600],"no":[602],"downloadable":[603],"file":[604],"PDF":[606],"version.":[607],"The":[608],"editorial":[610],"board":[611],"not":[613],"involved":[614],"peer":[617],"review":[618],"process.":[619]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}